Urban environmental quality and wellbeing in the context of incomplete urbanization in Brazil: integrating directly experienced ecosystem services into planning

The benefits of urban greenspace to residents are increasingly recognized as important to planning for sustainable and healthy cities. However, the way that people interact with and benefit from urban greenspace is context dependent and conditioned by a range of social and material factors. This paper applies and expands the ecosystems services based approach to understanding urban environmental quality and the way in which greenspace is appropriated by residents in the context of incomplete urbanization in three peri-urban target areas in Brazil. We develop and employ the notion of indirect (scientifically detected) and directly experienced ecosystems services, and undertake a science based ecosystem services assessment and a qualitative analysis of interviews, walking narratives and images captured with a smartphone application to understand what functions urban greenspace serves in the daily life of the studied neighborhoods. Findings demonstrate how elements of urban greenspace and what can be termed ecosystem services serve both material and signifying functions and produce subjective and collective benefits and dis-benefits that hinge on aspects of livability such as quality of urban service delivery, housing status and perceptions of crime and neighborhood character. We identify factors that enable, hinder and motivate both active material and interpretative interactions with urban greenspace. The findings suggest that the relationship between ecosystem service provision and wellbeing is better understood as reciprocal rather than one way. Although at the neighborhood scale, fear of crime and poor access to urban services can hinder positive engagements with urban greenspace and experienced benefits form ES, urban squares and fringe vegetation is also being appropriated to address experienced disadvantages. Presently however these local interactions and ecosystem service benefits are overlooked in formal planning and conservation efforts and are increasingly compromised by growing population density and environmental degradation. We make recommendations for a nuanced assessment of the material and interpretative human-nature interactions and associated ecosystem services in an urban context, and discuss the potential for planning initiatives that could be employed to articulate and nurture these important interactions in our target areas

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3448Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4.1 × 10(-10)). Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.We thank all participants of all the studies included for enabling this research by their participation in these studies. Computer resources for this project have been provided by the high-performance computing centers of the University of Michigan and the University of Regensburg. Group-specific acknowledgments can be found in the Supplementary Note. The Center for Inherited Diseases Research (CIDR) Program contract number is HHSN268201200008I. This and the main consortium work were predominantly funded by 1X01HG006934-01 to G.R.A. and R01 EY022310 to J.L.H

Embracing the Power of Community Engagement

This panel discussion explores how collaboration between various stakeholders can lead to positive outcomes in different areas, such as creating a strong Parent\u27s Council, fundraising, community engagement, and community partnerships