Alineación frontal de la rodilla. Concepto y determinación de la posición neutra en el vivo

Se estudiaron 28 rodillas asintomáticas con objeto de confirmar en el vivo la existencia de movilidad mediolateral, tomando como posición neutra aquella en la que el contacto articular se produce simultáneamente en ambos compartimentos. Hemos observado, que la interlínea articular en posición neutra es sensiblemente mas amplia en el compartimento lateral, en proporción de 1,3 a 1 respecto del medial. Se estudió la rodilla en diversas actitudes posturales durante la estación bípeda, hallando que al colocar la extremidad inferior en adducción de la cadera la altura de la interlínea aumenta significativamente en el compartimento lateral, alcanzando una proporción de 1,9 a 1 respecto del medial. Es decir, que en distintas actitudes fisiológicas, la amplitud de la interlínea articular de la rodilla y por tanto el ángulo fémorotibial, son variables, lo cual es compatible con la hipótesis del «Contacto articular alternativo». Creemos que la existencia de cierta movilidad mediolateral fisiológica en la rodilla, puede tener trascendencia en el diseño de la geometría frontal de las prótesis, así como en la realización de las técnicas radiográficas y su valoración

Sub-bandgap spectral photo-response analysis of Ti supersaturated Si

We have analyzed the increase of the sheet conductance (ΔG□) under spectral illumination in high dose Ti implanted Si samples subsequently processed by pulsed-laser melting. Samples with Ti concentration clearly above the insulator-metal transition limit show a remarkably high ΔG□, even higher than that measured in a silicon reference sample. This increase in the ΔG□ magnitude is contrary to the classic understanding of recombination centers action and supports the lifetime recovery predicted for concentrations of deep levels above the insulator-metal transition

Massive star formation in Wolf-Rayet galaxies: I. Optical and NIR photometric results

(Abridged) We have performed a comprehensive multiwavelength analysis of a sample of 20 starburst galaxies that show the presence of a substantial population of massive stars. The main aims are the study of the massive star formation and stellar populations in these galaxies, and the role that interactions with or between dwarf galaxies and/or low surface companion objects have in triggering the bursts. We completed new deep optical and \NIR\ broad-band images, as well as the new continuum-subtracted H$\alpha$ maps, of our sample of Wolf-Rayet galaxies. We analyze the morphology of each system and its surroundings and quantify the photometric properties of all important objects. All data were corrected for both extinction and nebular emission using our spectroscopic data. The age of the most recent star-formation burst is estimated and compared with the age of the underlying older low-luminosity population. The \Ha-based star-formation rate, number of O7V equivalent stars, mass of ionized gas, and mass of the ionizing star cluster are also derived. We found interaction features in many (15 up to 20) of the analyzed objects, which were extremely evident in the majority. We checked that the correction for nebular emission to the broad-band filter fluxes is important in compact objects and/or with intense nebular emission to obtain realistic colors and compare with the predictions of evolutionary synthesis models. The estimate of the age of the most recent star-formation burst is derived consistently. With respect to the results found in individual objects, we remark the strong \Ha\ emission found in IRAS 08208+2816, UM 420, and SBS 0948+532, the detection of a double-nucleus in SBS 0926+606A, a possible galactic wind in Tol 9, and one (two?) nearby dwarf star-forming galaxies surrounding Tol 1457-437.Comment: Published in A&A, 491, 131 (2008). 39 Figures have NOT been included here. Full version in http://www.atnf.csiro.au/people/Angel.Lopez-Sanchez/papers/9409WRG1.pdf False color pictures of the galaxies can be found in http://www.atnf.csiro.au/people/Angel.Lopez-Sanchez/pictures.htm

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD

Communication, development, and social change in Spain: A field between institutionalization and implosion

This paper renders an account of the rapid institutionalization of the academic field of Communication for Development and Social Change (CDCS) in Spain in recent years following a period of neglect and marginalization. The ongoing expansion of the field of CDSC in the Spanish context is understood as a process of implosion, i.e. a collapse inwards, which results from the inconsistencies and weaknesses of fast and late institutionalization. The methodological approach for this inquiry is a documental review of both academic literature and research and institutional reports produced in Spain between 1980 and 2010. Based on this review, the paper contrasts the trajectory of the field in Spain with the debates at the international level, establishing relevant continuities and differences.This article is part of the Research Project (Ministry of Economy and Competitiveness, Spain) CSO2014-52005-R titled ‘Evaluation and Monitoring of Communication for Development and Social Change in Spain: design of indicators to measure its social impact’ (2015–2017)17 página

Arm and interarm abundance gradients in CALIFA spiral galaxies

Spiral arms are the most singular features in disc galaxies. These structures can exhibit different patterns, namely grand design and flocculent arms, with easily distinguishable characteristics. However, their origin and the mechanisms shaping them are unclear. The overall role of spirals in the chemical evolution of disc galaxies is another unsolved question. In particular, it has not been fully explored if the H ii regions of spiral arms present different properties from those located in the interarm regions. Here we analyse the radial oxygen abundance gradient of the arm and interarm star forming regions of 63 face-on spiral galaxies using CALIFA Integral Field Spectroscopy data. We focus the analysis on three characteristic parameters of the profile: slope, zero-point, and scatter. The sample is morphologically separated into flocculent versus grand design spirals and barred versus unbarred galaxies. We find subtle but statistically significant differences betweenthe arm and interarm distributions for flocculent galaxies, suggesting that the mechanisms generating the spiral structure in these galaxies may be different to those producing grand design systems, for which no significant differences are found. We also find small differences in barred galaxies, not observed in unbarred systems, hinting that bars may affect the chemical distribution of these galaxies but not strongly enough as to be reflected in the overall abundance distribution. In light of these results, we propose bars and flocculent structure as two distinct mechanisms inducing differences in the abundance distribution between arm and interarm star forming regions

Estimation of neutron-equivalent dose in organs of patients undergoing radiotherapy by the use of a novel online digital detector.

Neutron peripheral contamination in patients undergoing high-energy photon radiotherapy is considered as a risk factor for secondary cancer induction. Organ-specific neutron-equivalent dose estimation is therefore essential for a reasonable assessment of these associated risks. This work aimed to develop a method to estimate neutron-equivalent doses in multiple organs of radiotherapy patients. The method involved the convolution, at 16 reference points in an anthropomorphic phantom, of the normalized Monte Carlo neutron fluence energy spectra with the kerma and energy-dependent radiation weighting factor. This was then scaled with the total neutron fluence measured with passive detectors, at the same reference points, in order to obtain the equivalent doses in organs. The latter were correlated with the readings of a neutron digital detector located inside the treatment room during phantom irradiation. This digital detector, designed and developed by our group, integrates the thermal neutron fluence. The correlation model, applied to the digital detector readings during patient irradiation, enables the online estimation of neutron-equivalent doses in organs. The model takes into account the specific irradiation site, the field parameters (energy, field size, angle incidence, etc) and the installation (linac and bunker geometry). This method, which is suitable for routine clinical use, will help to systematically generate the dosimetric data essential for the improvement of current risk-estimation models

Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis.

Systemic sclerosis (SSc) is a chronic fibrotic autoimmune disease of complex aetiology which shares genetic similarities with systemic lupus erythematosus (SLE).1 2 One of the novel risk loci that have been recently associated with SLE is the integrin α M (ITGAM) gene, which encodes the α subunit of the αMβ2-integrin.3 4 The most likely causal polymorphism that best explains this association is a non-synonymous single-nucleotide polymorphism (SNP) at the exon 3, rs1143679, which changes the 77th amino acid residue arginine to histidine (R77H). This functional SNP represents one of the highest associated signals with SLE and is predicted to alter the structure and function of the integrin.4 5 To determine whether ITGAM rs1143679 is also associated with SSc susceptibility and clinical manifestations, we genotyped a total of 3735 SSc patients and 3930 matched healthy individuals from seven independent European cohorts of Caucasian origin (Spain, Germany, The Netherlands, Italy, Norway, Sweden and UK) using a predesigned TaqMan® assay (ID: C___2847895_1_) in an ABI 7900HT (both from Applied Biosystems, Foster City, California, USA). Case …Peer Reviewe

Neutrino Target-of-Opportunity Observations with Space-based and Suborbital Optical Cherenkov Detectors

Cosmic-ray accelerators capable of reaching ultra-high energies are expected to also produce very-high energy neutrinos via hadronic interactions within the source or its surrounding environment. Many of the candidate astrophysical source classes are either transient in nature or exhibit flaring activity. Using the Earth as a neutrino converter, suborbital and space-based optical Cherenkov detectors, such as EUSO-SPB2 and POEMMA, will be able to detect upward-moving extensive air showers induced by decay tau-leptons generated from cosmic tau neutrinos with energies ∼10 PeV and above. Both EUSO-SPB2 and POEMMA will be able to quickly repoint, enabling rapid response to astrophysical transient events. we calculate the transient sensitivity and sky coverage for both EUSO-SPB2 and POEMMA, accounting for constraints imposed by the Sun and the Moon on the observation time. We also calculate both detectors\u27 neutrino horizons for a variety of modeled astrophysical neutrino fluences. We find that both EUSO-SPB2 and POEMMA will achieve transient sensitivities at the level of modeled neutrino fluences for nearby sources. We conclude with a discussion of the prospects of each mission detecting at least one transient event for various modeled astrophysical neutrino sources