Salinity Variations and Chemical Compositions of Waters in the Frio Formation, Texas Gulf Coast

Waters produced from sandstone reservoirs of the deep Frio Formation exhibit spatial variations in chemical composition that roughly coincide with the major tectonic elements (Houston and Rio Grande Embayments, San Marcos Arch) and corresponding depositional systems (Houston and Norias deltas, Greta-Carancahua barrier/strandplain system) that were respectively active along the upper, lower, and middle Texas Coast during Frio deposition. Waters of the upper coast typically have relatively high salinities (maximum total dissolved solids >80,000 mg/L), high calcium (200 to 9,000 mg/L), high sodium (>15,000 µg/L), relatively high potassium (>150 mg/L), low to moderate Cl/Na ratios (1.4 to 1.9), and high Cl/Br ratios (>400). When compared with adjacent areas of Frio production, waters of the middle coast have lower salinities (maximum total dissolved solids 80,000 mg/L, extremely high calcium (1,800 to 34,000 mg/L), high sodium (>15,000 mg/L), high potassium (>150), extremely high Cl/Na ratios (>2), and low Cl/Br ratios (<250). Calcium concentrations actually exceed sodium concentrations in some South Texas waters.Bureau of Economic Geolog

Oyster Reef Restoration: Convergence Of Harvest And Conservation Strategies

Oyster reef restoration, protection, and construction are important to meeting harvest, water quality, and fish habitat goals. However, the strategies needed to achieve harvest and conservation goals have often been considered to be at odds. We argue that these goals are. in fact, compatible and that the same strategies will promote a sustainable harvest of the resource, increased filtration of estuarine waters, and increased provision of structured habitat for finfish, crabs, and other organisms that utilize oyster reefs or receive benefit indirectly from them. Creation or designations of unharvested sites (refuge sites) are key components of these strategies. Unharvested reefs have the potential to provide vertical relief, which is typically destroyed by harvest practices, to act as a source of larvae, which potentially increases the supply of harvestable oysters, and to protect those individuals most likely to have some resistance to disease. Furthermore. proper monitoring and design of refuge and restoration efforts are critical to providing information needed to improve the success of future restoration efforts, and will simultaneously enhance the basic information needed to understand the ecology of oysters and their role in estuarine and coastal systems

A critical perspective on the concept of biocultural diversity and its emerging role in nature and heritage conservation

The continuing losses of biodiversity around the world remain problematic for nature conservation. A fundamental issue that has triggered debates in nature conservation is the relationship between human culture, heritage and history, and nature expressed as ecology or biodiversity. Traditionally, nature conservation has been pursued separately from aspects of cultural heritage; a situation which seems perplexing when we consider the importance of traditional management in the maintenance of biodiversity in many areas now “protected” for nature. To address these broad issues, fundamental to future landscape sustainability, we need to have clear definitions of concepts and terms. This paper considers the historical development of the key concepts that frame biocultural diversity and the paradigms relating to biocultural assets or eco-cultural landscapes. This is pertinent to both researchers and to practitioners or policymakers, and we suggest ways biocultural diversity can improve global conservation efforts

A novel COMP mutation in a pseudoachondroplasia family of Chinese origin

<p>Abstract</p> <p>Background</p> <p>Pseudoachondroplasia (PSACH) is caused exclusively by mutations in the gene for cartilage oligomeric matrix protein (<it>COMP</it>). Only a small number of studies have documented the clinical phenotype and genetic basis in Chinese PSACH patients.</p> <p>Case presentation</p> <p>We investigated a four-generation PSACH pedigree of Chinese Han origin. Two patients and two unaffected individuals were recruited for clinical evaluation and molecular genetic analysis. The genomic DNA was extracted from peripheral blood leukocytes. Polymerase chain reaction (PCR) was adopted to amplify the 8-19 exons of <it>COMP </it>gene. Then the products were sequenced bi-directionally for screening mutation. Clinical evaluation revealed that PSACH patients in this pedigree had a severe disproportionate short stature (-10SD). A heterozygous TGTCCCTGG insertion in exon 13, between nucleotide 1352T and 1353G, were identified in the patients except the unaffected individuals, which resulted in a three-amino-acid insertion (451V_452P ins VPG) in the sixth calmodulin-like repeat of the <it>COMP </it>protein.</p> <p>Conclusion</p> <p>This c. 1352_1353ins TGTCCCTGG is a novel mutation responsible for severe familial PSACH.</p

Determination of an optimal response cut-off able to predict progression-free survival in patients with well-differentiated advanced pancreatic neuroendocrine tumours treated with sunitinib: an alternative to the current RECIST-defined response.

BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent. METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study. The primary objective was to determine the optimal RECIST (v.1.0) response cut-off value to identify patients who were progression-free at 11 months (median PFS in phase III trial); and the most informative time-point (highest area under the curve (AUC) by receiver operating characteristic (ROC) analysis and logistic regression) for prediction of benefit (PFS) from sunitinib. RESULTS: Data for 237 patients (85 placebo; 152 sunitinib (n=66.50 mg \u274-weeks on/2-weeks off\u27 schedule; n=86 \u2737.5 mg continuous daily dosing (CDD)\u27)) and 788 scans were analysed. The median PFS for sunitinib and placebo were 9.3 months (95% CI 7.6-12.2) and 5.4 months (95% CI 3.5-6.01), respectively (hazard ratio (HR) 0.43 (95% CI 0.29-0.62); P CONCLUSIONS: A 10% reduction within marker lesions identifies pNET patients benefiting from sunitinib treatment with implications for maintenance of dose intensity and future trial design

Characterizing College Science Assessments: The Three-Dimensional Learning Assessment Protocol

Citation: Laverty, J. T., Underwood, S. M., Matz, R. L., Posey, L. A., Carmel, J. H., Caballero, M. D., . . . Cooper, M. M. (2016). Characterizing College Science Assessments: The Three-Dimensional Learning Assessment Protocol. Plos One, 11(9), 21. doi:10.1371/journal.pone.0162333Many calls to improve science education in college and university settings have focused on improving instructor pedagogy. Meanwhile, science education at the K-12 level is undergoing significant changes as a result of the emphasis on scientific and engineering practices, crosscutting concepts, and disciplinary core ideas. This framework of "three-dimensional learning" is based on the literature about how people learn science and how we can help students put their knowledge to use. Recently, similar changes are underway in higher education by incorporating three-dimensional learning into college science courses. As these transformations move forward, it will become important to assess three-dimensional learning both to align assessments with the learning environment, and to assess the extent of the transformations. In this paper we introduce the Three-Dimensional Learning Assessment Protocol (3D-LAP), which is designed to characterize and support the development of assessment tasks in biology, chemistry, and physics that align with transformation efforts. We describe the development process used by our interdisciplinary team, discuss the validity and reliability of the protocol, and provide evidence that the protocol can distinguish between assessments that have the potential to elicit evidence of three-dimensional learning and those that do not

Correlating PMC-MMC Bonded Joint 3D FEA with Test

A viewgraph presentation on the correlation of Polymer Matrix Composites (PMC) and Metal Matrix Composites (MMC) bonded joints using three dimensional finite element analyses with materials tests is shown

A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C

The Role of Public Health in Addressing Racial and Ethnic Disparities in Mental Health and Mental Illness

Racial/ethnic minority populations are underserved in the American mental health care system. Disparity in treatment between whites and African Americans has increased substantially since the 1990s. Racial/ethnic minorities may be disproportionately affected by limited English proficiency, remote geographic settings, stigma, fragmented services, cost, comorbidity of mental illness and chronic diseases, cultural understanding of health care services, and incarceration. We present a model that illustrates how social determinants of health, interventions, and outcomes interact to affect mental health and mental illness. Public health approaches to these concerns include preventive strategies and federal agency collaborations that optimize the resilience of racial/ethnic minorities. We recommend strategies such as enhanced surveillance, research, evidence-based practice, and public policies that set standards for tracking and reducing disparities