DICER1-associated central nervous system sarcoma: A comprehensive clinical and genomic characterization of case series of young adult patients

Las alteraciones de DICER1 están asociadas con tumores intracraneales en la población pediátrica, incluidos el pineoblastoma, el blastoma hipofisario y el recientemente descrito " sarcoma primario del SNC asociado a DICER1 " (DCS). DCS es un tumor extremadamente agresivo con una firma de metilación distinta y una alta frecuencia de mutaciones concurrentes. Sin embargo, se sabe poco sobre su enfoque de tratamiento y los cambios genómicos que ocurren después de la exposición a la quimiorradioterapia.DICER1 alterations are associated with intracranial tumors in the pediatric population, including pineoblastoma, pituitary blastoma and the recently described "DICER1-associated primary CNS sarcoma" (DCS). DCS is an extremely aggressive tumor with a distinct methylation signature and a high frequency of concurrent mutations. However, little is known about its treatment approach and the genomic changes that occur after exposure to chemoradiotherapy

Un discurrir en el hábitat más íntimo del ser [humano]

¿Qué es una Casa? ¿Qué significa LA CASA? Resulta muy diferente definir LA CASA en términos de concepto que definirla en términos de significado. En la Psicología, se utilizan dos términos relacionados con cada objeto: significado y significante. El significado hace referencia al concepto en sí y, en ese sentido, una casa sería un lugar para habitar, es decir, “un techo encima de la cabeza”, en palabras del profesor mencionado por el editor de este libro. El significante, por su lado, hace referencia al sentido, a la representación mental, al símbolo, a la imagen, a la percepción que, de ese concepto, pueda construir cada persona y, en ese sentido, puede evocar otros conceptos como hogar, refugio, protección, unión, afecto, recuerdos, oportunidades, valores, sabores, olores, eventos, familia, pareja, realización, pasado, futuro, etc

The European Solar Telescope

The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l'Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"

Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas. Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological. Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot

The European Solar Telescope

The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l’Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems

Factores determinantes del uso de sorgo para alimentación de ganado bovino en el noroeste de México

The objective of the study was to analyze the factors that determine the use of free pollination varieties of sorghum in the north of the state of Sinaloa, in order to characterize the type of producers that use this type of seeds. A discrete choice model was utilized to identify the factors that influence the adoption of sorghum by 199 farmers. Later, adopters (n= 11) and non-adopters (n= 188) of the technology were characterized based on non-parametric tests. The results show that 5.5 % of the producers have adopted sorghum varieties. The number of years with technical assistance and milk production were significant (P<0.05) for the adoption. Also, the characterization of the farmers showed that those who have more resources—infrastructure, machinery, livestock, land, wages and technical assistance, —were the ones who adopted the varieties of sorghum. It is concluded that the adoption of seeds is low and requires public goods, such as agricultural outreach programs, for the dissemination of its benefits to allow greater appropriation by farmers in the region of study.El objetivo del estudio fue analizar los factores que determinan el uso de variedades de polinización libre de sorgo en el norte del estado de Sinaloa, con la finalidad de caracterizar el tipo de productores que utilizan este tipo de semillas. Se utilizó un modelo de elección discreta para identificar los factores que inciden en la adopción de sorgo de 199 ganaderos. Posteriormente, a través de pruebas no paramétricas se caracterizaron los adoptadores (n= 11) y no adoptadores (n= 188) de la tecnología. Los resultados muestran que 5.5 % de los productores han adoptado variedades de sorgo. El número de años con asistencia técnica y la producción de leche resultaron significativas (P<0.05) para la adopción. En tanto, la caracterización de los ganaderos mostró que aquellos que cuentan con mayor cantidad de recursos: infraestructura, maquinaria, ganado, tierra, jornales y asistencia técnica, son los que adoptaron las variedades de sorgo. Se concluye que la adopción de semillas es baja y necesita de bienes públicos, como la extensión agrícola, para la difusión de sus beneficios que permita una mayor apropiación de los ganaderos en la región de estudio.

Costeño-201: nueva variedad de sorgo de temporal de doble propósito para Sinaloa

The new sorghum variety Costeño-201 was developed in the Experimental Field Culiacan (CEVACU) of the National Research Institute for Forestry, Agriculture and Livestock (INIFAP), with the registration number SOG-200389-182 in the Catalog of Feasible Certification Varieties (CVC) of Mexico. This variety is adapted to the sorghum-producing areas of Sinaloa State. Costeño-201, is a cream-grain variety and is recommended for irrigated and rainfed conditions. The average yield of the variety is 3 292 kg ha-1 grain and 25 517 kg ha-1 of green fodder, it outperforms on average of 8.8% and 12.4% respectively to commercial hybrids from private companies, which are grown in the region under the same conditions. Costeño-201 has better bromatological quality than commercial hybrids regarding to forage, with 9.5% protein and 64% digestibility, on average it exceeds in 2.7% and 5% respectively to commercial hybrids. It is tolerant to diseases that occur in the region, such as, ergot (Claviceps african), anthracnose (Colletotrichum graminicola), panicle blight (Fusarium moniliforme) and charcoal stalk rot (Macrophomina phaseolina). Forage of sorghum Costeño-201, is recommended as a dual-purpose material in fodder conservation practices such as hay and silage.La nueva variedad de sorgo Costeño-201, fue desarrollado en el Campo Experimental Valle de Culiacán (CEVACU) del Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP), con número de registro SOG-200389-182 en el Catálogo de Variedades Factibles de Certificación (CVC) de México. Esta variedad se adapta a las áreas productoras de sorgo para el estado de Sinaloa. Costeño-201 es una variedad de grano crema y se recomienda para condiciones de riego y temporal. El rendimiento promedio de la variedad es de 3 292 kg ha-1 de grano y 25 517 kg ha-1 de forraje verde, supera en rendimiento promedio de 8.8% y 12.4% respectivamente a híbridos comerciales de compañías privadas, que se cultivan en la región bajo las mismas condiciones. Costeño-201 tiene mejor calidad bromatológica que los híbridos comerciales en el forraje, con 9.5% de proteína y 64% de digestibilidad, supera en promedio 2.7% y 5% respectivamente a híbridos comerciales. Es tolerante a enfermedades que se presentan en la región, como son: ergot (Claviceps african), antracnosis (Colletotrichum graminícola), tizón de la panoja (Fusarium moniliforme) y pudrición carbonosa del tallo (Macrophomina phaseolina). El forraje de sorgo Costeño-201, se recomienda como un material de doble propósito en prácticas de conservación del forraje como henificado y ensilaje

Sinaloense-202, nueva variedad de sorgo para el estado de Sinaloa

The new sorghum variety Sinaloense-202 was developed in the Culiacán Valley Experiment Station of the National Forestry, Agriculture and Livestock Research Institute and was registered with the number 2204-SOG-528-090209/C in the Catalogue of Feasible Varieties of Certification in México. This variety is adapted to sorghum-producing areas in State of Sinaloa, Mexico. The variety Sinaloense-202 has cream grain and is recommended either for irrigation and rainfall areas. The average yield of the variety is 3 210 kg ha-1 of grain and 28 608 kg ha-1 of green forage, which is 8% and 18.1%respectively, higher than the grain and fresh forage yield of commercial hybrids from private companies cultivated in the region. Sinaloense-202 has better bromatologic quality in the forage than commercial hybrids, with 8.3% of protein and 59% of digestibility, which is 1.1% and 10% higher than commercial hybrids. It is tolerant to ergot (Claviceps african), anthracnose (Colletotrichum graminícola), head blight (Fusarium moniliforme) and charcoal rot (Macrophomina phaseolina).La nueva variedad de sorgo Sinaloense-202 fue desarrollado en el Campo Experimental Valle de Culiacán del Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias y registrado con el número 2204-SOG-528-090209/C en el Catálogo de Variedades Factibles de Certificación de México. Esta variedad se adapta a las áreas productoras de sorgo para el estado de Sinaloa. Sinaloense-202 es una variedad de grano crema y se recomienda para condiciones de riego y temporal. El rendimiento promedio de la variedad es de 3 210 kg ha-1 de grano y 28 608 kg ha-1 de forraje verde, supera en promedio 8% y 18.1% respectivamente; el rendimiento de híbridos comerciales de compañías privadas, que se cultivan en la región bajo las mismas condiciones. Sinaloense-202 tiene mejor calidad bromatológica que los híbridos comerciales en el forraje, con un 8.3% de proteína y 59% de digestibilidad, supera en promedio 1.1% y 10% respectivamente, a los híbridos comerciales. Es tolerante a enfermedades que se presentan en la región, como son: ergot (Claviceps african), antracnosis (Colletotrichum graminícola), tizón de la panoja (Fusarium moniliforme) y pudrición carbonosa del tallo (Macrophomina phaseolina)