The Multi-Colored Hot Interstellar Medium of "The Antennae" Galaxies (NGC 4038/39)

We report the results of the analysis of the extended soft emission discovered in the Chandra ACIS pointing at the merging system NGC 4038/39 (the Antennae). We present a `multi-color' X-ray image that suggests both extensive absorption by the dust in this system, peaking in the contact region, as well as variations in the temperature of different emitting regions of the hot interstellar medium (ISM). Spectral fits to multi-component thermal emission models confirm this picture and give a first evaluation of the parameters of the hot plasma. We compare the diffuse X-ray emission with radio continuum (6cm), HI, CO, and H$\alpha$ images to take a first look at the multi-phase ISM of the Antennae galaxies. We find that the hot (X-ray) and cold (CO) gas have comparable thermal pressures in the two nuclear regions. We also conclude that the displacement between the peak of the diffuse X-ray emission in the north of the galaxy system, towards the inner regions of the northern spiral arm (as defined by H$\alpha$, radio continuum and HI), could result from ram pressure of infalling HI clouds.Comment: Accepted by Ap

Regulatory Impact Assessment: A survey of selected developing and emerging economies

Regulatory impact assessment (RIA) involves a systematic appraisal of the social, economic and environmental impacts of proposed regulations and other kinds of policy instruments before they are adopted. A vast amount of academic literature in the last decade has charted the diffusion of RIA in OECD countries and EU member states. However, relatively little is known about the extent to which RIA has been adopted and implemented in developing countries. The last research attempting to shed light on this issue over a decade ago found that a number of were beginning to apply some form of regulatory assessment but that its development was at an early stage. Since then RIA has become almost universally adopted in OECD and EU member states as well as promoted as a tool for good (regulatory) governance in developing countries by international donors and organizations such as OECD, the International Finance Corporation of the World Bank Group (IFC). What, then, is the extent of RIA adoption and implementation in these countries today? This working paper addresses this question through a survey of RIA in 14 developing and emerging economies based on documentary analysis as well as semi-structured interviews with key stakeholders. The survey explores topics such as the legal and institutional framework of RIA, organizational capacity, and use of tools and methods (e.g. Cost Benefit Analysis). The results suggest that while an increasing number of developing countries have made efforts to introduce RIA in their decision making processes, these efforts have not yet led to a sustainable RIA system which significantly contributes to the good regulatory governance of these countries

Chemical enrichment of the complex hot ISM of the Antennae galaxies: I. Spatial and spectral analysis of the diffuse X-ray emission

We present an analysis of the properties of the hot interstellar medium (ISM) in the merging pair of galaxies known as The Antennae (NGC 4038/39), performed using the deep, coadded ~411 ks Chandra ACIS-S data set. These deep X-ray observations and Chandra's high angular resolution allow us to investigate the properties of the hot ISM with unprecedented spatial and spectral resolution. Through a spatially resolved spectral analysis, we find a variety of temperatures (from 0.2 to 0.7 keV) and Nh (from Galactic to 2x10^21 cm^-2). Metal abundances for Ne, Mg, Si, and Fe vary dramatically throughout the ISM from sub-solar values (~0.2) up to several times solar.Comment: 33 pages, 18 figures, revised version accepted by Astrophysical Journal Supplement Serie

Simultaneous Absolute Timing of the Crab Pulsar at Radio and Optical Wavelengths

The Crab pulsar emits across a large part of the electromagnetic spectrum. Determining the time delay between the emission at different wavelengths will allow to better constrain the site and mechanism of the emission. We have simultaneously observed the Crab Pulsar in the optical with S-Cam, an instrument based on Superconducting Tunneling Junctions (STJs) with $\mu$s time resolution and at 2 GHz using the Nan\c{c}ay radio telescope with an instrument doing coherent dedispersion and able to record giant pulses data. We have studied the delay between the radio and optical pulse using simultaneously obtained data therefore reducing possible uncertainties present in previous observations. We determined the arrival times of the (mean) optical and radio pulse and compared them using the tempo2 software package. We present the most accurate value for the optical-radio lag of 255 $\pm$ 21 $\mu$s and suggest the likelihood of a spectral dependence to the excess optical emission asociated with giant radio pulses.Comment: 8 pages; accepted for publication in Astronomy and Astrophysic

Chemical enrichment of the complex hot ISM of the Antennae Galaxies: II. Physical properties of the hot gas and supernova feedback

We investigate the physical properties of the interstellar medium (ISM) in the merging pair of galaxies known as The Antennae (NGC 4038/39), using the deep coadded ~411 ks Chandra ACIS-S data set. The method of analysis and some of the main results from the spectral analysis, such as metal abundances and their variations from ~0.2 to ~20-30 times solar, are described in Paper I (Baldi et al. submitted). In the present paper we investigate in detail the physics of the hot emitting gas, deriving measures for the hot-gas mass (~10^ M_sun), cooling times (10^7-10^8 yr), and pressure (3.5x10^-11-2.8x10^-10 dyne cm^-2). At least in one of the two nuclei (NGC 4038) the hot-gas pressure is significantly higher than the CO pressure, implying that shock waves may be driven into the CO clouds. Comparison of the metal abundances with the average stellar yields predicted by theoretical models of SN explosions points to SNe of Type II as the main contributors of metals to the hot ISM. There is no evidence of any correlation between radio-optical star-formation indicators and the measured metal abundances. Although due to uncertainties in the average gas density we cannot exclude that mixing may have played an important role, the short time required to produce the observed metal masses (<=2 Myr) suggests that the correlations are unlikely to have been destroyed by efficient mixing. More likely, a significant fraction of SN II ejecta may be in a cool phase, in grains, or escaping in hot winds. In each case, any such fraction of the ejecta would remain undetectable with soft X-ray observations.Comment: 29 pages, 6 figures, accepted by the Astrophysical Journa

New Observations of Extra-Disk Molecular Gas in Interacting Galaxy Systems, Including a Two-Component System in Stephan's Quintet

We present new CO (1 - 0) observations of eleven extragalactic tails and bridges in nine interacting galaxy systems, almost doubling the number of such features with sensitive CO measurements. Eight of these eleven features were undetected in CO to very low CO/HI limits, with the most extreme case being the NGC 7714/5 bridge. This bridge contains luminous H II regions and has a very high HI column density (1.6 X 10^21 cm^-2 in the 55" CO beam), yet was undetected in CO to rms T(R)* = 2.4 mK. The HI column density is higher than standard H2 and CO self-shielding limits for solar-metallicity gas, suggesting that the gas in this bridge is metal-poor and has an enhanced N(H2)/I(CO) ratio compared to the Galactic value. Only one of the eleven features in our sample was unambiguously detected in CO, a luminous HI-rich star formation region near an optical tail in the compact group Stephan's Quintet. We detect CO at two widely separated velocities in this feature, at ~6000 km/s and ~6700 km/s. Both of these components have HI and H-alpha counterparts. These velocities correspond to those of galaxies in the group, suggesting that this gas is material that has been removed from two galaxies in the group. The CO/HI/H-alpha ratios for both components are similar to global values for spiral galaxies.Comment: 39 pages, Latex, 15 figures, Astronomical Journal, in pres

Plasma neurofilament light chain as a potential biomarker in Charcot‐Marie‐Tooth disease

BACKGROUND: Charcot-Marie-Tooth disease (CMT) is a chronic, slowly progressing disorder. The lack of specific disease progression biomarkers limits the execution of clinical trials. However, neurofilament light chain (NfL) has been suggested as a potential biomarker for peripheral nervous system disorders. METHODS: Ninety-six CMT patients and 60 healthy controls were enrolled in the study. Disease severity assessment included clinical evaluation with CMT Neuropathy Score version 2 (CMTNSv2). Blood plasma NfL concentrations were measured using the single molecule array (Simoa) NfL assay. RESULTS: The NfL concentration was significantly higher in the CMT patient group than in the controls (p<0.001). Of the CMT patients, ones with type CMTX1 had a higher NfL level than those in the two other analysed subgroups (CMT1A and other CMT types) (p=0.0498). The NfL concentration had a significant but weak correlation with the CMTNSv2 (rs =0.25, p=0.012). In one CMT patient with an extremely elevated NfL level, overlap with chronic inflammatory demyelinating polyneuropathy was suspected. ROC analysis showed that an NfL concentration of 8.9 pg/mL could be used to discriminate CMT patients from controls, with an area under the curve of 0.881. CONCLUSIONS: Our study confirmed that the plasma NfL concentration is significantly higher in CMT patients than in controls. Plasma NfL concentration was found to significantly, albeit weakly, reflect the clinical severity of CMT. In the future, NfL may be used, either individually or collaboratively, as a biomarker in the clinical context of suspected CMT; however, several issues need to be addressed first

The relative and absolute timing accuracy of the EPIC-pn camera on XMM-Newton, from X-ray pulsations of the Crab and other pulsars

Reliable timing calibration is essential for the accurate comparison of XMM-Newton light curves with those from other observatories, to ultimately use them to derive precise physical quantities. The XMM-Newton timing calibration is based on pulsar analysis. However, as pulsars show both timing noise and glitches, it is essential to monitor these calibration sources regularly. To this end, the XMM-Newton observatory performs observations twice a year of the Crab pulsar to monitor the absolute timing accuracy of the EPIC-pn camera in the fast Timing and Burst modes. We present the results of this monitoring campaign, comparing XMM-Newton data from the Crab pulsar (PSR B0531+21) with radio measurements. In addition, we use five pulsars (PSR J0537-69, PSR B0540-69, PSR B0833-45, PSR B1509-58 and PSR B1055-52) with periods ranging from 16 ms to 197 ms to verify the relative timing accuracy. We analysed 38 XMM-Newton observations (0.2-12.0 keV) of the Crab taken over the first ten years of the mission and 13 observations from the five complementary pulsars. All the data were processed with the SAS, the XMM-Newton Scientific Analysis Software, version 9.0. Epoch folding techniques coupled with \chi^{2} tests were used to derive relative timing accuracies. The absolute timing accuracy was determined using the Crab data and comparing the time shift between the main X-ray and radio peaks in the phase folded light curves. The relative timing accuracy of XMM-Newton is found to be better than 10^{-8}. The strongest X-ray pulse peak precedes the corresponding radio peak by 306\pm9 \mus, which is in agreement with other high energy observatories such as Chandra, INTEGRAL and RXTE. The derived absolute timing accuracy from our analysis is \pm48 \mus.Comment: 16 pages, 9 figures. Accepted for publication on A&

The Metallicity-Luminosity Relation, Effective Yields, and Metal Loss in Spiral and Irregular Galaxies

I present results on the correlation between galaxy mass, luminosity, and metallicity for a sample of spiral and irregular galaxies having well-measured abundance profiles, distances, and rotation speeds. Additional data for low surface brightness galaxies from the literature are also included for comparison. These data are combined to study the metallicity-luminosity and metallicity-rotation speed correlations for spiral and irregular galaxies. The metallicity luminosity correlation shows its familiar form for these galaxies, a roughly uniform change in the average present-day O/H abundance of about a factor 100 over 11 magnitudes in B luminosity. However, the O/H - V(rot) relation shows a change in slope at a rotation speed of about 125 km/sec. At faster V(rot), there appears to be no relation between average metallicity and rotation speed. At lower V(rot), the metallicity correlates with rotation speed. This change in behavior could be the result of increasing loss of metals from the smaller galaxies in supernova-driven winds. This idea is tested by looking at the variation in effective yield, derived from observed abundances and gas fractions assuming closed box chemical evolution. The effective yields derived for spiral and irregular galaxies increase by a factor of 10-20 from V(rot) approximately 5 km/sec to V(rot) approximately 300 km/sec, asympotically increasing to approximately constant y(eff) for V(rot) > 150 km/sec. The trend suggests that galaxies with V(rot) < 100-150 km/sec may lose a large fraction of their SN ejecta, while galaxies above this value tend to retain metals.Comment: 40 pages total, including 7 encapsulated postscript figures. Accepted for publication in 20 Dec 2002 Ap

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

Background: Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) regulate goblet cell differentiation. This study aimed to (1) investigate DNA methylation and expression of SPDEF and FOXA2 during goblet cell differentiation and (2) compare this in airway epithelial cells from patients with COPD and controls during mucociliary differentiation. Methods: To assess DNA methylation and expression of SPDEF and FOXA2 during goblet cell differentiation, primary airway epithelial cells, isolated from trachea (non-COPD controls) and bronchial tissue (patients with COPD), were differentiated by culture at the air-liquid interface (ALI) in the presence of cytokine interleukin (IL)-13 to promote goblet cell differentiation. Results: We found that SPDEF expression was induced during goblet cell differentiation, while FOXA2 expression was decreased. Importantly, CpG number 8 in the SPDEF promoter was hypermethylated upon differentiation, whereas DNA methylation of FOXA2 promoter was not changed. In the absence of IL-13, COPD-derived ALI-cultured cells displayed higher SPDEF expression than control-derived ALI cultures, whereas no difference was found for FOXA2 expression. This was accompanied with hypomethylation of CpG number 6 in the SPDEF promoter and also hypomethylation of CpG numbers 10 and 11 in the FOXA2 promoter. Conclusions: These findings suggest that aberrant DNA methylation of SPDEF and FOXA2 is one of the factors underlying mucus hypersecretion in COPD, opening new avenues for epigenetic-based inhibition of mucus hypersecretion