4,064 research outputs found
Data-Driven Wheel Slip Diagnostics for Improved Railway Operations
Wheel slip activity detection is crucial in railway maintenance, as it can contribute to avoiding wheel damage but also track deteriorations leading to significant maintenance costs, trains delays, as well as the risk of accidents. Wheel slip activity is characterised by lower adhesion between track and wheel, especially in braking conditions, locking the wheels. It is complex to model or predict, being influenced by a multitude of factors including ambient conditions, global vehicle load, track and axle quality, leaves and objects present on the rail, steep incline, oxidation of the rails, and braking forces applied to the wheels. This paper presents a combined wavelet and tuned Long-Short Term Memory (LSTM) approach for the detection of wheel slip from time series data collected from real-world trains. Results provide evidence of superior performance over methods such as decision trees and random forests, naïve Bayes, k-nearest neighbours, logistic regression, and support vector machines
Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study
The capacity of hydrazone bonds to readily undergo component exchange processes sees their extensive utilization in dynamic combinatorial chemistry. The kinetics of hydrazone exchange are optimal at pH ∼4.5, which limits the use of hydrazone-based dynamic combinatorial libraries, particularly for biological targets which are only stable at near-neutral pH values. It would thus be advantageous if hydrazone exchange proceeded with faster rates at pH values closer to neutral. We experimentally and computationally evaluated the hypothesis that hydrazones possessing neighbouring acidic or basic functional groups within the carbonyl-derived moitety of the hydrazone would enhance exchange rates. Our work suggests that judiciously placed N- or O-hydrogen bond acceptors within the carbonyl-derived moiety of the hydrazone stabilize transition states via hydrogen bonding interactions, providing a valuable boost to exchange kinetics at near-neutral pH values. We anticipate these findings will be of interest in dynamic combinatorial chemistry, dynamic covalent polymers/materials, functionalized nanoparticles and interlocked molecules, all of which may benefit from hydrazone exchange processes able to operate at near-neutral pH values
Inspection of floating platform mooring chains with a climbing robot
This paper describes the development of Moorinspect, a novel robot that can climb on platform mooring chains both underwater and in air to non-destructively test (NDT) each link with long range ultrasound guided waves. The prototype robot is designed to be able to climb up/down a mooring chain for up to twenty metres below the surface, climb up through the splash zone to the first link which is located in air and connected to the turret of a Floating Production Storage and Offloading (FPSO) facility. This first link suffers the most intense stresses and fatigue failure and thus it is important to test its integrity. A robot that can climb through the splash zone (considered to be the most dangerous zone for human divers) will be the first of its kind. The robot is able to cope with link dimension variations due to corrosion and biological fouling and link curvatures caused by bent links, chain curvature due to gravity, and links twisted at angles of up to eight degrees around a nominal angle of ninety degrees. The robot places an NDT collar consisting of ultrasound probes around the full circumference of each link to be tested. The design has been analysed extensively using Von Mises stress analysis to ensure that the robot is strong and robust enough to carry a sensor payload of more than 70 kg and a robot weighing 500 kg in air and is able to operate in the splash zone. A first prototype chain climbing robot has been tested via trials on a four link mooring chain suspended in air and while immersed in a diving tank
Genetic origins of social networks in rhesus macaques
This is the final version of the article. Available from the publisher via the DOI in this record.Sociality is believed to have evolved as a strategy for animals to cope with their environments. Yet the genetic basis of sociality remains unclear. Here we provide evidence that social network tendencies are heritable in a gregarious primate. The tendency for rhesus macaques, Macaca mulatta, to be tied affiliatively to others via connections mediated by their social partners - analogous to friends of friends in people - demonstrated additive genetic variance. Affiliative tendencies were predicted by genetic variation at two loci involved in serotonergic signalling, although this result did not withstand correction for multiple tests. Aggressive tendencies were also heritable and were related to reproductive output, a fitness proxy. Our findings suggest that, like humans, the skills and temperaments that shape the formation of multi-agent relationships have a genetic basis in nonhuman primates, and, as such, begin to fill the gaps in our understanding of the genetic basis of sociality.We thank Bonn Aure, Jacqueline Buhl, Monica Carlson, Matthew McConnell, Elizabeth Maldonado, David Paulsen, Cecilia Penedo & the Caribbean Primate Research Center (CPRC) for assistance, and Roger Mundry for the use of PSAM software. The authors were supported by NIMH grant R01-MH089484, an Incubator Award from the Duke Institute for Brain Sciences, and a Duke Center for Interdisciplinary Decision Sciences Fellowship to LJNB. The CPRC is supported by grant 8-P40 OD012217-25 from the National Center for Research Resources (NCRR) and the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health
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Mexico City and the biogeochemistry of global urbanization
Mexico City is far advanced in its urban evolution, and cities in currently developing nations may soon follow a similar course. This paper investigates the strengths and weaknesses of infrastructures for the emerging megacities. The major driving force for infrastructure change in Mexico City is concern over air quality. Air chemistry data from recent field campaigns have been used to calculate fluxes in the atmosphere of the Valley of Mexico, for compounds that are important to biogeochemistry including methane (CH4), carbon monoxide (CO), nonmethane hydrocarbons (NMHCs), ammonia (NH3), sulfur dioxide (SO2), nitrogen oxides (NOx and NOy), soot, and dust. Leakage of liquified petroleum gas approached 10% during sampling periods, and automotive pollutant sources in Mexico City were found to match those in developed cities, despite a lower vehicle-to-person ratio of 0.1. Ammonia is released primarily from residential areas, at levels sufficient to titrate pollutant acids into particles across the entire basin. Enhancements of reduced nitrogen and hydrocarbons in the vapor phase skew the distribution of NOy species towards lower average deposition velocities. Partly as a result, downwind nutrient deposition occurs on a similar scale as nitrogen fixation across Central America, and augments marine nitrate upwelling. Dust suspension from unpaved roads and from the bed of Lake Texcoco was found to be comparable to that occurring on the periphery of the Sahara, Arabian, and Gobi deserts. In addition, sodium chloride (NaCl) in the dust may support heterogeneous chlorine oxide (ClOx) chemistry. The insights from our Mexico City analysis have been tentatively applied to the upcoming urbanization of Asia
Tycho Brahe's 1572 supernova as a standard type Ia explosion revealed from its light echo spectrum
Type Ia supernovae (SNe Ia) are thermonuclear explosions of white dwarf stars
in close binary systems. They play an important role as cosmological distance
indicators and have led to the discovery of the accelerated expansion of the
Universe. Among the most important unsolved questions are how the explosion
actually proceeds and whether accretion occurs from a companion or via the
merging of two white dwarfs. Tycho Brahe's supernova of 1572 (SN 1572) is
thought to be one of the best candidates for a SN Ia in the Milky Way. The
proximity of the SN 1572 remnant has allowed detailed studies, such as the
possible identification of the binary companion, and provides a unique
opportunity to test theories of the explosion mechanism and the nature of the
progenitor. The determination of the yet unknown exact spectroscopic type of SN
1572 is crucial to relate these results to the diverse population of SNe Ia.
Here we report an optical spectrum of Tycho Brahe's supernova near maximum
brightness, obtained from a scattered-light echo more than four centuries after
the direct light of the explosion swept past Earth. We find that SN 1572
belongs to the majority class of normal SNe Ia. The presence of a strong Ca II
IR feature at velocities exceeding 20,000 km/s, which is similar to the
previously observed polarized features in other SNe Ia, suggests asphericity in
SN 1572.Comment: 15 pages, 3 figures - accepted for publication in Natur
SN 2005hj: Evidence for Two Classes of Normal-Bright SNe Ia and Implications for Cosmology
HET Optical spectra covering the evolution from about 6 days before to about
5 weeks after maximum light and the ROTSE-IIIb unfiltered light curve of the
"Branch-normal" Type Ia Supernova SN 2005hj are presented. The host galaxy
shows HII region lines at redshift of z=0.0574, which puts the peak unfiltered
absolute magnitude at a somewhat over-luminous -19.6. The spectra show weak and
narrow SiII lines, and for a period of at least 10 days beginning around
maximum light these profiles do not change in width or depth and they indicate
a constant expansion velocity of ~10,600 km/s. We analyzed the observations
based on detailed radiation dynamical models in the literature. Whereas delayed
detonation and deflagration models have been used to explain the majority of
SNe Ia, they do not predict a long velocity plateau in the SiII minimum with an
unvarying line profile. Pulsating delayed detonations and merger scenarios form
shell-like density structures with properties mostly related to the mass of the
shell, M_shell, and we discuss how these models may explain the observed SiII
line evolution; however, these models are based on spherical calculations and
other possibilities may exist. SN 2005hj is consistent with respect to the
onset, duration, and velocity of the plateau, the peak luminosity and, within
the uncertainties, with the intrinsic colors for models with M_shell=0.2 M_sun.
Our analysis suggests a distinct class of events hidden within the
Branch-normal SNe Ia. If the predicted relations between observables are
confirmed, they may provide a way to separate these two groups. We discuss the
implications of two distinct progenitor classes on cosmological studies
employing SNe Ia, including possible differences in the peak luminosity to
light curve width relation.Comment: ApJ accepted, 31 page
Discovery of the progenitor of the type Ia supernova 2007on
Type Ia supernovae are exploding stars that are used to measure the
accelerated expansion of the Universe and are responsible for most of the iron
ever produced. Although there is general agreement that the exploding star is a
white dwarf in a binary system, the exact configuration and trigger of the
explosion is unclear, which could hamper their use for precision cosmology. Two
families of progenitor models have been proposed. In the first, a white dwarf
accretes material from a companion until it exceeds the Chandrasekhar mass,
collapses and explodes. Alternatively, two white dwarfs merge, again causing
catastrophic collapse and an explosion. It has hitherto been impossible to
determine if either model is correct. Here we report the discovery of an object
in pre-supernova archival X-ray images at the position of the recent type Ia
supernova (2007on) in the elliptical galaxy NGC 1404. Deep optical images (also
archival) show no sign of this object. From this we conclude that the X-ray
source is the progenitor of the supernova, which favours the accretion model
for this supernova, although the host galaxy is older (6-9 Gyr) than the age at
which the explosions are predicted in the accreting models.Comment: Published in Nature See also the two follow-up papers: Roelofs,
Bassa, Voss, Nelemans Nelemans, Voss, Roelofs, Bassa both on astro-ph
02/15/0
Discovery of a Supernova Explosion at Half the Age of the Universe and its Cosmological Implications
The ultimate fate of the universe, infinite expansion or a big crunch, can be
determined by measuring the redshifts, apparent brightnesses, and intrinsic
luminosities of very distant supernovae. Recent developments have provided
tools that make such a program practicable: (1) Studies of relatively nearby
Type Ia supernovae (SNe Ia) have shown that their intrinsic luminosities can be
accurately determined; (2) New research techniques have made it possible to
schedule the discovery and follow-up observations of distant supernovae,
producing well over 50 very distant (z = 0.3 -- 0.7) SNe Ia to date. These
distant supernovae provide a record of changes in the expansion rate over the
past several billion years. By making precise measurements of supernovae at
still greater distances, and thus extending this expansion history back far
enough in time, we can distinguish the slowing caused by the gravitational
attraction of the universe's mass density Omega_M from the effect of a possibly
inflationary pressure caused by a cosmological constant Lambda. We report here
the first such measurements, with our discovery of a Type Ia supernova (SN
1997ap) at z = 0.83. Measurements at the Keck II 10-m telescope make this the
most distant spectroscopically confirmed supernova. Over two months of
photometry of SN 1997ap with the Hubble Space Telescope and ground-based
telescopes, when combined with previous measurements of nearer SNe Ia, suggests
that we may live in a low mass-density universe. Further supernovae at
comparable distances are currently scheduled for ground and space-based
observations.Comment: 12 pages and 4 figures (figure 4 is repeated in color and black and
white) Nature, scheduled for publication in the 1 January, 1998 issue. Also
available at http://www-supernova.lbl.go
Functional divergence in the role of N-linked glycosylation in smoothened signaling
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active sub-cellular localization, and the ability of vertebrate Smo to induce distinct G protein-dependent and independent signals in response to ligand. Whereas the canonical Smo signal to Gli transcriptional effectors occurs in a G protein-independent manner, its non-canonical signal employs Gαi. Whether vertebrate Smo can selectively bias its signal between these routes is not yet known. N-linked glycosylation is a post-translational modification that can influence GPCR trafficking, ligand responsiveness and signal output. Smo proteins in Drosophila and vertebrate systems harbor N-linked glycans, but their role in Smo signaling has not been established. Herein, we present a comprehensive analysis of Drosophila and murine Smo glycosylation that supports a functional divergence in the contribution of N-linked glycans to signaling. Of the seven predicted glycan acceptor sites in Drosophila Smo, one is essential. Loss of N-glycosylation at this site disrupted Smo trafficking and attenuated its signaling capability. In stark contrast, we found that all four predicted N-glycosylation sites on murine Smo were dispensable for proper trafficking, agonist binding and canonical signal induction. However, the under-glycosylated protein was compromised in its ability to induce a non-canonical signal through Gαi, providing for the first time evidence that Smo can bias its signal and that a post-translational modification can impact this process. As such, we postulate a profound shift in N-glycan function from affecting Smo ER exit in flies to influencing its signal output in mice
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