Κβαντικοί Υπολογισμοί

We start this project by describing the quantum model on which the quantum computation theory has been built. The main part of this project has to do with the Fourier transform on finite abelian groups and its use in P.Shor0s quantum algorithm for factorizing integers in polynomial time. As well, we describe L.Grover0s quantum algorithm for searching an element in an unstructured database of N elements (which is of order O(pN)) and we prove that Grover0s algorithm is optimal

Highly Enantioselective Hetero-Diels–Alder Reaction of 1,3-Bis-(silyloxy)-1,3-dienes with Aldehydes Catalyzed by Chiral Disulfonimide

Bulking up with F: The title reaction proceeds using 1 mol % of the new perfluoroisopropyl chiral disulfonimide catalyst 1 to deliver several 2,6-disubstituted and 2,5,6-trisubstituted dihydropyrones in good yields and with excellent enantiomeric ratios. The utility of this methodology is illustrated with the first enantioselective synthesis of a potent aromatase inhibitor

A powerful chiral counteranion motif for asymmetric catalysis

García García, P.; Lay, F.; Garcia Garcia, P.; Rabalakos, C.; List, B. (2009). A powerful chiral counteranion motif for asymmetric catalysis. Angewandte Chemie International Edition. 48(24):4363-4366. doi:10.1002/anie.20090176843634366482

Enantioselective LaIII-pyBOX-Catalyzed Nitro-Michael Addition to (E)-2-Azachalcones

A [La(OTf)3] complex with a new pyBOX ligand bearing a bulky 1-naphthylmethyl substituent at the 4-position of the oxazoline ring catalyzes the conjugate addition of nitroalkanes to a broad range of (E)-2-azachalcones, providing the expected nitro-Michael products with good yields and enanItiomeric excesses up to 87%. The optical purity of the products can be increased by a single crystallization. A plausible stereochemical model to account for the observed stereochemistry has been proposed.Financial support from the Ministerio de Ciencia e Innovacion (MICINN) and Fundo Europeu de Desenvolvimento Regional (FEDER) (grant number CTQ2009-13083) and from Generalitat Valenciana (grant numbers ACOMP/2012/212 and ISIC 2012/001) is acknowledged.Blay Llinares, G.; Incerti, C.; Muñoz Roca, MDC.; Pedro Llinares, JR. (2013). Enantioselective LaIII-pyBOX-Catalyzed Nitro-Michael Addition to (E)-2-Azachalcones. 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Highly Enantioselective Direct Michael Addition of Nitroalkanes to Nitroalkenes Catalyzed by Amine−Thiourea Bearing Multiple Hydrogen-Bonding Donors. Organic Letters, 11(6), 1265-1268. doi:10.1021/ol900025bJiang, X., Zhang, Y., Chan, A. S. C., & Wang, R. (2009). Highly Enantioselective Synthesis of γ-Nitro Heteroaromatic Ketones in a Doubly Stereocontrolled Manner Catalyzed by Bifunctional Thiourea Catalysts Based on Dehydroabietic Amine: A Doubly Stereocontrolled Approach to Pyrrolidine Carboxylic Acids. Organic Letters, 11(1), 153-156. doi:10.1021/ol8025268Lu, H.-H., Wang, X.-F., Yao, C.-J., Zhang, J.-M., Wu, H., & Xiao, W.-J. (2009). Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates. Chemical Communications, (28), 4251. doi:10.1039/b905033gMei, K., Jin, M., Zhang, S., Li, P., Liu, W., Chen, X., … Wang, W. (2009). Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones. Organic Letters, 11(13), 2864-2867. doi:10.1021/ol9010322Yang, W., & Du, D.-M. (2010). Highly Enantioselective Michael Addition of Nitroalkanes to Chalcones Using Chiral Squaramides as Hydrogen Bonding Organocatalysts. Organic Letters, 12(23), 5450-5453. doi:10.1021/ol102294gManzano, R., Andrés, J. M., Álvarez, R., Muruzábal, M. D., de Lera, Á. R., & Pedrosa, R. (2011). Enantioselective Conjugate Addition of Nitro Compounds to α,β-Unsaturated Ketones: An Experimental and Computational Study. Chemistry - A European Journal, 17(21), 5931-5938. doi:10.1002/chem.201100241Keller, E., Veldman, N., Spek, A. L., & Feringa, B. L. (1997). Catalytic enantioselective Michael addition reactions of α-nitroesters to α,β-unsaturated ketones. 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