Diseño de un aula virtual como herramienta en el proceso de aprendizaje del concepto de función en estudiantes de grado noveno del Colegio Restrepo Millán jornada tarde IED

La propuesta de trabajo que a continuación se desarrolla es una estrategia para vincular los elementos que caracterizan a las Nuevas Tecnologías (comunicación, interacción y rapidez en la transmisión de la información) en el ámbito escolar y particularmente en el aprendizaje de las matemáticas. Su contexto principal, el Colegio Restrepo Millán en la jornada Tarde, y como beneficiarios de los resultados de dicha propuesta, los estudiantes de Grado Noveno. Esta propuesta, enmarcada en la Especialización en Diseño de Ambientes de Aprendizaje de la Corporación Minuto de Dios, Uniminuto, está encaminada a incluir el uso de las Nuevas Tecnologías, y en especial aquellos elementos virtuales, que bien puede ser parte de los procesos inherentes a la clase de matemáticas. El interés de la propuesta se centrará en establecer la viabilidad de utilizar, un Aula Virtual de matemáticas, como una herramienta que permita mejorar el proceso de aprendizaje del concepto matemático de Función. Esta propuesta pretende entonces, brindar a los estudiantes de Grado Noveno del colegio Restrepo Millán Jornada Tarde, un ambiente diferente donde desarrollar los procesos de pensamiento, habilidades, destrezas y competencias propias de las matemáticas

Diseño de un aula virtual como herramienta en el proceso de aprendizaje del concepto de función en estudiantes de grado noveno del Colegio Restrepo Millán jornada tarde IED

La propuesta de trabajo que a continuación se desarrolla es una estrategia para vincular los elementos que caracterizan a las Nuevas Tecnologías (comunicación, interacción y rapidez en la transmisión de la información) en el ámbito escolar y particularmente en el aprendizaje de las matemáticas. Su contexto principal, el Colegio Restrepo Millán en la jornada Tarde, y como beneficiarios de los resultados de dicha propuesta, los estudiantes de Grado Noveno. Esta propuesta, enmarcada en la Especialización en Diseño de Ambientes de Aprendizaje de la Corporación Minuto de Dios, Uniminuto, está encaminada a incluir el uso de las Nuevas Tecnologías, y en especial aquellos elementos virtuales, que bien puede ser parte de los procesos inherentes a la clase de matemáticas. El interés de la propuesta se centrará en establecer la viabilidad de utilizar, un Aula Virtual de matemáticas, como una herramienta que permita mejorar el proceso de aprendizaje del concepto matemático de Función. Esta propuesta pretende entonces, brindar a los estudiantes de Grado Noveno del colegio Restrepo Millán Jornada Tarde, un ambiente diferente donde desarrollar los procesos de pensamiento, habilidades, destrezas y competencias propias de las matemáticas

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Study of B meson production in pPb collisions at sNN=\sqrt{s_{ \rm{NN}}} = = 5.02 TeV

The production cross sections of the B+, B0, and B0s mesons, and of their charge conjugates, are measured via exclusive hadronic decays in pPb collisions at the center-of-mass energy $\sqrt{s_{ \rm{NN}}} =$ = 5.02 TeV with the CMS detector at the CERN LHC. The dataset used for this analysis corresponds to an integrated luminosity of 34.6 inverse-nanobarns. The production cross sections are measured in the transverse momentum range between 10 and 60 GeV/c. No significant modification is observed compared to proton-proton perturbative QCD calculations scaled by the number of incoherent nucleon-nucleon collisions. These results provide a baseline for the study of in-medium b quark energy loss in PbPb collisions