Trapping ultracold atoms at 100 nm from a chip surface in a 0.7-micrometer-period magnetic lattice

We report the trapping of ultracold 87Rb atoms in a 0.7 micron-period 2D triangular magnetic lattice on an atom chip. The magnetic lattice is created by a lithographically patterned magnetic Co/Pd multilayer film plus bias fields. Rubidium atoms in the F=1, mF=-1 low-field seeking state are trapped at estimated distances down to about 100 nm from the chip surface and with calculated mean trapping frequencies as high as 800 kHz. The measured lifetimes of the atoms trapped in the magnetic lattice are in the range 0.4 - 1.7 ms, depending on distance from the chip surface. Model calculations suggest the trap lifetimes are currently limited mainly by losses due to surface-induced thermal evaporation following loading of the atoms from the Z-wire trap into the very tight magnetic lattice traps, rather than by fundamental loss processes such as surface interactions, three-body recombination or spin flips due to Johnson magnetic noise. The trapping of atoms in a 0.7 micrometer-period magnetic lattice represents a significant step towards using magnetic lattices for quantum tunneling experiments and to simulate condensed matter and many-body phenomena in nontrivial lattice geometries.Comment: 11 pages, 7 figure

NACA Research Memorandums

Report presenting the performance characteristics of the XRJ43-MA-3 model 20B3 ramjet engine in a free-jet facility as part of the development program for the "Bomarc" ramjet powered interceptor-type missile

Radiofrequency spectroscopy of a linear array of Bose-Einstein condensates in a magnetic lattice

We report site-resolved radiofrequency spectroscopy measurements of Bose-Einstein condensates of 87Rb atoms in about 100 sites of a one-dimensional 10 micron-period magnetic lattice produced by a grooved magnetic film plus bias fields. Site-to-site variations of the trap bottom, atom temperature, condensate fraction and chemical potential indicate that the magnetic lattice is remarkably uniform, with variations in trap bottoms of only +/- 0.4 mG. At the lowest trap frequencies (radial and axial frequencies 1.5 kHz and 260 Hz, respectively), temperatures down to 0.16 microkelvin are achieved in the magnetic lattice and at the smallest trap depths (50 kHz) condensate fractions up to 80% are observed. With increasing radial trap frequency (up to 20 kHz, or aspect ratio up to about 80) large condensate fractions persist and the highly elongated clouds approach the quasi-1D Bose gas regime. The temperature estimated from analysis of the spectra is found to increase by a factor of about five which may be due to suppression of rethermalising collisions in the quasi-1D Bose gas. Measurements for different holding times in the lattice indicate a decay of the atom number with a half-life of about 0.9 s due to three-body losses and the appearance of a high temperature (about 1.5 microkelvin) component which is attributed to atoms that have acquired energy through collisions with energetic three-body decay products

Social network typologies and mortality risk among older people in China, India, and Latin America: A 10/66 Dementia Research Group population-based cohort study

BACKGROUND: Restricted social networks have been associated with higher mortality in several developed countries but there are no studies on this topic from developing countries. This gap exists despite potentially greater dependence on social networks for support and survival due to various barriers to health care and social protection schemes in this setting. Thus, this study aims to examine how social network type at baseline predicts all-cause mortality among older adults in six Latin American countries, China, and India. METHODS: Population-based surveys were conducted of all individuals aged 65+ years in eight countries (Cuba, Dominican Republic, Peru, Venezuela, Mexico, Puerto Rico, China, and India). Data on mortality were obtained at follow-up (mean 3.8 years after cohort inception). Follow-up data for 13,891 individuals were analysed. Social network types were assessed using Wenger's Practitioner Assessment of Network Type (PANT). Cox proportional hazard models were constructed to estimate the impact of social network type on mortality risk in each country, adjusting for socio-demographics, receipt of pension, disability, medical conditions, and depression. Meta-analysis was performed to obtain pooled estimates. RESULTS: The prevalence of private network type was 64.4% in urban China and 1.6% in rural China, while the prevalence of locally integrated type was 6.6% in urban China and 86.8% in rural China. The adjusted pooled estimates across (a) all countries and (b) Latin America showed that, compared to the locally integrated social network type, the locally self-contained [(b) HR = 1.24, 95%CI 1.01-1.51], family dependent [(a) HR = 1.13, 95%CI 1.01-1.26; (b) HR = 1.13, 95%CI 1.001-1.28], and private [(a) HR = 1.36, 95%CI 1.06-1.73; (b) HR = 1.45, 95%CI 1.20-1.75] social network types were significantly associated with higher mortality risk. CONCLUSION: Survival time is significantly reduced in individuals embedded in restricted social networks (i.e. locally self-contained, family dependent, and private network types). Social care interventions may be enhanced by addressing the needs of those most at risk of neglect and deteriorating health. Health policy makers in developing countries may use this information to plan efficient use of limited resources by targeting those embedded in restricted social networks. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. KEYWORDS: Ageing; Developing countries; Interpersonal relations; Mortality; Social networks; Social support; Survival rat

Investigation of noise suppression, pulse intensity and chirp of an actively mode-locked semiconductor fiber ring laser

An actively mode-locked fiber ring laser that utilizes an EDFA and semiconductor optical amplifier (SOA) is presented. The SOA enhances noise suppression. Active mode-locking was demonstrated at repetition rates up to 20 GHz. The effects of intra-cavity power and SOA current on noise suppression are studied for two types of commercially available SOA. The frequency resolved optical gating technique is used to characterize the output pulse stream intensity and frequency chirp

Antibody interference and response kinetics of isatuximab plus pomalidomide and dexamethasone in multiple myeloma

The ICARIA-MM study was sponsored by Sanofi. The authors thank, Helgi van de Velde, Valérie Boutet, Shujia Dai, Deborah DiNoto, Graziella Engelvin, Olivier Fedeli, Sébastien Hugla, Dominique Mouret, Béatrice Pradeilles, and Alain Roccon, all employees of Sanofi, for their contribution to the study, technology, and comments on the manuscript. The authors thank the participating patients and their families, and the study centers and investigators, for their contributions to the study. The medical writing support was provided by John Clarke, PhD and Stephanie Brillhart, PhD of Elevate Medical Affairs, contracted by Sanofi Genzyme for publication support services

Paleomagnetism of the ~860 Ma Manso dyke swarm, West Africa: implications for the assembly of Rodinia

The West African Craton (WAC) is one of the major cratons in the Rodinia jigsaw puzzle (~1000?750Ma). In the Rodinian models, the position of West Africa is mainly constrained by the assumptionthat it had been a partner of Amazonia since the Paleoproterozoic. Unfortunately, nopaleomagnetic data are available for these cratons when the Rodina supercontinent is consideredtectonically stable (~1000-750 Ma). Thus, every new reliable paleomagnetic pole for the WestAfrican Craton during the Neoproterozoic times is of paramount importance to constrain itsposition and testing the Rodinia models. In this study we present a combined paleomagnetic andgeochronological investigation for the Manso dyke swarm in the Leo-Man Shield, southern WestAfrica (Ghana). The ~860 Ma emplacement age for the NNW-trending Manso dykes is thus wellconstrainedby two new U-Pb apatite ages of 857.2 ± 8.5 Ma and 855 ± 16 Ma, in agreement withbaddeleyite data. Remanence of these coarse-to-fine grained dolerite dykes is carried by stablesingle to pseudo-single domain (SD-PSD) magnetite. A positive baked-contact test, associated to apositive reversal test (Class-C), support the primary remanence obtained for these dykes (13 sites).Moreover, our new paleomagnetic dataset satisfy all the seven R-criteria (R=7). The ~860 MaManso pole can thus be considered as the first key Tonian paleomagnetic pole for West Africa. Wepropose that the West Africa-Baltica-Amazonia-Congo-São Francisco were associated in a longlivedWABAMGO juxtaposition (~1100?800 Ma).Fil: Antonio, Paul Yves Jean. National Research Institute of Science and Technology. Centre de Montpellier; FranciaFil: Baratoux, Lenka. Université Paul Sabatier; FranciaFil: Ferreira Trindade, Ricardo Ivan. Universidade de Sao Paulo; BrasilFil: Rousse, Sonia. Université Paul Sabatier; FranciaFil: Ayite, Anani. University Of Ghana; GhanaFil: Lana, Cristiano. Universidade Federal de Ouro Preto; BrasilFil: Macouin, Melina. Université Paul Sabatier; FranciaFil: Kobby Adu, Emmanuel Williams. University Of Ghana; GhanaFil: Sanchez, Caroline. Université Paul Sabatier; FranciaFil: Silva, Marco. Universidade Federal de Ouro Preto; BrasilFil: Firmin, Anne Sophie. Université Paul Sabatier; FranciaFil: Martínez Dopico, Carmen Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Proietti, Arnaud. Centre de Microcaractérisation Raimond Castaing; FranciaFil: Amponsah, Prince Ofori. University Of Ghana; GhanaFil: Asamoah Sakyi, Patrick. University Of Ghana; GhanaEGU General Assembly 2021ViennaAustriaEuropean Geosciences Unio

FEL stochastic spectroscopy revealing silicon bond softening dynamics

Time-resolved X-ray Emission/Absorption Spectroscopy (Tr-XES/XAS) is an informative experimental tool sensitive to electronic dynamics in materials, widely exploited in diverse research fields. Typically, Tr-XES/XAS requires X-ray pulses with both a narrow bandwidth and sub-picosecond pulse duration, a combination that in principle finds its optimum with Fourier transform-limited pulses. In this work, we explore an alternative xperimental approach, capable of simultaneously retrieving information about unoccupied (XAS) and occupied (XES) states from the stochastic fluctuations of broadband extreme ultraviolet pulses of a free-electron laser. We used this method, in combination with singular value decomposition and Tikhonov regularization procedures, to determine the XAS/XES response from a crystalline silicon sample at the L2,3-edge, with an energy resolution of a few tens of meV. Finally, we combined this spectroscopic method with a pump-probe approach to measure structural and electronic dynamics of a silicon membrane. Tr-XAS/XES data obtained after photoexcitation with an optical laser pulse at 390 nm allowed us to observe perturbations of the band structure, which are compatible with the formation of the predicted precursor state of a non-thermal solid-liquid phase transition associated with a bond softening phenomenon

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline

Background: Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairmen

Primary Biliary Cholangitis : advances in management and treatment of the disease

Primary Biliary Cholangitis, previously known as Primary Biliary Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It is a chronic autoimmune disease characterized by a progressive damage of interlobular bile ducts leading to ductopenia, chronic cholestasis and bile acids retention. Even if the disease usually presents a long asymptomatic phase and a slow progression, in many patients it may progress faster toward cirrhosis and its complications. The 10\uc2\ua0year mortality is greater than in diseases such as human immunodeficiency virus/Hepatitis C Virus coinfection and breast cancer. Ursodeoxycholic acid is the only treatment available today, but even if effective in counteracting the disease progression for the majority of patients, in approximately 40% is not able to decrease effectively the alkaline phosphatase, a surrogate marker of disease activity. Recently, obeticholic acid received the European Medicines Agency conditional approval, as add on treatment in patients non responders or intolerant to ursodeoxycholic acid. The present paper illustrates the opinion of a working group, composed by clinical pharmacologists, gastroenterologists/hepatologists with specific expertise on Primary Biliary Cholangitis and patient associations, on the state of the art and future perspectives of the disease management. The agreement on the document was reached through an Expert Meeting