Studies on the aetiopathogenesis and treatment of feline chronic gingivostomatitis.

Available from British Library Document Supply Centre-DSC:DXN036178 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis

Recent evidence suggests that a mutation in the spike protein gene of feline coronavirus (FCoV), which results in an amino acid change from methionine to leucine at position 1058, may be associated with feline infectious peritonitis (FIP). Tissue and faecal samples collected post mortem from cats diagnosed with or without FIP were subjected to RNA extraction and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) to detect FCoV RNA. In cats with FIP, 95% of tissue, and 81% of faecal samples were PCR-positive, as opposed to 22% of tissue, and 60% of faecal samples in cats without FIP. Relative FCoV copy numbers were significantly higher in the cats with FIP, both in tissues (P < 0.001) and faeces (P = 0.02). PCR-positive samples underwent pyrosequencing encompassing position 1058 of the FCoV spike protein. This identified a methionine codon at position 1058, consistent with the shedding of an enteric form of FCoV, in 77% of the faecal samples from cats with FIP, and in 100% of the samples from cats without FIP. In contrast, 91% of the tissue samples from cats with FIP and 89% from cats without FIP had a leucine codon at position 1058, consistent with a systemic form of FCoV. These results suggest that the methionine to leucine substitution at position 1058 in the FCoV spike protein is indicative of systemic spread of FCoV from the intestine, rather than a virus with the potential to cause FIP

Patients report improvements in continuity of care when quality of life assessments are used routinely in oncology practice: Secondary outcomes of a randomised controlled trial.

INTRODUCTION AND AIM: In a randomised trial investigating the effects of regular use of health-related quality of life (HRQOL) in oncology practice, we previously reported an improvement in communication (objective analysis of recorded encounters) and patient well-being. The secondary aims of the trial were to measure any impact on patient satisfaction and patients' perspectives on continuity and coordination of their care. METHODS: In a prospective trial involving 28 oncologists, 286 cancer patients were randomised to: (1) intervention arm: regular touch-screen completion of HRQOL with feedback to physicians; (2) attention-control arm: completion of HRQOL without feedback; and (3) control arm: no HRQOL assessment. Secondary outcomes were patients' experience of continuity of care (Medical Care Questionnaire, MCQ) including 'Communication', 'Coordination' and 'Preferences to see usual doctor' subscales, patients' satisfaction, and patients' and physicians' evaluation of the intervention. Analysis employed mixed-effects modelling, multiple regression and descriptive statistics. RESULTS: Patients in the intervention arm rated their continuity of care as better than the control group for 'Communication' subscale (p=0.03). No significant effects were found for 'Coordination' or 'Preferences to see usual doctor'. Patients' evaluation of the intervention was positive. More patients in the intervention group rated the HRQOL assessment as useful compared to the attention-control group (86% versus 29%), and reported their doctors considered daily activities, emotions and quality of life. CONCLUSION: Regular use of HRQOL measures in oncology practice brought changes to doctor-patient communication of sufficient magnitude and importance to be reported by patients. HRQOL data may improve care through facilitating rapport and building inter-personal relationships

Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek’s disease virus (MDV)

Marek’s disease virus (MDV) is an alphaherpesvirus that causes lethal T-cell lymphomas in chickens. MDV is unique in that it harbors two copies of a viral telomerase RNA subunit (vTR) in its genome exhibiting 88% sequence identity to the chicken orthologue, chTR. The minimal telomerase ribonucleoprotein complex consists of a protein subunit with reverse transcriptase activity (TERT) and TR. Physiologically, the complex compensates for the progressive telomere shortening that occurs during mitosis and is involved in the process of cellular immortalization. Previous studies showed that MDV vTR performes an auxiliary function during oncogenesis. Comparative in vitro analysis of the viral and chicken TR promoters revealed that the vTR promoter (PvTR) was up to 3-fold more efficient than the chTR promoter (PchTR) in avian cells and that the stronger transcriptional activity of PvTR resulted largely from an E-box located two nucleotides downstream of the transcriptional start site of the vTR gene. To test the hypothesis that PvTR is required for vTR expression and, hence, efficient tumor formation, we generated a recombinant virus, vPchTR+/+, in which the vTR promoter was replaced by that of chTR. In vivo, growth of vPchTR+/+ was indistinguishable from that of parental virus; however, tumor induction was reduced by > 50% and lymphomas were smaller and less disseminated when compared to those induced by parental virus. We concluded that PvTR is not required for lytic replication in vivo but is essential for efficient transcription of vTR and thereby critical for efficient MDV lymphoma formation

The Grizzly, April 6, 1993

Mr. Ursinus, 1993 • ProTheatre\u27s Actors Deliver in Thornwood • Another Weekend of Fighting in Reimert • Changes in Housing Selection • Wismer Renovations • Waco Standoff Continues • Your Chance to Give • Access to the Vault • Congratulations to P.O.D. for Excelling in Blood Drive • Daffodils for Service • Senior Profile: Allen Clowers • Why Can\u27t I Pick my Classes? • Letters to the Editor • Seniors Return, but Bears Fall • Men\u27s LAX Wants to Be Official • Men\u27s Tennis Young and Improvinghttps://digitalcommons.ursinus.edu/grizzlynews/1314/thumbnail.jp

Cyclicity versus Movement: English Nominalization and Syntactic Approaches to Morpho-phonological Regularity

In this paper, I show that Embick’s (2010) cyclic head approach to regular morphology alone cannot account for the freely available variations in the realization of nominalizers in English nominalizations involving overt verbalizers. Instead, I offer an account of the regularity effects using the technology of Local Dislocation (Embick and Noyer 2001, Embick and Marantz 2008, Embick 2007a, 2007b). Using this analysis, I derive both the variable nominalization patterns and the restrictions on particles and results in derived nominals from Sichel (2010). By treating regularity as the by-product of extant morphosyntatic operations, we can better explain the distribution of regular and irregular nominalizers and account for particle/result restrictions in English derived nominals

The nanosyntax of spatial deixis

This paper provides a fine-grained morphosyntactic analysis of spatial deixis. We propose that the universal core of spatial deixis is a three-way contrast: Proximal close to speaker', Medial close to hearer', and Distal far from speaker and hearer'. This system arises from three features merged as heads in a single universal functional sequence: Dx(3) > Dx(2) > Dx(1). The hierarchy is understood in terms of superset-subset relations, such that Proximal [Dx(1)] is a subset of Medial [Dx(2) [Dx(1)]], which in turn is a subset of Distal [Dx(3) [Dx(2) [Dx(1)]]]. Evidence comes from patterns of syncretism and morphological containment in the demonstrative systems of a number of genetically diverse languages. Regarding syncretisms, languages can show a transparent three-way morphological contrast, or some sort of syncretism: Medial/Proximal vs. Distal, Distal/Medial vs. Proximal, or a totally syncretic Distal/Medial/Proximal (i.e. a neutral demonstrative). These syncretisms entail that the features responsible for the Proximal and Medial readings be adjacent and that the features responsible for the Distal and Medial readings be adjacent in the fseq. Regarding containment, we show that Proximal can be structurally contained within Medial and that Medial can be structurally contained within Distal, meaning that Medial structures are larger than Proximal structures, and that Distal structures are larger than Medial structures, confirming our hierarchy. We show that these facts are naturally accounted for by nanosyntactic principles of spellout. We end the paper by accounting for potential counterexamples and other issues

Resilience, apps and reluctant individualism: Technologies of self in the neoliberal academy

This paper is concerned with the deep crisis affecting universities, as large scale institutional and structural transformations produce a psychosocial and somatic catastrophe amongst academics (and other university workers) that manifests in experiences of chronic stress, anxiety, exhaustion, insomnia and spiralling rates of physical and mental illness. Elsewhere these have been discussed as the 'hidden injuries of the neoliberal university' (Gill, 2010), highlighting the ways in which such experiences are simultaneously acknowledged and recognised by university staff, yet silenced and exorcised from formal spaces of the contemporary academy and without 'proper channels' of expression - being the subject of conference coffee breaks but not keynotes, of after seminar drinks but not departmental meetings, committee minutes or Senate or Council documentation. For future historians seeking to understand through such official records something about the texture of experience of current academic life, the archives will offer no insights.However, in the last few years, this paper suggests, such injuries have moved from being almost completely silenced within universities to becoming the subject of a variety of new spaces and services designed with 'academics in crisis' at their heart. These include the rolling out of 'well-being' services within universities of programmes for stress management, mindfulness and resilience, the development of new 'apps' designed for busy or overworked people, and the rapidly expanding blogosphere which has become a key site for 'naming' and sharing such experiences of distress/injury. The paper looks critically at these three sites. It argues that whilst they recognise at least some aspects of the subjective experience of contemporary academic labouring, they remain locked into a profoundly individualist framework that turns away from systemic or collective politics to offer instead a set of individualised tools by which to 'cope' with the strains of the neoliberal academy