51 research outputs found
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Development of Cesium and Strontium Separation and Immobilization Technologies in Support of an Advanced Nuclear Fuel Cycle
As part of the Advanced Fuel Cycle Initiative, two solvent extraction technologies are being developed at the Idaho National Laboratory to simultaneously separate cesium and strontium from dissolved spent nuclear fuel. The chlorinated cobalt dicarbollide/polyethylene glycol (CCD/PEG) process utilizes a solvent consisting of chlorinated cobalt dicarbollide for the extraction of Cs and polyethylene glycol for the synergistic extraction of Sr in a phenyltrifluoromethyl sulfone diluent. Countercurrent flowsheets have been designed and tested on simulated and actual spent nuclear fuel feed streams with both cesium and strontium removal efficiencies of greater than 99%. The Fission Product Extraction (FPEX) process is based on two highly-specific extractants: 4,4',(5')-Di-(t-butyldicyclo-hexano)-18-crown-6 (DtBuCH18C6) for the extraction of Sr and Calix[4]arene-bis-(tert-octylbenzo-crown-6) (BOBCalixC6) for the extraction of Cs. Laboratory test results of the FPEX process, using simulated feed solution spiked with radiotracers, indicate good Cs and Sr extraction and stripping performance. A preliminary solvent extraction flowsheet for the treatment of spent nuclear fuel with the FPEX process has been developed, and testing of the flowsheet with simulated spent nuclear fuel solutions is planned in the near future. Steam reforming is currently being developed for stabilization of the Cs/Sr product stream because it can produce a solid waste form while retaining the Cs and Sr in the solid, destroy the nitrates and organics present in these aqueous solutions, and convert the Cs and Sr into leach resistant aluminosilicate minerals. A bench-scale steam reforming pilot plant has been operated with several potential feed compositions and steam reformed product has been generated and analyzed
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ADVANCED TECHNOLOGIES FOR THE SIMULTANEOUS SEPARATION OF CESIUM AND STRONTIUM FROM SPENT NUCLEAR FUEL
Two new solvent extraction technologies have been recently developed to simultaneously separate cesium and strontium from spent nuclear fuel, following dissolution in nitric acid. The first process utilizes a solvent consisting of chlorinated cobalt dicarbollide and polyethylene glycol extractants in a phenyltrifluoromethyl sulfone diluent. Recent improvements to the process include development of a new, non-nitroaromatic diluent and development of new stripping reagents, including a regenerable strip reagent that can be recovered and recycled. This new strip reagent reduces product volume by a factor of 20, over the baseline process. Countercurrent flowsheet tests on simulated spent nuclear fuel feed streams have been performed with both cesium and strontium removal efficiencies of greater than 99 %. The second process developed to simultaneously separate cesium and strontium from spent nuclear fuel is based on two highly-specific extractants: 4',4',(5')-Di-(t-butyldicyclo-hexano)-18-crown-6 (DtBuCH18C6) and Calix[4]arene-bis-(tert-octylbenzo-crown-6) (BOBCalixC6). The DtBuCH18C6 extractant is selective for strontium and the BOBCalixC6 extractant is selective for cesium. A solvent composition has been developed that enables both elements to be removed together and, in fact, a synergistic effect was observed with strontium distributions in the combined solvent that are much higher that in the strontium extraction (SREX) process. Initial laboratory test results of the new combined cesium and strontium extraction process indicate good extraction and stripping performance
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Development of Technologies for the Simultaneous Separation of Cesium and Strontium from Spent Nuclear Fuel as Part of an Advanced Fuel Cycle
As part of the Advanced Fuel Cycle Initiative, two solvent extraction technologies are being developed to simultaneously separate cesium and strontium from dissolved spent nuclear fuel. The first process utilizes a solvent consisting of chlorinated cobalt dicarbollide and polyethylene glycol extractants in a phenyltrifluoromethyl sulfone diluent. Recent improvements to the process include development of a new, non-nitroaromatic diluent and development of new stripping reagents, including a regenerable strip reagent that can be recovered and recycled. Countercurrent flowsheets have been designed and tested on simulated and actual spent nuclear fuel feed streams with both cesium and strontium removal efficiencies of greater than 99 %. The second process developed to simultaneously separate cesium and strontium from spent nuclear fuel is based on two highly-specific extractants: 4,4',(5')-Di-(t-butyldicyclo-hexano)-18-crown-6 (DtBuCH18C6) and Calix[4]arene-bis-(tert-octylbenzo-crown-6) (BOBCalixC6). The DtBuCH18C6 extractant is selective for strontium and the BOBCalixC6 extractant is selective for cesium. A solvent composition has been developed that enables both elements to be removed together and, in fact, a synergistic effect was observed with strontium distributions in the combined solvent that are much higher that in the strontium extraction (SREX) process. Initial laboratory test results of the new combined cesium and strontium extraction process indicate good extraction and stripping performance. A flowsheet for treatment of spent nuclear fuel is currently being developed
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Development of a novel solvent for the simultaneous separation of strontium and cesium from dissolved Spent Nuclear Fuel solutions
The recovery of Cs and Sr from acidic solutions by solvent extraction has been investigated. The goal of this project was to develop an extraction process to remove Cs and Sr from high-level waste in an effort to reduce the heat loading in storage. Solvents for the extraction of Cs and Sr separately have been used on both caustic and acidic spent nuclear fuel waste in the past. The objective of this research was to find a suitable solvent for the extraction of both Cs and Sr simultaneously from acidic nitrate media. The solvents selected for this research possess good stability and extraction behavior when mixed together. The extraction experiments were performed with 4 ,4,(5 )-Di-(tbutyldicyclohexano)- 18-crown-6 {DtBuCH18C6}, Calix[4]arene-bis-(tert-octylbenzocrown-6) {BOBCalixC6} and 1-(2,2,3,3-tetrafluoropropoxy)-3-(4-sec-butylphenoxy)-2-propanol {Cs-7SB modifier} in a branched aliphatic kerosene {Isopar® L}. The BOBCalixC6 and Cs-7SB modifier were developed at Oak Ridge National Laboratory (ORNL) by Bonnesen et al. [1]. The values obtained from the SREX solvent for DSr in 1 M nitric acid ranged from 0.7 to 2.2 at 25oC and 10oC respectively. The values for DCs in 1 M nitric acid with the CSSX solvent ranged from 8.0 to 46.0 at 25oC and 10oC respectively. A new mixed solvent, developed at the Idaho National Engineering and Environmental Laboratory (INEEL) by Riddle et al. [2], showed distributions for Sr ranging from 8.8 to 17.4 in 1 M nitric acid at 25oC and 10oC respectively. The DCs for the mixed solvent ranged from 7.7 to 20.2 in 1 M nitric acid at 25oC to 10oC respectively. The unexpectedly high distributions for Sr at both 25oC and 10oC show a synergy in the mixed solvent. The DCs, although lower than with CSSX solvent, still showed good extraction behavior
DAF-2/Insulin-Like Signaling in C. elegans Modifies Effects of Dietary Restriction and Nutrient Stress on Aging, Stress and Growth
Dietary restriction (DR) and reduced insulin/IGF-I-like signaling (IIS) are two regimens that promote longevity in a variety of organisms. Genetic analysis in C. elegans nematodes has shown that DR and IIS couple to distinct cellular signaling pathways. However, it is not known whether these pathways ultimately converge on overlapping or distinct targets to extend lifespan.We investigated this question by examining additional effects of DR in wildtype animals and in daf-2 mutants with either moderate or severe IIS deficits. Surprisingly, DR and IIS had opposing effects on these physiological processes. First, DR induced a stress-related change in intestinal vesicle trafficking, termed the FIRE response, which was suppressed in daf-2 mutants. Second, DR did not strongly affect expression of a daf-2- and stress-responsive transcriptional reporter. Finally, DR-related growth impairment was suppressed in daf-2 mutants.These findings reveal that an important biological function of DAF-2/IIS is to enhance growth and survival under nutrient-limited conditions. However, we also discovered that levels of DAF-2 pathway activity modified the effects of DR on longevity. Thus, while DR and IIS clearly affect lifespan through independent targets, there may also be some prolongevity targets that are convergently regulated by these pathways
The state of the Martian climate
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
Co-Regulation of the DAF-16 Target Gene, cyp-35B1/dod-13, by HSF-1 in C. elegans Dauer Larvae and daf-2 Insulin Pathway Mutants
Insulin/IGF-I-like signaling (IIS) has both cell autonomous and non-autonomous functions. In some cases, targets through which IIS regulates cell-autonomous functions, such as cell growth and metabolism, have been identified. In contrast, targets for many non-autonomous IIS functions, such as C. elegans dauer morphogenesis, remain elusive. Here, we report the use of genomic and genetic approaches to identify potential non-autonomous targets of C. elegans IIS. First, we used transcriptional microarrays to identify target genes regulated non-autonomously by IIS in the intestine or in neurons. C. elegans IIS controls expression of a number of stress response genes, which were differentially regulated by tissue-restricted IIS. In particular, expression of sod-3, a MnSOD enzyme, was not regulated by tissue-restricted IIS on the microarrays, while expression of hsp-16 genes was rescued back to wildtype by tissue restricted IIS. One IIS target regulated non-autonomously by age-1 was cyp-35B1/dod-13, encoding a cytochrome P450. Genetic analysis of the cyp-35B1 promoter showed both DAF-16 and HSF-1 are direct regulators. Based on these findings, we propose that hsf-1 may participate in the pathways mediating non-autonomous activities of age-1 in C. elegans
Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial
Background: African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has been limited engagement of African Americans in the development and evaluation of behavioral interventions for management of OA. Pain Coping Skills Training (CST) is a cognitive-behavioral intervention with shown efficacy to improve OA-related pain and other outcomes. Emerging data indicate pain CST may be a promising intervention for reducing racial disparities in OA symptom severity. However, there are important gaps in this research, including incorporation of stakeholder perspectives (e.g. cultural appropriateness, strategies for implementation into clinical practice) and testing pain CST specifically among African Americans with OA. This study will evaluate the effectiveness of a culturally enhanced pain CST program among African Americans with OA.
Methods/Design: This is a randomized controlled trial among 248 participants with symptomatic hip or knee OA, with equal allocation to a pain CST group and a wait list (WL) control group. The pain CST program incorporated feedback from patients and other stakeholders and involves 11 weekly telephone-based sessions. Outcomes are assessed at baseline, 12Â weeks (primary time point), and 36Â weeks (to assess maintenance of treatment effects). The primary outcome is the Western Ontario and McMaster Universities Osteoarthritis Index, and secondary outcomes include self-efficacy, pain coping, pain interference, quality of life, depressive symptoms, and global assessment of change. Linear mixed models will be used to compare the pain CST group to the WL control group and explore whether participant characteristics are associated with differential improvement in the pain CST program. This research is in compliance with the Helsinki Declaration and was approved by the Institutional Review Boards of the University of North Carolina at Chapel Hill, Durham Veterans Affairs Medical Center, East Carolina University, and Duke University Health System.
Discussion: This culturally enhanced pain CST program could have a substantial impact on outcomes for African Americans with OA and may be a key strategy in the reduction of racial health disparities.Funded by Patient-Centered Outcomes Research Institute (PCORI) Award (AD-1408-19519)
Chimpanzees (Pan troglodytes) do not develop contingent reciprocity in an experimental task
Chimpanzees provide help to unrelated individuals in a broad range of situations. The pattern of helping within pairs suggests that contingent reciprocity may have been an important mechanism in the evolution of altruism in chimpanzees. However, correlational analyses of the cumulative pattern of interactions over time do not demonstrate that helping is contingent upon previous acts of altruism, as required by the theory of reciprocal altruism. Experimental studies provide a controlled approach to examine the importance of contingency in helping interactions. In this study, we evaluated whether chimpanzees would be more likely to provide food to a social partner from their home group if their partner had previously provided food for them. The chimpanzees manipulated a barpull apparatus in which actors could deliver rewards either to themselves and their partners or only to themselves. Our findings indicate that the chimpanzees’ responses were not consistently influenced by the behavior of their partners in previous rounds. Only one of the 11 dyads that we tested demonstrated positive reciprocity. We conclude that contingent reciprocity does not spontaneously arise in experimental settings, despite the fact that patterns of behavior in the field indicate that individuals cooperate preferentially with reciprocating partners
Gene Expression Profile of Neuronal Progenitor Cells Derived from hESCs: Activation of Chromosome 11p15.5 and Comparison to Human Dopaminergic Neurons
BACKGROUND: We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription.
METHODOLOGY: Dopaminergic differentiation of hESCs was initiated by culturing hESCs with a feeder layer of PA6 cells. Differentiating cells were then sorted to obtain a pure population of PSA-NCAM-expressing neuronal precursors, which were then analyzed for gene expression using Massive Parallel Signature Sequencing (MPSS). Individual genes as well as regions of the genome which were activated were determined.
PRINCIPAL FINDINGS: A number of genes known to be involved in the specification of dopaminergic neurons, including MSX1, CDKN1C, Pitx1 and Pitx2, as well as several novel genes not previously associated with dopaminergic differentiation, were expressed. Notably, we found that a specific region of the genome located on chromosome 11p15.5 was highly activated. This region contains several genes which have previously been associated with the function of dopaminergic neurons, including the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, IGF2, and CDKN1C, which cooperates with Nurr1 in directing the differentiation of dopaminergic neurons. Other genes in this region not previously recognized as being involved in the functions of dopaminergic neurons were also activated, including H19, TSSC4, and HBG2. IGF2 and CDKN1C were also found to be highly expressed in mature human TH-positive dopamine neurons isolated from human brain samples by laser capture.
CONCLUSIONS: The present data suggest that the H19-IGF2 imprinting region on chromosome 11p15.5 is involved in the process through which undifferentiated cells are specified to become neuronal precursors and/or dopaminergic neurons
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