COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.

Funder: Bundesministerium für Bildung und ForschungFunder: Bundesministerium für Bildung und Forschung (BMBF)We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

The industrialization of buildings : the case of prefabrication in the construction of schools in France (1951-1973)

La thèse porte sur le rapport entre industrialisation du bâtiment et préfabrication dans la construction scolaire en France. Cette relation suggère de comprendre les interactions de la pensée technique et de la politique publique avec l’organisation des processus de production. La période d’étude s’étend de 1951, premier témoin d’une politique industrialiste des plans d'équipement scolaire, à 1973 année de remise en cause de ce type de construction. Durant cette période l’industrialisation du bâtiment est considérée comme la seule solution pour répondre à une construction massive, moins chère et plus rapide. Dès lors, la trajectoire technologique de la préfabrication se subdivise en deux périodes, dévoilantla séparation de la conception technique (centralisée par la DESUS) de la réalisation(représentée par les procédés constructifs). Dans la première période (1951-1962), les architectes sont les auteurs des projets, dans la deuxième (1964-1973) ce sont les procédés les manifestations visibles. Ce parcours met donc en exergue deux logiques opposées :série et volume d’une part, diversité et flexibilité, d’autre part. Le croisement de sources diverses (revues, archives, documentation technique…) révèlent le rapport des différentes acteurs : architectes (de conception et d’opération), concepteurs-éducateurs, industriels entrepreneurs,maîtres d’ouvrage ministériels et ordonnateurs secondaires (contrôle technique). Cette recherche contribue ainsi à l’histoire de la préfabrication et de ses développements. Le bâtiment scolaire représente un excellent échantillon de cette période de maturité de l’industrialisation du bâtiment, postérieure à la Seconde Guerre mondiale lorsque la préfabrication faisait ses preuves.This thesis examines the relationship between the industrialization of building methods andthe prefabrication of school buildings in France. This relationship relies on the interactionbetween technical reason and public policies with the organization of production processes.The boundary of this study begins in 1951, witnessed by a political drive to industrializeeducational establishments, until 1973 when this type of construction was put into question.During this period the industrialization of building methods was considered as the uniquesolution to the needs for mass production, cheaper and quicker. Subsequently, thetechnology of prefabrication occurred in two distinct periods, giving rise to the separationbetween conceptual design (centralized by the DESUS) and realization (represented byconstruction methods). In the first period (1951-1962), the architects are the authors of theprojects and in the second period (1964-1973) the construction methods are clearly visible.These events accentuate two logical opponents: mass production and series on one side,diversity and flexibility on the other. The encounter of such diverse sources (reviews,archives, technical documents) reveals the relationship between each domain: architects(design and operations), educational planners, industrial entrepreneurs, ministerial offices forconstruction and survey teams (technical controls). This research contributes to history ofprefabrication and its developments. The school building represents an excellent example ofthe evolution of construction methods when prefabrication was making its mark in the wakeof the Second World War

L’industrialisation du bâtiment : le cas de la préfabrication dans la construction scolaire en France (1951-1973)

This thesis examines the relationship between the industrialization of building methods andthe prefabrication of school buildings in France. This relationship relies on the interactionbetween technical reason and public policies with the organization of production processes.The boundary of this study begins in 1951, witnessed by a political drive to industrializeeducational establishments, until 1973 when this type of construction was put into question.During this period the industrialization of building methods was considered as the uniquesolution to the needs for mass production, cheaper and quicker. Subsequently, thetechnology of prefabrication occurred in two distinct periods, giving rise to the separationbetween conceptual design (centralized by the DESUS) and realization (represented byconstruction methods). In the first period (1951-1962), the architects are the authors of theprojects and in the second period (1964-1973) the construction methods are clearly visible.These events accentuate two logical opponents: mass production and series on one side,diversity and flexibility on the other. The encounter of such diverse sources (reviews,archives, technical documents) reveals the relationship between each domain: architects(design and operations), educational planners, industrial entrepreneurs, ministerial offices forconstruction and survey teams (technical controls). This research contributes to history ofprefabrication and its developments. The school building represents an excellent example ofthe evolution of construction methods when prefabrication was making its mark in the wakeof the Second World War.La thèse porte sur le rapport entre industrialisation du bâtiment et préfabrication dans la construction scolaire en France. Cette relation suggère de comprendre les interactions de la pensée technique et de la politique publique avec l’organisation des processus de production. La période d’étude s’étend de 1951, premier témoin d’une politique industrialiste des plans d'équipement scolaire, à 1973 année de remise en cause de ce type de construction. Durant cette période l’industrialisation du bâtiment est considérée comme la seule solution pour répondre à une construction massive, moins chère et plus rapide. Dès lors, la trajectoire technologique de la préfabrication se subdivise en deux périodes, dévoilantla séparation de la conception technique (centralisée par la DESUS) de la réalisation(représentée par les procédés constructifs). Dans la première période (1951-1962), les architectes sont les auteurs des projets, dans la deuxième (1964-1973) ce sont les procédés les manifestations visibles. Ce parcours met donc en exergue deux logiques opposées :série et volume d’une part, diversité et flexibilité, d’autre part. Le croisement de sources diverses (revues, archives, documentation technique…) révèlent le rapport des différentes acteurs : architectes (de conception et d’opération), concepteurs-éducateurs, industriels entrepreneurs,maîtres d’ouvrage ministériels et ordonnateurs secondaires (contrôle technique). Cette recherche contribue ainsi à l’histoire de la préfabrication et de ses développements. Le bâtiment scolaire représente un excellent échantillon de cette période de maturité de l’industrialisation du bâtiment, postérieure à la Seconde Guerre mondiale lorsque la préfabrication faisait ses preuves

L'industrialisation du bâtiment (le cas de la préfabrication dans la construction scolaire en France (1951-1973))

La thèse porte sur le rapport entre industrialisation du bâtiment et préfabrication dans la construction scolaire en France. Cette relation suggère de comprendre les interactions de la pensée technique et de la politique publique avec l organisation des processus de production. La période d étude s étend de 1951, premier témoin d une politique industrialiste des plans d'équipement scolaire, à 1973 année de remise en cause de ce type de construction. Durant cette période l industrialisation du bâtiment est considérée comme la seule solution pour répondre à une construction massive, moins chère et plus rapide. Dès lors, la trajectoire technologique de la préfabrication se subdivise en deux périodes, dévoilantla séparation de la conception technique (centralisée par la DESUS) de la réalisation(représentée par les procédés constructifs). Dans la première période (1951-1962), les architectes sont les auteurs des projets, dans la deuxième (1964-1973) ce sont les procédés les manifestations visibles. Ce parcours met donc en exergue deux logiques opposées :série et volume d une part, diversité et flexibilité, d autre part. Le croisement de sources diverses (revues, archives, documentation technique ) révèlent le rapport des différentes acteurs : architectes (de conception et d opération), concepteurs-éducateurs, industriels entrepreneurs,maîtres d ouvrage ministériels et ordonnateurs secondaires (contrôle technique). Cette recherche contribue ainsi à l histoire de la préfabrication et de ses développements. Le bâtiment scolaire représente un excellent échantillon de cette période de maturité de l industrialisation du bâtiment, postérieure à la Seconde Guerre mondiale lorsque la préfabrication faisait ses preuves.This thesis examines the relationship between the industrialization of building methods andthe prefabrication of school buildings in France. This relationship relies on the interactionbetween technical reason and public policies with the organization of production processes.The boundary of this study begins in 1951, witnessed by a political drive to industrializeeducational establishments, until 1973 when this type of construction was put into question.During this period the industrialization of building methods was considered as the uniquesolution to the needs for mass production, cheaper and quicker. Subsequently, thetechnology of prefabrication occurred in two distinct periods, giving rise to the separationbetween conceptual design (centralized by the DESUS) and realization (represented byconstruction methods). In the first period (1951-1962), the architects are the authors of theprojects and in the second period (1964-1973) the construction methods are clearly visible.These events accentuate two logical opponents: mass production and series on one side,diversity and flexibility on the other. The encounter of such diverse sources (reviews,archives, technical documents) reveals the relationship between each domain: architects(design and operations), educational planners, industrial entrepreneurs, ministerial offices forconstruction and survey teams (technical controls). This research contributes to history ofprefabrication and its developments. The school building represents an excellent example ofthe evolution of construction methods when prefabrication was making its mark in the wakeof the Second World War.PARIS-CNAM (751032301) / SudocSudocFranceF

Effect of Dehydration Conditions on the Chemical, Physical, and Rehydration Properties of Instant Whole Bean (Phaseolus vulgaris L. var. Azufrado)

The purpose of this study was to evaluate the effect of dehydration conditions on the chemical, physical, and rehydration properties of instant whole beans (Phaseolus vulgaris L. var. Azufrado) using a 22 factorial design (air temperature: 25°C and 30°C, air velocity: 0.5 m/s and 1.0 m/s). To determine the kinetic parameters, the rehydration data were fitted to three models: Peleg’s, First Order, and Sigmoid. The protein, fat, and ash contents of the beans were not significantly affected () by the dehydration conditions. Of the 11 physical properties of the instant whole beans, only water activity and splitting were significantly affected by dehydration conditions (), with a range from 0.58 to 0.67 and from 2.90% to 5.87%, respectively. Of the three models tested, the First Order model gave the best fit for rehydration, with no significant differences () between the observed and predicted equilibrium moisture contents of the instant whole beans. Regarding the rehydration kinetics for the instant whole beans, the activation energy values ranged from 23.56 kJ/mol to 30.48 kJ/mol, depending on the dehydration conditions. The dehydration conditions had no significant effect () on the rehydration properties of instant whole beans.El propósito de este estudio fue evaluar el efecto de las condiciones de deshidratación sobre las propiedades químicas, físicas y de rehidratación de los frijoles enteros instantáneos (Phaseolus vulgaris L. var. Azufrado) utilizando un diseño factorial 22 (temperatura del aire: 25 ° C y 30 ° C) C, velocidad del aire: 0,5 m / sy 1,0 m / s). Para determinar los parámetros cinéticos, los datos de rehidratación se ajustaron a tres modelos: Peleg's, First Order y Sigmoid. Los contenidos de proteína, grasa y cenizas de los frijoles no fueron afectados significativamente () por las condiciones de deshidratación. De las 11 propiedades físicas de los granos enteros instantáneos, sólo las condiciones de deshidratación afectaron significativamente la actividad y la división del agua (), con un rango de 0,58 a 0,67 y de 2,90% a 5,87%, respectivamente. De los tres modelos probados, el modelo de Primera Orden dio el mejor ajuste para la rehidratación, sin diferencias significativas () entre el contenido de humedad de equilibrio observado y predicho de los granos enteros instantáneos. Con respecto a la cinética de rehidratación de los frijoles enteros instantáneos, los valores de energía de activación oscilaron entre 23,56 kJ / mol y 30,48 kJ / mol, dependiendo de las condiciones de deshidratación. Las condiciones de deshidratación no tuvieron efecto significativo () sobre las propiedades de rehidratación de los granos enteros instantáneos

La miel de abeja y su importancia

Honey is the sweet natural substance produced by the bee Apis mallifera or by different subspecies, from the nectar of the flowers and other extra floral secretions that the bees liban, transport, transform, combine with other substances, dehydrate, concentrate and store in diapers. It is one of the most primitive foods that man took to nourish himself. Its composition is complex and carbohydrates represent the highest proportion, including fructose and glucose, but contains a large variety of minor substances including enzymes, amino acids, organic acids, antioxidants, vitamins and minerals.La miel es la sustancia natural dulce producida por la abeja Apis mallifera o por diferentes subespecies, a partir del néctar de las flores y de otras secreciones extra florales que las abejas liban, transportan, transforman, combinan con otras sustancias, deshidratan, concentran y almacenan en panales. Constituye uno de los alimentos más primitivos que el hombre aprovechó para nutrirse. Su composición es compleja y los carbohidratos representan la mayor proporción, dentro de los que destacan la fructosa y glucosa, pero contiene una gran variedad de sustancias menores dentro de los que destacan las enzimas, aminoácidos, ácidos orgánicos, antioxidantes, vitaminas y minerales