Dynamics of Dark-Bright Solitons in Cigar-Shaped Bose-Einstein Condensates

We explore the stability and dynamics of dark-bright solitons in two-component elongated Bose-Einstein condensates by developing effective 1D vector equations as well as solving the corresponding 3D Gross-Pitaevskii equations. A strong dependence of the oscillation frequency and of the stability of the dark-bright (DB) soliton on the atom number of its components is found. Spontaneous symmetry breaking leads to oscillatory dynamics in the transverse degrees of freedom for a large occupation of the component supporting the dark soliton. Moreover, the interactions of two DB solitons are investigated with special emphasis on the importance of their relative phases. Experimental results showcasing dark-bright soliton dynamics and collisions in a BEC consisting of two hyperfine states of $^{87}$Rb confined in an elongated optical dipole trap are presented.Comment: 4 pages, 5 figure

Paricalcitol reduces peritoneal fibrosis in mice through the activation of regulatory T cells and reduction in IL-17 production

Fibrosis is a significant health problem associated with a chronic inflammatory reaction. The precise mechanisms involved in the fibrotic process are still poorly understood. However, given that inflammation is a major causative factor, immunomodulation is a possible therapeutic approach to reduce fibrosis. The vitamin D receptor (VDR) that is present in all hematopoietic cells has been associated with immunomodulation. We investigated whether the intraperitoneal administration of paricalcitol, a specific activator of the VDR, modulates peritoneal dialysis fluid (PDF)-induced peritoneal fibrosis. We characterized the inflammatory process in the peritoneal cavity of mice treated or not treated with paricalcitol and analyzed the ensuing fibrosis. The treatment reduced peritoneal IL-17 levels, which strongly correlated with a significantly lower peritoneal fibrotic response. In vitro studies demonstrate that both CD4+ and CD8+ regulatory T cells appear to impact the regulation of IL-17. Paricalcitol treatment resulted in a significantly increased frequency of CD8+ T cells showing a regulatory phenotype. The frequency of CD4+ Tregs tends to be increased, but it did not achieve statistical significance. However, paricalcitol treatment increased the number of CD4+ and CD8+ Treg cells in vivo. In conclusion, the activation of immunological regulatory mechanisms by VDR signaling could prevent or reduce fibrosis, as shown in peritoneal fibrosis induced by PDF exposure in mice.This study was supported by RETICS 06/0016 (VFM, RS) and FIS PI 09/0064 (RS) from the Fondo de Investigaciones Sanitarias (Health Research Fund). MLC was funded by SAF 2013-47611-R, SAF 2010-21249, and SAF 2007-61201 from the Ministerio de Economía y competitividad. MRO was supported by RETICS 12/0021,S2012DMD2321 from the Comunidad Autónoma de Madrid, PI 11/01854 from Fondo Investigaciones Sanitarias. GTGM was supported by Renal Foundation Íñigo Álvarez de Toledo, FIBHULP, and by Severo Ochoa FoundationPeer Reviewe

Functional Massage of the Teres Major Muscle in Patients with Subacromial Impingement Syndrome. A Randomized Controlled Case Series Study.

Objective: the purpose of the present study was to analyze the concurrent validity and reliability of a force platform clinical COBS Feedback® for the estimation of the height of vertical jumps. Design: a cross-sectional correlational and comparative study. Setting: University Human Movement and Physiotherapy Laboratory. Participants: healthy university students (14 female and 13 male) aged between 18 and 25 years old (mean = 20.074 ±1.542). Main Outcome Measures: vertical jump heights, technical error and grade of agreement between methods of measurement. Results: after the 27 subjects performed a total of 135 vertical jumps on COBS Feedback®platform while simultaneously being recorded with a high-speed camera-based method, the intraclass correlation coefficient showed an almost perfect concordance between the two methods (ICC = 0.916, CI95%= 0.882 to 0.940, p<0.001). The technical error of the COBS Feedback® against HSC-Kinovea video analysis was at 0.310±0.223m, being higher in males than in females (t= -2.822, CI95%: -0.376 to -0.574, p=0.001). Conclusions: the COBS Feedback® method provided a valid measurement of the flight times for estimate the vertical jump height as a number of well-known tests and devices.Aims: Subacromial impingement syndrome is the most common shoulder condition. Myofascial trigger points in teres major muscle can be associated with this syndrome. Our objective is to determine whether adding manual therapy specifically for teres major trigger points can produce better results in these patients. Study Design: Randomized controlled case series. Place and Duration of Study: Public Primary Care Center in the Spanish National Health System (Cornellà de Llobregat - Barcelona) and the FREMAP Mutual Society for Work-related Injuries and Occupational Illness (Arnedo - La Rioja), between January and March 2014. Methodology: Fifty-eight people were recruited but 8 subjects were lost during the follow-up period. The sample consisted of 50 patients (17 male and 33 female, age range 23-80 years) randomly assigned to one of two groups: the intervention group or the control group. Both groups received a protocolized physical therapy treatment, while the intervention group also received manual therapy for teres major trigger points. Results: Pain intensity (p=.01) and function (p=.01) showed significant improvement in the control group, whereas pain intensity (p=.01), function (p=.01) and active range of motion (p=.01) showed significant improvement in the intervention group. Between-group differences were statistically significant for abduction (p=.01), extension (p=.02) and lateral rotation (p=.02), and clinically significant (Cohen’s d) for function, flexion, extension, lateral rotation and abduction. Conclusion: Although our findings must be considered as preliminary, they suggest that adding manual therapy to treat teres major trigger points achieves better results in the glenohumeral range of motion

Efectos de la tarea dual sobre el tiro libre en baloncesto

El objetivo de este estudio fue estudiar los efectos de una tarea dual en el tiro libre en baloncesto, comparando esa influencia en función de la categoría y el sexo de los jugadores. Los resultados muestran que existe un descenso del rendimiento provocado por la tarea dual de los baloncestistas de categoría infantil y junior (p&lt;0,05), no observándose lo mismo en la categoría senior. Tampoco se detectaron diferencias significativas entre el rendimiento de hombres y mujeres. Puede afirmarse, por tanto, que las tareas duales provocan un descenso en el rendimiento, sobre todo en etapas de formación, posiblemente por la automatización del patrón motor debido a un mayor tiempo de práctica en categorías senior. Por ello, las tareas duales pueden ser incluidas en los entrenamientos para crear situaciones estresantes y bajo presión similares a las que se pueden encontrar los deportistas en situaciones competitivas reales

Multiple-banked Register File Architectures

The register file access time is one of the critical delays in current superscalar processors. Its impact on processor performance is likely to increase in future processor generations, as they are expected to increase the issue width (which implies more register ports) and the size of the instruction window (which implies more registers), and to use some kind of multithreading. Under this scenario, the register file access time could be a dominant delay and a pipelined implementation would be desirable to allow for high clock rates. However, a multi-stage register file has severe implications for processor performance (e.g. higher branch misprediction penalty) and complexity (more levels of bypass logic). To tackle these two problems, in this paper we propose a register file architecture composed of multiple banks. In particular we focus on a multi-level organization of the register file, which provides lo

The Antioxidant Potential of the Mediterranean Diet in Patients at High Cardiovascular Risk: An In-Depth Review of the PREDIMED

Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols. Subgroup analysis of the PREDIMED trial revealed increased endogenous antioxidant and decreased pro-oxidant activity in the MedDiet groups. Moreover, higher polyphenol intake was associated with lower incidence of the primary outcome, overall mortality, blood pressure, inflammatory biomarkers, onset of new-onset type 2 diabetes mellitus (T2DM), and obesity. This suggests that polyphenols likely contributed to the lower incidence of the primary event in the MedDiet groups. In this article, we summarize the potential benefits of polyphenols found in the MedDiet, specifically the PREDIMED cohort. We also discuss the need for further research to confirm and expand the findings of the PREDIMED in a non-Mediterranean population and to determine the exact mechanisms of action of polyphenols

The AGB population of NGC 6822: distribution and the C/M ratio from JHK photometry

NGC 6822 is an irregular dwarf galaxy and part of the Local Group. Its close proximity and apparent isolation provide a unique opportunity to study galactic evolution without any obvious strong external influences. This paper aims to study the spatial distribution of the asymptotic giant branch (AGB) population and metallicity in NGC 6822. Using deep, high quality JHK photometry, taken with WFCAM on UKIRT, carbon- and oxygen-rich AGB stars have been isolated. The ratio between their number, the C/M ratio, has then been used to derive the [Fe/H] abundance across the galaxy. The tip of the red giant branch is located at K0 = 17.41 \pm 0.11 mag and the colour separation between carbon- and oxygen-rich AGB stars is at (J - K)0 = 1.20 \pm 0.03 mag (i.e. (J - K)2MAS S {\guillemotright} 1.28 mag). A C/M ratio of 0.62 \pm 0.03 has been derived in the inner 4 kpc of the galaxy, which translates into an iron abundance of [Fe/H] = -1.29\pm0.07 dex. Variations of these parameters were investigated as a function of distance from the galaxy centre and azimuthal angle. The AGB population of NGC 6822 has been detected out to a radius of 4 kpc giving a diameter of 56 arcmin. It is metal-poor, but there is no obvious gradient in metallicity with either radial distance from the centre or azimuthal angle. The detected spread in the TRGB magnitude is consistent with that of a galaxy surrounded by a halo of old stars. The C/M ratio has the potential to be a very useful tool for the determination of metallicity in resolved galaxies but a better calibration of the C/M vs. [Fe/H] relation and a better understanding of the sensitivities of the C/M ratio to stellar selection criteria is first required