Analisis dan Perancangan Aplikasi Berbasis Web E-Procurement di PT Pillar Utama Contrindo

The aim of this research is to analyze the current business process at the procurement department at PT Pillar Utama Contrindo as well as develop a web based e-procurement application prototype to supportprocurement process at the company. Interview, survey, as well as analysis and design to develop the prototype are used in the research. The research results in an e-procurement application prototype built to minimize errors on related document filling, help the company to get best price on their supply, and increase control. It can be concluded from the research that the protoype can be implemented to be a tool for the users to decide the best supplier, obtain the best price, and increase control in buying process at PT Pillar Utama Contrindo

Detection of orbital and superhump periods in Nova V2574 Ophiuchi (2004)

We present the results of 37 nights of CCD unfiltered photometry of nova V2574 Oph (2004) from 2004 and 2005. We find two periods of 0.14164 d (~3.40 h) and 0.14773 d (~3.55 h) in the 2005 data. The 2004 data show variability on a similar timescale, but no coherent periodicity was found. We suggest that the longer periodicity is the orbital period of the underlying binary system and that the shorter period represents a negative superhump. The 3.40 h period is about 4% shorter than the orbital period and obeys the relation between superhump period deficit and binary period. The detection of superhumps in the light curve is evidence of the presence of a precessing accretion disk in this binary system shortly after the nova outburst. From the maximum magnitude - rate of decline relation, we estimate the decay rate t_2 = 17+/-4 d and a maximum absolute visual magnitude of M_Vmax = -7.7+/-1.7 mag.Comment: 6 pages, 6 figures, 2 .sty files, AJ accepted, minor change to one of reference

KAPAO: a MEMS-based natural guide star adaptive optics system

We describe KAPAO, our project to develop and deploy a low-cost, remote-access, natural guide star adaptive optics (AO) system for the Pomona College Table Mountain Observatory (TMO) 1-meter telescope. We use a commercially available 140-actuator BMC MEMS deformable mirror and a version of the Robo-AO control software developed by Caltech and IUCAA. We have structured our development around the rapid building and testing of a prototype system, KAPAO-Alpha, while simultaneously designing our more capable final system, KAPAO-Prime. The main differences between these systems are the prototype's reliance on off-the-shelf optics and a single visible-light science camera versus the final design's improved throughput and capabilities due to the use of custom optics and dual-band, visible and near-infrared imaging. In this paper, we present the instrument design and on-sky closed-loop testing of KAPAO-Alpha as well as our plans for KAPAO-Prime. The primarily undergraduate-education nature of our partner institutions, both public (Sonoma State University) and private (Pomona and Harvey Mudd Colleges), has enabled us to engage physics, astronomy, and engineering undergraduates in all phases of this project. This material is based upon work supported by the National Science Foundation under Grant No. 0960343.Comment: 10 pages and 11 figure

KAPAO First Light: the design, construction and operation of a low-cost natural guide star adaptive optics system

We present the instrument design and first light observations of KAPAO, a natural guide star adaptive optics (AO) system for the Pomona College Table Mountain Observatory (TMO) 1-meter telescope. The KAPAO system has dual science channels with visible and near-infrared cameras, a Shack-Hartmann wavefront sensor, and a commercially available 140-actuator MEMS deformable mirror. The pupil relays are two pairs of custom off-axis parabolas and the control system is based on a version of the Robo-AO control software. The AO system and telescope are remotely operable, and KAPAO is designed to share the Cassegrain focus with the existing TMO polarimeter. We discuss the extensive integration of undergraduate students in the program including the multiple senior theses/capstones and summer assistantships amongst our partner institutions. This material is based upon work supported by the National Science Foundation under Grant No. 0960343

New insights into the classification and nomenclature of cortical GABAergic interneurons.

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus

Fermi Large Area Telescope Constraints on the Gamma-ray Opacity of the Universe

The Extragalactic Background Light (EBL) includes photons with wavelengths from ultraviolet to infrared, which are effective at attenuating gamma rays with energy above ~10 GeV during propagation from sources at cosmological distances. This results in a redshift- and energy-dependent attenuation of the gamma-ray flux of extragalactic sources such as blazars and Gamma-Ray Bursts (GRBs). The Large Area Telescope onboard Fermi detects a sample of gamma-ray blazars with redshift up to z~3, and GRBs with redshift up to z~4.3. Using photons above 10 GeV collected by Fermi over more than one year of observations for these sources, we investigate the effect of gamma-ray flux attenuation by the EBL. We place upper limits on the gamma-ray opacity of the Universe at various energies and redshifts, and compare this with predictions from well-known EBL models. We find that an EBL intensity in the optical-ultraviolet wavelengths as great as predicted by the "baseline" model of Stecker et al. (2006) can be ruled out with high confidence.Comment: 42 pages, 12 figures, accepted version (24 Aug.2010) for publication in ApJ; Contact authors: A. Bouvier, A. Chen, S. Raino, S. Razzaque, A. Reimer, L.C. Reye

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo