Multiphysics modeling for bone remodeling simulation: A methodological framework

In the present study an object oriented integrative modeling methodology is proposed for the construction of synthetic, computational models of bone-bone environment system that allow its simulation under in vivo conditions. The analytical mathematical approach to model and study ordinary materials will be outlined, indicating its limitations when dealing with biomaterials in physiological environments. The proposed object oriented integrative modeling will be explained emphasizing its advantages and possibilities. Finally, the architecture of the "in vivo" modeling and simulation software framework is shown, described and explained indicating further work based on this framework

Object oriented modeling frameworks for the social systems

In the present study, an object oriented approach and modeling framework is proposed for the construction of synthetic, computational models of social systems. The conventional approach to model and study social systems will be reviewed and outlined, indicating its limitations to deal with their associated complex turbulent phenomena. The proposed object oriented integrative modeling will be explained emphasizing its advantages compared to reductionist methods when dealing with complex systems. Finally, the main architecture of the UTOPIA computational modeling framework, an ongoing, development is shown and described

A Bibliometric review of sociocybernetics

Sociocyberetics is an emerging field of research, innovation and development whose proposed goal is the construction of knowledge on social systems from the systems science and cybemetics perspectives. Sociocyberetics assumes that social systems belong to the superclass of complex systems and promotes the computational modeling and simulation approach to support decision-making processes when dealing with social systems problems. In the present work, the results and analysis of a bibliometric review on sociocyberetics is reported. The main conclusion of the present work is the fact that at the present, sociocyberetics is at its initial stage of development but widely extended both geographcally and across scientific disciplines whch justifies efforts directed towards a sustained work in its development and its consolidation

Voxel based stochastic modeling of complex materials

In the present study an object oriented stochastic approach is proposed for the construction of synthetic, computational models of complex materials. The conventional approach to model and study materials mechanics will be outlined, indicating its limitations to deal with complex heterogeneous materials. The proposed object oriented integrative modeling will be explained emphasizing its advantages compared to continuum mechanics when dealing with complex materials. Finally, the stochastic assembly of complex materials synthetic samples is described and the architecture of the 3M2S (multiphysics materials modeling and simulation system) is shown, indicating further work based on 3M2s

Voxel based stochastic modeling of complex materials

In the present study an object oriented stochastic approach is proposed for the construction of synthetic, computational models of complex materials. The conventional approach to model and study materials mechanics will be outlined, indicating its limitations to deal with complex heterogeneous materials. The proposed object oriented integrative modeling will be explained emphasizing its advantages compared to continuum mechanics when dealing with complex materials. Finally, the stochastic assembly of complex materials synthetic samples is described and the architecture of the 3M2S (multiphysics materials modeling and simulation system) is shown, indicating further work based on 3M2s

Academic engagement: A diary study on the mediating role of academic support

© 2020 Elsevier Inc. Based on the Job Demands-Resources (JD-R) model, this diary study investigated the mediator role of academic resources in the relationship between personal resources and variables of well-being. The study postulates that the perceived level of academic support received by students during the day mediates the relationship between the levels of self-efficacy and curiosity, measured early in the day, and the level of academic engagement measured at the end of the day. Ninety-four undergraduates filled in a general questionnaire and subsequently completed a daily questionnaire, for 5 consecutive academic days (470 diary entries). The multilevel analysis showed a positive relationship between self-efficacy and curiosity and academic engagement. In addition, the results revealed a positive relationship between academic support and academic engagement. Finally, the results showed partial mediation of academic support in the relationship between self-efficacy and academic engagement and in the relationship between curiosity and academic engagement. The results can be used to improve teaching and learning programs in colleges and universities.This research was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES (Brazil), through a scholarship granted to the first author (process n° 99999.004301/2015-03

Efectividad bacteriostática de dos tipos de hidróxido de calcio, con dos vehiculos diferentes frente al Enterococcus Faecalis

Objetivo: comparar la efectividad bacteriostática del Hidróxido de Calcio (EUFAR)® asociado a los vehí­culos (lidocaí­na al 2% más epinefrina y Clorhexidina al 2%) y el Ultracal XS® (Ultradent), en la eliminación del Enterococcus faecalis. Métodos: estudio experimental en el que realizaron dos ensayos: Antibiograma y Concentración Mí­nima Inhibitoria. Antibiograma: se expuso el Enterococcus faecalis a las siguientes soluciones: 1. Hidróxido de calcio Eufar ® con Lidocaí­na al 2% más Epinefrina (GE-A1), 2. Hidróxido de calcio Eufar ® con Clorhexidina al 2% (GE-A2) y 3. Hidróxido de Calcio Ultracal XS® (GE-B). Esas preparaciones se incubaron a 35° C durante 48 horas y se observó el crecimiento de Enterococcus faecalis a las 12 y las 48 horas. Concentración Mí­nima Inhibitoria: el Enterococcus faecalis se expuso a diferentes concentraciones de Hidróxido de calcio (Eufar®) con Lidocaí­na y Clorhexidina e hidróxido de calcio Ultracal XS ®. Se examinó la presencia o ausencia de crecimiento bacteriano durante 48 horas en cada una de ellas. Resultados: antibiograma: se observó mayor inhibición al crecimiento del Enterococcus faecalis en la preparación de Hidróxido de calcio Eufar ® con Clorhexidina al 2% (GE-A2). Concentración mí­nima inhibitoria: la preparación de Hidróxido de calcio Eufar ® con Clorhexidina al 2% (GE-A2) presentó inhibición de crecimiento bacteriano en todas las concentraciones. Conclusiones: en este estudio, la efectividad bacteriostática fue mayor con el Hidróxido de calcio (EUFAR) ® con Clorhexidina. Palabras clave: Hidróxido de Calcio, Enterococcus faecalis, Bacteriostático

Beneficios del uso de vitamina C en el paciente séptico: ¿qué tanto la apoya la evidencia esta indicación?

Objetivo: resumir y analizar la evidencia más reciente sobre el efecto de la administración de vitamina C en el paciente con sepsis. Métodos: revisión narrativa. Se realizó una búsqueda bibliográfica, utilizando los términos de búsqueda “Vitamina C” y “Sepsis”, además de sinónimos, los cuales fueron combinados con los operadores “AND” y “OR”, en las bases de datos PubMed, ScienceDirect, Web of Science, y MEDLINE. Resultados: basados en los últimos estudios celulares y moleculares, se ha evidenciado que la vitamina C posee propiedades antioxidantes, antiinflamatorias, y microbicidas, pudiéndose obtener cierto beneficio de su uso en sepsis. Mientras algunos ensayos controlados aleatorizados han encontrado un incremento del riesgo de hasta el 20% de morir o presentar falla orgánica persistente, otros han observado una disminución de la mortalidad de hasta un 40%, además de la estancia hospitalaria y duración de ventilación mecánica. Conclusión: a la fecha, la evidencia es heterogénea respecto al posible beneficio en el uso de vitamina C intravenosa como terapia sola o combinada en el manejo del paciente con sepsis o shock séptico. Mientras los ensayos controlados aleatorizados parecieran demostrar ausencia de beneficio, principalmente respecto a mortalidad o persistencia de falla orgánica a los 28 días, algunos meta-análisis tienden a mostrar una reducción del riesgo de muerte. Por lo tanto, sigue faltando evidencia que amplíe este panorama

Open access solutions for biodiversity journals : Do not replace one problem with another

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