192 research outputs found
New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized
Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones
A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity
Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones
252-257A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity
PTSA CATALYZED KSF SOLID SUPPORTED MICHAEL ADDITION ON STYRYLISOXAZOLES AND THEIR REDUCTIVE CYCLIZATION TO AZEPINES
Abstract The Michel addition of styrylisoxazoles with ethyl benzoyl acetate in presence of ptoluene sulfonic acid (PTSA) catalyst supported on KSF solid furnished the Michael adducts in excellent yields in short time. The Michael adducts underwent reductive cyclization on treatment with SnCl 2 -MeOH to afford isoxazolo [4,5-b] azepines in high yields
One-pot Multicomponent Synthesis of Isoxazolyl Spiro[indoline-3,2′-pyrrolidine]-2,4′-diones Catalyzed by CAN
An efficient and modified biginelli one-pot synthesis of new isoxazole substitted 3,4-dihydropyrimidin-2(1 H
- …