Matched Shrunken Cone Detector (MSCD): Bayesian Derivations and Case Studies for Hyperspectral Target Detection

Hyperspectral images (HSIs) possess non-negative properties for both hyperspectral signatures and abundance coefficients, which can be naturally modeled using cone-based representation. However, in hyperspectral target detection, cone-based methods are barely studied. In this paper, we propose a new regularized cone-based representation approach to hyperspectral target detection, as well as its two working models by incorporating into the cone representation l2-norm and l1-norm regularizations, respectively. We call the new approach the matched shrunken cone detector (MSCD). Also important, we provide principled derivations of the proposed MSCD from the Bayesian perspective: we show that MSCD can be derived by assuming a multivariate half-Gaussian distribution or a multivariate half-Laplace distribution as the prior distribution of the coefficients of the models. In the experimental studies, we compare the proposed MSCD with the subspace methods and the sparse representation-based methods for HSI target detection. Two real hyperspectral data sets are used for evaluating the detection performances on sub-pixel targets and full-pixel targets, respectively. Results show that the proposed MSCD can outperform other methods in both cases, demonstrating the competitiveness of the regularized cone-based representation

Building a discriminatively ordered subspace on the generating matrix to classify high-dimensional spectral data

Soft independent modelling of class analogy (SIMCA) is a widely-used subspace method for spectral data classification. However, since the class subspaces are built independently in SIMCA, the discriminative between-class information is neglected. An appealing remedy is to first project the original data to a more discriminative subspace. For this, generalised difference subspace (GDS) that explores the information between class subspaces in the generating matrix can be a strong candidate. However, due to the difference between a class subspace (of infinite scale) and a class (of finite scale), the eigenvectors selected by GDS may not also be discriminative for classifying samples of classes. Therefore in this paper, we propose a discriminatively ordered subspace (DOS): different from GDS, our DOS selects the eigenvectors with high discriminative ability between classes rather than between class subspaces. The experiments on three real spectral datasets demonstrate that applying DOS before SIMCA outperforms its counterparts

Expression of neural cell adhesion molecule L1 in the brain of rats exposed to X-irradiation in utero

To gain insight to the cellular and molecular mechanisms involved abnormal neuronal migration induced by irradiation, we investigated expression of neuronal cell adhesion molecule L 1 and neuronal migration in the brains through comparison between rats prenatally exposed to X-ray and controls. To observe the pattern of neuronal migration, bromodeoxyuridine (BrdU) was chosen as a marker to label migrating cells. The results showed some of the labeled cells remained in the lower of the cortical plate in the irradiated rats, suggesting that neuronal migration was disrupted by X-ray. To study change of expressing neural cell molecule L1, rat brains were analyzed by SDS-PAGE after isolation of L1 by immunoaffinity chromatography. In the all brain membrane fraction, immunoaffinity purified L1 had bands at 200, 180, 140 and 80 kDa. However, the bands in the irradiated group were very weak when compared with the control. Taking these results into account, abnormal neuronal migration and reduction of expression L1 found in their radiated brain indicated that migration of neural cells may be largely dependent on radial glial fiber as well as neural cell molecules like L1. A decrease in L1 expressionmay be one of reasons of abnormal neuronal migration

Experimental model for irradiating a restricted region of the rat brain using heavy-ion beams

Heavy-ion beams have the feature to administer a large radiation dose in the vicinity of the endpoint in the beam range, its irradiation system and biophysical characteristics are different from ordinary irradiation instruments like X-rays or gamma-rays. In order to get clarify characteristic effects of heavy-ion beams on the brain, we have developed an experimental system for irradiating a restricted region of the rat brain using heavy-ion beams. The left cerebral hemispheres of the adult rat brain were irradiated at dose of 50Gy charged carbon particles (290MeV/nucleon 5mmspread-out Bragg peak). After irradiation, the characteristics of the heavy-ion beams and the animal model were studied. Histological examination and measurement showed that extensive necrosis was observed between 2.5mmand7.5mmdepth from the surface of the rat head, suggesting a relatively high dose and uniform dose was delivered among designed depths and the spread-out bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. We believe that our experimental model for irradiating a restricted region of the rat brain using heavy-ion beams is a good model for analyzing regional radiation susceptibility of the brain

Normal and abnormal neuronal migration in the developing cerebral cortex

Neuronal migration is the critical cellular process which initiates histogenesis of cerebral cortex. Migration involves a series of complex cell interactions and transformation. After completing their final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an “inside-out” gradient of maturation. This process is guided by radial glial fibers, requires proper receptors, ligands, other unknown extracellular factors, and local signaling to stop neuronal migration. This process is also highly sensitive to various physical, chemical and biological agents as well as to genetic mutations. Any disturbance of the normal process may result in neuronal migration disorder. Such neuronal migration disorder is believed as major cause of both gross brain malformation and more special cerebral structural and functional abnormalities in experimental animals and in humans. An increasing number of instructive studies on experimental models and several genetic model systems of neuronal migration disorder have established the foundation of cortex formation and provided deeper insights into the genetic and molecular mechanisms underlying normal and abnormal neuronal migration

Spatial learning and expression of neural cell adhesion molecule L1 in rats X-irradiated prenatally

The present study was designed to present evidence to clarify the relationships between learning ability, neuronal cell adhesion molecule L1 expression and hippocampal structural changes in the rat model received X-irradiation at an embryonic stage (E15). Water maze task indicated that all of the irradiated rats failed to learn the task in the whole training procedure. Their latency to the platform and swimming distance were significant differences from those sham-treated controls. Histological studies showed that the hippocampal ectopias induced by X-rays in the CA1 were involved in the spatial learning impairment, in which they hampered normal processes in learning development and transmission of information. Number, size and positions of the ectopias in the dorsal parts of the hippocampus were confirmed to be related to degrees of spatial learning impairment. On the other hand, L1 expression in the hippocampus was examined with Western blot analysis. The results indicated a lower content of L1 in the irradiated rats. A decrease in L1 might be one of reasons to cause disorganization of the septohippocampal pathways. These findings suggest some mechanisms of spatial learning impairment can be attributed to the formation of the hippocampal ectopias and redaction of L1 following prenatal exposure to X-irradiation

Supranormal orientation selectivity of visual neurons in orientation-restricted animals

Altered sensory experience in early life often leads to remarkable adaptations so that humans and animals can make the best use of the available information in a particular environment. By restricting visual input to a limited range of orientations in young animals, this investigation shows that stimulus selectivity, e.g., the sharpness of tuning of single neurons in the primary visual cortex, is modified to match a particular environment. Specifically, neurons tuned to an experienced orientation in orientation-restricted animals show sharper orientation tuning than neurons in normal animals, whereas the opposite was true for neurons tuned to non-experienced orientations. This sharpened tuning appears to be due to elongated receptive fields. Our results demonstrate that restricted sensory experiences can sculpt the supranormal functions of single neurons tailored for a particular environment. The above findings, in addition to the minimal population response to orientations close to the experienced one, agree with the predictions of a sparse coding hypothesis in which information is represented efficiently by a small number of activated neurons. This suggests that early brain areas adopt an efficient strategy for coding information even when animals are raised in a severely limited visual environment where sensory inputs have an unnatural statistical structure

Unveiling the physical properties and kinematics of molecular gas in the Antennae Galaxies (NGC 4038/9) through high resolution CO (J = 3-2) observations

We present a ~ 1" (100 pc) resolution 12CO (3-2) map of the nearby intermediate stage interacting galaxy pair NGC 4038/9 (the Antennae galaxies) obtained with the Submillimeter Array. We find that half the CO (3-2) emission originates in the overlap region where most of the tidally induced star formation had been previously found in shorter wavelength images, with the rest being centered on each of the nuclei. The gross distribution is consistent with lower resolution single dish images, but we show for the first time the detailed distribution of the warm and dense molecular gas across this galaxy pair at resolutions comparable to the size of a typical giant molecular complex. While we find that 58% (33/57) of the spatially resolved Giant Molecular Associations (GMAs; a few x 100 pc) are located in the overlap region, only \leqq 30% spatially coincides with the optically detected star clusters, suggesting that the bulk of the CO (3-2) emission traces the regions with very recent or near future star formation activity. The spatial distribution of the CO (3-2)/CO (1-0) integrated brightness temperature ratios mainly range between 0.3 and 0.8, which suggests that on average the CO (3-2) line in the Antennae is not completely thermalized and similar to the average values of nearby spirals. A higher ratio is seen in both nuclei and the southern complexes in the overlap region. Higher radiation field associated with intense star formation can account for the nucleus of NGC 4038 and the overlap region, but the nuclear region of NGC 4039 show relatively little star formation or AGN activities and cannot be easily explained. We show kinematical evidence that the high line ratio in NGC 4039 is possibly caused by gas inflow into the counter-rotating central disk.Comment: 20 pages, 12 figures, 4 tables, accepted for publication in Astrophysical Journa

Interstellar H I and H_2 in the Magellanic Clouds: An Expanded Sample Based on UV Absorption-Line Data

We have determined column densities of H I and/or H_2 for sight lines in the Magellanic Clouds from archival HST and FUSE spectra of H I Lyman-alpha and H_2 Lyman-band absorption. Together with some similar data from the literature, we now have absorption-based N(H I) and/or N(H_2) for 285 LMC and SMC sight lines (114 with a detection or limit for both species) -- enabling more extensive, direct, and accurate determinations of molecular fractions, gas-to-dust ratios, and elemental depletions in these two nearby, low-metallicity galaxies. For sight lines where the N(H I) estimated from 21 cm emission is significantly higher than the value derived from Lyman-alpha absorption (presumably due to emission from gas beyond the target stars), integration of the 21 cm profile only over the velocity range seen in Na I or H_2 absorption generally yields much better agreement. Conversely, N(21 cm) can be lower than N(Ly-alpha) by factors of 2--3 in some LMC sight lines -- suggestive of small-scale structure within the 21 cm beam(s) and/or some saturation in the emission. The mean gas-to-dust ratios obtained from N(H_tot)/E(B-V) are larger than in our Galaxy, by factors of 2.8--2.9 in the LMC and 4.1--5.2 in the SMC -- i.e., factors similar to the differences in metallicity. The N(H_2)/E(B-V) ratios are more similar in the three galaxies, but with considerable scatter within each galaxy. These data may be used to test models of the atomic-to-molecular transition at low metallicities and predictions of N(H_2) based on comparisons of 21 cm emission and the IR emission from dust.Comment: 67 pages; 18 figures; aastex; accepted to ApJ; higher quality figures (1, 2, 9, 18) are available at http://astro.uchicago.edu/~dwelty/MCH

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference