Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil

The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single cristal X-ray diffraction

Polymorphism of Cocrystals: The Promiscuous Behavior of Agomelatine

It has been traditionally suggested that polymorphism of cocrystals is a phenomenon seen less frequently than in monocomponent crystals. However, since the research on cocrystals has recently experienced a big growth, the number of solved structures of polymorphic cocrystals in the Cambridge Structural Database has increased, which can help to understand better whether a lower impact of this phenomenon exists or not in multicomponent crystals. In this paper we describe the cocrystal landscape of agomelatine, a particularly promiscuous drug able to cocrystallize with up to nine different coformers. Interestingly, two of those coformers have produced polymorphic cocrystals during the screening, which converts agomelatine into a new example that questions the traditional belief of the lesser impact of polymorphism in cocrystals and highlights the importance of polymorphism studies in cocrystal screening. Our work is completed with the determination of the crystal structures of the new forms from combined single crystal/laboratory X-ray powder diffraction data

Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s) = 1.96 TeV using Dilepton Events

We report a measurement of the ttbar production cross section using dilepton events with jets and missing transverse energy in ppbar collisions at a center-of-mass energy of 1.96 TeV. Using a 197 +/- 12 pb-1 data sample recorded by the upgraded Collider Detector at Fermilab, we use two complementary techniques to select candidate events. We compare the number of observed events and selected kinematical distributions with the predictions of the Standard Model and find good agreement. The combined result of the two techniques yields a ttbar production cross section of 7.0 +2.4/-2.1(stat.) +1.6/-1.1(syst.) +/- 0.4(lum.) pb.Comment: 15 pages, 2 figures, accepted by Phys.Rev.Let

Measurement of the W+W- Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Dilepton Events

We present a measurement of the W+W- production cross section using 184/pb of ppbar collisions at a center-of-mass energy of 1.96 TeV collected with the Collider Detector at Fermilab. Using the dilepton decay channel W+W- -> l+l-vvbar, where the charged leptons can be either electrons or muons, we find 17 candidate events compared to an expected background of 5.0+2.2-0.8 events. The resulting W+W- production cross section measurement of sigma(ppbar -> W+W-) = 14.6 +5.8 -5.1 (stat) +1.8 -3.0 (syst) +-0.9 (lum) pb agrees well with the Standard Model expectation.Comment: 8 pages, 2 figures, 2 tables. To be submitted to Physical Review Letter

Search for large extra dimensions in the production of jets and missing transverse energy in p(p)over-bar collisions at root s=1.96 TeV

We present the results of a search for new physics in the jets plus missing transverse energy data sample collected from 368 pb(-1) of p (p) over bar collisions at root s = 1.96 TeV recorded by the Collider Detector at Fermilab. We compare the number of events observed in the data with a data-based estimate of the standard model backgrounds contributing to this signature. We observe no significant excess of events, and we interpret this null result in terms of lower limits on the fundamental Planck scale for a large extra dimensions scenario

Search for gluino and squark production in multi-jets plus missing transverse energy final states at the tevatron using the CDF detector

Consultable des del TDXTítol obtingut de la portada digitalitzadaEl model estandar (ME) és actualment el marc teòric més complet que descriu la física de les partícules elementals. En ell s'hi descriuen les partícules de matèria (fermions) i les seves interaccions (bosons). Fins ara no s'ha trobat cap desviació significativa entre l'experiment i les prediccions del model. Així i tot, el ME no pot ser la teoria final que descriu la física de partícules perquè pateix dificultats teòriques importants a més altes energies. Una de les possibles extensions del ME amb més acceptació és la Supersimetria (SUSY) que relaciona masses i acoblaments entre bosons i fermions. D'aquesta forma, per cada bosó existent al ME ha d'existir una "super-parella" fermiònica i a l'inrevés. A més, una altra simetria anomenada "paritat R" s'hi acostuma a introduir per tal d'evitar la violació del nombre bariònic i leptònic. Si això és així, aquestes noves partícules, que apareixerien a l'escala energètica dels TeV, s'haurien de formar per parelles i no podrien desintegrar-se completament en partícules del ME. Això implica l'existència d'una partícula supersimètrica que sigui la més lleugera de totes (LSP), la qual serà estable i un candidat a explicar la presència de matèria fosca freda a l'univers. Precisament l'escala energètica dels TeV és el rang d'energies accessible per al col·lisionador protó-antiprotó Tevatron (Fermilab). Tevatron i els seus dos experiments, els detectors CDF i D0 van ser preparats per l'anomenat "Run II" en el que les col·lisions se succeeixen cada 396 ns amb un centre de masses d'1.96 TeV. Degut a què les noves partícules són molt massives, es desintegren en cascades amb múltiples raigs de partícules (jets) d'alt moment transversal. Quan la paritat R es conserva, dos LSP són produïts que escapen del detector deixant un important desequilibri en el balanç energètic del succés. Aquesta tesi tracta de la recerca de les super-parelles dels quarks (squarks) i gluons (gluinos) en múltiples jets i energia transversa mancant, amb les dades recollides amb el detector CDF durant gran part del Run II (371 pb-1 de lluminositat). Per aquest motiu, s'ha dut a terme un estudi curós de les condicions del feix i dels diferents processos del ME que tenen estats finals similars al senyal. Diferents talls per reduir la seva presència tot potenciant el possible senyal s'han estudiat i optimitzat. També s'han considerat les diferents fonts d'errors experimentals i teòrics per tal de fer una bona caracterització de les dades. Observant les dades, no s'ha trobat cap desviació significativa de les prediccions del ME. Degut a aquests resultats, s'han posat límits inferiors a la massa squarks i gluinos (menor de 387 GeV/c2) en un determinat escenari del model teòric anomenat mSUGRA. Aquest estudi és pioner al Run II de CDF i els resultats presenten millores significatives respecte a anteriors límits. En aquest sentit, el present treball constitueix la base i serà la referència per a futures extensions amb més dades

Search for long-lived doubly charged Higgs bosons in pp- collisions at √s=1.96TeV

We present a search for long-lived doubly charged Higgs bosons (H±±), with signatures of high ionization energy loss and muonlike penetration. We use 292  pb−1 of data collected in pp¯ collisions at √s=1.96  TeV by the CDF II detector at the Fermilab Tevatron. Observing no evidence of long-lived doubly charged particle production, we exclude H±±L and H±±R bosons with masses below 133  GeV/c2 and 109  GeV/c2, respectively. In the degenerate case we exclude H±± mass below 146  GeV/c2. All limits are quoted at the 95% confidence level

Search for anomalous kinematics in t(t)over-bar Dilepton events at CDF II

We report on a search for anomalous kinematics of ttbar dilepton events in ppbar collisions at sqrt{s}=1.96 TeV using 193 {pb}^{-1} of data collected with the CDF II detector. We developed a new a priori technique designed to isolate the subset in a data sample revealing the largest deviation from standard model (SM) expectations and to quantify the significance of this departure. In the four-variable space considered, no particular subset shows a significant discrepancy and we find that the probability of obtaining a data sample less consistent with the SM than what is observed is 1.0-4.5%.Comment: 14 pages, 2 figure

Search for a neutral higgs boson decaying to a W boson pair in pp¯ collisions at √s=1.96 TeV

We present the results of a search for standard model Higgs boson production with decay to WW*, identified through the leptonic final states e+e-vv,e±µ±vv and µ+µ-vv. This search uses 360 pb-1 of data collected from pp¯ collisions at sv=1.96 TeV by the upgraded Collider Detector at Fermilab (CDF II). We observe no signal excess and set 95% confidence level upper limits on the production cross section times branching ratio for the Higgs boson to WW* or any new scalar particle with similar decay products. These upper limits range from 5.5 to 3.2 pb for Higgs boson masses between 120 and 200 GeV/c2

Measurement of the W+W− production cross section in pp¯ collisions at √s=1.96 TeV using dilepton events

We present a measurement of the W+W- production cross section using 184/pb of ppbar collisions at a center-of-mass energy of 1.96 TeV collected with the Collider Detector at Fermilab. Using the dilepton decay channel W+W- -> l+l-vvbar, where the charged leptons can be either electrons or muons, we find 17 candidate events compared to an expected background of 5.0+2.2-0.8 events. The resulting W+W- production cross section measurement of sigma(ppbar -> W+W-) = 14.6 +5.8 -5.1 (stat) +1.8 -3.0 (syst) +-0.9 (lum) pb agrees well with the Standard Model expectation