490 research outputs found

    Media assistance M&E and democratization measurement characteristics in USAID program reporting documents

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    Title from PDF of title page (University of Missouri--Columbia, viewed on September 17, 2012).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Thesis advisor: Professor Byron T. ScottIncludes bibliographical references.M.A. University of Missouri--Columbia 2012."May 2012"The original file of this thesis contains errors in the display of the histograms on page 73. A corrected version of this page has been added.International media assistance, the endeavor to help emerging nations and developing countries build or develop media similar in nature and function to those in existing liberal democracies, has greatly expanded since the fall of the Soviet Union in the early 1990s. U.S. media assistance funders have linked media assistance to democratization efforts. This case study of USAID media assistance program reporting documents (n=68) looks at specific monitoring and evaluation characteristics as reported over a 20-year period and how reporting documents make the link to democratization. The analysis found that although M&E activity has improved as reported over the 20-year period of the study, 75 percent of the documents ranked in the lower half of cumulative M&E characteristics scoring. It also found that the relationship between democratization characteristics and media assistance are not clarified by the monitoring and evaluation data as reported. The study does show the USAID database to be a rich source of data about how media assistance programs have been implemented in different cultures, countries and political environments

    Serum Amyloid A induces toll-like receptor 2-dependent inflammatory cytokine expression and atrophy in C2C12 skeletal muscle myotubes

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    Background Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly correlated with morbidity and mortality. Patients who experience frequent acute exacerbations of COPD (AECOPD) have more severe muscle wasting and reduced recovery of muscle mass and function after each exacerbation. Serum levels of the pro-inflammatory acute phase protein Serum Amyloid A (SAA) can rise more than 1000-fold in AECOPD and are predictively correlated with exacerbation severity. The direct effects of SAA on skeletal muscle are poorly understood. Here we have examined SAA effects on pro-inflammatory cachectic cytokine expression (IL-6 and TNFĪ±) and atrophy in C2C12 myotubes. Results SAA increased IL-6 (31-fold) and TNFĪ± (6.5-fold) mRNA levels compared to control untreated cells after 3h of SAA treatment, and increased secreted IL-6 protein at 24h. OxPAPC, a dual TLR2 and TLR4 inhibitor, reduced the response to SAA by approximately 84% compared to SAA alone, and the TLR2 neutralising antibody T2.5 abolished SAA-induced expression of IL-6, indicating that SAA signalling in C2C12 myotubes is primarily via TLR2. SAA also reduced myotube width by 10-13% and induced a 2.5-fold increase in the expression of the muscle atrophy gene Atrogin-1, suggesting direct effects of SAA on muscle wasting. Blocking of TLR2 inhibited the SAA-induced decrease in myotube width and Atrogin-1 gene expression, indicating that SAA induces atrophy through TLR2. Conclusions These data demonstrate that SAA stimulates a robust pro-inflammatory response in skeletal muscle myotubes via the TLR2-dependent release of IL-6 and TNFĪ±. Furthermore, the observed atrophy effects indicate that SAA could also be directly contributing to the wasting and poor recovery of muscle mass. Therapeutic strategies targeting this SAA-TLR2 axis may therefore ameliorate muscle wasting in AECOPD and a range of other inflammatory conditions associated with loss of m

    Transient mantle cooling linked to regional volcanic shut-down and early rifting in the North Atlantic Igneous Province

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    Open Access via the Springer Compact AgreementPeer reviewedPublisher PD

    Smoking Mull: a grounded theory model on the dynamics of combined tobacco and cannabis use among men

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    Issue addressed: Australiansā€™ use of cannabis has been increasing. Over a third of Australians (35.4%) have used cannabis at some time in their lives and 10.3% are recent users. Almost two-thirds of cannabis users combine cannabis with tobacco. The aim of this study was to understand the process of mulling ā€“ smoking tobacco and cannabis together ā€“ using a grounded theory approach. Methods: Twenty-one in-depth semi structured interviews were conducted with men aged 25ā€“34 and living on the North Coast of New South Wales. Interviews explored participantsā€™ smoking practices, histories and cessation attempts. Results: A model describing mulling behaviour and the dynamics of smoking cannabis and tobacco was developed. It provides an explanatory framework that demonstrates the flexibility in smoking practices, including substance substitution ā€“ participants changed the type of cannabis they smoked, the amount of tobacco they mixed with it and the devices they used to smoke according to the situations they were in and the effects sought. Conclusion: Understanding these dynamic smoking practices and the importance of situations and effects, as well as the specific role of tobacco in mulling, may allow health workers to design more relevant and appropriate interventions. So what?: Combining tobacco with cannabis is the most common way of smoking cannabis in Australia. However, tobacco cessation programmes rarely address cannabis use. Further research to develop evidence-based approaches for mull use would improve cessation outcomes. Keywords: concomitant use, marijuana, mulling, nicotineNHMR

    Seasonal Bias in Soil Carbonate Formation and Its Implications for Interpreting Highā€Resolution Paleoarchives: Evidence From Southern Utah

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    Pedogenic carbonate is commonly used as a paleoarchive, but its interpretation is limited by our understanding of its formation conditions. We investigated laminated soil carbonate rinds as a highā€resolution paleoarchive in Torrey, Utah, USA, by characterizing and modeling their formation conditions. We compared late Holocene (<5Ā ka) soil carbonate conventional (C and O) and ā€œclumpedā€ isotopes to modern soil environment and isotope measurements: soil CO2 partial pressure, soil temperature, soil moisture, Ī“13Cā€soil CO2, Ī“18O precipitation, and Ī“18Oā€soil water. Data unambiguously identified a strong summer seasonality bias, but modeling suggested soil carbonate formed several times throughout the year during infiltration events causing dissolutionā€formation reactions. This apparent discrepancy resulted from preferential preservation of calcite formed from the largest annual infiltration events (summer) overprinting previously formed calcite. Soil carbonate therefore formed predominantly due to changes in soil water content. As soil CO2 was at its annual maximum during soil carbonate formation, assuming uniformly low soil CO2 formation conditions for soil carbonate in estimating paleoatmospheric CO2 is likely not viable. Additionally, we showed modern summer Ī“13Cā€soil CO2 and soil CO2 measurements could not produce a modeled Ī“13Cā€soil carbonate consistent with late Holocene observations. We suggest using multiple lines of evidence to identify nonanalogous modern conditions. Finally, a nearly linear radiocarbon age model from a laminated rind showed that rinds can be used as a highā€resolution paleoarchive if samples are from a single depth and the timing and conditions of soil carbonate formation can be constrained through time.Key PointsAt Torrey, UT, comparison between modern soil and late Holocene soil carbonate isotopes shows soil carbonate forms during the summerSummer formation seasonality occurs because calcite dissolutionā€formation reactions during infiltration events overprint prior materialTorrey soil carbonate rinds are suitable material for highā€resolution paleorecords as proxies of summer soil and vegetation conditionsPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149224/1/jgrg21287_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149224/2/jgrg21287.pd

    Geochemical stratigraphy and correlation within Large Igneous Provinces : the final preserved stages of the Faroe Islands Basalt Group

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    Acknowledgements The authors would like to thank Andrew Kerr for editorial handling of the manuscript. Lotte Larsen and Bob Gooday are kindly thanked for detailed and constructive reviews of the original submission which substantially improved the manuscript.Peer reviewedPostprin

    Pre-service teachersā€™ engagement in a cross-curricular television news project: impact on professional identity

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    This paper focuses on the impact of pre-service teachersā€™ engagement in the annual BBC News School Report project on their emerging professional identity and on the evidence they provide as part of the process of becoming qualified. The research reported on is drawn from three years of enquiry. Respondents included pre-service teachers themselves, their tutors as representatives of teacher education providers and their mentors as representatives of schools in which they were placed. The methodological approach was interpretative and phenomenological with qualitative and quantitative data being analysed for emergent themes. Two years of evaluations were followed by a third year in which a set of case studies were developed. The research showed that professional identity is enhanced through being in a leading role in respect of curriculum and working with other staff. Through engagement in such projects, this paper moots that preservice teachers develop richer evidence of emerging professionalism as defined by standards of initial teacher training. Moreover, self-perception of role was modified to one in which they saw themselves, and were seen, as equals to qualified staff rather than subservient to or dependent on them. A new more equal power relationship developed as they took on responsibility for the project. Preservice teachersā€™ move to become full members of the professional community for which they are training was accelerated

    Volunteering and wellbeing in the pandemic. Part I: Learning from practice

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    This report explores the relationship between volunteering and wellbeing during the pandemic in Wales by analysing practice-based case studies of volunteering

    Stable isotope ecology of Cape dune mole-rats (Bathyergus suillus) from Elandsfontein, South Africa: implications for C4 vegetation and hominin paleobiology in the Cape Floral Region

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    The archaeological and paleontological records from the west coast of South Africa have potential to provide insights into ecosystem dynamics in the region during the mid Pleistocene. Although the fossil record suggests an ecosystem quite different than that of the region today, we understand little about the ecological factors that contributed to this disparity. The site of Elandsfontein (EFT) dates to between 1.0 and 0.6 million years ago (Ma), preserves in situ lithic and faunal materials found in direct association with each other, and provides the rare opportunity to examine the relationship between hominin behavioural variability and landscape heterogeneity in a winter rainfall ecosystem. In this study, we examine the stable carbon isotopic composition of a large sample (n = 81) of Cape dune mole-rats (Bathyergus suillus) and contemporaneous large mammals (> 6 kg; n = 194) from EFT. We find that Ī“13C values of B. suillus are significantly different to those of contemporaneous large mammals from EFT indicating a significant presence of plants utilizing the C4 photosynthetic pathway during the mid-Pleistocene, in contrast to present C3 dominated ecosystems along the west coast of South Africa. Additionally, we find that artifact density at EFT localities is positively correlated with Ī“13C values in B. suillus enamel suggesting that evidence of more intense hominin occupation may be associated with the presence of more C4 vegetation. Lastly, we hypothesize that this unique distribution of vegetation 1) provided abundant resources for both hominin and non-hominin taxa and 2) may have concentrated hominin and animal behavior in certain places on the ancient landscape
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