Bettine Menke, Prosopopoiia. Stimme und Text bei Brentano, Hoffmann, Kleist und Kafka. 2000

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.Bereits dem Blick auf das noch unaufgeschlagene Buch präsentiert sich Bettine Menkes Studie zu Stimme und Text in Romantik und Moderne, zu „sprechenden Steinen“ und einer „singenden Maus“ (S. 7), als emblematisch gefaßtes Monument ihres eigenen wissenschaftlichen Projekts: Mit dem Namen der rhetorischen Gedankenfigur „Prosopopoiia“ (etymologisch: ein Gesicht geben, rhetorisch: Nicht-Personalem eine Stimme geben) ist das Buch überschrieben; den Umschlag ziert ein Stich des Memnonkolosses im ägyptischen Theben, von dem schon die deutschen Barockdichter wußten, daß er im Lichte der aufgehenden Sonne zu klingen begann; und Menkes Text schließlich setzt sich an die Stelle der subscriptio. Daß dieser Text mit seinen 850 Seiten Umfang und seinen 1,31 kg Gewicht selbst einen jener Steine verkörpert, deren Sprechen-Machen er als „romantische Figur der Lesbarkeit“ (S. 8) diskutiert, scheint dabei zunächst von einer höchst sympathischen Selbstironie zu zeugen.Peer Reviewe

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

We have shown recently that vascular endothelial protein tyrosine phosphatase (VE-PTP), an endothelial-specific membrane protein, associates with vascular endothelial (VE)–cadherin and enhances VE-cadherin function in transfected cells (Nawroth, R., G. Poell, A. Ranft, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber. 2002. EMBO J. 21:4885–4895). We show that VE-PTP is indeed required for endothelial cell contact integrity, because down-regulation of its expression enhanced endothelial cell permeability, augmented leukocyte transmigration, and inhibited VE-cadherin–mediated adhesion. Binding of neutrophils as well as lymphocytes to endothelial cells triggered rapid (5 min) dissociation of VE-PTP from VE-cadherin. This dissociation was only seen with tumor necrosis factor α–activated, but not resting, endothelial cells. Besides leukocytes, vascular endothelial growth factor also rapidly dissociated VE-PTP from VE-cadherin, indicative of a more general role of VE-PTP in the regulation of endothelial cell contacts. Dissociation of VE-PTP and VE-cadherin in endothelial cells was accompanied by tyrosine phoshorylation of VE-cadherin, β-catenin, and plakoglobin. Surprisingly, only plakoglobin but not β-catenin was necessary for VE-PTP to support VE-cadherin adhesion in endothelial cells. In addition, inhibiting the expression of VE-PTP preferentially increased tyrosine phosphorylation of plakoglobin but not β-catenin. In conclusion, leukocytes interacting with endothelial cells rapidly dissociate VE-PTP from VE-cadherin, weakening endothelial cell contacts via a mechanism that requires plakoglobin but not β-catenin

Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens)

Background. Microbial infections are the most serious complications associated with indwelling central venous catheters. A catheter lock solution that is both antibacterial and antithrombotic is needed. The goal of this study was to determine whether a new catheter lock solution containing citrate, methylene blue and parabens has antimicrobial properties against planktonic bacteria and against sessile bacteria within a biofilm. These effects were compared to the antimicrobial properties of heparin at 2500 units/ml

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

Cortactin is required for endothelial barrier function and leukocyte recruitment in vivo

Advancing the contributions of European stakeholders in farming systems to transitions to agroecology

The concept of a ‘just transition’ is gaining traction in international policy discourses. It has particular significance in relation to achieving net zero greenhouse gas emissions and the need for ensuring rights and responsibilities of all actors in transitions to agroecological farming systems. Research plays an important role in accompanying this transformation. It explores pathways for more sustainable and fair food systems, barriers to them being achieved, and where and what risks arise for communities of interest and of place. Researchers and practitioners across levels and sectors were brought together in H2020 projects LIFT and UNISECO using processes of stakeholder engagement. Both projects analysed the perceptions of actors towards agroecological farming, and their active involvement in the transitions required. This article summarises lessons learnt regarding multi‐actor engagement in different participatory settings in both projects, including a Multi‐Actor Platform approach, Q method, DELPHI and Hybrid forum workshops. The interactions involved several hundred actors from 18 countries across Europe. The article reflects on implications of the Covid‐19 pandemic on the processes and effectiveness of multi‐actor engagement, and assessments of the impacts on the empowerment of the actors. The findings are contextualised by contemporary European Union and national policy objectives of tackling climate change, the loss of biodiversity, and inequalities