Sharing Power? Prospects for a U.S. Concert-Balance Strategy

View the Executive SummaryThe subject of U.S. grand strategy has been getting increasing attention from the policy and academic communities. However, too often the debate suffers from being too reductionist, limiting America’s choices to worldwide hegemony or narrow isolation. There is a wide spectrum of choices before Washington that lie “somewhere in the middle.” Frequently, not enough thought is given to how such alternative strategies should be designed and implemented. The future cannot be known, and earlier predictions of American decline have proven to be premature. However, there is a shift in wealth and power to the extent that America may not be able to hold on to its position as an unrivalled unipolar superpower. Therefore, it is worth thinking about how the United States could shape and adjust to the changing landscape around it. What is more, there are a number of interlocking factors that mean such a shift would make sense: transnational problems needing collaborative efforts, the military advantages of defenders, the reluctance of states to engage in unbridled competition, and “hegemony fatigue” among the American people. Alternative strategies that are smaller than global hegemony, but bigger than narrow isolationism, would be defined by the logic of “concerts” and “balancing,” in other words, some mixture of collaboration and competition. Can the United States adjust to a Concert-Balance grand strategy that made space for other rising powers without sacrificing too much of its forward military presence, without unleashing too much regional instability, and without losing the domestic political will? It is not certain that a cumulative shift to a new grand strategy would necessarily succeed, since other powers might turn down the chance to cooperate. But with soaring budget deficits and national debt, increasing burdens on social security, and possible agonizing choices in the future between guns and butter, it is surely worth a try.https://press.armywarcollege.edu/monographs/1530/thumbnail.jp

Investigating The Three-Click Rule: A Pilot Study

Human-computer interaction is a part of our everyday lives. A component of HCI is usability, often used as a measure of ease-of use. People have been studying usability for a long time and a standard scale, the System Usability Scale, has been created to measure the usability of systems. To increase ease of use in websites, designers have been following the Three-Click Rule. As technology evolves, user expectations can be expected to evolve as well. Therefore, a pilot study was created and conducted to evaluate measures for testing the relevancy of this rule

The Role of Cell Cycle Mediators in the Progression of Non-alcoholic Steatohepatitis in Male and Female Murine Models

Hepatocellular carcinoma (HCC) is the most prevalent primary cancer of the liver and one of the leading causes of cancer-related deaths worldwide. There are a multitude of risk factors that contribute to the development of HCC including viral infection, obesity, alcoholism, as well as non-alcoholic steatohepatitis (NASH). In the case of these chronic diseases and repeated injury, the liver continuously repairs itself to maintain its structural integrity, resulting in fibrosis, and in more serious cases, cirrhosis– major risk factors in the development of HCC. Men are 3-5x more likely to develop liver cancer than women; however, the exact mechanism for this remains undetermined. Previous work in our lab using a transgenic mouse model overexpressing the cyclin-like protein Spy1 showed an increased incidence of HCC and decrease in rates of fibrosis, suggesting a link between cell cycle regulation and progression to HCC. Spy1 binds and activates CDKs at the G1-S and G2-M checkpoints, leading to cell cycle progression independent of cyclin-based regulation. Using a methionine-choline deficient diet to induce NASH, the role of various cell cycle mediators will be investigated to uncover the link between cell cycle regulation and NASH disease progression. In addition, differences between female and male mouse responses to the diet with respect to cell cycle regulation will be analyzed. A better understanding of the relationship between cell cycle regulation and NASH disease progression in both female and male mouse models will help identify novel diagnostic markers and pathways of therapeutic importance in HCC

The Curry/Samara Model and The Model Classrooms Project Background and Research Foundations

The Curry/Samara Model(CSM) is an integrated, standards based approach to curriculum development that addresses differentiation from three dimensions (content, process & product). CSM is comprised of strategies related to curriculum, instruction and assessment that helps teachers to: (1) complement factual subject matter with rich, global concepts; (2) foster basic and abstract levels of thinking as related to core content; and (3) engage and assess students through traditional as well as innovative, authentic products

Spy1 Levels Predict Sensitivity of Refractory Multiple Myeloma to Therapy

Multiple myeloma (MM) is an aggressive hematopoietic malignancy with a poor prognosis that is caused by the abnormal growth of plasma cells in the bone marrow. Cyclin-dependent kinase inhibitors (CKIs) have been explored as a possible treatment for MM, with limited clinical success. We postulate that the cyclin-like protein, Spy1 (SPDYA), which is capable of overriding cell-cycle checkpoints, may play a role in limiting therapeutic effectiveness. To support this hypothesis, we have found that Spy1 is highly expressed in MM patient samples and human cell lines. We aim to explore the role that Spy1 plays in CKI resistance in MM using a variety of in vitro and in vivo techniques. Firstly, we intend to create and optimize an in vitro platform to study MM using patient samples collected from clinicians at Windsor Regional Hospital. Using this culture, and human cell lines, we intend to investigate the methylation status of Spy1 and other MM genes in Spy1 overexpression and knockout conditions to see the effects of epigenetic regulation. Then, we will perform drug and toxicity assays with standard CKIs using our Spy1 overexpression and knock-down lines to observe response to CKIs, expecting lines with higher Spy1 to demonstrate increased therapy resistance. Finally, our cells with manipulated Spy1 levels will be injected into zebrafish to test the effects of CKIs in vivo. Collectively, we aim to explore the role Spy1 may play in resistance to CKI therapy in MM, to improve disease understanding and identify areas treatments may be improved

Agroecology Education and Research: An Academic Platform for Organic Farming

Agroecology education and research programs are gaining prominence in universities. This emerging field provides an appropriate and convenient platform for bringing organic farming into academia. Agroecology deals with complex systems, uncertainty, and the future. Examples from organic farming and local food systems often provide valuable examples of applications of the principles of ecology in designing a sustainable agriculture. The agroecology MSc program in the NOVA network is a successful example of how organic farming can be brought into university programs, and how interdisciplinary education and research can tap into a regional faculty in agriculture

Comparison of 20nm silver nanoparticles synthesized with and without a gold core: Structure, dissolution in cell culture media, and biological impact on macrophages

Widespread use of silver nanoparticles raises questions of environmental and biological impact. Many synthesis approaches are used to produce pure silver and silver-shell gold-core particles optimized for specific applications. Since both nanoparticles and silver dissolved from the particles may impact the biological response, it is important to understand the physicochemical characteristics along with the biological impact of nanoparticles produced by different processes. The authors have examined the structure, dissolution, and impact of particle exposure to macrophage cells of two 20 nm silver particles synthesized in different ways, which have different internal structures. The structures were examined by electron microscopy and dissolution measured in Rosewell Park Memorial Institute media with 10% fetal bovine serum. Cytotoxicity and oxidative stress were used to measure biological impact on RAW 264.7 macrophage cells. The particles were polycrystalline, but 20 nm particles grown on gold seed particles had smaller crystallite size with many high-energy grain boundaries and defects, and an apparent higher solubility than 20 nm pure silver particles. Greater oxidative stress and cytotoxicity were observed for 20 nm particles containing the Au core than for 20 nm pure silver particles. A simple dissolution model described the time variation of particle size and dissolved silver for particle loadings larger than 9 μg/ml for the 24-h period characteristic of many in-vitro studies

Innovation and venture capital exit performance

Venture capital is a potent source of R&D financing which contributes significantly to technological innovation output in the form of patented inventions. Scholars have argued that tighter protection of intellectual property rights reduces expropriation risks and encourages venture capitalists to invest in technology firms. Prior studies have showed that early stage technology investors give much weight to investment selection criteria related to innovation e.g. protection of intellectual property, platform and uniqueness. However, VC investors generally receive little on their investments until a liquidation event occurs – IPO and M&A (trade sale) exits define venture capital performance. A review of the literature indicates that few empirical studies have examined the influence of patented innovation on the exit performance of VC-backed technology firms. This paper seeks to address this specific knowledge gap in venture capital research and practice. It builds on resource-based view (RBV) theory which argues that technological innovation is an important strategic resource of the entrepreneurial firm that can attract VC investment, provide competitive advantage and produce superior performance. This study is based on matched data compiled from VentureXpertTM, DelphionTM and NBER/USPTO databases. The resulting unique and proprietary dataset consists of 1504 U.S. VC-backed exits across 7 technology sectors in the 20 years from 1980-2000, 961 IPOs and 543 M&As. The influence of technological innovation on the exit performance of VC-backed technology firms is examined. As predicted by RBV theory, technology firms engaged in patenting activity were found more likely to be associated with the more profitable IPO exit route, higher VC investment and exit value