Morphological and population aspects of Diabrotica speciosa speciosa (Germar) (Coleoptera: Chrysomelidae) under laboratory conditions

Diabrotica speciosa speciosa (Germar) es uno de los crisomélidos más ampliamente distribuídos en cultivos de la Argentina. Se estudió la morfología de los estados preimaginales, tabla de vida y el comportamiento reproductivo. El desarrollo se llevó a cabo bajo condiciones controladas de laboratorio. Bajo estas condiciones se establecieron los siguientes parámetros poblacionales: tiempo de desarrollo, tasa reproductiva, tasa de crecimiento intrínseco y se confeccionó una tabla de vida horizontal.Diabrotica speciosa speciosa (Germar) is one of the most widely distributed chrysomelid in crops in Argentina. The morphology of preimaginal stages, life span and reproductive behavior were studied. The development were carried out under controlled conditions. Under these conditions the following population parameters were computed: generation time, reproductive rate, intrinsic rate of increase and an horizontal life table was made.Fil: Defagó, María Teresa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Investigaciones Entomológicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabrera, Nora Clara. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. Departamento Científico de Entomologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Laguzzi, Stella M.. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Investigaciones Entomológicas de Córdoba; ArgentinaFil: Novara, Claudia R.. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Investigaciones Entomológicas de Córdoba; Argentin

Morphological and population aspects of <i>Diabrotica speciosa speciosa</i> (Germar) (Coleoptera: Chrysomelidae) under laboratory conditions

Diabrotica speciosa speciosa (Germar) es uno de los crisomélidos más ampliamente distribuídos en cultivos de la Argentina. Se estudió la morfología de los estados preimaginales, tabla de vida y el comportamiento reproductivo. El desarrollo se llevó a cabo bajo condiciones controladas de laboratorio. Bajo estas condiciones se establecieron los siguientes parámetros poblacionales: tiempo de desarrollo, tasa reproductiva, tasa de crecimiento intrínseco y se confeccionó una tabla de vida horizontal.Diabrotica speciosa speciosa (Germar) is one of the most widely distributed chrysomelid in crops in Argentina. The morphology of preimaginal stages, life span and reproductive behavior were studied. The development were carried out under controlled conditions. Under these conditions the following population parameters were computed: generation time, reproductive rate, intrinsic rate of increase and an horizontal life table was made.Facultad de Ciencias Naturales y Muse

Morphological and population aspects of <i>Diabrotica speciosa speciosa</i> (Germar) (Coleoptera: Chrysomelidae) under laboratory conditions

Diabrotica speciosa speciosa (Germar) es uno de los crisomélidos más ampliamente distribuídos en cultivos de la Argentina. Se estudió la morfología de los estados preimaginales, tabla de vida y el comportamiento reproductivo. El desarrollo se llevó a cabo bajo condiciones controladas de laboratorio. Bajo estas condiciones se establecieron los siguientes parámetros poblacionales: tiempo de desarrollo, tasa reproductiva, tasa de crecimiento intrínseco y se confeccionó una tabla de vida horizontal.Diabrotica speciosa speciosa (Germar) is one of the most widely distributed chrysomelid in crops in Argentina. The morphology of preimaginal stages, life span and reproductive behavior were studied. The development were carried out under controlled conditions. Under these conditions the following population parameters were computed: generation time, reproductive rate, intrinsic rate of increase and an horizontal life table was made.Facultad de Ciencias Naturales y Muse

I Jornada de expertos en ictiosis

On June 22, 2012 the First Symposium of Ichthyosis Experts in Spain was held at the Hospital Niño de Jesús in Madrid. It was a one-day symposium for dermatologists, pediatricians, and physicians-in-training interested in this disease, as well as for other health care professionals involved in the care of patients with ichthyosis. The aim of the meeting was to try to structure the care of ichthyosis patients in Spain. As happens in other rare diseases, because of the low prevalence of ichthyosis and the absence of designated referral centers, the number of patients treated in each center is very low and few dermatologists have any real clinical experience with this condition or know how to order diagnostic genetic tests. This article summarizes the presentations given at the symposium and is intended as a reference for anyone interested in the subject.El día 22 de junio de 2012 se celebró en el Hospital Niño Jesús la I Jornada de expertos en ictiosis, una jornada monográfica dirigida a dermatólogos, pediatras y médicos en formación interesados en esta enfermedad, así como al resto de profesionales sanitarios que participan en su atención. El objetivo de la l Jornada de expertos en ictiosis fue intentar estructurar la atención de los pacientes con ictiosis en España. Como ocurre con el resto de las enfermedades raras, su escasa prevalencia y la ausencia de centros de referencia formales diluyen el número de pacientes atendidos en cada centro, y pocos dermatólogos tienen verdadera experiencia clínica o conocen la manera de solicitar diagnóstico genético. En este artículo se resumen las ponencias expuestas en la Jornada para consulta de aquellas personas interesadas en el tema.Pathophysiology of Keratinization Disorders / Ángela Hernández . -- Extracutaneous Manifestations of Ichthyosis / Antonio Torrelo . -- New Clinical Classification of the Ichthyoses / Raúl de Lucas . -- Use of Histologic Diagnosis in Ichthyosis / Fernando Casco . -- Genetic Diagnosis of Ichthyosis / Rogelio González Sarmiento . -- The Multidisciplinary Approach in Ichthyosis: Psychological Care / José Luis Pedreira Massa . -- Collodion Baby and Congenital Erythroderma: Clinical Management and Course / Heiko Traupe . -- Treatment of Ichthyosis / Heiko Traupe . -- Lessons Learned from Experience / Pablo de Unamuno . -- Looking Towards the Future: Humanized Models of Ichthyosis and other Hyperkeratotic Disorders / Fernando Larcher, Marcela del Río . -- What Patients Need / The Leader ship Team of the Spanish Ichthyosis Association . -- Conclusions / Ángela HernándezPublicad

Morphological and population aspects of <i>Diabrotica speciosa speciosa</i> (Germar) (Coleoptera: Chrysomelidae) under laboratory conditions

Diabrotica speciosa speciosa (Germar) es uno de los crisomélidos más ampliamente distribuídos en cultivos de la Argentina. Se estudió la morfología de los estados preimaginales, tabla de vida y el comportamiento reproductivo. El desarrollo se llevó a cabo bajo condiciones controladas de laboratorio. Bajo estas condiciones se establecieron los siguientes parámetros poblacionales: tiempo de desarrollo, tasa reproductiva, tasa de crecimiento intrínseco y se confeccionó una tabla de vida horizontal.Diabrotica speciosa speciosa (Germar) is one of the most widely distributed chrysomelid in crops in Argentina. The morphology of preimaginal stages, life span and reproductive behavior were studied. The development were carried out under controlled conditions. Under these conditions the following population parameters were computed: generation time, reproductive rate, intrinsic rate of increase and an horizontal life table was made.Facultad de Ciencias Naturales y Muse

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels

Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children

Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)

Acrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014–2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000–2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis

Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator–activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD. Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed. Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98–1.05 and rs7672915, HR: 0.97, 95% CI 0.94–1.00; rs3755863, HR: 1.02, 95% CI 0.99–1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intron 2) and the primary outcome among 1) individuals aged ≥65, 2) individuals with renal impairment, and 3) antiplatelet users. Conclusion: We found no clear associations between polymorphisms in the PPARGC1A gene and subsequent CHD events in patients with established CHD at baseline

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease : An Individual-Level Meta-Analysis

Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD.Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed.Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98-1.05 and rs7672915, HR: 0.97, 95% CI 0.94-1.00; rs3755863, HR: 1.02, 95% CI 0.99-1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intron 2) and the primary outcome among 1) individuals aged >= 65, 2) individuals with renal impairment, and 3) antiplatelet users.Conclusion: We found no clear associations between polymorphisms in the PPARGC1A gene and subsequent CHD events in patients with established CHD at baseline.Peer reviewe