The Incorporation of Moral-Development Language for Machine-Learning Companion Robots

Among the ongoing debates over ethical implications of artificial-intelligence development and applications, AI morality, and the nature of autonomous agency for robots, how to think about the moral assumptions implicit in machine-learning capacities for so-called companion robots is arguably an urgent one. This project links the development of machine-learning algorithmic design with moral-development theory language. It argues that robotic algorithmic responses should incorporate language linked to higher-order moral reasoning, reflecting notions of universal respect, community obligation and justice to encourage similar deliberation among human subjects

A Daphnane Diterpenoid Isolated from Wikstroemia polyantha Induces an Inflammatory Response and Modulates miRNA Activity

MicroRNAs (miRNAs) are endogenously expressed single-stranded ∼21–23 nucleotide RNAs that inhibit gene expression post-transcriptionally by binding imperfectly to elements usually within the 3′untranslated region (3′UTR) of mRNAs. Small interfering RNAs (siRNAs) mediate site-specific cleavage by binding with perfect complementarity to RNA. Here, a cell-based miRNA reporter system was developed to screen for compounds from marine and plant extracts that inhibit miRNA or siRNA activity. The daphnane diterpenoid genkwanine M (GENK) isolated from the plant Wikstroemia polyantha induces an early inflammatory response and can moderately inhibit miR-122 activity in the liver Huh-7 cell line. GENK does not alter miR-122 levels nor does it directly inhibit siRNA activity in an in vitro cleavage assay. Finally, we demonstrate that GENK can inhibit HCV infection in Huh-7 cells. In summary, the development of the cell-based miRNA sensor system should prove useful in identifying compounds that affect miRNA/siRNA activity

Questions of judgment in the newsroom: A journalistic instrumental-value theory for media ethics

Current media ethics theorizing remains preoccupied with building competing normative philosophical frameworks, yet does not often focus on the construction and operation of human value systems--which arguably are the engines that drive most ethical deliberations. This study draws from extensive social psychology research on value systems to construct a profile of journalistic values using a modified version of the Rokeach Value Survey. By examining the relationships between journalists\u27 value rankings, the journalistic roles they embrace and how they rate different types of ethical questions in terms of difficulty, this study suggests an avenue for more useful theorizing about the process of ethical decision making among journalists. A nationwide probability-sample survey of 600 newspaper journalists produced a response rate of 58 percent (N = 349). Results show a series of relationships between individual prioritized values and journalists\u27 perceptions of the difficulty of different types of ethical issues. Results also show relationships between values and various roles that journalists play in society. A series of personal, in-depth interviews with journalists also explores the ways in which journalists perceive the role of personal values and how those values manifest themselves in everyday decision-making

An Observational Study of Dyspnea in Emergency Departments: The Asia, Australia, and New Zealand Dyspnea in Emergency Departments Study ( AANZDEM )

International audienceObjectives: The objective was to describe the epidemiology of dyspnea presenting to emergency departments (EDs) in the Asia-Pacific region, to understand how it is investigated and treated and its outcome.Methods: Prospective interrupted time series cohort study conducted at three time points in EDs in Australia, New Zealand, Singapore, Hong Kong, and Malaysia of adult patients presenting to the ED with dyspnea as a main symptom. Data were collected over three 72-hour periods and included demographics, comorbidities, mode of arrival, usual medications, prehospital treatment, initial assessment, ED investigations, treatment in the ED, ED diagnosis, disposition from ED, in-hospital outcome, and final hospital diagnosis. The primary outcomes of interest are the epidemiology, investigation, treatment, and outcome of patients presenting to ED with dyspnea.Results: A total of 3,044 patients were studied. Patients with dyspnea made up 5.2% (3,105/60,059, 95% confidence interval [CI] = 5.0% to 5.4%) of ED presentations, 11.4% of ward admissions (1,956/17,184, 95% CI = 10.9% to 11.9%), and 19.9% of intensive care unit (ICU) admissions (104/523, 95% CI = 16.7% to 23.5%). The most common diagnoses were lower respiratory tract infection (20.2%), heart failure (14.9%), chronic obstructive pulmonary disease (13.6%), and asthma (12.7%). Hospital ward admission was required for 64% of patients (95% CI = 62% to 66%) with 3.3% (95% CI = 2.8% to 4.1%) requiring ICU admission. In-hospital mortality was 6% (95% CI = 5.0% to 7.2%).Conclusion: Dyspnea is a common symptom in ED patients contributing substantially to ED, hospital, and ICU workload. It is also associated with significant mortality. There are a wide variety of causes however chronic disease accounts for a large proportion