Help-seeking in emerging adults with and without a history of mental health referral: a qualitative study.

BACKGROUND: Young people are generally reluctant to seek professional help when experiencing problems. However, past experience of services is often cited as increasing the intention to seek help, therefore those with a history of mental health referral may adopt more adaptive help seeking strategies. The current study investigated whether the pattern of different help seeking strategies and barriers to help seeking differed as a function of previous referral history. METHODS: Semi-structured interviews were conducted with 29 emerging adults (12 males, 17 females); 17 with a history of mental health referral and 12 without and analysed using thematic analysis. RESULTS: Overall, those with a referral to services were more likely than those without to rely on avoidant coping, especially techniques that depended upon suppression. This could help account for the increased use of strategies involving self-harm and substances in those with past referral. An exploration of barriers to help seeking showed those with a history of mental health referral were much more likely to self-stigmatise and this became attached to their sense of identity. CONCLUSIONS: Emerging adults with a history of referral are more likely to adopt avoidant coping strategies when dealing with problems and self-stigmatise to a greater degree than those without a history of referral. This suggests that current approaches to mental health in emerging adults are not decreasing the sense of stigma with potentially far-reaching consequences for the developing sense of self and choice of help seeking strategies

Augmented Reality for the Control Tower: The RETINA Concept

The SESAR (Single European Sky Air Traffic Management Research) Joint Undertaking has recently granted the Resilient Synthetic Vision for Ad- vanced Control Tower Air Navigation Service Provision project within the framework of the H2020 research on High Performing Airport Operations. Here- after, we describe the project motivations, the objectives, the proposed method- ology and the expected impacts, i.e. the consequences of using virtual/augmented reality technologies in the control tower

Effectiveness of the spot-on combination of moxidectin and imidacloprid (Advocate®) in the treatment of ocular thelaziosis by Thelazia callipaeda in naturally infected cats

Background: The present study evaluated the therapeutic effectiveness of moxidectin 1.0% (w/v) and imidacloprid 10% (w/v) (Advocate® spot-on solution for cats, Bayer Animal Health) against natural infections with the eyeworm Thelazia callipaeda in cats. This study was conducted as a GCP, negative-controlled, blinded and randomised field study in privately owned cats living in an area in southern Italy where T. callipaeda is enzootic. Methods: The study was carried out in 30 cats (19 females and 11 males, aged from 8 months to 5 years, weighing 1.2-5.2 kg) of different breeds, naturally infected by T. callipaeda. At study inclusion (Day 0), animals were physically examined and the infection level was assessed by examination of both eyes for clinical score and live adult T. callipaeda count. Each cat was weighed and randomly assigned to one of the treatment groups (G1: Advocate, G2: untreated control). Clinical assessments and T. callipaeda adult counts were performed on Day 14. At the study completion visit on Day 28, clinical assessments and counts of T. callipaeda adults and larvae were performed. All cats were daily observed by their owners and general health conditions were recorded during the entire period of the study. Results: The primary effectiveness variable was the percentage of animals in G1 group (Advocate) showing a complete elimination (parasitological cure) of adult eye worms at Day 14 and Day 28. The effectiveness of the treatment in the G1 group was 93.3 and 100% at Day 14 and Day 28, respectively, when compared to group G2. Total worm count reduction from both eyes for Advocate was 96.3% on Day 14 and 100% on Day 28. Clinical data were confirmed by the examination of conjunctival pouch flushing. An overall reduction in the number of cats with lacrimation and conjunctivitis was observed following treatment despite the fact that in a few cats treated with Advocate clinical signs persisted due to the chronic nature of the disease. Conclusions: Based on the results of the present trial, a single dose of Advocate was found to be safe and highly effective in the treatment of natural T. callipaeda infection in cats

Nonlinear Interaction of Transversal Modes in a CO2 Laser

We show the possibility of achieving experimentally a Takens-Bogdanov bifurcation for the nonlinear interaction of two transverse modes ($l = \pm 1$) in a $CO_2$ laser. The system has a basic O(2) symmetry which is perturbed by some symmetry-breaking effects that still preserve the $Z_2$ symmetry. The pattern dynamics near this codimension two bifurcation under such symmetries is described. This dynamics changes drastically when the laser properties are modified.Comment: 16 pages, 0 figure

Teste de heptanos para uso na quantificação de N-alcanos em plantas forrageiras e fezes de ruminantes.

Resumo

Gustatory Sensitivity and Food Acceptance in Two Phylogenetically Closely Related Papilionid Species: Papilio hospiton and Papilio machaon.

In herbivorous insects, food selection depends on sensitivity to specific chemical stimuli from host-plants as well as to secondary metabolites (bitter) and to sugars (phagostimulatory). Bitter compounds are noxious, unpalatable or both and evoke an aversive feeding response. Instead, sugars and sugar alcohols play a critical role in determining and enhancing the palatability of foods. We assumed that peripheral taste sensitivity may be related to the width of the host selection. Our model consists of two closely phylogenetically related Papilionid species exhibiting a difference in host plant choice: Papilio hospiton and Papilio machaon. The spike activity of the lateral and medial maxillary styloconic taste sensilla was recorded following stimulation with several carbohydrates, nicotine and NaCl, with the aim of characterizing their gustatory receptor neurons and of comparing their response patterns in the light of their different acceptability in feeding behaviour. The results show that: a) each sensillum houses phagostimulant and phagodeterrent cells; b) the spike activity of the gustatory neurons in response to different taste stimuli is higher in P. hospiton than in P. machaon; c) sugar solutions inhibit the spike activity of the deterrent and salt cells, and the suppression is higher in P. machaon than in P. hospiton. In conclusion, we propose that the different balance between the phagostimulant and phagodeterrent inputs from GRNs of maxillary sensilla may contribute in determining the difference in food choice and host range

Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study

Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. Methods: This multicenter retrospective analysis reviewed patients who underwent electrochemotherapy from 2007 to 2014 for superficial advanced angiosarcomas. Bleomycin was administered intravenously and delivered within tumors by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. Tumor assessment was performed using RECIST (version 1.1). Toxicity (CTCAE, v4.0) and local progression-free survival (LPFS) were also evaluated. Results: Nineteen patients (13 with locally advanced and 6 with metastatic angiosarcomas) were treated. Tumor sites were: scalp (n¼5), breast(n¼8), other skin sites (n¼3), and soft tissue (n¼3). Target lesions (n¼54) ranged in size from 1.5 to 2.5 cm (median, 2 cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12/19 (63%) patients, complete in 8 (42%). One-year LPFS within treatment field was 68%. Local symptom improvement included palliation of bleeding (5/19 patients) and pain relief (6/19 patients). Conclusions: Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas

Morphology determined by waves in fluvial beaches. "La Concordia" in the Uruguay River, a case study.

Sediment characteristics and the direction and magnitude of the velocity of the current in the river, amongst other factors, usually established the pro file and the plan shape of fluvial beaches. However, in sorne cases, even far from its estuary or river mouth, this morphology can be determined by the incidence of the waves despite not being a marine environment. In this paper a qualitative methodology will be presented which will allow us to recognize the aspects that influence the existen ce of such morphologies. For this purpose a case study will be analyzed: the beach of La Concordia located on the left bank ofthe Uruguay River, 70 km upstreamfrom its mouth at the estuwy of Rio de la Plata. Furthermore, plan shape will be analyzed and its determination by wave action will be proved.Tanto el perfil como la forma en planta de las playas fluviales vienen establecidos por numerosos factores entre los que cabría destacar las características del sedimento y la dirección y módulo de la velocidad de la corriente en el río. Sin embargo, en ciertos casos, lejos incluso de su estuario o desembocadura, esta morfología puede estar determinada principalmente por la incidencia del oleaje pese a no tratarse de un entorno marítimo. Se presenta aquí una metodología cualitativa que nos permitirá reconocer los aspectos que influyen en la existencia de este tipo de morfologías. Para ello, se estudiará un caso particular, el de la playa de La Concordia ubicada en la margen izquierda del río Uruguay a 70 km de su desembocadura en el estuario del Rio de la Plata. Asimismo se analizará la forma en planta y se verificará que la misma está determinada por la acción del oleaje

Chromosomal control of non-gliadin proteins from the 70% ethanol extract of wheat endosperm

The non-gliadin fraction of the 70% ethanol extracts of compensated nulli-tetrasomics and ditelosomics of Triticum aestivum cv. Chinese Spring has been analyzed by combined electrofocusing and electrophoresis. Seventeen of the 21 protein map components of the euploid have been ascribed to eight chromosomes: 4A, 3BS, 6BS, 7BS, 3D, 4D, 5D and 7DS. The relationship of the different map components with other proteins previously associated with the same chromosomes is discusse

Geochemical and geochronological constraints on the geologic evolution of the western Sonobari Complex, northwestern Mexico

In the southern Sierra Sonobari, NW Mexico, U-Pb and 40Ar/39Ar geochronology studies allowed to define the provenance and maximum depositional age of the Francisco Gneiss basement of the Sonobari terrane, and to establish the age of some magmatic events in that area. The youngest zircon cluster in paragneisses of the Francisco Gneiss indicates a maximum depositional age of 509 ± 29Ma. The main peaks of the relative probability plot yield ages of 1690 and 1404Ma with minor peaks at 1156, 921, and 517Ma. Major peaks suggest that the main source of sediments was the Paleo- and Mesoproterozoic crust of Laurentia. Orthogneiss from the Francisco Gneiss yields a U-Pb zircon upper intercept age of 248 ± 28Ma, which is interpreted as the crystallization age. Crosscutting dykes of metabasite yield an 40Ar/39Ar age of 67 ± 5Ma, which is interpreted as indicating cooling after either a latest Early Cretaceous orogenic event or Late Cretaceous contact metamorphism. Granodiorite intruding the Francisco Gneiss yields a U-Pb age of 64 ± 1Ma, which is interpreted as a magmatic age. The hornblende-plagioclase Macochin Gabbro yields 40Ar/39Ar isochron ages of 54 ± 10Ma and 47 ± 5Ma, which are interpreted as cooling ages after the gabbro intrusion. Geochemical data indicate that the mafic rocks of the Francisco Gneiss correspond to subalkaline basalts of tholeiitic affinity with concentrations of high field strength elements similar to oceanic basalts, suggesting an asthenospheric upper mantle source. However, according to the variation in Th/Yb and U/Yb, the amphibolites display a significant influence of the upper continental crust. The Macochin Gabbro also has a geochemical signature characteristic of subalkaline basalt with tholeiitic affinity, and high field strength elements similar to oceanic basalts. Tectonic discrimination diagrams and elemental distribution suggest that the mafic rocks of both the Francisco Gneiss and Macochin Gabbro were emplaced during rifting in a back-arc setting