431 research outputs found
Cost Modeling Techniques for Design Maturity
Cost modeling techniques and factors which either add to or subtract from these estimates are examined. The most important factors for increasing costs are interfacing subsystems, subsystem design and software maturity. Cost decrease depends on hardware, software, and support equipment availability. A cost modeling analysis for reentry shield and aerodynamic decelerator subsystems of a reentry vehicle is presented. Integration problems for the subsystems are also discussed
A Note On Job Market Conditions And Students Academic Performance
This paper presents a model of student effort and resulting grade performance under varying labor market conditions. Following previous studies that have found a negative relationship between the expected income and grades by discipline, we extend the analysis to the effect of changing labor market conditions on student effort and the resulting changes in the average grades. The empirical results support the theoretical models conclusion that reduced employment opportunities result in higher average grades by discipline
Relationship between blood attributes and predicted breeding value for milk yield in calves
International audienc
Stellar Population Variations in the Milky Way's Stellar Halo
If the stellar halos of disk galaxies are built up from the disruption of
dwarf galaxies, models predict highly structured variations in the stellar
populations within these halos. We test this prediction by studying the ratio
of blue horizontal branch stars (BHB stars; more abundant in old, metal-poor
populations) to main-sequence turn-off stars (MSTO stars; a feature of all
populations) in the stellar halo of the Milky Way using data from the Sloan
Digital Sky Survey. We develop and apply an improved technique to select BHB
stars using ugr color information alone, yielding a sample of ~9000 g<18
candidates where ~70% of them are BHB stars. We map the BHB/MSTO ratio across
~1/4 of the sky at the distance resolution permitted by the absolute magnitude
distribution of MSTO stars. We find large variations of BHB/MSTO star ratio in
the stellar halo. Previously identified, stream-like halo structures have
distinctive BHB/MSTO ratios, indicating different ages/metallicities. Some halo
features, e.g., the low-latitude structure, appear to be almost completely
devoid of BHB stars, whereas other structures appear to be rich in BHB stars.
The Sagittarius tidal stream shows an apparent variation in BHB/MSTO ratio
along its extent, which we interpret in terms of population gradients within
the progenitor dwarf galaxy. Our detection of coherent stellar population
variations between different stellar halo substructures provides yet more
support to cosmologically motivated models for stellar halo growth.Comment: Astronomical Journal, in press. 10 pages, 5 color figures. Much
better printed in colo
Galaxy Pairs in the Sloan Digital Sky Survey - III: Evidence of Induced Star Formation from Optical Colours
We have assembled a large, high quality catalogue of galaxy colours from the
Sloan Digital Sky Survey Data Release 7, and have identified 21,347 galaxies in
pairs spanning a range of projected separations (r_p < 80 h_{70}^{-1} kpc),
relative velocities (\Delta v < 10,000 km/s, which includes projected pairs
that are essential for quality control), and stellar mass ratios (from 1:10 to
10:1). We find that the red fraction of galaxies in pairs is higher than that
of a control sample matched in stellar mass and redshift, and demonstrate that
this difference is likely due to the fact that galaxy pairs reside in higher
density environments than non-paired galaxies. We detect clear signs of
interaction-induced star formation within the blue galaxies in pairs, as
evidenced by a higher fraction of extremely blue galaxies, along with blueward
offsets between the colours of paired versus control galaxies. These signs are
strongest in close pairs (r_p < 30 h_{70}^{-1} kpc and \Delta v < 200 km/s),
diminish for more widely separated pairs (r_p > 60 h_{70}^{-1} kpc and \Delta v
< 200 km/s) and disappear for close projected pairs (r_p < 30 h_{70}^{-1} kpc
and \Delta v > 3000 km/s). These effects are also stronger in central (fibre)
colours than in global colours, and are found primarily in low- to
medium-density environments. Conversely, no such trends are seen in red
galaxies, apart from a small reddening at small separations which may result
from residual errors with photometry in crowded fields. When interpreted in
conjunction with a simple model of induced starbursts, these results are
consistent with a scenario in which close peri-centre passages trigger induced
star formation in the centres of galaxies which are sufficiently gas rich,
after which time the galaxies gradually redden as they separate and their
starbursts age.Comment: 17 pages. Accepted for publication in MNRA
What is Scirrhia?
The ascomycetous genus Scirrhia is presently treated as a member of Dothideomycetidae, though uncertainty remains as to which family it belongs in Capnodiales, Ascomycota. Recent collections on stems of a fern, Pteridium aquilinum (Dennstaedtiaceae) in Brazil, led to the discovery of a new species of Scirrhia, described here as S.
brasiliensis. Based on DNA sequence data of the nuclear ribosomal DNA (LSU), Scirrhia is revealed to represent a member of Dothideomycetes, Capnodiales, Mycosphaerellaceae. Scirrhia is the first confirmed genus in Mycosphaerellaceae to have well developed pseudoparaphyses and a prominent hypostroma in which ascomata are arranged in parallel rows. Given the extremely slow growth rate and difficulty in obtaining cultures of S. brasiliensis on various growth media, it appears that Scirrhia represents a genus of potentially obligate plant pathogens within Mycosphaerellaceae
Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms
Background: The increasing prevalence of invasive fungal infections in immuno-compromised patients is a considerable cause of morbidity and mortality. With the rapid emergence of antifungal resistance and an inadequate pipeline of new therapies, novel treatment strategies are now urgently required.
Methods: The antifungal activity of the alginate oligosaccharide OligoG in conjunction with nystatin was tested against a range of Candida spp. (C. albicans, C. glabrata, C. parapsilosis, C. auris, C. tropicalis and C. dubliniensis), in both planktonic and biofilm assays, to determine its potential clinical utility to enhance the treatment of candidal infections. The effect of OligoG (0-6%) ± nystatin on Candida spp. was examined in minimum inhibitory concentration (MIC) and growth curve assays. Antifungal effects of OligoG and nystatin treatment on biofilm formation and disruption were characterized using confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM) and ATP cellular viability assays. Effects on the cell membrane were determined using permeability assays and transmission electron microscopy (TEM).
Results: MIC and growth curve assays demonstrated the synergistic effects of OligoG (0-6%) with nystatin, resulting in an up to 32-fold reduction in MIC, and a significant reduction in the growth of C. parapsilosis and C. auris (minimum significant difference = 0.2 and 0.12 respectively). CLSM and SEM imaging demonstrated that the combination treatment of OligoG (4%) with nystatin (1 µg/ml) resulted in significant inhibition of candidal biofilm formation on glass and clinical grade silicone surfaces (p < 0.001), with increased cell death (p < 0.0001). The ATP biofilm disruption assay demonstrated a significant reduction in cell viability with OligoG (4%) alone and the combined OligoG/nystatin (MIC value) treatment (p < 0.04) for all Candida strains tested. TEM studies revealed the combined OligoG/nystatin treatment induced structural reorganization of the Candida cell membrane, with increased permeability when compared to the untreated control (p < 0.001).
Conclusions: Antimicrobial synergy between OligoG and nystatin against Candida spp. highlights the potential utility of this combination therapy in the prevention and topical treatment of candidal biofilm infections, to overcome the inherent tolerance of biofilm structures to antifungal agents
Secretory structures in plants: lessons from the Plumbaginaceae on their origin, evolution and roles in stress tolerance
Special IssueThe Plumbaginaceae (non-core Caryophyllales) is a family well known for species
adapted to a wide range of arid and saline habitats. Of its salt-tolerant species, at
least 45 are in the genus Limonium; two in each of Aegialitis, Limoniastrum and
Myriolimon, and one each in Psylliostachys, Armeria, Ceratostigma, Goniolimon and
Plumbago. All the halophytic members of the family have salt glands, which are also
common in the closely related Tamaricaceae and Frankeniaceae. The halophytic species
of the three families can secrete a range of ions (Na+, K+, Ca2+, Mg2+, Cl−,
HCO3
−, SO4
2-) and other elements (As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn). Salt glands
are, however, absent in salt-tolerant members of the sister family Polygonaceae. We
describe the structure of the salt glands in the three families and consider whether
glands might have arisen as a means to avoid the toxicity of Na+ and/or Cl− or to regulate
Ca2+ concentrations within the leaves. We conclude that the establishment of
lineages with salt glands took place after the split between the Polygonaceae and its
sister group the Plumbaginaceaeinfo:eu-repo/semantics/publishedVersio
Murein and pseudomurein cell wall binding domains of bacteria and archaea—a comparative view
The cell wall, a major barrier protecting cells from their environment, is an essential compartment of both bacteria and archaea. It protects the organism from internal turgor pressure and gives a defined shape to the cell. The cell wall serves also as an anchoring surface for various proteins and acts as an adhesion platform for bacteriophages. The walls of bacteria and archaea are mostly composed of murein and pseudomurein, respectively. Cell wall binding domains play a crucial role in the non-covalent attachment of proteins to cell walls. Here, we give an overview of the similarities and differences in the biochemical and functional properties of the two major murein and pseudomurein cell wall binding domains, i.e., the Lysin Motif (LysM) domain (Pfam PF01476) and the pseudomurein binding (PMB) domain (Pfam PF09373) of bacteria and archaea, respectively
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