Compartmentalization of Cells Bearing "Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease

Monoclonal antibodies that recognize "rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this diseas

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans

Date of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans published 20-01-2015 DOI: 10.1128/mBio.02489-14Peer reviewedPublisher PD

Social integration processes in Estonia and Slovakia

Studies of interethnic integration in Central Eastern Europe have sought to account for the impact that institutional settings, structural conditions and elite-level interaction have on the accommodation of and conflict resolution between ethnic groups. Much existing literature has placed particular emphasis on the importance of institutional factors, both domestically and as a result of international pressure. Simultaneously, scholarship on the issue has left out of focus the contributions of non-dominant minority actors to the dynamics of interethnic relations. Where minorities are taken into account, this happens largely in terms of their failure to recognise structural opportunities for their inclusion into majority society. This study analyses interethnic integration in the Central Eastern European context from the perspective of structuration theory. Structuration theory provides a sound theoretical foundation in order to study non-dominant agency and its impact on the structures of integration, owing to its ability to reconcile dichotomies. The thesis comprises a comparative case study of interethnic interaction in Estonia and Slovakia, focusing on the Russian-speaking and the Hungarian minority respectively. A structuration approach is applied to the empirical findings in order to problematise practices of integration and their constraints that lie in the institutional and interaction context of Estonian and Slovak post-Communist society. I argue that although Russian-speakers in Estonia and Hungarians in Slovakia are constrained by institutional environs and majority-dominated structures, minority members actively participate in and shape institution-building and group formation in their interaction with majorities. Minority integration is analysed in terms of the minorities’ co-operation within, counteraction against and formulation of alternatives to the status quo structures of interethnic relations

Economic evaluation of different implementation variants and categories of the EU Biodiversity Strategy 2030 using forestry in Germany as a case study

The EU Biodiversity Strategy 2030 (EUBDS) aims to preserve and restore biodiversity by protecting large areas in the EU. An extensive part of these protected areas will presumably be covered by forests. This study analyses the economic effects of EUBDS implementation on German forestry in two scenarios, based on different possible interpretations of the EUBDS’ key commitments, using a forest economic simulation model. A special focus is placed on the opportunity costs of coarse wood debris (CWD). Over a simulated 200-year period, a decrease in timber harvest of 13% and 44% is estimated under the respective scenario assumptions. This leads to a reduction in the silvicultural contribution margin (SCM) of on average 0.25 B EUR a−1 (14%) and 0.79 B EUR a−1 (45%). In terms of the total SCM, protected forests contribute 35% and 15% in the two scenarios. The accumulation and preservation of CWD incurs a substantial loss of utility, as 15% and 19% of annual logging is required for conservation purposes. However, the EUBDS may also provide economically tangible benefits. A rational decision would be to implement a scenario if the “net benefit” from the protected status exceeds the losses from set-aside and conservation requirements

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.Peer reviewedPublisher PD

Philipp Greters Landtaffel der schönen Gelegenheit und Landschaft umb Boll anno 1602

PHILIPP GRETERS LANDTAFFEL DER SCHÖNEN GELEGENHEIT UND LANDSCHAFT UMB BOLL ANNO 1602 Philipp Greters Landtaffel der schönen Gelegenheit und Landschaft umb Boll anno 1602 (-) Einband (-) Titelseite (-) Vorwort ([3]) Einleitung ([5]) Die Landtaffel der schönen Gelegenheit und Landschaft umb Boll vom Jahre 1602. Ein Kartenjubiläum. (7) Landtaffel der schönen Gelegenheit und Landschaft umb Boll / Anno 1602. ([10-11]) Die Ortsnamen der Boller Landtafel. / Zum Teil erläutert durch die Textworte des zugehörigen Bauhin-Förterßchen Neuen Boller Badbuchs. Stuttgart 1602. (13) Die Bergformen der Boller Landtafel. (14) Die Landtafeln des Herzogtums Württemberg im ehemaligen Lusthaus zu Stuttgart. / Gemalt in den Jahren 1590 - 1592. (15) Landtaffel der schönen Gelegenheit und Landschafft umb Boll / Anno 1602. (-) Einband (-

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis

BACKGROUND: Cystic fibrosis is a multi-system disease characterised by the production of thick secretions causing recurrent pulmonary infection, often with unusual bacteria. Intravenous antibiotics are commonly used in the treatment of acute deteriorations in symptoms (pulmonary exacerbations); however, recently the assumption that exacerbations are due to increases in bacterial burden has been questioned. OBJECTIVES: To establish if intravenous antibiotics for the treatment of pulmonary exacerbations in people with cystic fibrosis improve short- and long-term clinical outcomes. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews and ongoing trials registers.Date of last search of Cochrane trials register: 27 July 2015. SELECTION CRITERIA: Randomised controlled trials and the first treatment cycle of cross-over studies comparing intravenous antibiotics (given alone or in an antibiotic combination) with placebo, inhaled or oral antibiotics for people with cystic fibrosis experiencing a pulmonary exacerbation. DATA COLLECTION AND ANALYSIS: The authors assessed studies for eligibility and risk of bias and extracted data. MAIN RESULTS: We included 40 studies involving 1717 participants. The quality of the included studies was largely poor and, with a few exceptions, these comprised of mainly small, inadequately reported studies.When comparing treatment with a single antibiotic to a combined antibiotic regimen, those participants receiving a combination of antibiotics experienced a greater improvement in lung function when considered as a whole group across a number of different measurements of lung function, but with very low quality evidence. When limited to the four placebo-controlled studies (n = 214), no difference was observed, again with very low quality evidence. With regard to the review's remaining primary outcomes, there was no effect upon time to next exacerbation and no studies in any comparison reported on quality of life. There were no effects on the secondary outcomes weight or adverse effects. When comparing specific antibiotic combinations there were no significant differences between groups on any measure. In the comparisons between intravenous and nebulised antibiotic or oral antibiotic (low quality evidence), there were no significant differences between groups on any measure. No studies in any comparison reported on quality of life. AUTHORS' CONCLUSIONS: The quality of evidence comparing intravenous antibiotics with placebo is poor. No specific antibiotic combination can be considered to be superior to any other, and neither is there evidence showing that the intravenous route is superior to the inhaled or oral routes. There remains a need to understand host-bacteria interactions and in particular to understand why many people fail to fully respond to treatment

Forest management strategies for climate change

• Active adaptation of forests to climate change demands significant financial investments by the present generation for the benefit of future generations. • Despite high upfront investment costs, the “active climate adaptation” scenario proves to be more economically advantageous in the long run