574 research outputs found
Climbing Robot for Steel Bridge Inspection: Design Challenges
Inspection of bridges often requires high risk operations such as working at heights, in confined spaces, in hazardous environments; or sites inaccessible by humans. There is significant motivation for robotic solutions which can carry out these inspection tasks. When inspection robots are deployed in real world inspection scenarios, it is inevitable that unforeseen challenges will be encountered. Since 2011, the New South Wales Roads & Maritime Services and the Centre of Excellence for Autonomous Systems at the University of Technology, Sydney, have been working together to develop an innovative climbing robot to inspect high risk locations on the Sydney Harbour Bridge. Many engineering challenges have been faced throughout the development of several prototype climbing robots, and through field trials in the archways of the Sydney Harbour Bridge. This paper will highlight some of the key challenges faced in designing a climbing robot for inspection, and then present an inchworm inspired robot which addresses many of these challenges
Optical properties of exfoliated MoS2 coaxial nanotubes - analogues of graphene
We report on the first exfoliation of MoS2 coaxial nanotubes. The single-layer flakes, as the result of exfoliation, represent the transition metal dichalcogenides' analogue of graphene. They show a very low degree of restacking in comparison with exfoliation of MoS2 plate-like crystals. MoS2 monolayers were investigated by means of electron and atomic force microscopies, showing their structure, and ultraviolet-visible spectrometry, revealing quantum confinement as the consequence of the nanoscale size in the z-direction
Discovery of an intermediate-luminosity red transient in M51 and its likely dust-obscured, infrared-variable progenitor
We present the discovery of an optical transient (OT) in Messier 51,
designated M51 OT2019-1 (also ZTF19aadyppr, AT 2019abn, ATLAS19bzl), by the
Zwicky Transient Facility (ZTF). The OT rose over 15 days to an observed
luminosity of (), in the
luminosity gap between novae and typical supernovae (SNe). Spectra during the
outburst show a red continuum, Balmer emission with a velocity width of
km s, Ca II and [Ca II] emission, and absorption features
characteristic of an F-type supergiant. The spectra and multiband light curves
are similar to the so-called "SN impostors" and intermediate-luminosity red
transients (ILRTs). We directly identify the likely progenitor in archival
Spitzer Space Telescope imaging with a m luminosity of
and a color redder than 0.74 mag, similar
to those of the prototype ILRTs SN 2008S and NGC 300 OT2008-1. Intensive
monitoring of M51 with Spitzer further reveals evidence for variability of the
progenitor candidate at [4.5] in the years before the OT. The progenitor is not
detected in pre-outburst Hubble Space Telescope optical and near-IR images. The
optical colors during outburst combined with spectroscopic temperature
constraints imply a higher reddening of mag and higher
intrinsic luminosity of
() near peak than seen in previous ILRT
candidates. Moreover, the extinction estimate is higher on the rise than on the
plateau, suggestive of an extended phase of circumstellar dust destruction.
These results, enabled by the early discovery of M51 OT2019-1 and extensive
pre-outburst archival coverage, offer new clues about the debated origins of
ILRTs and may challenge the hypothesis that they arise from the
electron-capture induced collapse of extreme asymptotic giant branch stars.Comment: 21 pages, 5 figures, published in ApJ
Form Factors in the radiative pion decay
We perform an analysis of the form factors that rule the structure-dependent
amplitude in the radiative pion decay. The resonance contributions to pion -> e
nu_e gamma decays are computed through the proper construction of the vector
and axial-vector form factors by setting the QCD driven asymptotic properties
of the three-point Green functions VVP and VAP, and by demanding the smoothing
of the form factors at high transfer of momentum. A comparison between
theoretical and experimental determinations of the form factors is also carried
out. We also consider and evaluate the role played by a non-standard tensor
form factor. We conclude that, at present and due to the hadronic incertitudes,
the search for New Physics in this process is not feasible.Comment: 14 pages, no figures. Typos corrected. Accepted for publication in
The European Physical Journal
Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore
Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity
Detection of interstellar oxidaniumyl: abundant H2O+ towards the star-forming regions DR21, Sgr B2, and NGC6334
We identify a prominent absorption feature at 1115 GHz, detected in first
HIFI spectra towards high-mass star-forming regions, and interpret its
astrophysical origin. The characteristic hyperfine pattern of the H2O+
ground-state rotational transition, and the lack of other known low-energy
transitions in this frequency range, identifies the feature as H2O+ absorption
against the dust continuum background and allows us to derive the velocity
profile of the absorbing gas. By comparing this velocity profile with velocity
profiles of other tracers in the DR21 star-forming region, we constrain the
frequency of the transition and the conditions for its formation. In DR21, the
velocity distribution of H2O+ matches that of the [CII] line at 158\mu\m and of
OH cm-wave absorption, both stemming from the hot and dense clump surfaces
facing the HII-region and dynamically affected by the blister outflow. Diffuse
foreground gas dominates the absorption towards Sgr B2. The integrated
intensity of the absorption line allows us to derive lower limits to the H2O+
column density of 7.2e12 cm^-2 in NGC 6334, 2.3e13 cm^-2 in DR21, and 1.1e15
cm^-2 in Sgr B2.Comment: Accepted for publication in A&
Use Of The BigSol Time Of Flight Spectrometer In The Study Of Superheavy Element Production
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98691/1/APC000594.pd
Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis
OBJECTIVE:
The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP).
METHODS:
We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations.
RESULTS:
Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups.
CONCLUSIONS:
Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study
Nasopharyngeal Colonization and Invasive Disease Are Enhanced by the Cell Wall Hydrolases LytB and LytC of Streptococcus pneumoniae
Background: Streptococcus pneumoniae is a common colonizer of the human nasopharynx and one of the major pathogens causing invasive disease worldwide. Dissection of the molecular pathways responsible for colonization, invasion, and evasion of the immune system will provide new targets for antimicrobial or vaccine therapies for this common pathogen. Methodology/Principal Findings: We have constructed mutants lacking the pneumococcal cell wall hydrolases (CWHs) LytB and LytC to investigate the role of these proteins in different phases of the pneumococcal pathogenesis. Our results show that LytB and LytC are involved in the attachment of S. pneumoniae to human nasopharyngeal cells both in vitro and in vivo. The interaction of both proteins with phagocytic cells demonstrated that LytB and LytC act in concert avoiding pneumococcal phagocytosis mediated by neutrophils and alveolar macrophages. Furthermore, C3b deposition was increased on the lytC mutant confirming that LytC is involved in complement evasion. As a result, the lytC mutant showed a reduced ability to successfully cause pneumococcal pneumonia and sepsis. Bacterial mutants lacking both LytB and LytC showed a dramatically impaired attachment to nasopharyngeal cells as well as a marked degree of attenuation in a mouse model of colonization. In addition, C3b deposition and phagocytosis was more efficient for the double lytB lytC mutant and its virulence was greatly impaired in both systemic and pulmonary models of infection. Conclusions/Significance: This study confirms that the CWHs LytB and LytC of S. pneumoniae are essential virulence factor
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation
Synchronization of mitochondrial and cytoplasmic translation rates is critical for the maintenance of cellular fitness, with cancer cells being especially vulnerable to translational uncoupling. Although alterations of cytosolic protein synthesis are common in human cancer, compensating mechanisms in mitochondrial translation remain elusive. Here we show that the malignant long non-coding RNA (lncRNA) SAMMSON promotes a balanced increase in ribosomal RNA (rRNA) maturation and protein synthesis in the cytosol and mitochondria by modulating the localization of CARF, an RNA-binding protein that sequesters the exo-ribonuclease XRN2 in the nucleoplasm, which under normal circumstances limits nucleolar rRNA maturation. SAMMSON interferes with XRN2 binding to CARF in the nucleus by favoring the formation of an aberrant cytoplasmic RNA-protein complex containing CARF and p32, a mitochondrial protein required for the processing of the mitochondrial rRNAs. These data highlight how a single oncogenic lncRNA can simultaneously modulate RNA-protein complex formation in two distinct cellular compartments to promote cell growth
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