Compilation of Selected Vegetable Crop Reports Dealing with Research and Demonstration Plots Located at the Muck Crops Branch, 1983

Spinach cultivar trials, 1982 ; Celery cultivar trials, 1982 / James M. Pisarczyk and Richard L. Hassell -- Potato cultivar trials, 1982 / James M. Pisarczyk -- Celery transplant study, 1982 / Richard L. Hassell -- Parsley 1982 variety trials ; Onion 1982 variety trials ; Broccoli variety trials, 1982 / Richard L. Hassell -- Carrot variety trials, 1982 / R. Mack Riedel and Richard C. Henne -- Control of early blight of celery with fungicides, 1982 ; Control of crucifer downy mildew with fungicide sprays, 1982 / Randall C. Rowe and Richard L. Hassell -- Synergistic interaction between species of lesion nematodes and Verticillium dahliae, 1982 / R. M. Riedel and R. C. Rowe -- Transplants vs. bare-root in controlling root-knot nematode / R. M. Riedel -- Rotations for control of root-knot nematode / R. M. Riedel and J. A. Chatfield -- Fertilizer guidelines for vegetable crops grown on muck soils in Ohio / William M. Brooks, E. C. Wittmeyer and Richard Hassel

Classification of Major Depressive Disorder via Multi-Site Weighted LASSO Model

Large-scale collaborative analysis of brain imaging data, in psychiatry and neurology, offers a new source of statistical power to discover features that boost accuracy in disease classification, differential diagnosis, and outcome prediction. However, due to data privacy regulations or limited accessibility to large datasets across the world, it is challenging to efficiently integrate distributed information. Here we propose a novel classification framework through multi-site weighted LASSO: each site performs an iterative weighted LASSO for feature selection separately. Within each iteration, the classification result and the selected features are collected to update the weighting parameters for each feature. This new weight is used to guide the LASSO process at the next iteration. Only the features that help to improve the classification accuracy are preserved. In tests on data from five sites (299 patients with major depressive disorder (MDD) and 258 normal controls), our method boosted classification accuracy for MDD by 4.9% on average. This result shows the potential of the proposed new strategy as an effective and practical collaborative platform for machine learning on large scale distributed imaging and biobank data

A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cells could conceivably cure this disease. We report a novel high-throughput screening platform that exploits multi-parameter high-content analysis to determine the effect of compounds on beta-cell survival, as well as the promoter activity of two key beta-cell genes, insulin and pdx1. Dispersed human pancreatic islets and MIN6 beta-cells were infected with a dual reporter lentivirus containing both eGFP driven by the insulin promoter and mRFP driven by the pdx1 promoter. B-score statistical transformation was used to correct systemic row and column biases. Using this approach and 5 replicate screens, we identified 7 extracts that reproducibly changed insulin and/or pdx1 promoter activity from a library of 1319 marine invertebrate extracts. The ability of compounds purified from these extracts to significantly modulate insulin mRNA levels was confirmed with real-time PCR. Insulin secretion was analyzed by RIA. Follow-up studies focused on two lead compounds, one that stimulates insulin gene expression and one that inhibits insulin gene expression. Thus, we demonstrate that multi-parameter, high-content screening can identify novel regulators of beta-cell gene expression, such as bivittoside D. This work represents an important step towards the development of drugs to increase insulin expression in diabetes and during in vitro differentiation of beta-cell replacements

Site 503: Eastern Equatorial Pacific

Our primary objective at Site 503 (Fig. 1) was to re- cover a complete, undisturbed Neogene and Quaternary section in the eastern equatorial Pacific. Site 503 is located near Site 83 in an area that contains an almost continuous pelagic record of the past 10 m.y. (Hays et al., 1972). Unfortunately, Site 83 was only spot-cored, and the recovered sediment is so badly disturbed by rotary drilling that most of the detailed record is lost. The section has an average sedimentation rate of 2.0 to 2.5 cm/k.y. with good-to-moderate preservation of all the major microfossil groups. We returned to Site 83 to core the same section, using the Hydraulic Piston Corer (HPC) to obtain an undisturbed, continuous section for high-resolution stratigraphic studies

Site 502: Colombia Basin, Western Caribbean

Our specific objective at Site 502 was to recover an undisturbed, complete section that could be used as a Neogene and Quaternary reference section. A complete record such as this would allow intercorrelations between (1) paleomagnetic stratigraphy, (2) calcareous biostratigraphy, (3) cyclic accumulation of sediment, (4) paleoceanographic changes, (5) oxygen and carbon isotope stratigraphies, (6) the chronology of Central American volcanism, (7) the timing and effects of the emergence of the Isthmus of Panama, and (8) the timing and effects of the initiation of Northern Hemisphere glaciation

Australian Sphingidae – DNA Barcodes Challenge Current Species Boundaries and Distributions

© 2014 Rougerie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

Trumpeting M Dwarfs with CONCH-SHELL: a Catalog of Nearby Cool Host-Stars for Habitable ExopLanets and Life

We present an all-sky catalog of 2970 nearby ($d \lesssim 50$ pc), bright ($J< 9$) M- or late K-type dwarf stars, 86% of which have been confirmed by spectroscopy. This catalog will be useful for searches for Earth-size and possibly Earth-like planets by future space-based transit missions and ground-based infrared Doppler radial velocity surveys. Stars were selected from the SUPERBLINK proper motion catalog according to absolute magnitudes, spectra, or a combination of reduced proper motions and photometric colors. From our spectra we determined gravity-sensitive indices, and identified and removed 0.2% of these as interloping hotter or evolved stars. Thirteen percent of the stars exhibit H-alpha emission, an indication of stellar magnetic activity and possible youth. The mean metallicity is [Fe/H] = -0.07 with a standard deviation of 0.22 dex, similar to nearby solar-type stars. We determined stellar effective temperatures by least-squares fitting of spectra to model predictions calibrated by fits to stars with established bolometric temperatures, and estimated radii, luminosities, and masses using empirical relations. Six percent of stars with images from integral field spectra are resolved doubles. We inferred the planet population around M dwarfs using $Kepler$ data and applied this to our catalog to predict detections by future exoplanet surveys.Comment: Accepted to MNRAS 22 figures, 3 tables, 2 electronic tables. Electronic tables are available as links on this pag

Approximately self-consistent resummations for the thermodynamics of the quark-gluon plasma. I. Entropy and density

We propose a gauge-invariant and manifestly UV finite resummation of the physics of hard thermal/dense loops (HTL/HDL) in the thermodynamics of the quark-gluon plasma. The starting point is a simple, effectively one-loop expression for the entropy or the quark density which is derived from the fully self-consistent two-loop skeleton approximation to the free energy, but subject to further approximations, whose quality is tested in a scalar toy model. In contrast to the direct HTL/HDL-resummation of the one-loop free energy, in our approach both the leading-order (LO) and the next-to-leading order (NLO) effects of interactions are correctly reproduced and arise from kinematical regimes where the HTL/HDL are justifiable approximations. The LO effects are entirely due to the (asymptotic) thermal masses of the hard particles. The NLO ones receive contributions both from soft excitations, as described by the HTL/HDL propagators, and from corrections to the dispersion relation of the hard excitations, as given by HTL/HDL perturbation theory. The numerical evaluations of our final expressions show very good agreement with lattice data for zero-density QCD, for temperatures above twice the transition temperature.Comment: 62 pages REVTEX, 14 figures; v2: numerous clarifications, sect. 2C shortened, new material in sect. 3C; v3: more clarifications, one appendix removed, alternative implementation of the NLO effects, corrected eq. (5.16