186 research outputs found
Self-force on a scalar charge in radial infall from rest using the Hadamard-WKB expansion
We present an analytic method based on the Hadamard-WKB expansion to
calculate the self-force for a particle with scalar charge that undergoes
radial infall in a Schwarzschild spacetime after being held at rest until a
time t = 0. Our result is valid in the case of short duration from the start.
It is possible to use the Hadamard-WKB expansion in this case because the value
of the integral of the retarded Green's function over the particle's entire
past trajectory can be expressed in terms of two integrals over the time period
that the particle has been falling. This analytic result is expected to be
useful as a check for numerical prescriptions including those involving mode
sum regularization and for any other analytical approximations to self-force
calculations.Comment: 22 pages, 2 figures, Physical Review D version along with the
corrections given in the erratu
Noise kernel for a quantum field in Schwarzschild spacetime under the Gaussian approximation
A method is given to compute an approximation to the noise kernel, defined as
the symmetrized connected 2-point function of the stress tensor, for the
conformally invariant scalar field in any spacetime conformal to an
ultra-static spacetime for the case in which the field is in a thermal state at
an arbitrary temperature. The most useful applications of the method are flat
space where the approximation is exact and Schwarzschild spacetime where the
approximation is better than it is in most other spacetimes. The two points are
assumed to be separated in a timelike or spacelike direction. The method
involves the use of a Gaussian approximation which is of the same type as that
used by Page to compute an approximate form of the stress tensor for this field
in Schwarzschild spacetime. All components of the noise kernel have been
computed exactly for hot flat space and one component is explicitly displayed.
Several components have also been computed for Schwarzschild spacetime and
again one component is explicitly displayed.Comment: 34 pages, no figures. Substantial revisions in Secs. I, IV, and V;
minor revisions elsewhere; new results include computation of the exact noise
kernel for hot flat space and an approximate computation of the noise kernel
for a thermal state at an arbitrary temperature in Schwarzschild spacetime
when the points are split in the time directio
Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in understanding how their aggregation behavior is influenced by the sequences flanking them. We used solution NMR to study at single-residue resolution a 156-residue proteolytic fragment of the androgen receptor that contains a polyQ tract associated with the disease spinobulbar muscular atrophy, also known as Kennedy disease. Our findings indicate that a Leu-rich region preceding the polyQ tract causes it to become α-helical and appears to protect the protein against aggregation, which represents a new, to our knowledge, mechanism by which sequence context can minimize the deleterious properties of these repetitive regions. Our results have implications for drug discovery for polyQ diseases because they suggest that the residues flanking these repetitive sequences may represent viable therapeutic targets
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that these molecular chaperones recognize a region of the AR N-terminal domain (NTD), including a FQNLF motif, that interacts with the AR ligand-binding domain (LBD) upon activation. This suggests that competition between molecular chaperones and the LBD for the FQNLF motif regulates AR activation. We also show that, while the free NTD oligomerizes, binding to Hsp70 increases its solubility. Stabilizing the NTD-Hsp70 interaction with small molecules reduces AR aggregation and promotes its degradation in cellular and mouse models of the neuromuscular disorder spinal bulbar muscular atrophy. These results help resolve the mechanisms by which molecular chaperones regulate the balance between AR aggregation, activation and quality control
Exponentially growing bubbles around early super massive black holes
We addressed the so far unexplored issue of outflows induced by exponentially
growing power sources, focusing on early supermassive black holes (BHs). We
assumed that these objects grow to by z=6 by
Eddington-limited accretion and convert 5% of their bolometric output into a
wind. We first considered the case of energy-driven and momentum-driven
outflows expanding in a region where the gas and total mass densities are
uniform and equal to the average values in the Universe at . We derived
analytic solutions for the evolution of the outflow, finding that, for an
exponentially growing power with e-folding time , the late time
expansion of the outflow radius is also exponential, with e-folding time of
and in the energy-driven and momentum-driven limit,
respectively.
We then considered energy-driven outflows produced by QSOs at the center of
early dark matter halos of different masses and powered by BHs growing from
different seeds. We followed the evolution of the source power and of the gas
and dark matter density profiles in the halos from the beginning of the
accretion until . The final bubble radius and velocity do not depend on
the seed BH mass but are instead smaller for larger halo masses. At z=6, bubble
radii in the range 50-180 kpc and velocities in the range 400-1000 km s
are expected for QSOs hosted by halos in the mass range
.
By the time the QSO is observed, we found that the total thermal energy
injected within the bubble in the case of an energy-driven outflow is
erg. This is in excellent agreement with the value
of erg measured through the detection of
the thermal Sunyaev-Zeldovich effect around a large population of luminous QSOs
at lower redshift. [abridged]Comment: 17 pages and 14 figures. Typos corrected. It matches the version
published in A&
The Sloan Digital Sky Survey Reverberation Mapping Project: Technical Overview
The Sloan Digital Sky Survey Reverberation Mapping project (SDSS-RM) is a
dedicated multi-object RM experiment that has spectroscopically monitored a
sample of 849 broad-line quasars in a single 7 deg field with the SDSS-III
BOSS spectrograph. The RM quasar sample is flux-limited to i_psf=21.7 mag, and
covers a redshift range of 0.1<z<4.5. Optical spectroscopy was performed during
2014 Jan-Jul dark/grey time, with an average cadence of ~4 days, totaling more
than 30 epochs. Supporting photometric monitoring in the g and i bands was
conducted at multiple facilities including the CFHT and the Steward Observatory
Bok telescopes in 2014, with a cadence of ~2 days and covering all lunar
phases. The RM field (RA, DEC=14:14:49.00, +53:05:00.0) lies within the CFHT-LS
W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07,
with three prior years of multi-band PS1 light curves. The SDSS-RM 6-month
baseline program aims to detect time lags between the quasar continuum and
broad line region (BLR) variability on timescales of up to several months (in
the observed frame) for ~10% of the sample, and to anchor the time baseline for
continued monitoring in the future to detect lags on longer timescales and at
higher redshift. SDSS-RM is the first major program to systematically explore
the potential of RM for broad-line quasars at z>0.3, and will investigate the
prospects of RM with all major broad lines covered in optical spectroscopy.
SDSS-RM will provide guidance on future multi-object RM campaigns on larger
scales, and is aiming to deliver more than tens of BLR lag detections for a
homogeneous sample of quasars. We describe the motivation, design and
implementation of this program, and outline the science impact expected from
the resulting data for RM and general quasar science.Comment: 25 pages, submitted to ApJS; project website at http://www.sdssrm.or
Recommended from our members
Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Hesperidin improves the follicular development in 3D culture of isolated preantral ovarian follicles of mice
In vitro follicular culture systems provide optimal culture models for research about the physiology of the ovary and support the clinical practices to achieve competent mature oocytes for in vitro fertilization. In vitro maturation of preantral follicles makes it possible to study the effects of therapeutic agents on various conditions or disorders of the ovary. Nowadays, preventive bioflavonoids against cancer, hypercholesterolemia, fatty liver, or a variety of toxic agents are in focus. The aim of this study was to design and investigate the impacts of different concentrations of hesperidin, a glycoside flavonoid, on the in vitro preantral follicle growth and maturation in the three-dimensional (3D) culture system which was made with sodium alginate. Preantral follicles (n = 1363) were mechanically isolated from immature mice ovaries, then, after capsulating, they were randomly divided into four groups: the control group received no concentration of hesperidin, and three experimental groups were supplemented with 10, 22.5, and 50 µmol/L of hesperidin. All groups were cultured for 12 days. At the end of the culture period, the percentage of survival rate, antrum formation, obtained metaphase II oocytes, and the secretion of 17β-estradiol and progesterone were significantly higher in the group Hesp 50 (50 µmol/L hesperidin). Moreover, the mean average of follicular diameter cultured in the group Hesp 50 was also increased and the mRNA expression levels of PCNA, FSH-R, and Bcl-2 genes were higher, while Bax mRNA expression was significantly reduced compared with the other groups. Follicles cultured in the presence of 50 µmol/L of hesperidin had a higher fertilization rate and embryo development. Adding hesperidin at the concentration of 50 µmol/L to the culture medium resulted in higher follicular growth and maturation and increased the rate of in vitro fertilization and embryo development. Impact statement: It has been stated that hesperidin has many pharmacological effects, such as anti-inflammatory and antioxidant effects, antimicrobial activity, and anti-carcinogenic activity; but hesperidin and its derivatives have been under investigation as anti-fertility factors for a very long time. However, our results show that hesperidin can improve mice follicular growth and maturation during in vitro 3D culture. Hesperidin as an antioxidant factor could enhance the mRNA expression levels of two important genes involved in folliculogenesis, PCNA, and FSH-R. Our results prove for the first time that hesperidin not only has deleterious effects on follicular development but can also increase rates of in vitro fertilization and embryo development. © 2019 by the Society for Experimental Biology and Medicine
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