Mechanics of liquid helium in a partially filled rotating dewar in low gravity with application to Gravity Probe-B

The Gravity Probe-B spacecraft is composed largely of a liquid helium dewar containing an experiment package. It is shown that an unsymmetric liquid helium distribution in the dewar can cause unacceptably high forces, gravitational and gravity gradient forces, at the experiment location. It is further shown that for the planned spacecraft configuration and operational parameters, it is very likely that the liquid helium distribution in the dewar will be unsymmetric. The required symmetry can be attained by using higher operational spacecraft rotation rates

Further Characterization of Dopamine Release by Permeabilized PC 12 Cells

Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells). We also observed Ca2+-dependent [3H]-dopamine release from digitonin-permeabilized PC 12 cells. Permeabilization with α-toxin or digitonin and stimulation of the cells were done consecutively to wash out endogenous Mg2+-ATP. During permeabilization, ATP was removed effectively from the cytoplasm by both agents but the cells released [3H]dopamine in response to micromolar Ca2+ alone. Replacement by chloride of glutamate, which could sustain mitochondrial ATP production in permeabilized cells, does not significantly alter catecholamine release induced by Ca2+. However, Mg2+ without ATP augments the Ca2+-induced release. The release was unaltered by thiol-, hydroxyl-, or calmodulin-interfering substances. Thus Mg2+-ATP, calmodulin, or proteins containing -SH or -OH groups are not necessary for exocytosis in permeabilized PC 12 cells

A new approach to modelling impacts on rubble pile asteroid simulants

Many asteroids with low bulk densities must have a rubble pile structure and internal voids. Although little is known about their internal structure, numerical simulations of impact events on these asteroids rely on assumptions on how the voids are distributed. We present a new approach to model impacts on rubble pile asteroids that explicitly takes into account their internal structure. The formation of the asteroid is modelled as a rubble pile aggregate of spherical pebbles of different sizes. This aggregate is then converted into a high-resolution smoothed particle hydrodynamics (SPH) model, accounting for macroporosity inside the pebbles. We compare impact-event outcomes for a large set of internal configurations to explore the parameter space of our model-building process. The analysis of the fragment size distribution and the disruption threshold quantifies the specific influence of each input parameter. The size distribution of the pebbles used in our model is a simple power law, containing three free parameters: the slope α, the lower cut-off radius rmin and the upper cut-off radius rmax. The influence of all three parameters on the outcome is assessed in this paper. The existence of void space in our model increases the resistance against collisional disruption, a behaviour previously reported based on numerical simulations using a continuum description of porous material (Holsapple 2009). We show, for a set of asteroid collisions typical for small asteroids in the main belt, that no a priori knowledge of the exact size distribution of the pebbles inside the asteroid is needed, as the choice of the corresponding parameters does not directly correlate with the impact outcome

Bingham Dai, Adolf Storfer, and the tentative beginnings of psychoanalytic culture in China, 1935-1941.

This paper looks at the work of two figures who, while marginal to theoretical developments within the history of psychoanalysis, each briefly played an important role in the dissemination of analytical ideas in China, contributing to an early psychoanalytic culture there. Bingham Dai, a native of China, while studying for a PhD in sociology at Chicago, received instruction from Harry Stack Sullivan and a psychoanalytic training under Karen Horney's supervision. However, the neo-Freudian outlook with which this experience imbued him had its roots in an earlier encounter with his experiments in personality education first conducted on students in a Tientsin high school, and later in Shantung under the direction of the conservative Confucian scholar and reformer, Liang Shu Ming. These experiences convinced him that a less orthodox psychoanalytic perspective was what Chinese patients with psychological problems required. He returned in 1935 to teach medical psychology to doctors at Peking Union Medical College, taking a few into analysis and treating some patients. However, the Sino-Japanese war brought these activities to a close and he left in 1939, just a few months after the former Freud publisher and Viennese émigré, Adolf Storfer, arrived. Storfer set about publishing "Gelbe Post," a German language periodical replete with articles on psychoanalysis, linguistics and Chinese culture. But limited finances, severe competition from a rival publisher, plus his own ill health, forced him to abandon this in spite of the support offered him through the many contributors in the international psychoanalytic community whose articles he published. The paper concludes by considering the relative historiographic fate of the men upon whom subsequent scholarship has been very unevenly focused.published_or_final_versio

Satellite Tracking of Eastern Chukchi Sea Beluga Whales into the Arctic Ocean

Beluga whales (Delphinapterus leucas) congregate in nearshore waters of the eastern Chukchi Sea, especially in Kotzebue Sound and Kasegaluk Lagoon, in June and July. Where they travel after they leave this area was unknown before this study. We live-captured five belugas in Kasegaluk Lagoon and attached satellite-linked depth recorders to them. The belugas, caught between 26 June and 1 July 1998, were all males, ranging in length from 398 to 440 cm. A 310 cm gray beluga accompanied the smallest male. Two tags transmitted for only about two weeks, during which time one animal remained in the vicinity of Icy Cape, 80 km north of the capture site, and the other traveled to Point Barrow, about 300 km north. The other three tags operated for 60-104 days, and those belugas traveled more than 2000 km, reaching 80° N and 133° W, almost 1100 km north of the Alaska coast. This journey required them to move through 700 km of more than 90% ice cover. Two of the whales then moved southward into the Beaufort Sea north and east of Point Barrow. Two whales later moved to an area north of the Mackenzie River delta, where they spent 2-3 weeks before once again heading southwest towards Barrow. En juin et juillet, des bélougas (Delphinapterus leucas) se rassemblent dans les eaux littorales de l'est de la mer des Tchouktches, en particulier dans le détroit de Kotzebue et la lagune de Kasegaluk. Avant la présente étude, on ne savait pas où ils allaient après avoir quitté la région. Dans la lagune de Kasegaluk, on a capturé vivants cinq bélougas qu'on a équipés de sondeurs acoustiques en liaison avec un satellite. Les bélougas, capturés entre le 26 juin et le 1er juillet 1998, étaient tous de mâles, et mesuraient de 398 à 440 cm de long. Un bélouga gris de 310 cm accompagnait le plus petit mâle. Deux sondes n'ont retransmis que durant deux semaines, au cours desquelles un individu est resté aux environs du cap Icy, à 80 km au nord du site de capture, tandis que l'autre s'est rendu à la pointe Barrow, à environ 300 km au nord. Les trois autres sondes ont fonctionné de 60 à 104 jours, période durant laquelle les bélougas ont parcouru plus de 2000 km, atteignant un point situé à 80° de lat. N. et 133° de long. O., à environ 1100 km au nord de la côte alaskienne. Ce voyage exigeait d'eux qu'ils franchissent 700 km d'eau couverte de glace à plus de 90 p. cent. Deux des baleines ont ensuite viré vers le sud pour pénétrer dans la mer de Beaufort au nord et à l'est de la pointe Barrow. Deux baleines se sont ensuite rendues dans une zone située au nord du delta du Mackenzie, où elles ont passé de 2 à 3 semaines avant de mettre à nouveau le cap sur le sud-ouest, en direction de Barrow.

Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy

This is the author accepted manuscript. The final version is available from Future Medicine via the DOI in this recordAim: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQD) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. Materials & methods: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. Results: GQDs demonstrated excellent photo-luminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. Conclusion: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.This work was supported by the EPSRC Centre for Doctoral Training in Metamaterials, XM2 (grant number EP/L015331/1

A new estimation of the recent tropospheric molecular hydrogen budget using atmospheric observations and variational inversion

This paper presents an analysis of the recent tropospheric molecular hydrogen (H2) budget with a particular focus on soil uptake and European surface emissions. A variational inversion scheme is combined with observations from the RAMCES and EUROHYDROS atmospheric networks, which include continuous measurements performed between mid-2006 and mid-2009. Net H2 surface flux, then deposition velocity and surface emissions and finally, deposition velocity, biomass burning, anthropogenic and N2 fixation-related emissions were simultaneously inverted in several scenarios. These scenarios have focused on the sensibility of the soil uptake value to different spatio-temporal distributions. The range of variations of these diverse inversion sets generate an estimate of the uncertainty for each term of the H2 budget. The net H2 flux per region (High Northern Hemisphere, Tropics and High Southern Hemisphere) varies between −8 and +8 Tg yr−1. The best inversion in terms of fit to the observations combines updated prior surface emissions and a soil deposition velocity map that is based on bottom-up and top-down estimations. Our estimate of global H2 soil uptake is −59±9 Tg yr−1. Forty per cent of this uptake is located in the High Northern Hemisphere and 55% is located in the Tropics. In terms of surface emissions, seasonality is mainly driven by biomass burning emissions. The inferred European anthropogenic emissions are consistent with independent H2 emissions estimated using a H2/CO mass ratio of 0.034 and CO emissions within the range of their respective uncertainties. Additional constraints, such as isotopic measurements would be needed to infer a more robust partition of H2 sources and sinks

Spitzer observations of the asteroid-comet transition object and potential spacecraft target 107P (4015) Wilson-Harrington

Context. Near-Earth asteroid-comet transition object 107P/ (4015) Wilson-Harrington is a possible target of the joint European Space Agency (ESA) and Japanese Aerospace Exploration Agency (JAXA) Marco Polo sample return mission. Physical studies of this object are relevant to this mission, and also to understanding its asteroidal or cometary nature. Aims. Our aim is to obtain significant new constraints on the surface thermal properties of this object. Methods. We present mid-infrared photometry in two filters (16 and 22 microns) obtained with NASA's Spitzer Space Telescope on February 12, 2007, and results from the application of the Near Earth Asteroid Thermal Model (NEATM).We obtained high S/N in two mid-IR bands allowing accurate measurements of its thermal emission. Results. We obtain a well constrained beaming parameter (eta = 1.39 +/- 0.26) and obtain a diameter and geometric albedo of D = 3.46 +/- 0.32 km, and pV = 0.059 +/- 0.011. We also obtain similar results when we apply this best-fitting thermal model to single-band mid-IR photometry reported by Campins et al. (1995), Kraemer et al. (2005) and Reach et al. (2007). Conclusions. The albedo of 4015 Wilson-Harrington is low, consistent with those of comet nuclei and primitive C-, P-, D-type asteorids. We establish a rough lower limit for the thermal inertia of W-H of 60 Jm^-2s^(-0.5)K^-1 when it is at r=1AU, which is slightly over the limit of 30 Jm^-2s^(-0.5)K-1 derived by Groussin et al. (2009) for the thermal inertia of the nucleus of comet 22P/Kopff.Comment: 4 pages, 1 figure and 3 tables. Paper accepted for publicatio

Physical Investigation of the Potentially Hazardous Asteroid (144898) 2004 VD17

In this paper we present the observational campaign carried out at ESO NTT and VLT in April and May 2006 to investigate the nature and the structure of the Near Earth Object (144898) 2004 VD17. In spite of a great quantity of dynamical information, according to which it will have a close approach with the Earth in the next century, the physical properties of this asteroid are largely unknown. We performed visible and near--infrared photometry and spectroscopy, as well as polarimetric observations. Polarimetric and spectroscopic data allowed us to classify 2004 VD17 as an E-type asteroid. A good agreement was also found with the spectrum of the aubrite meteorite Mayo Belwa. On the basis of the polarimetric albedo (p_v=0.45) and of photometric data, we estimated a diameter of about 320 m and a rotational period of about 2 hours. The analysis of the results obtained by our complete survey have shown that (144898) 2004 VD17 is a peculiar NEO, since it is close to the breakup limits for fast rotator asteroids, as defined by Pravec and Harris (2000). These results suggest that a more robust structure must be expected, as a fractured monolith or a rubble pile in a "strength regime" (Holsapple 2002).Comment: 32 pages, 7 figure, paper accepted for publication in Icaru