Modeling and Optimization of Fiber Optic Chemical Vapor Sensor

This paper discusses the application of Box– Behnken Design (BBD) to get a mathematical model for chemical vapor liquid detection with the objective of optimizing the optical fiber optic sensor probe. The parameters of input process were considered as variables to create the output parameters (response) using Response Surface Methodology (RSM). Input parameters such as length of probe, diameter of probe, photo-initiator liquid, vacuum pressure of chamber and purity of liquid detector were processed with Box – Behnken design approach for making POF (plastic optical fiber) probe of chemical sensor. Design Expert software was used to design the experiments with randomized runs. The main aim is to create an equation model as a platform for the probe design of POF chemical vapors detection similar to acetone, ethanol and methanol liquid. The experimental data were processed by considering the input parameters. The contribution of this research is the mathematic equation model that applies the polynomial equation. The final result of the wavelength application was between five to be three wavelengths, 434.05 nm, 486.13 nm and 656.03 nm. These wavelengths are the significant result of optimization measured using three chemical vapors. The optimization process uses the analysis of variables (ANOVA) to produce the quadratic model equation

Specific treatment of problems of the spine (STOPS): design of a randomised controlled trial comparing specific physiotherapy versus advice for people with subacute low back disorders

<p>Abstract</p> <p>Background</p> <p>Low back disorders are a common and costly cause of pain and activity limitation in adults. Few treatment options have demonstrated clinically meaningful benefits apart from advice which is recommended in all international guidelines. Clinical heterogeneity of participants in clinical trials is hypothesised as reducing the likelihood of demonstrating treatment effects, and sampling of more homogenous subgroups is recommended. We propose five subgroups that allow the delivery of specific physiotherapy treatment targeting the pathoanatomical, neurophysiological and psychosocial components of low back disorders. The aim of this article is to describe the methodology of a randomised controlled trial comparing specific physiotherapy treatment to advice for people classified into five subacute low back disorder subgroups.</p> <p>Methods/Design</p> <p>A multi-centre parallel group randomised controlled trial is proposed. A minimum of 250 participants with subacute (6 weeks to 6 months) low back pain and/or referred leg pain will be classified into one of five subgroups and then randomly allocated to receive either physiotherapy advice (2 sessions over 10 weeks) or specific physiotherapy treatment (10 sessions over 10 weeks) tailored according to the subgroup of the participant. Outcomes will be assessed at 5 weeks, 10 weeks, 6 months and 12 months following randomisation. Primary outcomes will be activity limitation measured with a modified Oswestry Disability Index as well as leg and back pain intensity measured on separate 0-10 Numerical Rating Scales. Secondary outcomes will include a 7-point global rating of change scale, satisfaction with physiotherapy treatment, satisfaction with treatment results, the Sciatica Frequency and Bothersomeness Scale, quality of life (EuroQol-5D), interference with work, and psychosocial risk factors (Orebro Musculoskeletal Pain Questionnaire). Adverse events and co-interventions will also be measured. Data will be analysed according to intention to treat principles, using linear mixed models for continuous outcomes, Mann Whitney U tests for ordinal outcomes, and Chi-square, risk ratios and risk differences for dichotomous outcomes.</p> <p>Discussion</p> <p>This trial will determine the difference in outcomes between specific physiotherapy treatment tailored to each of the five subgroups versus advice which is recommended in guidelines as a suitable treatment for most people with a low back disorder.</p> <p>Trial registration</p> <p>Australia and New Zealand Clinical Trials Register (ANZCTR): <a href="http://www.anzctr.org.au/ACTRN12609000834257.aspx">ACTRN12609000834257</a>.</p

Establishing a Core Outcome Measure for Fatigue in Patients on Hemodialysis: A Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) Consensus Workshop Report

Fatigue is one of the most highly prioritized outcomes for patients and clinicians, but remains infrequently and inconsistently reported across trials in hemodialysis. We convened an international Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) consensus workshop with stakeholders to discuss the development and implementation of a core outcome measure for fatigue. 15 patients/caregivers and 42 health professionals (clinicians, researchers, policy makers, and industry representatives) from 9 countries participated in breakout discussions. Transcripts were analyzed thematically. 4 themes for a core outcome measure emerged. Drawing attention to a distinct and all-encompassing symptom was explicitly recognizing fatigue as a multifaceted symptom unique to hemodialysis. Emphasizing the pervasive impact of fatigue on life participation justified the focus on how fatigue severely impaired the patient’s ability to do usual activities. Ensuring relevance and accuracy in measuring fatigue would facilitate shared decision making about treatment. Minimizing burden of administration meant avoiding the cognitive burden, additional time, and resources required to use the measure. A core outcome measure that is simple, is short, and includes a focus on the severity of the impact of fatigue on life participation may facilitate consistent and meaningful measurement of fatigue in all trials to inform decision making and care of patients receiving hemodialysis

Permafrost and climate in Europe: Monitoring and modelling thermal, geomorphological and geotechnical responses

We present a review of the changing state of European permafrost within a spatial zone that includes the continuous high latitude arctic permafrost of Svalbard and the discontinuous high altitude mountain permafrost of Iceland, Fennoscandia and the Alps. The paper focuses on methodological developments and data collection over the last decade or so, including research associated with the continent-scale network of instrumented permafrost boreholes established between 1998 and 2001 under the European Union PACE project. Data indicate recent warming trends, with greatest warming at higher latitudes. Equally important are the impacts of shorter-term extreme climatic events, most immediately reflected in changes in active layer thickness. A large number of complex variables, including altitude, topography, insolation and snow distribution, determine permafrost temperatures. The development of regionally calibrated empirical-statistical models, and physically based process-oriented models, is described, and it is shown that, though more complex and data dependent, process-oriented approaches are better suited to estimating transient effects of climate change in complex mountain topography. Mapping and characterisation of permafrost depth and distribution requires integrated multiple geophysical approaches and recent advances are discussed. We report on recent research into ground ice formation, including ice segregation within bedrock and vein ice formation within ice wedge systems. The potential impacts of climate change on rock weathering, permafrost creep, landslides, rock falls, debris flows and slow mass movements are also discussed. Recent engineering responses to the potentially damaging effects of climate warming are outlined, and risk assessment strategies to minimise geological hazards are described. We conclude that forecasting changes in hazard occurrence, magnitude and frequency is likely to depend on process-based modelling, demanding improved understanding of geomorphological process-response systems and their impacts on human activity