The Healing Power of Creative Storytelling: Utilizing Fiction as a Means of Therapy in the Writer/Reader Relationship

What if we wrote the challenging portions of our lives as comedies or the boring parts as grand adventures? What if we recast painful experiences into creative stories that allow us to live in proximity to our circumstances and not be overwhelmed? Storytelling is how we bridge our lives with creativity as a way to heal from the past, process the present, and hope for the future. This thesis explores how the tradition of creative storytelling has evolved to enable writers and readers to uncover and connect elements of life that would otherwise be too painful to process. By bridging life events through creative writing, not only does the writer benefit from the therapeutic power of storytelling, but they also participate in building community through testimony. As readers discover shared challenges from writers who cast their experiences into the work, they find pathways to their ability to cope. Readers are then encouraged to utilize creative storytelling to discover their own journeys toward wholeness

Automated Modelling of Cortical Bone from Clinical CT

Osteoporosis is an age-related skeletal disease characterised by an increased incidence of fragility fractures. In this thesis I develop a new technique capable of measuring the thickness of the previously unmeasured endocortical region, and providing an improved measure of the cortical bone mineral density (cBMD) from in-vivo clinical CT scans. These features are of interest as both have been linked to fracture risk. \\ The new technique is developed within the cortical bone mapping (CBM) framework so that it provides localised architectural measurements over a bone's surface. Its performance is assessed using simulated QCT data from three simulated phantoms with differing bone architecture, and two paired datasets of ex-vivo QCT and HR-pQCT scans across the proximal femur and the lumbar spine. The simulated data allows for inaccuracies in CBM measurements caused by beam hardening effects to be considered for the first time: I show that beam hardening leads to an underestimation in cortical thickness and an overestimation in trabecular BMD and that these inaccuracies can be reduced through adjustments to the CBM optimisation process. \\ A new technique of analysing HR-pQCT scans is also developed, for the validation of the new CBM method. It was used in place of other established HR-pQCT techniques for its ability to provide localised measurements of the endocortical region. A comparison with the well known full-width half-maximum (FWHM) method shows that it is less susceptible to errors caused by beam hardening. It also measures the mean cBMD, which has a greater clinical relevance than the peak cBMD measured by the FWHM method as it includes the impact of porosity. I demonstrate that the endocortical thickness can be measured to an accuracy of $-0.15\pm0.71\thinspace\mathrm{mm}$, and that local cBMD measurements are possible down to $300\thinspace\mathrm{mg/cm}^3$ from QCT scans over the proximal femur. I also validate CBM methods over the vertebrae for the first time and demonstrate that the cortical thickness and endocortical thickness can be measured with accuracies of $0.10\pm0.30\thinspace\mathrm{mm}$ and $-0.20\pm0.53\thinspace\mathrm{mm}$. \\ Two clinical trials involving Teriparatide are used to demonstrate that the new CBM method is able to detect significant regional changes in the dense cortical and endocortical bone over the proximal femur and lumbar spine, which can be attributed to changes in intracortical remodelling and endosteal apposition. The analysis of a cross-sectional fracture discrimination trial shows that fracture incidence is associated with significant decreases in endocortical thickness over specific regions.UK commonwealth scholarship commissio

Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A.

Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency. Since FVIII is primarily produced in endothelial cells (ECs) in a non-diseased human being, ECs hold great potential for development as a cell therapy for HA. We showed that HA patient-specific induced pluripotent stem cells (HA-iPSCs) could provide a renewable supply of ECs. The HA-iPSC-derived ECs were transduced with lentiviral vectors to stably express the functional B domain deleted F8 gene, the luciferase gene, and the enhanced green fluorescent protein gene (GFP). When transplanted intramuscularly into neonatal and adult immune deficient mice, the HA-iPSC-derived ECs were retained in the animals for at least 10-16 weeks and maintained their expression of FVIII, GFP, and the endothelial marker CD31, as demonstrated by bioluminescence imaging and immunostaining, respectively. When transplanted into HA mice, these transduced HA-iPSC-derived ECs significantly reduced blood loss in a tail-clip bleeding test and produced therapeutic plasma levels (11.2%-369.2%) of FVIII. Thus, our studies provide proof-of-concept that HA-iPSC-derived ECs can serve as a factory to deliver FVIII for the treatment of HA not only in adults but also in newborns

Barriers to Utilizing Medicaid Smoking Cessation Benefits

Introduction. Smoking is the number one preventable cause of deathin the United States. Under the Affordable Care Act, Kansas Medicaidcovers all seven FDA-approved smoking cessation therapies.However, it is estimated only 3% of Kansas Medicaid smokers usetreatment compared to the national estimate of 10%. The objectiveis to determine systemic barriers in place that prevent optimal utilizationof Medicaid smoking cessation benefits among KU MedicalCenter Internal Medicine patients. Methods. For this quality improvement project, a population of 169Kansas Medicaid smokers was identified who had been seen at the KUInternal Medicine Clinic from January 1, 2015 - February 16, 2016.Phone surveys were completed with 62 individuals about smokingstatus, interest in using smoking cessation treatment options, andawareness of Medicaid coverage of treatment. Results. Of the 62 respondents, 24 (39%) were prescribed pharmacotherapyand 41 (66%) were interested in using smoking cessationtreatment. There were eight who had quit smoking. Of the remaining54 smokers, 31 (57%) were unaware that Medicaid would coverpharmacotherapy. Of 24 participants who received a prescription forpharmacotherapy, 13 (54%) were able to fill the prescription at no costusing the Medicaid benefit. Conclusion. The majority of respondents were interested in usingsmoking cessation treatment, yet three main barriers existed to usingMedicaid smoking cessation benefits: physicians not prescribingtreatment to patients, patients not aware of Medicaid coverage, andinadequate pharmacy filling. Improved physician and patient awarenessof Medicaid coverage will facilitate more patients receivingsmoking cessation therapy and ultimately quitting smoking.KS J Med 2017;10(4):88-91

Energy efficiency of information transmission by electrically coupled neurons

The generation of spikes by neurons is energetically a costly process. This paper studies the consumption of energy and the information entropy in the signalling activity of a model neuron both when it is supposed isolated and when it is coupled to another neuron by an electrical synapse. The neuron has been modelled by a four dimensional Hindmarsh-Rose type kinetic model for which an energy function has been deduced. For the isolated neuron values of energy consumption and information entropy at different signalling regimes have been computed. For two neurons coupled by a gap junction we have analyzed the roles of the membrane and synapse in the contribution of the energy that is required for their organized signalling. Computational results are provided for cases of identical and nonidentical neurons coupled by unidirectional and bidirectional gap junctions. One relevant result is that there are values of the coupling strength at which the organized signalling of two neurons induced by the gap junction takes place at relatively low values of energy consumption and the ratio of mutual information to energy consumption is relatively high. Therefore, communicating at these coupling values could be energetically the most efficient option

Platform Politics and Silicon Savannahs: Fintech and the platformed motorcycle: speculating on ordinary mobility economies in urban Africa

Despite the economic challenges caused by the COVID-19 pandemic, venture capital (VC) investments in African startups have remained resilient, surpassing $5 billion in 2021 and experiencing a staggering 264% growth compared to the previous year. Notably, more than 60% of these investments were directed towards fintech companies. The surge in fintech investments in Africa is driven by several factors that make the continent an attractive market. Africa still has a large unbanked population, presenting an opportunity for financial services that offer alternatives to traditional banking methods. The rise of mobile money and cryptocurrencies has brought accessible financial solutions to individuals and informal businesses without access to traditional banking systems. Furthermore, Africa has emerged as a significant market for cryptocurrency trading, providing alternative options in volatile monetary climates and facilitating cross-border transactions. The report draws on empirical research in three case-study cities – Cape Town (South Africa), Kigali (Rwanda), and Nairobi (Kenya) – to showcase some important trends at the interface of fintech and the platformisation of motorcycle economies in urban Africa. It builds on the insight that fintech is not ‘just’ facilitated by digital platforms, but it deploys the same business logics of intermediation and, in doing so, is often part of platformisation itself (Langley and Leyshon, 2021). More specifically, the report shows the importance of the financial-inclusion thrust in linking fintech to two-wheel paratransit, as well as the multiple ways in which digital platforms create new financial pathways in rapport to the physical commodity of the motorcycle; the crucial importance of payment gateways as infrastructures of additional data-driven financial innovation; the promises of risk-management through data and the pilot-based experimental practices through which these promises are given effect; and linkages to the decarbonisation of mobility systems in African cities. For each of these points, the report highlights key policy implications that will require careful attention by researchers, regulators, and private actors in the field

Infancias vulneradas: la parentalidad en el Siglo XXI

El objetivo de esta mesa es presentar trabajos sobre los dilemas y recursos de niños pequeños en contextos de vulnerabilidad social en Latinoamérica y Europa. Los estudios comportan observaciones de las relaciones tempranas entre el niño y sus padres arrojando luz sobre el hecho de que, a pesar de su voluntad, muchas veces los padres se encuentran en la incapacidad responder adecuadamente a las necesidades de su hijo pequeño. Se hace evidente la necesidad de comprender, actualizar paradigmas sobre infancias y ayudar a las madres / padres en las diversas dificultades y en situaciones de vulnerabilidad social. Existen historias de vida infantil tan graves, serias y tristes, con apegos desorganizados que tienen profundos efectos clínicos sobre la personalidad y se transmiten de una generación a otra. Las experiencias que se presentaran confirman que la historia no es destino (Fonagy, 1999). La Dra. Marie Rose Moro acompañó en este campo y continúa el trabajo en Francia .La Lic. Aurora Lucero acompaña desde el Programa Reanimación Vincular del CGBA en esta tarea. y la Dra. Oiberman desde el Programa de Estimulación y Tratamiento para Mejorar la Salud Psíquica y Cognoscitiva de Bebés y Niños sin Cuidados Parentales, Proyecto de Desarrollo Tecnológico Social (PDTS) Del Ciipme-Conicet.Fil: Moro, Marie Rose. Sorbonne University; FranciaFil: Oiberman, Alicia Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Lucero, Aurora Graciela. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Galíndez, Elena Teresa. Universidad de Buenos Aires; ArgentinaXI Congreso Internacional de Investigación y Práctica Profesional en Psicología; XXVI Jornadas de Investigación; XV Encuentro de Investigadores en Psicología del MERCOSUR; I Encuentro de Investigación de Terapia Ocupacional; I Encuentro de MusicoterapiaCiudad Autónoma de Buenos AiresArgentinaUniversidad de Buenos Aires. Facultad de Psicologí

Swab Materials and Bacillus anthracis Spore Recovery from Nonporous Surfaces

Four swab materials were evaluated for their efficiency in recovery of Bacillus anthracis spores from steel coupons. Cotton, macrofoam, polyester, and rayon swabs were used to sample coupons inoculated with a spore suspension of known concentration. Three methods of processing for the removal of spores from the swabs (vortexing, sonication, or minimal agitation) and two swab preparations (premoistened and dry) were evaluated. Results indicated that premoistened swabs were more efficient at recovering spores than dry swabs (14.3% vs. 4.4%). Vortexing swabs for 2 min during processing resulted in superior extraction of spores when compared to sonicating them for 12 min or subjecting them to minimal agitation. Premoistened macrofoam and cotton swabs that were vortexed during processing recovered the greatest proportions of spores with a mean recovery of 43.6% (standard deviation [SD] 11.1%) and 41.7% (SD 14.6%), respectively. Premoistened and vortexed polyester and rayon swabs were less efficient, at 9.9% (SD 3.8%) and 11.5% (SD 7.9%), respectively

Comparative Study of Coupling Techniques in Lamb Wave Testing of Metallic and Cementitious Plates

[Otros] Lamb waves have emerged as a valuable tool to examine long plate-like structures in a faster way compared to conventional bulk wave techniques, which make them attractive in non-destructive testing. However, they present a multimodal and dispersive nature, which hinders signal identification. Oblique incidence is one of the most known methods to generate and receive Lamb waves and it is applied in different experimental arrangements with different types of sensors. In this work, several setups were conducted and compared to determine the optimal ones to launch and detect ultrasonic Lamb waves, especially in non-homogeneous specimens. The chosen arrangements were contact with angle beam transducers, immersion in a water tank, localised water coupling using conical containers and air coupling. Plates of two different materials were used, stainless steel and Portland cement mortar. Theoretical and experimental dispersion curves were compared to verify the existence of Lamb modes and good correspondence was achieved.This research was funded by the Spanish Administration, grants number BES-2015-071958 and BIA2017-87573-C2.Vazquez-Martinez, S.; Gosálbez Castillo, J.; Bosch Roig, I.; Carrión García, A.; Gallardo-Llopis, C.; Paya Bernabeu, JJ. (2019). Comparative Study of Coupling Techniques in Lamb Wave Testing of Metallic and Cementitious Plates. Sensors. 19(19):1-30. https://doi.org/10.3390/s19194068S1301919Birgani, P. T., Tahan, K. N., Sodagar, S., & Shishesaz, M. (2015). Theoretical modeling of low-attenuation lamb wave modes generation in three-layer adhesive joints using angle beam transducer. Latin American Journal of Solids and Structures, 12(3), 461-476. doi:10.1590/1679-78251143Seale, M. D., Smith, B. T., & Prosser, W. H. (1998). Lamb wave assessment of fatigue and thermal damage in composites. 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Materials, 9(6), 437. doi:10.3390/ma9060437Schaal, C., Samajder, H., Baid, H., & Mal, A. (2015). Rayleigh to Lamb wave conversion at a delamination-like crack. Journal of Sound and Vibration, 353, 150-163. doi:10.1016/j.jsv.2015.05.016Rui Zhang, Mingxi Wan, & Wenwu Cao. (2001). Parameter measurement of thin elastic layers using low-frequency multi-mode ultrasonic lamb waves. IEEE Transactions on Instrumentation and Measurement, 50(5), 1397-1403. doi:10.1109/19.963216Balasubramaniam, K., & Rose, J. L. (1991). Physically Based Dispersion Curve Feature Analysis in the NDE of Composites. Research in Nondestructive Evaluation, 3(1), 41-67. doi:10.1080/09349849109409501Niethammer, M., Jacobs, L. J., Qu, J., & Jarzynski, J. (2001). Time-frequency representations of Lamb waves. The Journal of the Acoustical Society of America, 109(5), 1841-1847. doi:10.1121/1.1357813Kuttig, H., Niethammer, M., Hurlebaus, S., & Jacobs, L. J. (2006). Model-based analysis of dispersion curves using chirplets. The Journal of the Acoustical Society of America, 119(4), 2122-2130. doi:10.1121/1.2177587Prosser, W. H., Seale, M. D., & Smith, B. T. (1999). Time-frequency analysis of the dispersion of Lamb modes. The Journal of the Acoustical Society of America, 105(5), 2669-2676. doi:10.1121/1.426883Genovés, V., Gosálbez, J., Carrión, A., Miralles, R., & Payá, J. (2016). Optimized ultrasonic attenuation measures for non-homogeneous materials. Ultrasonics, 65, 345-352. doi:10.1016/j.ultras.2015.09.007Alleyne, D. N., & Cawley, P. (1996). The excitation of Lamb waves in pipes using dry-coupled piezoelectric transducers. Journal of Nondestructive Evaluation, 15(1), 11-20. doi:10.1007/bf00733822Ruiz, A., Ortiz, N., Medina, A., Kim, J.-Y., & Jacobs, L. J. (2013). Application of ultrasonic methods for early detection of thermal damage in 2205 duplex stainless steel. NDT & E International, 54, 19-26. doi:10.1016/j.ndteint.2012.11.009Goueygou, M., Piwakowski, B., Fnine, A., Kaczmarek, M., & Buyle-Bodin, F. (2004). NDE of two-layered mortar samples using high-frequency Rayleigh waves. Ultrasonics, 42(1-9), 889-895. doi:10.1016/j.ultras.2004.01.075Kim, G., Kim, J.-Y., Kurtis, K. E., Jacobs, L. J., Le Pape, Y., & Guimaraes, M. (2014). Quantitative evaluation of carbonation in concrete using nonlinear ultrasound. Materials and Structures, 49(1-2), 399-409. doi:10.1617/s11527-014-0506-1Carrión, A., Genovés, V., Pérez, G., Payá, J., & Gosálbez, J. (2018). Flipped Accumulative Non-Linear Single Impact Resonance Acoustic Spectroscopy (FANSIRAS): A novel feature extraction algorithm for global damage assessment. Journal of Sound and Vibration, 432, 454-469. doi:10.1016/j.jsv.2018.06.031Greve, D. W., Zheng, P., & Oppenheim, I. J. (2008). The transition from Lamb waves to longitudinal waves in plates. Smart Materials and Structures, 17(3), 035029. doi:10.1088/0964-1726/17/3/035029Li, F., Murayama, H., Kageyama, K., & Shirai, T. (2009). Guided Wave and Damage Detection in Composite Laminates Using Different Fiber Optic Sensors. Sensors, 9(5), 4005-4021. doi:10.3390/s90504005Yan-Xun, X., Fu-Zhen, X., & Ming-Xi, D. (2010). Evaluation of Thermal Degradation Induced Material Damage Using Nonlinear Lamb Waves. Chinese Physics Letters, 27(1), 016202. doi:10.1088/0256-307x/27/1/016202Carrión, A., Genovés, V., Gosálbez, J., Miralles, R., & Payá, J. (2017). Ultrasonic signal modality: A novel approach for concrete damage evaluation. Cement and Concrete Research, 101, 25-32. doi:10.1016/j.cemconres.2017.08.011Goueygou, M., Lafhaj, Z., & Soltani, F. (2009). Assessment of porosity of mortar using ultrasonic Rayleigh waves. NDT & E International, 42(5), 353-360. doi:10.1016/j.ndteint.2009.01.002Sancho-Knapik, D., Calas, H., Peguero-Pina, J. J., Ramos Fernandez, A., Gil-Pelegrin, E., & Alvarez-Arenas, T. E. G. (2012). Air-coupled ultrasonic resonant spectroscopy for the study of the relationship between plant leaves’ elasticity and their water content. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 59(2), 319-325. doi:10.1109/tuffc.2012.2194Neuenschwander, J., Schmidt, T., Lüthi, T., & Romer, M. (2006). Leaky Rayleigh wave investigation on mortar samples. Ultrasonics, 45(1-4), 50-55. doi:10.1016/j.ultras.2006.06.00