Reapropiándonos de nuestras vidas. Un espacio para el empoderamiento y la visibilización de mujeres lesbianas, bisexuales y pansexuales

El presente artículo busca difundir el proyecto Reapropiándonos de nuestras vidas. En él, un grupo de mujeres lesbianas, bisexuales y pansexuales elaboramos colaborativamente relatos de nuestras vidas con el objetivo de visibilizar experiencias fuera de los discursos producidos por el sistema patriarcal y heteronormativo. En el proceso construimos un espacio de seguridad, confianza e intimidad que nos ha permitido repensar nuestra vida junto con otras, además de generar un material didáctico para trabajar la diversidad sexual a partir de mostrar modelos, prácticas y deseos alternativos a la heterosexualidad.Aquest article busca difondre el projecte Reapropiant-nos de les nostres vides. En aquest, un grup de dones lesbianes, bisexuals i pansexuals elaborem col·laborativament relats de les nostres vides amb l’objectiu de visibilitzar experiències fora dels discursos produïts pel sistema patriarcal i heteronormatiu. En el procés construïm un espai de seguretat, confiança i intimitat que ens ha permès repensar la nostra vida al costat d’altres, a més de generar un material didàctic per a treballar la diversitat sexual a partir de mostrar models, pràctiques i desitjos alternatius a l’heterosexualitat.This article seeks to spread the project Reapropiándonos de nuestras vidas. In it, a group of lesbians, bisexual and pansexual collaboratively elaborate stories of our lives in order to make visible practices outside the discourses produced by the patriarchal and heteronormative system. In the process we construct a space of safety, trust and intimacy that allowed us think our life with others, and generate a didactic material to work with sexual diversity by showing models, practices and desires alternative to heterosexuality

TRANSFORMAR LA LGTBIQ+FOBIA A TRAVÉS DE RELATOS DE VIDA

En esta comunicación presentamos la experiencia del proyecto “Reapropiándonos de nuestras historias. Relatos de vida de mujeres lesbianas y bisexuales”. En ella, un grupo de mujeres con prácticas y deseos sexuales fuera de la heteronormatividad participaron en un taller donde construyeron relatos de vida para trabajar la diversidad sexual con estudiantado de Educación Secundaria Obligatoria. El método biográfico-­‐narrativo resulta de gran relevancia para sensibilizar y reflexionar sobre colectivos minoritarios que pueden vivir procesos de marginación o violencia cultural y estructural en la actual sociedad capitalista, patriarcal y heteronormativa. Con este proyecto se pretende dar voz al colectivo LGTBIQ y facilitar un proceso de empoderamiento, una posibilidad de cambio y de transformación personal, mediante el cual las mujeres fortalecen sus capacidades, la confianza, la visión y el protagonismo para impulsar cambios positivos en las situaciones que viven. A su vez pretendemos abordar estas historias y reflexionar sobre la diversidad afectivo-­‐sexual con el estudiantado de Educación Secundaria Obligatoria

Identification of Ammonium Salts on Comet 67P/C-G Surface from Infrared VIRTIS/Rosetta Data Based on Laboratory Experiments. Implications and Perspectives

The nucleus of comet 67P/Churyumov-Gerasimenko exhibits a broad spectral reflectance feature around 3.2 $\mu$m, which is omnipresent in all spectra of the surface, and whose attribution has remained elusive since its discovery. Based on laboratory experiments, we have shown that most of this absorption feature is due to ammonium (NH4+) salts mixed with the dark surface material. The depth of the band is compatible with semi-volatile ammonium salts being a major reservoir of nitrogen in the comet, which could dominate over refractory organic matter and volatile species. These salts may thus represent the long-sought reservoir of nitrogen in comets, possibly bringing their nitrogen-to-carbon ratio in agreement with the solar value. Moreover, the reflectance spectra of several asteroids are compatible with the presence of NH4+ salts at their surfaces. The presence of such salts, and other NH4+-bearing compounds on asteroids, comets, and possibly in proto-stellar environments, suggests that NH4+ may be a tracer of the incorporation and transformation of nitrogen in ices, minerals and organics, at different phases of the formation of the Solar System

Markers of endothelial damage in patients with chronic kidney disease on hemodialysis

Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.Support for this work was provided by Plan Nacional de IDi Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)–Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER; PI11/01536, PI12/01489, PI14/00806, PI15/01785); Junta de Andalucía grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. P. Buendía, A. Carmona, and C. Luna-Ruiz are fellows from Consejería de Innovacion, Ciencia y Empresa, Junta de Andalucía

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice

Spinal cord injuries (SCIs) irreversibly disrupt spinal connectivity, leading to permanent neurological disabilities. Current medical treatments for reducing the secondary damage that follows the initial injury are limited to surgical decompression and anti-inflammatory drugs, so there is a pressing need for new therapeutic strategies. Inhibition of the type 2 lysophosphatidic acid receptor (LPA2) has recently emerged as a new potential pharmacological approach to decrease SCIassociated damage. Toward validating this receptor as a target in SCI, we have developed a new series of LPA2 antagonists, among which compound 54 (UCM14216) stands out as a potent and selective LPA2 receptor antagonist (Emax = 90%, IC50 = 1.9 μM, KD = 1.3 nM; inactive at LPA1,3−6 receptors). This compound shows efficacy in an in vivo mouse model of SCI in an LPA2-dependent manner, confirming the potential of LPA2 inhibition for providing a new alternative for treating SCI

Mowat-Wilson syndrome : growth charts

Background Mowat-Wilson syndrome (MWS; OMIM #235730) is a genetic condition caused by heterozygous mutations or deletions of theZEB2gene. It is characterized by moderate-severe intellectual disability, epilepsy, Hirschsprung disease and multiple organ malformations of which congenital heart defects and urogenital anomalies are the most frequent ones. To date, a clear description of the physical development of MWS patients does not exist. The aim of this study is to provide up-to-date growth charts specific for infants and children with MWS. Charts for males and females aged from 0 to 16 years were generated using a total of 2865 measurements from 99 MWS patients of different ancestries. All data were collected through extensive collaborations with the Italian MWS association (AIMW) and the MWS Foundation. The GAMLSS package for the R statistical computing software was used to model the growth charts. Height, weight, body mass index (BMI) and head circumference were compared to those from standard international growth charts for healthy children. Results In newborns, weight and length were distributed as in the general population, while head circumference was slightly smaller, with an average below the 30th centile. Up to the age of 7 years, weight and height distribution was shifted to slightly lower values than in the general population; after that, the difference increased further, with 50% of the affected children below the 5th centile of the general population. BMI distribution was similar to that of non-affected children until the age of 7 years, at which point values in MWS children increased with a less steep slope, particularly in males. Microcephaly was sometimes present at birth, but in most cases it developed gradually during infancy; many children had a small head circumference, between the 3rd and the 10th centile, rather than being truly microcephalic (at least 2 SD below the mean). Most patients were of slender build. Conclusions These charts contribute to the understanding of the natural history of MWS and should assist pediatricians and other caregivers in providing optimal care to MWS individuals who show problems related to physical growth. This is the first study on growth in patients with MWS.Peer reviewe

Phenotype and genotype of 87 patients with Mowat-Wilson syndrome and recommendations for care

Mowat-Wilson syndrome (MWS) is a rare intellectual disability/multiple congenital anomalies syndrome caused by heterozygous mutation of the ZEB2 gene. It is generally underestimated because its rarity and phenotypic variability sometimes make it difficult to recognize. Here, we aimed to better delineate the phenotype, natural history, and genotype-phenotype correlations of MWS.MethodsIn a collaborative study, we analyzed clinical data for 87 patients with molecularly confirmed diagnosis. We described the prevalence of all clinical aspects, including attainment of neurodevelopmental milestones, and compared the data with the various types of underlying ZEB2 pathogenic variations.ResultsAll anthropometric, somatic, and behavioral features reported here outline a variable but highly consistent phenotype. By presenting the most comprehensive evaluation of MWS to date, we define its clinical evolution occurring with age and derive suggestions for patient management. Furthermore, we observe that its severity correlates with the kind of ZEB2 variation involved, ranging from ZEB2 locus deletions, associated with severe phenotypes, to rare nonmissense intragenic mutations predicted to preserve some ZEB2 protein functionality, accompanying milder clinical presentations.ConclusionKnowledge of the phenotypic spectrum of MWS and its correlation with the genotype will improve its detection rate and the prediction of its features, thus improving patient care.GENETICS in MEDICINE advance online publication, 4 January 2018; doi:10.1038/gim.2017.221

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI