Shopping for Hose

Another pair of hose gone! Betty Coed sighs deeply and wonders if she can possibly buy another pair out of this month\u27s allowance. Perhaps a few pointers would help Betty to buy more efficiently, and thereby cut her hosiery bill

The Iowa Homemaker vol.16, no.6

Cooperation Transforms Work Into Play by Helen Clark and Charlotte Heffner, page 2 Modernize Your Walls by Virginia Berry, page 3 Take a Hint from Sally by Gaynold Carroll, page 4 Should Women Have Careers? by Josephine Betty, page 6 Many Foods Make Their Debut by Jean Reis and Clare Pell, page 7 What’s New in Home Economics, page 8 The Woman’s Place in Politics by Dorothy Fedderson, page 11 Mrs. Chang Serves a Chinese Dinner by Helen Peg Belken, page 12 Graduates in New Positions by Faithe Danielson, page 13 Extend the Holiday Hilarity by Marie Larson, page 14 Shopping for Hose by Rosalie Ralston, page 15 Hints for the Coed, page 1

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Shopping for Hose

Another pair of hose gone! Betty Coed sighs deeply and wonders if she can possibly buy another pair out of this month's allowance. Perhaps a few pointers would help Betty to buy more efficiently, and thereby cut her hosiery bill.</p

The Iowa Homemaker vol.16, no.6

Cooperation Transforms Work Into Play by Helen Clark and Charlotte Heffner, page 2 Modernize Your Walls by Virginia Berry, page 3 Take a Hint from Sally by Gaynold Carroll, page 4 Should Women Have Careers? by Josephine Betty, page 6 Many Foods Make Their Debut by Jean Reis and Clare Pell, page 7 What’s New in Home Economics, page 8 The Woman’s Place in Politics by Dorothy Fedderson, page 11 Mrs. Chang Serves a Chinese Dinner by Helen Peg Belken, page 12 Graduates in New Positions by Faithe Danielson, page 13 Extend the Holiday Hilarity by Marie Larson, page 14 Shopping for Hose by Rosalie Ralston, page 15 Hints for the Coed, page 15</p

The cross-cultural research imperative: the need to balance cross-national and intra-national diversity

This paper provides a brief overview of the evolution of comparative management theories/paradigms, and highlights the contribution of the ‘cross-vergence’ construct. Despite progress, most studies of work values across countries continue to suffer from two primary limitations. The first is the fallacious assumption of cultural homogeneity with nations. Given the growing diversity of the workforce within country, intra-national variations can often be as significant as cross-national differences. The second is the fallacious assumption of cultural stability over time. Since cultures evolve, albeit slowly, it is important to take these changes over time into consideration, and be aware of the paradoxes inherent within any given society. Hence the paper calls for the need to balance cross-national and intra-national diversity in order to truly understand cross-cultural phenomena, and thus further improve the quality of cross-cultural research. Journal of International Business Studies (2008) 39, 41–46. doi:10.1057/palgrave.jibs.8400331