Evolution of a long-lived volcanic complex: the Chachani case study (south Peru)

The study of numerous individual volcanoes carried out in the Central Andean Volcanic Zone over the past 20 years has provided information to better understand active volcanism in the Peruvian Andes. However, large-sized, dormant volcanic complexes remain much less understood due to their complexity or because the impact of individual active volcanoes on populated areas has led researchers to prioritize their study on the most recent composite cones. Large, long-lived volcanic complexes have not yet been considered in volcanological studies in Peru, although they belie a rich history of eruptive activity that may be more recent than previously thought. The Chachani Volcanic Complex (CVC) is one of the few Andean volcanic complexes in which the relationships between stratigraphy, chronology and compositional changes are considered to understand the compositional evolution of a long-lived magmatic system

Implicancias de los sistemas de fallas regionales en el magmatismo del sur del Perú: estratigrafía del Complejo Volcánico Chachani

La mayoría de los arcos magmáticos continentales ocurren en contextos convergentes oblicuos y muestran movimientos de rumbo dentro del arco magmático o adyacentes a estos (Saint Blanquat et al., 1998). El volcanismo tiende a estar asociado con ambientes transtensionales porque estos ofrecen zonas con menor resistencia como fracturas subverticales o fallas por las cuales el magma sale hacia la superficie (Acocella et al., 1999). El complejo volcánico Chachani, ubicado a 22 km aprox. al NNE de la ciudad de Arequipa (del centro de la ciudad a la cumbre del complejo); es uno de los más grandes centros eruptivos de la Zona Volcánica de los Andes Centrales (ZVC) en el Sur del Perú, la cual está relacionada al proceso de subducción. El Chachani es un conjunto de domos y estrato volcanes de composición andesítica principalmente (Suaña, 2011) y tiene como basamento a depósitos de flujos piroclásticos y depósitos volcanoclásticos atribuidos a unidades conocidas como Tufo de Yura, Ignimbrita del Aeropuerto e Ignimbrita del Rió Chili (Paquereau et al., 2006, 2008). Tiene aproximadamente un área de 526.6 Km2 y un volumen 864 Km3

RBX: The new X-band SAR system from INTA

Revista oficial de la Asociación Española de Teledetección[EN] This paper describes the characteristics and the first results of the RBX system, the new airborne Synthetic Aperture Radar developed at Spanish National Institute of Aerospace Technology. The new system supports submetric resolution with interferometric and polarimetric capabilities. The system architecture has been designed taking into account an easy upgrade ability and the quality of the acquired data, including multiple internal calibration loops.[ES] Este artículo describe las características y los primeros resultados del sistema RBX, nuevo radar de apertura sintética aerotransportado que ha sido desarrollado en el Instituto Nacional de Técnica Aeroespacial. El nuevo sistema soporta resoluciones submétricas con capacidades interferométricas y polarimétricas. La arquitectura del sistema se ha diseñado teniendo en cuenta la facilidad de incorporar mejoras y la calidad de los datos adquiridos, incluyendo múltiples lazos de calibración interna.Larrañaga, J. R., De Porras Bernácer, R., Del Castillo, J., Gimeno, N., Aguilar, P., Baquero, A. M., . . . Sánchez, S. (2014). RBX: The new X-band SAR system from INTA. [RBX: El nuevo radar SAR en banda X del INTA] Revista De Teledeteccion, (41), 89-96. doi:10.4995/raet.2014.2285SWORD899641G. Bonin, P. Dreuillet. 2008. The new ONERA airborne SAR system SETHI. EUSAR, Dresden, Germany.Rodriguez, M. G. (2008). Design of a Coherent Generation and Acquisition System at 1,2GHz. 2008 4th Southern Conference on Programmable Logic. doi:10.1109/spl.2008.4547745Gonzalez Bonilla, M. J., Gomez Miguel, B., Cuerda Muñoz, J. M., Larrañaga Sudupe, J. R., Garcia Rodriguez, M., 2009. INTASAR program. Proceedings IGARSSHORN, RALF; NOTTENSTEINER, ANTON; SCHEIBER, ROLF. 2008. F-SAR – DLR's advanced airborne SAR system onboard DO228. Proceedings EUSARMoreira, A., & Yonghong Huang. (1994). Airborne SAR processing of highly squinted data using a chirp scaling approach with integrated motion compensation. IEEE Transactions on Geoscience and Remote Sensing, 32(5), 1029-1040. doi:10.1109/36.31289

Economía y finanzas sociales: avances en la investigación

Esta obra colectiva propone un cambio de paradigma en la investigación científica, financiera y económica, cuyo centro de atención es reducir las desigualdades sociales y económicas, mejorar la sostenibilidad ambiental y la creación eficiente de valor económico. Desde un punto de vista crítico y mediante diversos enfoques teóricos, metodológicos y disciplinares, los autores analizan el esquema financiero predominante en las economías de mercado, al tiempo que abordan temas como la inclusión financiera, la banca ética o las experiencias e intervenciones en y sobre la economía social.ITESO, A.C

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders

Inherited platelet disorders are a heterogeneous group of rare diseases, caused by inherited defects in platelet production and/or function. Their genetic diagnosis would benefit clinical care, prognosis and preventative treatments. Until recently, this diagnosis has usually been performed via Sanger sequencing of a limited number of candidate genes. High-throughput sequencing is revolutionizing the genetic diagnosis of diseases, including bleeding disorders. We have designed a novel high-throughput sequencing platform to investigate the unknown molecular pathology in a cohort of 82 patients with inherited platelet disorders. Thirty-four (41.5%) patients presented with a phenotype strongly indicative of a particular type of platelet disorder. The other patients had clinical bleeding indicative of platelet dysfunction, but with no identifiable features. The high-throughput sequencing test enabled a molecular diagnosis in 70% of these patients. This sensitivity increased to 90% among patients suspected of having a defined platelet disorder. We found 57 different candidate variants in 28 genes, of which 70% had not previously been described. Following consensus guidelines, we qualified 68.4% and 26.3% of the candidate variants as being pathogenic and likely pathogenic, respectively. In addition to establishing definitive diagnoses of well-known inherited platelet disorders, high-throughput sequencing also identified rarer disorders such as sitosterolemia, filamin and actinin deficiencies, and G protein-coupled receptor defects. This included disease-causing variants in DIAPH1 (n=2) and RASGRP2 (n=3). Our study reinforces the feasibility of introducing high-throughput sequencing technology into the mainstream laboratory for the genetic diagnostic practice in inherited platelet disorders.This study was supported by research grants from the Gerencia Regional de Salud (GRS 1370/A/16), ISCIII & Feder (PI14/01956), CIBERER CB15/00055, Fundación Séneca (19873/GERM/15) and Sociedad Española de Trombosis y Hemostasia (SETH). SPW holds a British Heart Foundation chair.Peer Reviewe

Novel genes and sex differences in COVID-19 severity

[EN] Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.S

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income&nbsp;countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was &lt;1.1 kg m–2 in the vast majority of&nbsp;countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified

Informe: Derecho del trabajo y de la seguridad social en España en 2013. Algunos puntos críticos

Este documento intenta reflejar algunos de los principales cambios y novedades del ordenamiento laboral español en 2013, levantando acta de cómo la mutabilidad de nuestro Derecho del Trabajo es imparable. Este informe, consciente de ello, ofrece una selección de elementos esenciales, a juicio de sus autores, especialistas en cada una de las materias, encuadrados en la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social. En él, conforme a la organización de dicha Sección en grupos de trabajo, se abordan las novedades más relevantes en materia de derechos fundamentales inespecíficos, contratación laboral, vicisitudes del contrato de trabajo, Derecho colectivo, conciliación y corresponsabilidad, protección social y prevención de riesgos laborales. This paper tries to show some of the many changes and novelties in Spanish Labour Law during 2013, drawing up a record of the unstoppable character of our Labour legal system. This report offers a selection of essential elements, according to its authors, all of them specialists in each one of the subjects, being part of the Young Scholars’ Section of the Spanish Association for Labour and Social Security Law. According to the organization of the said Section in working groups, we can find novelties concerning unspecific fundamental rights, work contracts, the life of the work contract and collective Labour Law, reconciliation and co responsibility, social protection and occupational risk prevention

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality