Network Structure, Efficiency, and Performance in WikiProjects

The internet has enabled collaborations at a scale never before possible, but the best practices for organizing such large collaborations are still not clear. Wikipedia is a visible and successful example of such a collaboration which might offer insight into what makes large-scale, decentralized collaborations successful. We analyze the relationship between the structural properties of WikiProject coeditor networks and the performance and efficiency of those projects. We confirm the existence of an overall performance-efficiency trade-off, while observing that some projects are higher than others in both performance and efficiency, suggesting the existence factors correlating positively with both. Namely, we find an association between low-degree coeditor networks and both high performance and high efficiency. We also confirm results seen in previous numerical and small-scale lab studies: higher performance with less skewed node distributions, and higher performance with shorter path lengths. We use agent-based models to explore possible mechanisms for degree-dependent performance and efficiency. We present a novel local-majority learning strategy designed to satisfy properties of real-world collaborations. The local-majority strategy as well as a localized conformity-based strategy both show degree-dependent performance and efficiency, but in opposite directions, suggesting that these factors depend on both network structure and learning strategy. Our results suggest possible benefits to decentralized collaborations made of smaller, more tightly-knit teams, and that these benefits may be modulated by the particular learning strategies in use.Comment: 11 pages, 5 figures, to appear in ICWSM 201

The International Affiliation Network of YouTube Trends

Online video, a ubiquitous, visual, and highly shareable medium, is well-suited to crossing geographic, cultural, and linguistic barriers. Trending videos in particular, by virtue of reaching a large number of viewers in a short span of time, are powerful as both influencers and indicators of international communication flows. In this work, we study a large set of videos trending across 57 nations, collected from YouTube over a 7-month period. We consider the set as a network of content flowing between nations, then develop conditional co-affiliation, a nation-nation co-affiliation index that enables a meaningful interpretation of network path length and the application of betweenness centrality. We observe a highly-interlinked network with remarkably similar co-affiliation levels between very different nations. However, Arabic-speaking nations appear more isolated, with the U.A.E. emerging as a key bridge. By analyzing video trend lifespans, we show that nations having many globally-popular video trends are reliably not the nation where those trends are strongest: we see no evidence to support the widely discussed idea of cultural exporter or trendsetter nations. We model correlations between co-affiliation and a selection of contextual factors. We note a surprisingly complex interaction between migration and shared video trends. Consistent with existing work on video popularity, we find that long trending times within one nation do not necessarily translate to reaching a wide global audience. This work expands on previous studies of the geographic popularity of videos by incorporating trending data and extending our analysis from video-nation affiliations to nation-nation co-affiliations. Characterizing these relationships is key to understanding the international cultural impact and potential of online video

Effects of control error on an adiabatic quantum algorithm

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2006.Includes bibliographical references (p. 59-60).Noise in adiabatic quantum computation can be modelled as a perturbation of the problem Hamiltonian. For a type of noise called control error, the perturbation can be considered to have the same structure as the problem Hamiltonian. If the problem Hamiltonian, and therefore the noise, are 2-local, then the result of the adiabatic algorithm can be simulated somewhat more efficiently than an algorithm with an arbitrary problem Hamiltonain. Using optimized numerical methods, I present an analysis of the effect of 1-local and 2-local control error on the success of an adiabatic algorithm that solves the agree problem. Furthermore, I examine how the maximum allowable noise, or success threshold, scales with the number of qubits. These analyses suggest the existence of a minimum success threshold for the particular algorithm considered in the presence of only 2-local noise on an arbitrarily large number of qubits, as well as a polynomial decrease in success threshold with the number of qubits.by Edward L. Platt.S.B

Quantifying the UK's carbon dioxide flux: An atmospheric inverse modelling approach using a regional measurement network

We present a method to derive atmosphericobservation-based estimates of carbon dioxide (CO 2 ) fluxes at the national scale, demonstrated using data from a network of surface tall-tower sites across the UK and Ireland over the period 2013-2014. The inversion is carried out using simulations from a Lagrangian chemical transport model and an innovative hierarchical Bayesian Markov chain Monte Carlo (MCMC) framework, which addresses some of the traditional problems faced by inverse modelling studies, such as subjectivity in the specification of model and prior uncertainties. Biospheric fluxes related to gross primary productivity and terrestrial ecosystem respiration are solved separately in the inversion and then combined a posteriori to determine net ecosystem exchange of CO 2 . Two different models, Data Assimilation Linked Ecosystem Carbon (DALEC) and Joint UK Land Environment Simulator (JULES), provide prior estimates for these fluxes. We carry out separate inversions to assess the impact of these different priors on the posterior flux estimates and evaluate the differences between the prior and posterior estimates in terms of missing model components. The Numerical Atmospheric dispersion Modelling Environment (NAME) is used to relate fluxes to the measurements taken across the regional network. Posterior CO2 estimates from the two inversions agree within estimated uncertainties, despite large differences in the prior fluxes from the different models. With our method, averaging results from 2013 and 2014, we find a total annual net biospheric flux for the UK of 8±79 TgCO 2 yr -1 (DALEC prior) and 64±85 TgCO 2 yr -1 (JULES prior), where negative values represent an uptake of CO 2 . These biospheric CO 2 estimates show that annual UK biospheric sources and sinks are roughly in balance. These annual mean estimates consistently indicate a greater net release of CO 2 than the prior estimates, which show much more pronounced uptake in summer months

Aβ Vaccination in Combination with Behavioral Enrichment in Aged Beagles: Effects on Cognition, Aβ, and Microhemorrhages

Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer’s disease (AD). Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1–42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11–12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); (4) ENR and VAC (E/V) and treated for 20 months. VAC decreased brain Aβ, pyroglutamate Aβ, increased CSF Aβ42 and BDNF RNA levels but also increased microhemorrhages. ENR reduced brain Aβ and prevented microhemorrhages. The combination treatment resulted in a significant maintenance of learning over time, reduced Aβ and increased BDNF mRNA despite increased microhemorrhages, however there were no benefits to memory. These results suggest that the combination of immunotherapy with behavioral enrichment leads to cognitive maintenance associated with reduced neuropathology that may benefit people with AD

International Veterinary Epilepsy Task Force consensus report on epilepsy definition, classification and terminology in companion animals

Dogs with epilepsy are among the commonest neurological patients in veterinary practice and therefore have historically attracted much attention with regard to definitions, clinical approach and management. A number of classification proposals for canine epilepsy have been published during the years reflecting always in parts the current proposals coming from the human epilepsy organisation the International League Against Epilepsy (ILAE). It has however not been possible to gain agreed consensus, “a common language”, for the classification and terminology used between veterinary and human neurologists and neuroscientists, practitioners, neuropharmacologists and neuropathologists. This has led to an unfortunate situation where different veterinary publications and textbook chapters on epilepsy merely reflect individual author preferences with respect to terminology, which can be confusing to the readers and influence the definition and diagnosis of epilepsy in first line practice and research studies. In this document the International Veterinary Epilepsy Task Force (IVETF) discusses current understanding of canine epilepsy and presents our 2015 proposal for terminology and classification of epilepsy and epileptic seizures. We propose a classification system which reflects new thoughts from the human ILAE but also roots in former well accepted terminology. We think that this classification system can be used by all stakeholders

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol

Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature. There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6–7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed

International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe

In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible