THE RESOURCES MANAGEMENT MOVEMENT (The Coming Death of Production Management Education)

Production management, taught in nearly all colleges of business administration, is not a popular course. One reason it is not popular is that it does not relate to the typical young student\u27s life experiences. This typical student has for 18 years or more been a social animal, and thus he can relate to college courses in the sociopsychological realm. The rare student who has considerable work experience is the only one likely to appreciate and perhaps even enjoy a course in production management (or operations management, as it is called in some schools). But this kind of problem is found in many fields: engineering, the physical sciences, foreign languages, etc. The instructor in such areas tends to shrug his shoulders and occasionally express the forlorn wish that more students would go to work for a few years before entering college

Book Reviews

Reviews of the following books: Sir William Pepperrell of Colonial New England by Neil Rolde; New England and Foreign Relations 1789-1850 by Paul A. Varg; The Peace Reform in American History by Charles DeBenedetti

Explorations, Vol. 2, No. 3

Cover image: Ezra Pound Dedication: With affection and respect, this issue of EXPLORATIONS is dedicated to Carroll Terrell, Professor Emeritus of English. Articles include: Carroll Terrell and the Great American Poetry Wars, by Burton Hatlen Adventures in China, by H.Y. Forsythe, Jr. Harry Kern and the Making of the New Japan, by Howard B. Schonberger From the Dispatch Case: update on malnutrition in Maine, by Richard Cook Changing Approaches to Protein Structure Determination, by Robert Anderegg The Search of Effective Policy: Meeting the Challenge of an Aging Society, by Dennis A. Watkins and Julia M. Watkins Citizen Survey of the Maine State Police, by Robert A. Stron

Performance measurement : challenges for tomorrow

This paper demonstrates that the context within which performance measurement is used is changing. The key questions posed are: Is performance measurement ready for the emerging context? What are the gaps in our knowledge? and Which lines of enquiry do we need to pursue? A literature synthesis conducted by a team of multidisciplinary researchers charts the evolution of the performance-measurement literature and identifies that the literature largely follows the emerging business and global trends. The ensuing discussion introduces the currently emerging and predicted future trends and explores how current knowledge on performance measurement may deal with the emerging context. This results in identification of specific challenges for performance measurement within a holistic systems-based framework. The principle limitation of the paper is that it covers a broad literature base without in-depth analysis of a particular aspect of performance measurement. However, this weakness is also the strength of the paper. What is perhaps most significant is that there is a need for rethinking how we research the field of performance measurement by taking a holistic systems-based approach, recognizing the integrated and concurrent nature of challenges that the practitioners, and consequently the field, face

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone

Eyes Absents (EYA) are multifunctional proteins best known for their role in organogenesis. There is accumulating evidence that overexpression of EYAs in breast and ovarian cancers, and in malignant peripheral nerve sheath tumors, correlates with tumor growth and increased metastasis. The EYA protein is both a transcriptional activator and a tyrosine phosphatase, and the tyrosine phosphatase activity promotes single cell motility of mammary epithelial cells. Since EYAs are expressed in vascular endothelial cells and cell motility is a critical feature of angiogenesis we investigated the role of EYAs in this process. Using RNA interference techniques we show that EYA3 depletion in human umbilical vein endothelial cells inhibits transwell migration as well as Matrigel-induced tube formation. To specifically query the role of the EYA tyrosine phosphatase activity we employed a chemical biology approach. Through an experimental screen the uricosuric agents Benzbromarone and Benzarone were found to be potent EYA inhibitors, and Benzarone in particular exhibited selectivity towards EYA versus a representative classical protein tyrosine phosphatase, PTP1B. These compounds inhibit the motility of mammary epithelial cells over-expressing EYA2 as well as the motility of endothelial cells. Furthermore, they attenuate tubulogenesis in matrigel and sprouting angiogenesis in the ex vivo aortic ring assay in a dose-dependent fashion. The anti-angiogenic effect of the inhibitors was also demonstrated in vivo, as treatment of zebrafish embryos led to significant and dose-dependent defects in the developing vasculature. Taken together our results demonstrate that the EYA tyrosine phosphatase activity is pro-angiogenic and that Benzbromarone and Benzarone are attractive candidates for repurposing as drugs for the treatment of cancer metastasis, tumor angiogenesis, and vasculopathies

Big Data and Causality

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Causality analysis continues to remain one of the fundamental research questions and the ultimate objective for a tremendous amount of scientific studies. In line with the rapid progress of science and technology, the age of big data has significantly influenced the causality analysis on various disciplines especially for the last decade due to the fact that the complexity and difficulty on identifying causality among big data has dramatically increased. Data mining, the process of uncovering hidden information from big data is now an important tool for causality analysis, and has been extensively exploited by scholars around the world. The primary aim of this paper is to provide a concise review of the causality analysis in big data. To this end the paper reviews recent significant applications of data mining techniques in causality analysis covering a substantial quantity of research to date, presented in chronological order with an overview table of data mining applications in causality analysis domain as a reference directory

Principles of cellular manufacturing/engineering/management: case studies and explications

[EN] Process improvement through cellular manufacturing, engineering, and management (CEM) is largely dated and neglected. This article aims at rejuvenating the topic through re-conceptualization in the form of twelve principles of workcell design, operation, and management, plus six corollary principles. An assessment model, based on the twelve principles is suggested for planning and evaluating proposed or operational CEM cases. Much of the attendant research emerges from published case studies, along with authors own extensive, on-site visitations and analyses. Collectively, an intent to present rationale for considering and treating the workcell/cellular construct as among the more significant concepts/methodologies within the field of manufacturing/engineering/production management.Schonberger, RJ. (2023). Principles of cellular manufacturing/engineering/management: case studies and explications. 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THE RESOURCES MANAGEMENT MOVEMENT (The Coming Death of Production Management Education)

Production management, taught in nearly all colleges of business administration, is not a popular course. One reason it is not popular is that it does not relate to the typical young student\u27s life experiences. This typical student has for 18 years or more been a social animal, and thus he can relate to college courses in the sociopsychological realm. The rare student who has considerable work experience is the only one likely to appreciate and perhaps even enjoy a course in production management (or operations management, as it is called in some schools). But this kind of problem is found in many fields: engineering, the physical sciences, foreign languages, etc. The instructor in such areas tends to shrug his shoulders and occasionally express the forlorn wish that more students would go to work for a few years before entering college

The Transfer of Japanese Manufacturing Management Approaches to U. S. Industry

Just-in-time (JIT) provisioning of manufacturing inventories is a notable feature of Japanese manufacturing management. Kawasaki Motors, USA, has committed itself to JIT objectives, which result in moving toward lotless repetitive manufacturing, a streamlined mode of operation characterized by minimal inventories and shop paper, plus flexible market response. Kawasaki USA has forged a hybrid process of effecting change, featuring Japanese JIT objectives but without Japanese-style consensus mechanisms for making decisions and effecting change