La seguridad física y sus componentes como parte fundamental en la continuidad de los negocios

La seguridad física tiene un valor fundamental en las organizaciones y requiere de mucha atención por parte de las altas gerencias, buscando la protección del personal, los bienes, instalaciones y los procesos, mediante la generación de estrategias organizacionales, de tal forma que se cuente con un diseño de seguridad efectivo, fundamentado en capas de seguridad, determinando en cada una de ellas la detección, el retardo y la respuesta logrando tener los riesgos plenamente identificados y controlados. La seguridad física, toma parte activa en la continuidad de los negocios, siendo este ultimo el tema de mayor relevancia en las organizaciones en la gestión de riesgos, para permitir que la compañía perdure en el tiempo, ante la materialización de los riesgos

Mechanism of Alkyl Migration in Diorganomagnesium 2,6-Bis(imino)pyridine Complexes: Formation of Grignard-Type Complexes with Square-Planar Mg(II) Centers

Dialkylmagnesium compounds [MgR2L2] (R = n-Bu, L = none or R = Bn, L = THF) react with 2,6-bis(imino)pyridines (BIP) to afford different types of Mg(II) alkyl complexes, depending on the nature of R. For R = n-Bu, thermally stable products resulting from selective alkyl transfer to the pyridine nitrogen (N1) atom are obtained. However, NMR studies showed that the reaction of [Mg(Bn)2THF2] with iPrBIP at −65 °C leads to a thermally unstable product arising from benzyl migration to position C2 in the pyridine ring. Above +5 °C, this compound rearranges, cleanly yielding a mixture of two isomeric complexes, in which the benzyl group has migrated to positions C3 or C4 of the central ring, respectively. Similar isomeric mixtures were obtained when [Mg(Bn)2THF2] was reacted with iPrBIP or MesBIP at room temperature. Such mixtures are thermally stable below 80 °C, but at this temperature, the 3-benzyl isomer converts into the thermodynamically favored 4-benzyl product, albeit not quantitatively. An alternate route was devised for the selective syntheses of the latter type of compounds. The X-ray diffraction structure of one of them provided an unusual example of a square-planar alkylmagnesium(II) center.Ministerio de Economía e Innovación CTQ2015-68978-

Evaluación de impacto de un fondo de financiamiento para la innovación en pymes

ArtículoPurpose – The purpose of this paper is to estimate the impact of one productive development program (PROPYME) in a developing nation like Costa Rica. This program seeks to increase the capacity of small and medium-sized firms (SMEs) to innovate. Design/methodology/approach – Impacts have been estimated assuming that beneficiary firms are trying to maximize their profits and that PROPYME aims to increase these firms productivity. The impacts were measured in terms of three result variables real average wages employment demand and the probability of exporting. A combination of fixed effects and propensity score matching techniques was used in estimations to correct for any selection bias. The authors worked with panel data companies treated and untreated for the period 2001-2011. Findings – PROPYME’s beneficiaries performed better than other firms in terms of labor demand and their probability of exporting. In addition, the dose and the duration of the effects of the treatment (timing effects) are important. Originality/value – The authors study the impact in ways that go beyond the average treatment effects on the treated (ATT) usually estimated in the existing literature. Specifically, the research focusses on the identification of the timing or dynamic effects (i.e. how long should we wait to see results?) and treatment intensity (dosage effects). Keywords Impact evaluation, Innovation, Financing, Probability of exporting, Labour demand, R&D, SMEs, Costa Rica Paper type Research pape

Modelling and Management of Irrigation System

Irrigation is becoming an activity of precision, where combining information collected from various sources is necessary to optimally manage resources. New management strategies, such as big data techniques, sensors, artificial intelligence, unmanned aerial vehicles (UAV), and new technologies in general, are becoming more relevant every day. As such, modeling techniques, both at the water distribution network and the farm levels, will be essential to gather information from various sources and offer useful recommendations for decision-making processes. In this book, 10 high quality papers were selected that cover a wide range of issues that are relevant to the different aspects related to irrigation management: water source and distribution network, plot irrigation systems, and crop water management

Oxygen-Induced Dimerization of Alkyl-Manganese(II) 2,6-Bisiminopyridine Complexes: Selective Synthesis of a New Ditopic NNN-Pincer Ligand

The outcome of the reaction of manganese(II) dialkyls with 2,6-bisiminopyridine (BIP) ligands is dramatically altered by the presence of very small amounts of oxygen (< 0.5 mol %), leading to binuclear species. These arise from the dimerization of the initial product, a Mn(II) 4-alkyl-2,6-bisiminodihydropyridinate alkyl complex. Cleavage of the binuclear Mn products with methanol affords the free dimeric bases, which can be regarded as a special type of ditopic NNN pincer ligand with an unusual tricyclic framework. The coordinative ability of the new ligands has been probed with the syntheses of Zn and Pd organometallic derivativesMinisterio de Economía e Innovación TQ2015- 68978-

Doppler de arterias uterinas en la predicción de trastornos hipertensivos del embarazo en un grupo de pacientes que asisten a tamizaje integrado en semana 11- 13 6/7 . En una unidad de alto riesgo obstétrico

Objetivo: Describir la utilidad diagnóstica y el poder de detección del índice de pulsatilidad anormal de las arterias uterinas durante el primer trimestre del embarazo en relación con la aparición de trastornos hipertensivos asociados al embarazo. Metodología: Estudio retrospectivo, longitudinal con alcances de tipo descriptivo de gestantes con embarazo único que se presentaron a control prenatal en obstetricia y ginecología y a quienes se les realizó tamizaje integrado entre las 11 y136/7 semanas, con determinación de Doppler arterias uterinas (IP); se revisaron historias clínicas, con seguimiento hasta el final del embarazo y comparación de los resultados en las pacientes que desarrollaron trastornos hipertensivos del embarazo con las que no. Conclusiones: Se concluye que el doppler de arterias uterinas podría ser una herramienta útil para la predicción de trastornos hipertensivos del embarazo, específicamente pre eclampsia no complicada, ya que se describen de acuerdo al tamizaje realizado en el estudio, la probabilidad de presentar relación de la alteración de Doppler de arterias uterinas con respecto al desenlace final del trastorno hipertensivo. Hallazgo importante para implementar acciones preventivas o de detección precoz en estas pacientes y evitar complicaciones en la gestación, por lo que se sugiere el complemento de este estudio descriptivo con los aportes que podrían ser más enriquecedores con estudios analíticos.Abstract. Uterine artery Doppler in the prediction of hypertensive disorders of pregnancy in a group of patients attending INTEGRATED SCREENING ATWEEK 11 to 13 6/7In a unit of high-risk obstetrics. objective: Describe the diagnostic utility and power sensing abnormal pulsatility indexof the uterine arteries during the first trimester of pregnancy in relation to the occurrence of pregnancy-related hypertensive disorders methodology: retrospective study, longitudinal, descriptive of pregnant women with singlet on pregnancies presenting to prenatal care in obstetrics and gynecology and who underwentscreeningintegratedbetween11 and 136/7weeks with uterine artery Doppler determination(IP) were review edstories clinical follow-upuntil the endof pregnancy and compared there sultsin patients who developed hypertensive disorders of pregnancy with no. Conclusions: We conclude that the uterine artery Doppler could be auseful tool for the prediction of hypertensive disorders during pregnancy, pre-eclampsias pecifically un complicated described as a ratio of impair eduterine artery Doppler relative to hypertensive disorder final out come. Important finding to implement preventive ors cree ningin the sepatients and prevent complications in pregnancy, so it is suggested to complement this descriptive study the contributions that could be more enriching with analytical studies.Otr

Improvement of Edge Brightening by Means of Q Factor Minimization in Circular Antenna Apertures: High Efficient Taylor-Like Patterns

Implications and improvements of edge brightening effects led by Q factor minimization restricted to keep the same level of directivity for high efficiency continuous circular aperture distributions are here reported. In this manner, an optimization strategy for a minimum Q value-keeping the same level of efficiency and restricting the maximum sidelobe level (SLL)- is envisaged. As application of the method, a design procedure devoted to reduce the Q factor of the antenna aperture distributions while keeping a high level of efficiency is outlined. Then, these optimal Taylor distributions are used as initial point to develop an optimization strategy. This procedure is devoted to search Taylor-like distributions which offer a good compromise between low Q factor and high efficiency values with potentials for the antenna design scenario, based on a decrease in edge brightening effects led by the minimization of the aforementioned Q ratioS

Inter-rater and intra-rater reliability of the extended TUG test in elderly participants

Background: To analyse the reliability, variance and execution time of the Extended Timed Up and Go (Extended TUG) test in three age groups of elderly participants (G1: 55–64 years; G2: 65–74 years; G3: 75–85 years). Methods: An analytical cross-sectional study of 114 recruited participants (63 women) of average age 70.17 (± 7.3) years was undertaken. Each participant performed the Extended TUG three consecutive times, with a rest break between tests of 120 s. Both the intragroup and intergroup reliability of the measurements in the Extended TUG were analysed. Results: The reliability of the Extended TUG test is excellent for the first and second decades but drops down to good for the third decade. Specifically, intragroup reliability ranged from 0.784 for G3 to 0.977 for G1 (G2 = 0.858). Intergroup reliability, compared with intragroup reliability, was slightly lower, ranging between 0.779 for G3 and 0.972 for G1 (G2 = 0.853). Conclusion: The reliability of the Extended TUG test progressively decreases with increasing age, being excellent for the younger age groups and good for the oldest age group

Editorial: Role of Nrf2 in disease: Novel molecular mechanisms and therapeutic approaches

This is supported by FIS/FEDER CP14/00008, CP16/00014, CP16/00017, PI15/00448, PI16/00735, PI16/02057, PI17/00130, Spanish Ministry of Economy and Competitiveness (RYC-2017- 22369), Sociedad Española de Nefrología, Fundacion Renal Iñigo Álvarez de Toledo (FRIAT). Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)

A data mining framework based on boundary-points for gene selection from DNA-microarrays: Pancreatic Ductal Adenocarcinoma as a case study

[EN] Gene selection (or feature selection) from DNA-microarray data can be focused on different techniques, which generally involve statistical tests, data mining and machine learning. In recent years there has been an increasing interest in using hybrid-technique sets to face the problem of meaningful gene selection; nevertheless, this issue remains a challenge. In an effort to address the situation, this paper proposes a novel hybrid framework based on data mining techniques and tuned to select gene subsets, which are meaningfully related to the target disease conducted in DNA-microarray experiments. For this purpose, the framework above deals with approaches such as statistical significance tests, cluster analysis, evolutionary computation, visual analytics and boundary points. The latter is the core technique of our proposal, allowing the framework to define two methods of gene selection. Another novelty of this work is the inclusion of the age of patients as an additional factor in our analysis, which can leading to gaining more insight into the disease. In fact, the results reached in this research have been very promising and have shown their biological validity. Hence, our proposal has resulted in a methodology that can be followed in the gene selection process from DNA-microarray data