Ultracompact HII regions with extended emission: The complete view

\ua9 2019 The Author(s). In this paper, we present the results of a morphological study performed on a sample of 28 ultracompact HII (UC HII) regions located near extended free-free emission, using radio continuum (RC) observations at 3.6 cm with the C and D Very Large Array (VLA) configurations, with the aim of determining a direct connection between them. By using previously published observations in B and D VLA configurations, we compiled a final catalogue of 21 UC HII regions directly connected with the surrounding extended emission (EE). The observed morphology of most of the UC HII regions in RC emission is irregular (single- or multipeaked sources) and resembles a classical bubble structure in the Galactic plane with well-defined cometary arcs. RC images superimposed on colour composite Spitzer images reinforce the assignations of direct connection by the spatial coincidence between the UC components and regions of saturated 24 μm emission. We also find that the presence of EE may be crucial to understand the observed infrared excess because an underestimation of ionizing Lyman photons was considered in previous works (e.g. Wood & Churchwell; Kurtz, Churchwell & Wood)

Ultracompact HII regions with extended emission: The case of G43.89-0.78 and its molecular environment

The Karl Jansky Very Large Array (VLA), Owens Valley Radio Observatory (OVRO), Atacama Large Millimetric Array (ALMA), and the infrared \textit{Spitzer} observatories, are powerful facilities to study massive star formation regions and related objects such as ultra--compact (UC) \hii regions, molecular clumps, and cores. We used these telescopes to study the \uchiir G43.89--0.78. The morphological study at arcminute scales using NVSS and \textit{Spitzer} data shows that this region is similar to those observed in the \textit{ bubble--like} structures revealed by \textit{Spitzer} observations. With this result, and including a physical characterization based on 3.6 cm data, we suggest G43.89--0.78 be classified as an \uchiir with Extended Emission because it meets the operational definition given in this paper comparing radio continuum data at 3.6 and 20~cm. For the ultra-compact component, we use VLA data to obtain physical parameters at 3.6~cm confirming this region as an \uchii region. Using ALMA observations, we detect the presence of a dense ($2.6\times10^7$ cm$^{-3}$) and small ($\sim$ 2.0\arcsec; 0.08 pc) molecular clump with a mass of 220 M$_{\odot}$ and average kinetic temperature of 21~K, located near to the \uchii region. In this clump, catalogued as G43.890--0.784, water masers also exist, possibly tracing a bipolar outflow. We discover in this vicinity two additional clumps which we label as G43.899--0.786 (T$_d$ = 50 K; M = 11 M$_{\odot}$), and G43.888--0.787 (T$_d$ = 50 K; M = 15 M$_{\odot}$).Comment: 13 pages, 8 figures, 2 tables. Accepted for publication in the Monthly Notices of the Royal Astronomical Society Main Journal (2020

Effect of tri- and tetravalent metal doping on the electrochemical properties of lanthanum tungstate proton conductors

Metal doping on lanthanum tungstates at W2 site was confirmed by TOF-NPD. TGA and EIS demonstrated proton conductivity.</p

The cefazolin inoculum effect is associated with increased mortality in methicillin-susceptible staphylococcus aureus bacteremia

Background. Recent studies have favored the use of cefazolin over nafcillin for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The clinical influence of the cefazolin inoculum effect (CzIE) in the effectiveness of cephalosporins for severe MSSA infections has not been evaluated. Methods. We prospectively included patients from 3 Argentinian hospitals with S. aureus bacteremia. Cefazolin minimum inhibitory concentrations (MICs) were determined at standard (105 colony-forming units [CFU]/mL) and high (107 CFU/mL) inoculum. The CzIE was defined as an increase of MIC to ≥16 µg/mL when tested at high inoculum. Whole-genome sequencing was performed in all isolates. Results. A total of 77 patients, contributing 89 MSSA isolates, were included in the study; 42 patients (54.5%) had isolates with the CzIE. In univariate analysis, patients with MSSA exhibiting the CzIE had increased 30-day mortality (P = .034) and were more likely to have catheter-associated or unknown source of bacteremia (P = .033) compared with patients infected with MSSA isolates without the CzIE. No statistically significant difference between the groups was observed in age, clinical illness severity, place of acquisition (community vs hospital), or presence of endocarditis. The CzIE remained associated with increased 30-day mortality in multivariate analysis (risk ratio, 2.65; 95% confidence interval, 1.10-6.42; P = .03). MSSA genomes displayed a high degree of heterogeneity, and the CzIE was not associated with a specific lineage. Conclusions. In patients with MSSA bacteremia where cephalosporins are used as firstline therapy, the CzIE was associated with increased 30-day mortality. Clinicians should be cautious when using cefazolin as firstline therapy for these infections.Fil: Goss, William Miller. University of Texas; Estados UnidosFil: Seas, Carlos. Universidad Peruana Cayetano Heredia; PerúFil: Carvajal, Lina P.. Universidad El Bosque; ColombiaFil: Diaz, Lorena. Universidad El Bosque; Colombia. UTHealth McGovern Medical School; Estados UnidosFil: Echeverri, Aura M.. Universidad El Bosque; ColombiaFil: Ferro, Carolina. Universidad El Bosque; ColombiaFil: Rios, Rafael. Universidad El Bosque; ColombiaFil: Porras, Paola. Universidad El Bosque; ColombiaFil: Luna, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; PerúFil: Munita, Jose M.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Carcamo, Cesar. Universidad Peruana Cayetano Heredia; PerúFil: Reyes, Jinnethe. Universidad El Bosque; ColombiaFil: Arias, Cesar A.. University of Texas; Estados Unido

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide

Trobareu correccions de l'article a: http://dx.doi.org/10.1371/annotation/0b485bd9-b1b2-4c60-ab22-3ac5d271dc59Cells respond to different kind of stress through the coordinated activation of signaling pathways such as MAPK or p53. To find which molecular mechanisms are involved, we need to understand their cell adaptation. The ribosomal protein, S6 kinase 1 (S6K1), is a common downstream target of signaling by hormonal or nutritional stress. Here, we investigated the initial contribution of S6K1/MAPK signaling pathways in the cell response to oxidative stress produced by hydrogen peroxide (H2O2). To analyze S6K1 activation, we used the commercial anti-phospho-Thr389-S6K1 antibody most frequently mentioned in the bibliography. We found that this antibody detected an 80-90 kDa protein that was rapidly phosphorylated in response to H2O2 in several human cells. Unexpectedly, this phosphorylation was insensitive to both mTOR and PI3K inhibitors, and knock-down experiments showed that this protein was not S6K1. RSK and MSK proteins were candidate targets of this phosphorylation. We demonstrated that H2O2 stimulated phosphorylation of RSK and MSK kinases at residues that are homologous to Thr389 in S6K1. This phosphorylation required the activity of either p38 or ERK MAP kinases. Kinase assays showed activation of RSK and MSK by H2O2. Experiments with mouse embryonic fibroblasts from p38 animals" knockout confirmed these observations. Altogether, these findings show that the S6K1 signaling pathway is not activated under these conditions, clarify previous observations probably misinterpreted by non-specific detection of proteins RSK and MSK by the anti-phospho-Thr389-S6K1 antibody, and demonstrate the specific activation of MAPK signaling pathways through ERK/p38/RSK/MSK by H2O2

Controlo químico de infestantes

Uma planta é considerada infestante quando nasce espontaneamente num local e momento indesejados, podendo interferir negativamente com a cultura instalada. As infestantes competem com as culturas para o espaço, a luz, água e nutrientes, podendo atrasar e prejudicar as operações de colheita, depreciar o produto final e assegurarem a reinfestação nas culturas seguintes. Dado o modo de propagação diferenciado das diversas espécies de infestantes, com as anuais a propagarem-se por semente e as perenes ou vivazes a assegurarem a sua propagação através de órgãos vegetativos (rizomas, bolbos, tubérculos, etc.), assim, também o seu controlo quer químico, quer mecânico terá que ser diferenciado, ou seja, para controlar infestantes anuais será suficiente destruir a sua parte aérea, enquanto para controlar infestantes perenes teremos que destruir os seus órgãos reprodutivos. O controlo de infestantes poderá ser químico, através da utilização de herbicidas, ou mecânico pela utilização de alfaias agrícolas, tais como a charrua de aivecas, a charrua de discos, a grade de discos, o escarificador e a fresa. Quando a técnica utilizada na instalação das culturas é a sementeira directa, o controlo das infestantes terá que ser obrigatoriamente químico, enquanto se o recurso à mobilização do solo for a técnica mais utilizada (sistema de mobilização tradicional ou sistema de mobilização reduzida), o controlo das infestantes tanto poderá ser químico como mecânico. Neste trabalho iremos abordar apenas, o controlo químico de infestantes

Multi-dimensional trio coherent states

We introduce a novel class of higher-order, three-mode states called K-dimensional trio coherent states. We study their mathematical properties and prove that they form a complete set in a truncated Fock space. We also study their physical content by explicitly showing that they exhibit nonclassical features such as oscillatory number distribution, sub-poissonian statistics, Cauchy-Schwarz inequality violation and phase-space quantum interferences. Finally, we propose an experimental scheme to realize the state with K=2 in the quantized vibronic motion of a trapped ion.Comment: 17 pages, 12 figures, accepted for publication in J. Phys. A: Math. Ge

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

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