History Held Hostage: Learned Lesson from the Conflict over the Smithsonian Institute Enola Gay Exhibit

Excerpt This paper presents findings from a two year field research project focusing on the public conflict that erupted over the Enola Gay exhibit at the National Air and Space Museum (NASM). This conflict did not end with people reaching consensus, ceremoniously signing documents, shaking hands and piling accolades upon one another for solving a serious problem. It can more accurately be described as a stalemate and ultimately a lose-lose proposition even in light of the many opportunities that arose that could have produced at least a partial if not total agreement. The reason for studying this failed public conflict is to point out the major benefits that such cases have in regard to our understanding of the factors, dynamics and observable patterns that are endemic of many types of public conflicts. In fact, it makes sense for scholars of conflict resolution to place as much emphasis on what works and what does not--for we ultimately learn more from mistakes than we do from success. I contend that as conflict scholars and practitioners, we have deliberately done ourselves and the public a great disservice by ignoring cases like the Enola Gay. This paper is not about failure but about the hidden riches of information, knowledge and wisdom we can gain from a critical examination of less than perfect cases. As conflict specialists, we do not have to be pressured to live in a world of the thrill of victory or the agony of defeat if we learn to accept the assumption I make here that there is likely more to be learned from so called failed public conflicts than from those that are deemed normal cases. Ironically, once a form of conflict intervention becomes normal or predictable it is likely to receive even less critical examination. We are, then, stuck with a paradox of thinking like naive empiricists, wherein we ignore the obvious and shun the uncomfortable, leaving us in no better a position than if we had done nothing at all. So here, I examine a supposedly uncomfortable, unpredictable, uncontrollable and uncertain public conflict to demonstrate analytically that it is none of these

“The Real Target”: Medical Racism and AIDS Genocide Conspiracy Theory

The emergence of acquired immunodeficiency syndrome (AIDS), and the human immunodeficiency virus (HIV) that causes it, left an indelible mark on the social and cultural fabric of the late twentieth century. The pandemic – which was largely worsened by institutional ignorance and inaction – disproportionately harmed already marginalized existing populations, particularly Black Americans. As the disease began to situate itself firmly in the American consciousness, conspiracy theories that disputed its origins became pervasive. Given the legacy of violent racism that has formed the modern institution of American medicine, some began to proclaim and promulgate the theory that HIV was intentionally created in a laboratory as a means of systematic genocide against the Black population. In this project, I hope to interrogate the content and origins of these theories; and trace the historical instances of anti-Black medicalized racism that enabled them. More particularly, this study explores the ways in which American medicine has, over centuries, made violent attempts at interfering with Black reproductive potential, and how HIV became the perfect platform wherein these historical concerns could shift modes into organized conspiracies and political discourses, particularly for Black men. Finally, this paper will provide an ideological framework by which we may understand these conspiracy theories as attempts at ideologically organizing against state medical narratives

University Students from Four Ethnopolitical Conflict Zones: An Exploratory Study of Perceptions of Self and Country

This exploratory comparative case study examines hopes and fears for self and country of 300 students attending university in Bosnia-Herzegovina, Northern Ireland, South Africa, and Sri Lanka. Students report living in stressful societies where ethno political and state violence were the norm. The results of this qualitative study indicate that while the young people are optimistic about their life changes, they are concerned that the conflicts could re-ignite and spiral out of control. In particular, the students’ images indicate the importance of the self-society relationship and that these young adults relish the challenge of being productive citizens in their post-conflict societies

Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5

<p>Abstract</p> <p>Background</p> <p>Hepatocyte growth factor (HGF) and its receptor c-MET are commonly expressed in malignant gliomas and embryonic neuroectodermal tumors including medulloblastoma and appear to play an important role in the growth and dissemination of these malignancies. Dependent on cell context and the involvement of specific downstream effectors, both pro- and anti-apoptotic effects of HGF have been reported.</p> <p>Methods</p> <p>Human medulloblastoma cells were treated with HGF for 24–72 hours followed by death receptor ligand TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand) for 24 hours. Cell death was measured by MTT and Annexin-V/PI flow cytometric analysis. Changes in expression levels of targets of interest were measured by Northern blot analysis, quantitative reverse transcription-PCR, Western blot analysis as well as immunoprecipitation.</p> <p>Results</p> <p>In this study, we show that HGF promotes medulloblastoma cell death induced by TRAIL. TRAIL alone triggered apoptosis in DAOY cells and death was enhanced by pre-treating the cells with HGF for 24–72 h prior to the addition of TRAIL. HGF (100 ng/ml) enhanced TRAIL (10 ng/ml) induced cell death by 36% (<it>P </it>< 0.001). No cell death was associated with HGF alone. Treating cells with PHA-665752, a specific c-Met receptor tyrosine kinase inhibitor, significantly abrogated the enhancement of TRAIL-induced cell death by HGF, indicating that its death promoting effect requires activation of its canonical receptor tyrosine kinase. Cell death induced by TRAIL+HGF was predominately apoptotic involving both extrinsic and intrinsic pathways as evidenced by the increased activation of caspase-3, 8, 9. Promotion of apoptosis by HGF occurred via the increased expression of the death receptor DR5 and enhanced formation of death-inducing signal complexes (DISC).</p> <p>Conclusion</p> <p>Taken together, these and previous findings indicate that HGF:c-Met pathway either promotes or inhibits medulloblastoma cell death via pathway and context specific mechanisms.</p

DNA Repair in Prostate Cancer: Biology and Clinical Implications

CONTEXT: For more precise, personalized care in prostate cancer (PC), a new classification based on molecular features relevant for prognostication and treatment stratification is needed. Genomic aberrations in the DNA damage repair pathway are common in PC, particularly in late-stage disease, and may be relevant for treatment stratification. OBJECTIVE: To review current knowledge on the prevalence and clinical significance of aberrations in DNA repair genes in PC, particularly in metastatic disease. EVIDENCE ACQUISITION: A literature search up to July 2016 was conducted, including clinical trials and preclinical basic research studies. Keywords included DNA repair, BRCA, ATM, CRPC, prostate cancer, PARP, platinum, predictive biomarkers, and hereditary cancer. EVIDENCE SYNTHESIS: We review how the DNA repair pathway is relevant to prostate carcinogenesis and progression. Data on how this may be relevant to hereditary cancer and genetic counseling are included, as well as data from clinical trials of PARP inhibitors and platinum therapeutics in PC. CONCLUSIONS: Relevant studies have identified genomic defects in DNA repair in PCs in 20-30% of advanced castration-resistant PC cases, a proportion of which are germline aberrations and heritable. Phase 1/2 clinical trial data, and other supporting clinical data, support the development of PARP inhibitors and DNA-damaging agents in this molecularly defined subgroup of PC following success in other cancer types. These studies may be an opportunity to improve patient care with personalized therapeutic strategies. PATIENT SUMMARY: Key literature on how genomic defects in the DNA damage repair pathway are relevant for prostate cancer biology and clinical management is reviewed. Potential implications for future changes in patient care are discussed

Australian chiropractic sports medicine: half way there or living on a prayer?

Sports chiropractic within Australia has a chequered historical background of unorthodox individualistic displays of egocentric treatment approaches that emphasise specific technique preference and individual prowess rather than standardised evidence based management. This situation has changed in recent years with the acceptance of many within sports chiropractic to operate under an evidence informed banner and to embrace a research culture. Despite recent developments within the sports chiropractic movement, the profession is still plagued by a minority of practitioners continuing to espouse certain marginal and outlandish technique systems that beleaguer the mainstream core of sports chiropractic as a cohesive and homogeneous group. Modern chiropractic management is frequently multimodal in nature and incorporates components of passive and active care. Such management typically incorporates spinal and peripheral manipulation, mobilisation, soft tissue techniques, rehabilitation and therapeutic exercises. Externally, sports chiropractic has faced hurdles too, with a lack of recognition and acceptance by organized and orthodox sports medical groups. Whilst some arguments against the inclusion of chiropractic may be legitimate due to its historical baggage, much of the argument appears to be anti-competitive, insecure and driven by a closed-shop mentality.sequently, chiropractic as a profession still remains a pariah to the organised sports medicine world. Add to this an uncertain continuing education system, a lack of protection for the title 'sports chiropractor', a lack of a recognized specialist status and a lack of support from traditional chiropractic, the challenges for the growth and acceptance of the sports chiropractor are considerable. This article outlines the historical and current challenges, both internal and external, faced by sports chiropractic within Australia and proposes positive changes that will assist in recognition and inclusion of sports chiropractic in both chiropractic and multi-disciplinary sports medicine alike

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutations. Through the temporal dissection of aberrations, we identified driver mutations specifically associated with steps in the progression of prostate cancer, establishing, for example, loss of CHD1 and BRCA2 as early events in cancer development of ETS fusion-negative cancers. Computational chemogenomic (canSAR) analysis of prostate cancer mutations identified 11 targets of approved drugs, 7 targets of investigational drugs, and 62 targets of compounds that may be active and should be considered candidates for future clinical trials