5,449 research outputs found
Polariton lasing in high-quality Selenide-based micropillars in the strong coupling regime
We have designed and fabricated all-epitaxial ZnSe-based optical micropillars
exhibiting the strong coupling regime between the excitonic transition and the
confined optical cavity modes. At cryogenic temperatures, under non-resonant
pulsed optical excitation, we demonstrate single transverse mode polariton
lasing operation in the micropillars. Owing to the high quality factors of
these microstructures, the lasing threshold remains low even in micropillars of
the smallest diameter. We show that this feature can be traced back to a
sidewall roughness grain size below 3 nm, and to suppressed in-plane polariton
escape.Comment: 5 pages, 3 figure
How Protostellar Outflows Help Massive Stars Form
We consider the effects of an outflow on radiation escaping from the
infalling envelope around a massive protostar. Using numerical radiative
transfer calculations, we show that outflows with properties comparable to
those observed around massive stars lead to significant anisotropy in the
stellar radiation field, which greatly reduces the radiation pressure
experienced by gas in the infalling envelope. This means that radiation
pressure is a much less significant barrier to massive star formation than has
previously been thought.Comment: 4 pages, 2 figures, emulateapj, accepted for publication in ApJ
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.
Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells1. Whereas dynamics of epithelial stem cells during homeostasis are increasingly well understood, how stem cells are redirected from a tissue-maintenance program to initiate repair after injury remains unclear. Here we examined infection by Heligmosomoides polygyrus, a co-evolved pathosymbiont of mice, to assess the epithelial response to disruption of the mucosal barrier. H. polygyrus disrupts tissue integrity by penetrating the duodenal mucosa, where it develops while surrounded by a multicellular granulomatous infiltrate2. Crypts overlying larvae-associated granulomas did not express intestinal stem cell markers, including Lgr53, in spite of continued epithelial proliferation. Granuloma-associated Lgr5- crypt epithelium activated an interferon-gamma (IFN-γ)-dependent transcriptional program, highlighted by Sca-1 expression, and IFN-γ-producing immune cells were found in granulomas. A similar epithelial response accompanied systemic activation of immune cells, intestinal irradiation, or ablation of Lgr5+ intestinal stem cells. When cultured in vitro, granuloma-associated crypt cells formed spheroids similar to those formed by fetal epithelium, and a sub-population of H. polygyrus-induced cells activated a fetal-like transcriptional program, demonstrating that adult intestinal tissues can repurpose aspects of fetal development. Therefore, re-initiation of the developmental program represents a fundamental mechanism by which the intestinal crypt can remodel itself to sustain function after injury
Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and to investigate in detail the mechanisms underlying the responses. FHL-124 cells were treated with quercetin (10 µM) and changes in gene expression were measured by microarray. It was found that 65% of the genes with increased expression were regulated by the hypoxia-inducible factor-1 (HIF-1) pathway. Quercetin (10 and 30 µM) induced a time-dependent increase in HIF-1a protein levels. Quercetin (30 µM) was also responsible for a rapid and long-lasting translocation of HIF-1a from the cytoplasm to the nucleus. Activation of HIF-1 signaling by quercetin was confirmed by qRT–PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3. Analysis of medium taken from FHL-124 cells showed a sustained dose-dependent increase in VEGF secretion following quercetin treatment. The quercetin-induced increase and nuclear translocation of HIF-1a was reversed by addition of excess iron (100 µM). These results demonstrate that quercetin activates the HIF-1 signaling pathway in human lens epithelial cells
Program transformations using temporal logic side conditions
This paper describes an approach to program optimisation based on transformations, where temporal logic is used to specify side conditions, and strategies are created which expand the repertoire of transformations and provide a suitable level of abstraction. We demonstrate the power of this approach by developing a set of optimisations using our transformation language and showing how the transformations can be converted into a form which makes it easier to apply them, while maintaining trust in the resulting optimising steps. The approach is illustrated through a transformational case study where we apply several optimisations to a small program
Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes
Lack of physical activity results in muscle atrophy and bone loss, which can be counteracted by mechanical loading. Similar molecular signaling pathways are involved in the adaptation of muscle and bone mass to mechanical loading. Whether anabolic and metabolic factors regulating muscle mass, i.e., insulin-like growth factor-I isoforms (IGF-I Ea), mechano growth factor (MGF), myostatin, vascular endothelial growth factor (VEGF), or hepatocyte growth factor (HGF), are also produced by osteocytes in bone in response to mechanical loading is largely unknown. Therefore, we investigated whether mechanical loading by pulsating fluid flow (PFF) modulates the mRNA and/or protein levels of muscle anabolic and metabolic factors in MLO-Y4 osteocytes. Unloaded MLO-Y4 osteocytes expressed mRNA of VEGF, HGF, IGF-I Ea, and MGF, but not myostatin. PFF increased mRNA levels of IGF-I Ea (2.1-fold) and MGF (2.0-fold) at a peak shear stress rate of 44Pa/s, but not at 22Pa/s. PFF at 22 Pa/s increased VEGF mRNA levels (1.8- to 2.5-fold) and VEGF protein release (2.0- to 2.9-fold). Inhibition of nitric oxide production decreased (2.0-fold) PFF-induced VEGF protein release. PFF at 22 Pa/s decreased HGF mRNA levels (1.5-fold) but increased HGF protein release (2.3-fold). PFF-induced HGF protein release was nitric oxide dependent. Our data show that mechanically loaded MLO-Y4 osteocytes differentially express anabolic and metabolic factors involved in the adaptive response of muscle to mechanical loading (i.e., IGF-I Ea, MGF, VEGF, and HGF). Similarly to muscle fibers, mechanical loading enhanced expression levels of these growth factors in MLO-Y4 osteocytes. Although in MLO-Y4 osteocytes expression levels of IGF-I Ea and MGF of myostatin were very low or absent, it is known that the activity of osteoblasts and osteoclasts is strongly affected by them. The abundant expression levels of these factors in muscle cells, in combination with low expression in MLO-Y4 osteocytes, provide a possibility that growth factors expressed in muscle could affect signaling in bone cells
On the Role of Disks in the Formation of Stellar Systems: A Numerical Parameter Study of Rapid Accretion
We study rapidly accreting, gravitationally unstable disks with a series of
global, three dimensional, numerical experiments using the code ORION. In this
paper we conduct a numerical parameter study focused on protostellar disks, and
show that one can predict disk behavior and the multiplicity of the accreting
star system as a function of two dimensionless parameters which compare the
disk's accretion rate to its sound speed and orbital period. Although
gravitational instabilities become strong, we find that fragmentation into
binary or multiple systems occurs only when material falls in several times
more rapidly than the canonical isothermal limit. The disk-to-star accretion
rate is proportional to the infall rate, and governed by gravitational torques
generated by low-m spiral modes. We also confirm the existence of a maximum
stable disk mass: disks that exceed ~50% of the total system mass are subject
to fragmentation and the subsequent formation of binary companions.Comment: 16 pages, 12 figures, submitte
Resummation of Singlet Parton Evolution at Small x
We propose an improvement of the splitting functions at small x which
overcomes the apparent problems encountered by the BFKL approach. We obtain a
stable expansion for the x-evolution function chi(M) near M=0 by including in
it a sequence of terms derived from the one- and two-loop anomalous dimension
gamma. The requirement of momentum conservation is always satisfied. The
residual ambiguity on the splitting functions is effectively parameterized in
terms of the value of lambda, which fixes the small x asymptotic behaviour
x^-lambda of the singlet parton distributions. We derive from this improved
evolution function an expansion of the splitting function which leads to good
apparent convergence, and to a description of scaling violations valid both at
large and small x.Comment: 16 pages, 6 figures, LaTeX with epsfig; final version, to be
published in Nucl. Phys. B. A few typos corrected for the recor
Bregman Voronoi Diagrams: Properties, Algorithms and Applications
The Voronoi diagram of a finite set of objects is a fundamental geometric
structure that subdivides the embedding space into regions, each region
consisting of the points that are closer to a given object than to the others.
We may define many variants of Voronoi diagrams depending on the class of
objects, the distance functions and the embedding space. In this paper, we
investigate a framework for defining and building Voronoi diagrams for a broad
class of distance functions called Bregman divergences. Bregman divergences
include not only the traditional (squared) Euclidean distance but also various
divergence measures based on entropic functions. Accordingly, Bregman Voronoi
diagrams allow to define information-theoretic Voronoi diagrams in statistical
parametric spaces based on the relative entropy of distributions. We define
several types of Bregman diagrams, establish correspondences between those
diagrams (using the Legendre transformation), and show how to compute them
efficiently. We also introduce extensions of these diagrams, e.g. k-order and
k-bag Bregman Voronoi diagrams, and introduce Bregman triangulations of a set
of points and their connexion with Bregman Voronoi diagrams. We show that these
triangulations capture many of the properties of the celebrated Delaunay
triangulation. Finally, we give some applications of Bregman Voronoi diagrams
which are of interest in the context of computational geometry and machine
learning.Comment: Extend the proceedings abstract of SODA 2007 (46 pages, 15 figures
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