Desempeño y perspectivas de la inversión extranjera directa en la economía argentina en la posconvertibilidad

El trabajo propone el análisis de la IED en la Argentina en la convertibilidad y la pos convertibilidad con la finalidad de encontrar continuidades y rupturas en las características del ingreso de capitales extranjeros a nuestro país. Se analiza la procedencia de los flujos de IED, en qué sectores de la economía se insertaron y sus componentes. Los ejes articuladores del trabajo serán los siguientes: 1) evaluar la cantidad y la calidad de los flujos de IED recibidos con la finalidad de analizar su influencia sobre el desarrollo productivo, económico, tecnológico y social de los países; 2) indagar las políticas públicas implementadas, su incentivo o des-incentivo para la promoción de los flujos de IED ; 3) identificar los principales sectores receptores de IED y si existió permanencia o cambio de sectores en ambos períodos analizados.Fil: Dossi, Marina Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Economía, Desarr.y Planeamiento Agrícola. Cátedra de Economía General; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales. Centro de Estudios Sociales de la Economía; ArgentinaFil: Dal Pont, Silvina Mabel. Universidad de Buenos Aires. Facultad de Agronomia. Departamento de Economía, Desarr.y Planeamiento Agrícola. Cátedra de Economía General; Argentin

Curso de Laboratorio Junior para el estudio del procesador

El estudio del procesador en los actuales planes de estudio de las carreras universitarias de informática, varia ligeramente de unas universidades a otras dentro del territorio nacional. El presente trabajo se enmarca dentro de la Universidad Politécnica de Valencia por estar los autores adscritos a ella. Este trabajo presenta un curso de laboratorio para la asignatura de Estructura de Computadores I (ECD) enfocado al estudio del procesador. La herramienta de diseño digital que se utiliza para la implementación de los circuitos propuestos es el CASCAD que corre sobre un entorno PC. La herramienta, aunque no analiza con detalle los retardos de tiempo de los componentes, es adecuada para un estudiante de primer curso ya que ofrece entre sus ventajas, la incorporación de muchos objetos como unidades aritmético-lógicas y registros, que se utilizan en la implementación de la ruta de datos. Además, al ser el entorno gráfico, se puede apreciar con claridad, qué líneas de control se encuentran activas en cada momento

Análise de inundações nos rios Canoas, Sertão e Mampituba, Sul do Brasil por meio de modelagem hidrológica e hidrodinâmica

Floods that occur in hydrographic basins with high slopes are more susceptible to natural hazards due to the occurrence of high intensity hydrological events and the type of sloping relief. These two associated factors contribute to an increase in the destructive potential of these regions, causing economic damage and loss of life for people and animals. This study sought to assess the floodplain areas in the Canoas, Sertão, and Mampituba Rivers that contribute to the Mampituba River basin in southern Brazil, to support emergency procedures for dealing with floods and contribute to the territorial management of these spaces. From the hydrological data of the Mampituba River basin, a hydrological model was used, which generated flows that were inserted as input to a hydrodynamic model, resulting in flood patches in the plains of the modeled rivers. The calibration and integration studies of the models were carried out on a computational platform that employs the hydrometeorological knowledge represented by the models of the basin under study. The hydrodynamic modeling represented in the maps indicated that the flooding patches occur within the river channels and in the plains occupied by agriculture, with a predominance of irrigated rice paddies, pasture fields, forestry, urbanized areas, and native vegetation. In the urban region along the floodplains of the Praia Grande and Mampituba Cities, there are inns, restaurants, and residences which can suffer structural damage and expose people to the danger of a flood event of this magnitude. The results achieved allow us to infer that the integrated modeling system proved to be capable of performing efficient hydrological and hydrodynamic simulations. The methods used can be replicated in other basins and the results can support public managers for greater assertiveness in decision-making when facing the dangers of extreme weather events.As inundações que ocorrem em bacias hidrográficas com declividades elevadas são mais susceptíveis a perigos naturais, devido à ocorrência de eventos hidrológicos de alta intensidade e ao tipo de relevo declivoso. Esses dois fatores associados contribuem para um aumento do potencial destrutivo desses locais, trazendo prejuízo econômico e perda de vida de pessoas e animais. Esse estudo buscou avaliar as áreas de planície de inundação nos rios Canoas, Sertão e Mampituba contribuintes da bacia do rio Mampituba, Sul do Brasil, com intuito de apoiar os procedimentos emergenciais de enfrentamentos de inundações, e contribuir com a gestão territorial destes espaços. A partir dos dados hidrológicos da bacia do rio Mampituba, foi utilizado um modelo hidrológico, o qual gerou vazões que foram inseridas como entrada para um modelo hidrodinâmico, resultando em manchas de inundação nas planícies dos rios modelados. Os estudos de calibração e integração dos modelos foram realizados numa plataforma computacional que emprega o conhecimento hidrometeorológico representado pelos modelos da bacia em estudo. A modelagem hidrodinâmica representada nos mapas indicou que as manchas de inundação ocorrem dentro da calha dos rios e nas planícies ocupadas por agricultura, predominando canchas de arroz irrigado, campo de pastagem, silvicultura, área urbanizada e vegetação nativa. Na região urbana junto as planícies de inundação dos municípios de Praia Grande e Mampituba, existem pousadas, restaurantes e residências, que podem sofrer danos estruturais e expor as pessoas ao perigo de um evento de inundação dessa magnitude. Os resultados alcançados, permitem inferir que o sistema de modelagem integrada se mostrou capaz de realizar simulações hidrológicas e hidrodinâmicas eficientes. Os métodos empregados podem ser replicados em outras bacias e os resultados poderão subsidiar os gestores públicos para maior assertividade na tomada de decisão ao enfrentamento dos perigos dos eventos climáticos extremos

Conceptos básicos del metaanálisis en red

ResumenLas revisiones sistemáticas y los metaanálisis se han consolidado como una herramienta fundamental para la práctica clínica basada en la evidencia. Inicialmente, el metaanálisis fue propuesto como una técnica que podría mejorar la precisión y la potencia estadística de la investigación procedente de estudios individuales con pequeño tamaño muestral. Sin embargo, uno de sus principales inconvenientes es que suelen comparar no más de 2 intervenciones alternativas a la vez. Los «metaanálisis en red» utilizan técnicas novedosas de análisis que permiten incorporar la información procedente de comparaciones directas e indirectas a partir de una red de estudios que examina los efectos de diversos tratamientos de una manera más completa. Pese a sus potenciales limitaciones, su aplicación en epidemiología clínica podría ser potencialmente útil en situaciones en las que existen varios tratamientos que se han comparado frente a un comparador común.Además, estas técnicas pueden ser relevantes ante una pregunta clínica o de investigación cuando existen múltiples tratamientos que deben ser considerados, o cuando se dispone tanto de información directa como indirecta en el cuerpo de la evidencia.AbstractSystematic reviews and meta-analyses have long been fundamental tools for evidence-based clinical practice. Initially, meta-analyses were proposed as a technique that could improve the accuracy and the statistical power of previous research from individual studies with small sample size. However, one of its main limitations has been the fact of being able to compare no more than two treatments in an analysis, even when the clinical research question necessitates that we compare multiple interventions. Network meta-analysis (NMA) uses novel statistical methods that incorporate information from both direct and indirect treatment comparisons in a network of studies examining the effects of various competing treatments, estimating comparisons between many treatments in a single analysis. Despite its potential limitations, NMA applications in clinical epidemiology can be of great value in situations where there are several treatments that have been compared against a common comparator. Also, NMA can be relevant to a research or clinical question when many treatments must be considered or when there is a mix of both direct and indirect information in the body of evidence

COPD is a clear risk factor for increased use of resources and adverse outcomes in patients undergoing intervention for colorectal cancer : a nationwide study in Spain

We hypothesized that patients undergoing surgery for colorectal cancer (CRC) with COPD as a comorbidity would consume more resources and have worse in-hospital outcomes than similar patients without COPD. Therefore, we compared different aspects of the care process and short-term outcomes in patients undergoing surgery for CRC, with and without COPD. This was a prospective study and it included patients from 22 hospitals located in Spain - 472 patients with COPD and 2,276 patients without COPD undergoing surgery for CRC. Clinical variables, postintervention intensive care unit (ICU) admission, use of invasive mechanical ventilation, and postintervention antibiotic treatment or blood transfusion were compared between the two groups. The reintervention rate, presence and type of complications, length of stay, and in-hospital mortality were also estimated. Hazard ratio (HR) for hospital mortality was estimated by Cox regression models. COPD was associated with higher rates of in-hospital complications, ICU admission, antibiotic treatment, reinterventions, and mortality. Moreover, after adjusting for other factors, COPD remained clearly associated with higher and earlier in-hospital mortality. To reduce in-hospital morbidity and mortality in patients undergoing surgery for CRC and with COPD as a comorbidity, several aspects of perioperative management should be optimized and attention should be given to the usual comorbidities in these patients

COPD is a clear risk factor for increased use of resources and adverse outcomes in patients undergoing intervention for colorectal cancer: a nationwide study in Spain

We hypothesized that patients undergoing surgery for colorectal cancer (CRC) with COPD as a comorbidity would consume more resources and have worse in-hospital outcomes than similar patients without COPD. Therefore, we compared different aspects of the care process and short-term outcomes in patients undergoing surgery for CRC, with and without COPD. This was a prospective study and it included patients from 22 hospitals located in Spain - 472 patients with COPD and 2,276 patients without COPD undergoing surgery for CRC. Clinical variables, postintervention intensive care unit (ICU) admission, use of invasive mechanical ventilation, and postintervention antibiotic treatment or blood transfusion were compared between the two groups. The reintervention rate, presence and type of complications, length of stay, and in-hospital mortality were also estimated. Hazard ratio (HR) for hospital mortality was estimated by Cox regression models. COPD was associated with higher rates of in-hospital complications, ICU admission, antibiotic treatment, reinterventions, and mortality. Moreover, after adjusting for other factors, COPD remained clearly associated with higher and earlier in-hospital mortality. To reduce in-hospital morbidity and mortality in patients undergoing surgery for CRC and with COPD as a comorbidity, several aspects of perioperative management should be optimized and attention should be given to the usual comorbidities in these patients

Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis

Bandes oligoclonals; Esclerosi múltiple; Disfunció cognitivaBandas oligoclonales; Esclerosis múltiple; Disfunción cognitivaOligoclonal bands; Multiple sclerosis; Cognitive dysfunctionBackground: An association has been found between the presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective: To investigate lipid-specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods: Forty-four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow-up was compared adjusting by age, education, anxiety-depression, and baseline performance. Results: LS-OCMB+ patients only performed worse for Long-Term Storage in the Selective Reminding Test (p = .018). Conclusion: There are no remarkable cognitive differences between LS-OCMB- and LS-OCMB+ patients in the early stages of MS

PERFIL HEMATO-LABORATORIAL DE PACIENTES COVID-19 NO EXTREMO SUL CATARINENSE/BRASIL

To assess the clinical and laboratory profile of patients hospitalized for COVID-19. Descriptive retrospective observational study, collecting secondary data from medical records of patients hospitalized for COVID-19 between January and June 2021 at a high-complexity hospital in Criciúma, Santa Catarina, Brazil. The study population consisted of a total of 497 patients, with a mean age of 59.2 years and a standard deviation of 15.44, with a predominance of male patients (55.3%). The most prevalent comorbidities were diabetes mellitus (23.54%) and arterial hypertension (35.01%). The main clinical outcome was discharge (62.8%). Regarding laboratory tests, patients initially showed elevated inflammatory markers and leukocytosis. During hospitalization, they developed anemia, thrombocytopenia, improvement in inflammatory markers, and maintained leukocytosis. In this context, patients may present laboratory abnormalities, particularly a pro-inflammatory state and chenges in hematimetric parameters, anemia, thrombocytopenia, and leukocytosis. Therefore, the data presented in this study can contribute to a better understanding and confirmation of the multiple effects of the virus on the human body, especially concerning the hematopoietic system.Verificar o perfil clínico e laboratorial de pacientes internados por COVID-19. Estudo observacional descritivo retrospectivo, com coleta de dados secundários de prontuários de pacientes internados por COVID-19 no período de janeiro a junho de 2021 em um hospital de alta complexidade no município de Criciúma/SC. A população estudada constituiu um total de 497 pacientes, sendo a média de idade de 59,2 anos com desvio padrão de 15,44 e predomínio do sexo masculino (55,3%). Em relação às comorbidades, as mais prevalentes foram diabetes mellitus (23,54%) e hipertensão arterial (35,01%). O principal desfecho clínico foi a alta (62,8%). Quanto aos exames laboratoriais, os pacientes inicialmente apresentaram elevação das provas inflamatórias e leucocitose. E no decorrer da internação, desenvolveram anemia, plaquetopenia e melhora das provas inflamatórias, além de manter a leucocitose. Nesse âmbito, pode-se encontrar alterações laboratoriais nos pacientes, com destaque para o estado pró-inflamatório para os parâmetros hematimétricos. Portanto, os dados apresentados no presente estudo podem contribuir para a melhoria do entendimento e confirmação acerca dos múltiplos efeitos do vírus sobre o corpo humano, especialmente no que tange o sistema hematopoiético

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

With innumerable clinical failures of target-specific drug candidates for multifactorial diseases, such as Alzheimer's disease (AD), which remains inefficiently treated, the advent of multitarget drug discovery has brought a new breath of hope. Here, we disclose a class of 6-chlorotacrine (huprine)‒TPPU hybrids as dual inhibitors of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), a multitarget profile to provide cumulative effects against neuroinflammation and memory impairment. Computational studies confirmed the gorge-wide occupancy of both enzymes, from the main site to a secondary site, including a so far non-described AChE cryptic pocket. The lead compound displayed in vitro dual nanomolar potencies, adequate brain permeability, aqueous solubility, and human microsomal stability and lack of neurotoxicity, and rescued memory, synaptic plasticity and neuroinflammation in an AD mouse model, after low dose chronic oral administration