Analysis of inequality in fertility curves fitted by gamma distributions

The aim of this paper is to analyse fertility curves from a novel viewpoint, that of inequality. Through sufficient conditions that can be easily verified, we compare inequality, in the Lorenz and Generalized Lorenz sense, in fertility curves fitted by gamma distributions, thus achieving a useful complementary instrument for demographic analysis. As a practical application, we examine inequality behaviour in the distributions of specific fertility curves in Spain from 1975 to 2009.Peer Reviewe

Are Migrants Selected on Motivational Orientations? Selectivity Patterns amongst International Migrants in Europe

Migration scholars often assume migrants are the most ambitious and motivated individuals of their home countries. Yet research on motivational selectivity is scant. We present the first systematic cross-national analysis of migrants' selectivity on achievement-related motivational orientations (ARMOs). We measure ARMOs using a validated scale that combines orientations towards socio-economic success, risk, and money. Matching the European Social Survey and the World Value Survey cumulative data sets, we examine whether international migrants recently arrived in Europe are more achievement-oriented than those observational equivalents that do not migrate. We focus on migrants from nine different origins (France, Germany, the United Kingdom, Poland, Romania, Turkey, Morocco, Brazil, and Andean countries) sampled at different European destinations varying in gross domestic product, type of welfare state, and linguistic distance. Our findings seem to contradict the arguments about a common migrant personality put forward by social psychologists, as well as most of the predictions of standard economic models. We do find, however, some support for the welfare magnet hypothesis, as well as for the expectation that gender traditionalism favours negative selectivity of migrant women. We show that reported estimates are not driven by educational selectivity and are unlikely to be biased by destination effects.This study received financial support from the following two projects: Growth, Equal Opportunities, Migration, and Markets, GEMM, funded by the European Commission Horizon 2020 programme (ID 649255), and New Approaches to Immigration Research, NewAIR, funded by the Spanish Ministry of Economy and Competitiveness (CSO2016-78452)

Characterization of Pediococcus ethanolidurans CUPV141: A b-D-glucan- and Heteropolysaccharide-Producing Bacterium

Pediococcus ethanolidurans CUPV141 is an exopolysaccharide (EPS)-producing lactic acid bacterium, first isolated from Basque Country cider (Spain). Physicochemical analysis of the EPS synthesized by the bacterium revealed that CUPV141 produces mostly a homopolysaccharide (HoPS), characterized as a 2-substituted (1,3)-beta-D-glucan, together with a small quantity of a heteropolysaccharide (HePS) composed of glucose, galactose, glucosamine, and glycerol-3-phosphate, this being the first Pediococcus strain described to produce this kind of polymer. On the contrary, an isogenic strain CUPV141NR, generated by chemical mutagenesis of CUPV141, produced the HePS as the main extracellular polysaccharide and a barely detectable amount of 2-substituted (1,3)-beta-D-glucan. This HoPS is synthesized by the transmembrane GTF glycosyltransferase (GTF), encoded by the gtf gene, which has been previously reported to be located in the pPP2 plasmid of the Pediococcus parvulus 2.6 strain. Southern blot hybridization revealed that in CUPV141 the gtf gene is located in a plasmid designated as pPE3, whose molecular mass (34.4 kbp) is different from that of pPP2 (24.5 kbp). Analysis of the influence of the EPS on the ability of the producing bacteria to adhere to the eukaryotic Caco-2 cells revealed higher affinity for the human enterocytes of CUPV141NR compared to that of CUPV141. This result indicates that, in contrast to the 2.6 strain, the presence of the HoPS does not potentiate the binding ability of P. ethanolidurans. Moreover, it supports that the phosphate-containing bacterial HePS improved the interaction between P. ethanolidurans and the eukaryotic cells.This work was supported by a grant from the Department of Environment, Territorial Planification, Agriculture and Fishing and the project no. IT 866-13 from the Basque Government and by the Spanish Ministry of Science and Innovation (AGL 2015-65010-C3-1-R)

Minimizing the social impact of construction work on mobility: a decision-making method

Minimising the impacts of construction work on mobility, especially in urban areas, is a major issue for local authorities and construction planners that has not been sufficiently studied. This paper proposes a deterministic decision-making method for quantifying the impacts of construction work on mobility, including emergency vehicles, mass transit, individual transport, bicycles, and pedestrians. The method is based on multi-attribute utility theory, interviews with experts representing various stakeholders in construction, and a review of the literature and legislation. The practical use is illustrated with a real case study in which two shaft-construction processes (diaphragm wall excavated using a hydromill and vertical shaft sinking machine) are compared and ranked. The sensitivity analysis shows the robustness of the results. The resulting Mobility Impact Index can easily be integrated with other social, economic, and environmental criteria, thereby enabling the evaluation of alternatives from a multi-criteria perspective, e.g., in tender processes. The method could be useful to public authorities and design and construction companies and is being piloted in construction projects of the city of Barcelona. It has implications for corporate social responsibility, social/sustainable procurement, and social/sustainable impact assessment in construction

Genetic Dissection of the Regulatory Network Associated with High c-di-GMP Levels in Pseudomonas putida KT2440

Most bacteria grow in nature forming multicellular structures named biofilms. The bacterial second messenger cyclic diguanosine monophosphate (c-di-GMP) is a key player in the regulation of the transition from planktonic to sessile lifestyles and this regulation is crucial in the development of biofilms. In Pseudomonas putida KT2440, Rup4959, a multidomain response regulator with diguanylate cyclase activity, when overexpressed causes an increment in the intracellular levels of c-di-GMP that gives rise to a pleiotropic phenotype consisting of increased biofilm formation and crinkly colony morphology. In a broad genomic screen we have isolated mutant derivatives that lose the crinkly morphology, designed as cfc (crinkle free colony). A total of 19 different genes have been identified as being related with the emergence of the cfc phenotype either because the expression or functionality of Rup4959 is compromised, or due to a lack of transduction of the c-di-GMP signal to downstream elements involved in the acquisition of the phenotype. Discernment between these possibilities was investigated by using a c-di-GMP biosensor and by HPLC-MS quantification of the second messenger. Interestingly five of the identified genes encode proteins with AAA+ ATPase domain. Among the bacterial determinants found in this screen are the global transcriptional regulators GacA, AlgU and FleQ and two enzymes involved in the arginine biosynthesis pathway. We present evidences that this pathway seems to be an important element to both the availability of the free pool of the second messenger c-di-GMP and to its further transduction as a signal for biosynthesis of biopolimers. In addition we have identified an uncharacterized hybrid sensor histidine kinase whose phosphoaceptor conserved histidine residue has been shown in this work to be required for in vivo activation of the orphan response regulator Rup4959, which suggests these two elements constitute a two-component phosphorelay system.This work was supported by grants BFU2010-17946 and BFU2013-43469-P from Plan Nacional de I+D+I (Spanish Government) and by EDFR funds. OH-R was supported by a FPI fellowship and LB-M by predoctoral fund from Junta de Andalucía. MAM was supported by the Postdoctoral Juan de la Cierva Spanish Research Program (JCI-2012-11815).Peer reviewedPeer Reviewe

Applying a model-based methodology to develop web-based systems of systems

Systems of Systems (SoS) are emerging applications composed by subsystems that interacts in a distributed and heterogeneous environment. Web-based technologies are a current trend to achieve SoS user interaction. Model Driven Web Engineering (MDWE) is the application of Model Driven Engineering (MDE) into the Web development domain. This paper presents a MDWE methodology to include Web-based interaction into SoS development. It's composed of ten models and seven model transformations and it's fully implemented in a support tool for its usage in practice. Quality aspects covered through the traceability from the requirements to the nal code are exposed. The feasibility of the approach is validated by its application into a real-world project. A preliminary analysis of potential benets (reduction of eort, time, cost; improve of quality; design vs code ratio, etc) is done by comparison to other project as an initial hypothesis for a future planned experimentation research.Ministerio de Economía, Industria y Competitividad TIN2013-46928-C3- 3-RMinisterio de Economía, Industria y Competitividad TIN2015-71938-RED

Local Development Applied to Energy Scheme

Manabí is a province with great potential, either in the agri-food sector or in the renewable generation of energy. However, the limitations inherited from traditional development models prevent achieving the sustainable development of this territory. This paper proposes a development model at the local level, aimed at achieving equity and, through the use of renewable energy sources and other potentials present in specific territories, to improve the quality of life and reduce the risks of societies present there. Through geographic information systems, it was possible to generate and display on maps information related to the energy demand at the provincial and cantonal levels, as well as the province's energy behavior considering the population density

Effect of Ionizing Radiation on Human Myeloperoxidase: Reaction With Hydrated Electrons

Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG[Abstract] Myeloperoxidase (MPO) is a myeloid-lineage restricted enzyme largely expressed in the azurophilic granules of neutrophils. It catalyses the formation of reactive oxygen species, mainly hypochlorous acid, contributing to anti-pathogenic defense. Disorders in the production or regulation of MPO may lead to a variety of health conditions, mainly of inflammatory origin, including autoimmune inflammation. We have studied the effect of ionizing radiation on the activity of MPO, as measured by the capacity retained by the enzyme to produce hypochlorous acid as reactive oxygen species after exposure to successive doses of solvated electrons, the strongest possible one-e− reducing agent in water. Chlorination activity was still present after a very high irradiation dose, indicating that radiation damage does not take place at the active site, hindered in the core of MPO structure. Decay kinetics show a dependence on the wavelength, supporting that the process must occur at peripheral functional groups situated on external and readily accessible locations of the enzyme. These results are relevant to understand the mechanism of resistance of our innate anti-pathogenic defense system and also to get insight into potential strategies to regulate MPO levels as a therapeutic target in autoimmune diseases.This work was supported by: the Spanish Ministerio de Ciencia y Tecnología (CTQ2004-00534/BQU), the European Commission through the Access to Large-Scale Scientific Facilities Program (ref 41365), and the regional government of the Xunta de Galicia (Project GPC ED431B 2020/52)Xunta de Galicia; ED431B 2020/5