762 research outputs found
First-principles study of electron transport through cages
Electron transport properties of C molecules suspended between gold
electrodes are investigated using first-principles calculations. Our study
reveals that the conductances are quite sensitive to the number of C
molecules between electrodes: the conductances of C monomers are near 1
G, while those of dimers are markedly smaller, since incident electrons
easily pass the C molecules and are predominantly scattered at the
C-C junctions. Moreover, we find both channel currents locally
circulating the outermost carbon atoms.Comment: 8 pages and 3 figure
Large-eddy simulation of the lid-driven cubic cavity flow by the spectral element method
This paper presents the large-eddy simulation of the lid-driven cubic cavity
flow by the spectral element method (SEM) using the dynamic model. Two spectral
filtering techniques suitable for these simulations have been implemented.
Numerical results for Reynolds number are showing very good
agreement with other experimental and DNS results found in the literature
Simulating Cosmic Microwave Background maps in multi-connected spaces
This article describes the computation of cosmic microwave background
anisotropies in a universe with multi-connected spatial sections and focuses on
the implementation of the topology in standard CMB computer codes. The key
ingredient is the computation of the eigenmodes of the Laplacian with boundary
conditions compatible with multi-connected space topology. The correlators of
the coefficients of the decomposition of the temperature fluctuation in
spherical harmonics are computed and examples are given for spatially flat
spaces and one family of spherical spaces, namely the lens spaces. Under the
hypothesis of Gaussian initial conditions, these correlators encode all the
topological information of the CMB and suffice to simulate CMB maps.Comment: 33 pages, 55 figures, submitted to PRD. Higher resolution figures
available on deman
Cosmic microwave background anisotropies in multi-connected flat spaces
This article investigates the signature of the seventeen multi-connected flat
spaces in cosmic microwave background (CMB) maps. For each such space it
recalls a fundamental domain and a set of generating matrices, and then goes on
to find an orthonormal basis for the set of eigenmodes of the Laplace operator
on that space. The basis eigenmodes are expressed as linear combinations of
eigenmodes of the simply connected Euclidean space. A preceding work, which
provides a general method for implementing multi-connected topologies in
standard CMB codes, is then applied to simulate CMB maps and angular power
spectra for each space. Unlike in the 3-torus, the results in most
multi-connected flat spaces depend on the location of the observer. This effect
is discussed in detail. In particular, it is shown that the correlated circles
on a CMB map are generically not back-to-back, so that negative search of
back-to-back circles in the WMAP data does not exclude a vast majority of flat
or nearly flat topologies.Comment: 33 pages, 19 figures, 1 table. Submitted to PR
Clinical significance of cerebral microbleeds on MRI
__Background:__ Cerebral microbleeds can confer a high risk of intracerebral hemorrhage, ischemic stroke, death and dementia, but estimated risks remain imprecise and often conflicting. We investigated the association between cerebral microbleeds presence and these outcomes in a large meta-analysis of all published cohorts including: ischemic stroke/TIA, memory clinic, “high risk” elderly populations, and healthy individuals in population-based studies.
__Methods:__ Cohorts (with > 100 participants) that assessed cerebral microbleeds presence on MRI, with subsequent follow-up (≥3 months) were identified. The association between cerebral microbleeds and each of the outcomes (ischemic stroke, intracerebral hemorrhage, death, and dementia) was quantified using random effects models of (a) unadjusted crude odds ratios and (b) covariate-adjusted hazard rations. Results: We identified 31 cohorts (n = 20,368): 19 ischemic stroke/TIA (n = 7672), 4 memory clinic (n = 1957), 3 high risk elderly (n = 1458) and 5 population-based cohorts (n = 11,722). Cerebral microbleeds were associated with an increased risk of ischemic stroke (OR: 2.14; 95% CI: 1.58–2.89 and adj-HR: 2.09; 95% CI: 1.71–2.57), but the relative increase in future intracerebral hemorrhage risk was greater (OR: 4.65; 95% CI: 2.68–8.08 and adj-HR: 3.93; 95% CI: 2.71–5.69). Cerebral microbleeds were an independent predictor of all-cause mortality (adj-HR: 1.36; 95% CI: 1.24–1.48). In three population-based studies, cerebral microbleeds were independently associated with incident dementia (adj-HR: 1.35; 95% CI: 1.00–1.82). Results were overall consistent in analyses stratified by different populations, but with different degrees of heterogeneity.
__Conclusions:__ Our meta-analysis shows that cerebral microbleeds predict an increased risk of stroke, death, and dementia and provides up-to-date effect sizes across different clinical settings. These pooled estimates can inform clinical decisions and trials, further supporting cerebral microbleeds role as biomarkers of underlying subclinical brain pathology in research and clinical settings
Loss of signalling via Gα13 in germinal center B-cell-derived lymphoma
Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined1,2. Work in mice showed that sphingosine-1-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells3,4. Recent deep sequencing studies of GCB-DLBCL have revealed mutations in many genes in this cancer, including in GNA13 (encoding Gα13) and S1PR2 (refs 5,6, 7). Here we show, using in vitro and in vivo assays, that GCB-DLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor's Akt and migration inhibitory functions. Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. Germinal centre B cells, unlike most lymphocytes, are tightly confined in lymphoid organs and do not recirculate. Remarkably, deficiency in Gα13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and blood. GCB-DLBCL cell lines frequently carried mutations in the Gα13 effector ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination. The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13. These findings identify a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Decoherence, irreversibility and the selection by decoherence of quantum states with definite probabilities
The problem investigated in this paper is einselection, i. e. the selection
of mutually exclusive quantum states with definite probabilities through
decoherence. Its study is based on a theory of decoherence resulting from the
projection method in the quantum theory of irreversible processes, which is
general enough for giving reliable predictions. This approach leads to a
definition (or redefinition) of the coupling with the environment involving
only fluctuations. The range of application of perturbation calculus is then
wide, resulting in a rather general master equation.
Two distinct cases of decoherence are then found: (i) A ``degenerate'' case
(already encountered with solvable models) where decoherence amounts
essentially to approximate diagonalization; (ii) A general case where the
einselected states are essentially classical. They are mixed states. Their
density operators are proportional to microlocal projection operators (or
``quasi projectors'') which were previously introduced in the quantum
expression of classical properties.
It is found at various places that the main limitation in our understanding
of decoherence is the lack of a systematic method for constructing collective
observables.Comment: 54 page
Global Search for New Physics with 2.0/fb at CDF
Data collected in Run II of the Fermilab Tevatron are searched for
indications of new electroweak-scale physics. Rather than focusing on
particular new physics scenarios, CDF data are analyzed for discrepancies with
the standard model prediction. A model-independent approach (Vista) considers
gross features of the data, and is sensitive to new large cross-section
physics. Further sensitivity to new physics is provided by two additional
algorithms: a Bump Hunter searches invariant mass distributions for "bumps"
that could indicate resonant production of new particles; and the Sleuth
procedure scans for data excesses at large summed transverse momentum. This
combined global search for new physics in 2.0/fb of ppbar collisions at
sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D
Rapid Communication
Observation of Orbitally Excited B_s Mesons
We report the first observation of two narrow resonances consistent with
states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar
collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the
Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed
as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+,
\bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1})
= 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let
Energy Flow in the Hadronic Final State of Diffractive and Non-Diffractive Deep-Inelastic Scattering at HERA
An investigation of the hadronic final state in diffractive and
non--diffractive deep--inelastic electron--proton scattering at HERA is
presented, where diffractive data are selected experimentally by demanding a
large gap in pseudo --rapidity around the proton remnant direction. The
transverse energy flow in the hadronic final state is evaluated using a set of
estimators which quantify topological properties. Using available Monte Carlo
QCD calculations, it is demonstrated that the final state in diffractive DIS
exhibits the features expected if the interaction is interpreted as the
scattering of an electron off a current quark with associated effects of
perturbative QCD. A model in which deep--inelastic diffraction is taken to be
the exchange of a pomeron with partonic structure is found to reproduce the
measurements well. Models for deep--inelastic scattering, in which a
sizeable diffractive contribution is present because of non--perturbative
effects in the production of the hadronic final state, reproduce the general
tendencies of the data but in all give a worse description.Comment: 22 pages, latex, 6 Figures appended as uuencoded fil
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