Wrappings of power: a woman’s burial in cattle hide at Langwell Farm, Strath Oykel

A well-preserved burial, discovered during peat clearing on Langwell Farm in Strath Oykel, Easter Ross, consisted of a stone cist that held the skeleton of a woman who had died in 2200–1960 cal BC. Although the cist contents were disturbed and partly removed before archaeological investigation took place, the burial rite can be interpreted to some extent. The woman, who died in her late 20s, had been wrapped in brown cattle hide, and wooden and woven objects were placed with her body. Periodic waterlogging created conditions that allowed the rare, partial preservation of the organic materials. Analysis of bone histology indicated that decay of the human remains had been arrested, either by deliberate mummification or waterlogging. The cist had been set into a low knoll on the valley floor and it may have been covered with a low cairn or barrow. This spot had been the site of a fire several hundred years earlier, and it may have been a node on a cross-country route linking east and west coasts in the Early Bronze Age. The use of animal hide suggests the creation and use of particular identities, linking the dead to ancestors and to powerful spiritual properties attributed to the natural world. The work was carried out for Historic Scotland under the Human Remains Call-off Contract

The MNI data-sharing and processing ecosystem

AbstractNeuroimaging has been facing a data deluge characterized by the exponential growth of both raw and processed data. As a result, mining the massive quantities of digital data collected in these studies offers unprecedented opportunities and has become paramount for today's research. As the neuroimaging community enters the world of “Big Data”, there has been a concerted push for enhanced sharing initiatives, whether within a multisite study, across studies, or federated and shared publicly. This article will focus on the database and processing ecosystem developed at the Montreal Neurological Institute (MNI) to support multicenter data acquisition both nationally and internationally, create database repositories, facilitate data-sharing initiatives, and leverage existing software toolkits for large-scale data processing

De dubbele waterput uit het laat-Romeinse castellum van Oudenburg (prov. West-Vlaanderen): tafonomie, chronologie en interpretatie

This article focuses on a remarkable well structure that was brought to light by the Flemish Heritage Institute during recent archaeological research at the south-western corner of the Saxon Shore fort at Oudenburg (2001-2005). The site of Oudenburg is situated 8 km from the Flemish coastline, in the polder area between Bruges and Ostend. During Roman times however, positioned strategically on an elevated sandy ridge, the site overlooked the coastal plain consisting of mudflats and marshes intersected by natural gullies. The remains of the fort at Oudenburg were discovered in 1956-1957 by J. Mertenslater excavation campaigns in 1960 and 1970 on the western defence area revealed a sequence of three successive forts. The 1960s excavations on two late Roman military cemeteries more than 400 m to the west of the castellum revealed burials of 4th-century fort inhabitants with rich grave goods. During archaeological research within the fort walls in 1976-1977 the first information was collected about the inner organisation of the fort and the remains of a stone building of late 3rd-century date were excavated. It was only in 2001 that new excavations could take place on the fort area. This systematic research resulted in a finer chronology for the occupation of the castellum. A succession of five main fort periods was revealed, dating between ca. 200 and the beginning of the 5th century AD. These excavations yielded insight into the spatial organisation of the south west area of the fort, which had different functions in each successive fort period. The first three phases belonged to wood and earthen fortstemporary installations in times of trouble and Germanic threat. Probably in the later 3rd century AD, a more permanent fort measuring 153 by 176 m was built in stonethis was renovated and reoccupied during the second quarter of the 4th century AD. The characteristics of the ground plan, its topographical position and several finds pointing to a close link with the Saxon Shore forts on the coast of south Britannia, suggest that Oudenburg was probably part of the Litus Saxonicum. In this paper the so-called double well, a context of the fifth fort period (4th centurybeginning 5th century), is analysed. During this period the south-western area of the castellum was dominated by a stone bath building with hypocaust system. Later in the 4th century, long fences were constructed to divide the area into yards, a timber-framed construction with simple plan may be identified as a stable structure, and a large oak basin was probably a reservoir for drinking water. The double well, which received feature number OS 2562, seems to be a key context for this fort period

Time- but not sleep-dependent consolidation promotes the emergence of cross-modal conceptual representations

Conceptual knowledge about objects comprises a diverse set of multi-modal and generalisable information, which allows us to bring meaning to the stimuli in our environment. The formation of conceptual representations requires two key computational challenges: integrating information from different sensory modalities and abstracting statistical regularities across exemplars. Although these processes are thought to be facilitated by offline memory consolidation, investigations into how cross-modal concepts evolve offline, over time, rather than with continuous category exposure are still missing. Here, we aimed to mimic the formation of new conceptual representations by reducing this process to its two key computational challenges and exploring its evolution over an offline retention period. Participants learned to distinguish between members of two abstract categories based on a simple one-dimensional visual rule. Underlying the task was a more complex hidden indicator of category structure, which required the integration of information across two sensory modalities. In two experiments we investigated the impact of time- and sleep-dependent consolidation on category learning. Our results show that offline memory consolidation facilitated cross-modal category learning. Surprisingly, consolidation across wake, but not across sleep showed this beneficial effect. By demonstrating the importance of offline consolidation the current study provided further insights into the processes that underlie the formation of conceptual representations

Provenancing Archaeological Wool Textiles from Medieval Northern Europe by Light Stable Isotope Analysis (δ13C, δ15N, δ2H)

We investigate the origin of archaeological wool textiles preserved by anoxic waterlogging from seven medieval archaeological deposits in north-western Europe (c. 700-1600 AD), using geospatial patterning in carbon (δ13C), nitrogen (δ15N) and non-exchangeable hydrogen (δ2H) composition of modern and ancient sheep proteins. δ13C, δ15N and δ2H values from archaeological wool keratin (n = 83) and bone collagen (n = 59) from four sites were interpreted with reference to the composition of modern sheep wool from the same regions. The isotopic composition of wool and bone collagen samples clustered strongly by settlement; inter-regional relationships were largely parallel in modern and ancient samples, though landscape change was also significant. Degradation in archaeological wool samples, examined by elemental and amino acid composition, was greater in samples from Iceland (Reykholt) than in samples from north-east England (York, Newcastle) or northern Germany (Hessens). A nominal assignment approach was used to classify textiles into local/non-local at each site, based on maximal estimates of isotopic variability in modern sheep wool. Light element stable isotope analysis provided new insights into the origins of wool textiles, and demonstrates that isotopic provenancing of keratin preserved in anoxic waterlogged contexts is feasible. We also demonstrate the utility of δ2H analysis to understand the location of origin of archaeological protein samples

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

The Base Excision Repair System of Salmonella enterica serovar Typhimurium Counteracts DNA Damage by Host Nitric Oxide

Intracellular pathogens must withstand nitric oxide (NO·) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO·. Consequently, the level of NO· stress encountered by S. Typhimurium during infection in vivo has been unknown. The Base Excision Repair (BER) system recognizes and repairs damaged DNA bases including cytosine and guanine residues modified by reactive nitrogen species. Apurinic/apyrimidinic (AP) sites generated by BER glycosylases require subsequent processing by AP endonucleases. S. Typhimurium xth nfo mutants lacking AP endonuclease activity exhibit increased NO· sensitivity resulting from chromosomal fragmentation at unprocessed AP sites. BER mutant strains were thus used to probe the nature and extent of nitrosative damage sustained by intracellular bacteria during infection. Here we show that an xth nfo S. Typhimurium mutant is attenuated for virulence in C3H/HeN mice, and virulence can be completely restored by the iNOS inhibitor L-NIL. Inactivation of the ung or fpg glycosylase genes partially restores virulence to xth nfo mutant S. Typhimurium, demonstrating that NO· fluxes in vivo are sufficient to modify cytosine and guanine bases, respectively. Mutants lacking ung or fpg exhibit NO·–dependent hypermutability during infection, underscoring the importance of BER in protecting Salmonella from the genotoxic effects of host NO·. These observations demonstrate that host-derived NO· damages Salmonella DNA in vivo, and the BER system is required to maintain bacterial genomic integrity