Transmission fiber chromatic dispersion dependence on temperature: implications on 40 Gb/s performance

In this letter we will evaluate the performance degradation of a 40 km high-speed (40 Gb/s) optical System, induced by optical fiber variations of the chromatic dispersion induced by temperature changes. The chromatic dispersion temperature sensitivity will be estimated based on the signal quality parameters

Formation and Evolution of the Disk System of the Milky Way: [alpha/Fe] Ratios and Kinematics of the SEGUE G-Dwarf Sample

We employ measurements of the [alpha/Fe] ratio derived from low-resolution (R~2000) spectra of 17,277 G-type dwarfs from the SEGUE survey to separate them into likely thin- and thick-disk subsamples. Both subsamples exhibit strong gradients of orbital rotational velocity with metallicity, of opposite signs, -20 to -30 km/s/dex for the thin-disk and +40 to +50 km/s/dex for the thick-disk population. The rotational velocity is uncorrelated with Galactocentric distance for the thin-disk subsample, and exhibits a small trend for the thick-disk subsample. The rotational velocity decreases with distance from the plane for both disk components, with similar slopes (-9.0 {\pm} 1.0 km/s/kpc). Thick-disk stars exhibit a strong trend of orbital eccentricity with metallicity (about -0.2/dex), while the eccentricity does not change with metallicity for the thin-disk subsample. The eccentricity is almost independent of Galactocentric radius for the thin-disk population, while a marginal gradient of the eccentricity with radius exists for the thick-disk population. Both subsamples possess similar positive gradients of eccentricity with distance from the Galactic plane. The shapes of the eccentricity distributions for the thin- and thick-disk populations are independent of distance from the plane, and include no significant numbers of stars with eccentricity above 0.6. Among several contemporary models of disk evolution we consider, radial migration appears to have played an important role in the evolution of the thin-disk population, but possibly less so for the thick disk, relative to the gas-rich merger or disk heating scenarios. We emphasize that more physically realistic models and simulations need to be constructed in order to carry out the detailed quantitative comparisons that our new data enable.Comment: Accepted for publication in ApJ, 18 pages, 12 figures, 2 tables, emulateapj forma

Update on the Nature of Virgo Overdensity

We use the Eighth Data Release of Sloan Digital Sky Survey (SDSS DR8) catalog with its additional sky coverage of the southern Galactic hemisphere, to measure the extent and study the nature of the Virgo Overdensity (VOD; Juric et al. 2008). The data show that the VOD extends over no less than 2000 deg^2, with its true extent likely closer to 3000 deg^2. We test whether the VOD can be attributed to a tilt in the stellar halo ellipsoid with respect to the plane of the Galactic disk and find that the observed symmetry of the north-south Galactic hemisphere star counts excludes this possibility. We argue that the Virgo Overdensity, in spite of its wide area and cloud-like appearance, is still best explained by a minor merger. Its appearance and position is qualitatively similar to a near perigalacticon merger event and, assuming that the VOD and the Virgo Stellar Stream share the same progenitor, consistent with the VSS orbit determined by Casetti-Dinescu et al. (2009).Comment: 9 pages,6 figures; accepted for publication in A

The Metallicity Distribution Functions of SEGUE G and K dwarfs: Constraints for Disk Chemical Evolution and Formation

We present the metallicity distribution function (MDF) for 24,270 G and 16,847 K dwarfs at distances from 0.2 to 2.3 kpc from the Galactic plane, based on spectroscopy from the Sloan Extension for Galactic Understanding and Exploration (SEGUE) survey. This stellar sample is significantly larger in both number and volume than previous spectroscopic analyses, which were limited to the solar vicinity, making it ideal for comparison with local volume-limited samples and Galactic models. For the first time, we have corrected the MDF for the various observational biases introduced by the SEGUE target selection strategy. The SEGUE sample is particularly notable for K dwarfs, which are too faint to examine spectroscopically far from the solar neighborhood. The MDF of both spectral types becomes more metal-poor with increasing |Z|, which reflects the transition from a sample with small [alpha/Fe] values at small heights to one with enhanced [alpha/Fe] above 1 kpc. Comparison of our SEGUE distributions to those of two different Milky Way models reveals that both are more metal-rich than our observed distributions at all heights above the plane. Our unbiased observations of G and K dwarfs provide valuable constraints over the |Z|-height range of the Milky Way disk for chemical and dynamical Galaxy evolution models, previously only calibrated to the solar neighborhood, with particular utility for thin- and thick-disk formation models.Comment: 70 pages, 25 figures, 7 tables. Accepted by The Astrophysical Journa

Insight Into the Formation of the Milky Way Through Cold Halo Substructure. II. The Elemental Abundances of ECHOS

We determine the average metallicities of the elements of cold halo substructure (ECHOS) that we previously identified in the inner halo of the Milky Way within 17.5 kpc of the Sun. As a population, we find that stars kinematically associated with ECHOS are chemically distinct from the background kinematically smooth inner halo stellar population along the same Sloan Extension for Galactic Understanding and Exploration (SEGUE) line of sight. ECHOS are systematically more iron-rich, but less alpha-enhanced than the kinematically-smooth component of the inner halo. ECHOS are also chemically distinct from other Milky Way components: more iron-poor than typical thick-disk stars and both more iron-poor and alpha-enhanced than typical thin-disk stars. In addition, the radial velocity dispersion distribution of ECHOS extends beyond sigma ~ 20 km s^-1. Globular clusters are unlikely ECHOS progenitors, as ECHOS have large velocity dispersions and are found in a region of the Galaxy in which iron-rich globular clusters are very rare. Likewise, the chemical composition of stars in ECHOS do not match predictions for stars formed in the Milky Way and subsequently scattered into the inner halo. Dwarf spheroidal (dSph) galaxies are possible ECHOS progenitors, and if ECHOS are formed through the tidal disruption of one or more dSph galaxies, the typical ECHOS [Fe/H] ~ -1.0 and radial velocity dispersion sigma ~ 20 km s^-1 implies a dSph with M_tot >~ 10^9 M_Sun. Our observations confirm the predictions of theoretical models of Milky Way halo formation that suggest that prominent substructures are likely to be metal-rich, and our result implies that the most likely metallicity for a recently accreted star currently in the inner halo is [Fe/H] ~ -1.0.Comment: 31 pages and 16 figures, and 3 tables in emulateapj format; accepted for publication in ApJ. Full tables can be extracted from TeX sourc

Binary Contamination in the SEGUE sample: Effects on SSPP Determinations of Stellar Atmospheric Parameters

Using numerical modeling and a grid of synthetic spectra, we examine the effects that unresolved binaries have on the determination of various stellar atmospheric parameters for SEGUE targets measured using the SEGUE Stellar Parameter Pipeline (SSPP). To model undetected binaries that may be in the SEGUE sample, we use a variety of mass distributions for the primary and secondary stars in conjunction with empirically determined relationships for orbital parameters to determine the fraction of G-K dwarf stars, as defined by SDSS color cuts, that will be blended with a secondary companion. We focus on the G-K dwarf sample in SEGUE as it records the history of chemical enrichment in our galaxy. To determine the effect of the secondary on the spectroscopic parameters, we synthesize a grid of model spectra from 3275 to 7850 K (~0.1 to 1.0 \msun) and [Fe/H]=-0.5 to -2.5 from MARCS model atmospheres using TurboSpectrum. We analyze both "infinite" signal-to-noise ratio (S/N) models and degraded versions, at median S/N of 50, 25 and 10. By running individual and combined spectra (representing the binaries) through the SSPP, we determine that ~10% of the blended G-K dwarf pairs with S/N>=25 will have their atmospheric parameter determinations, in particular temperature and metallicity, noticeably affected by the presence of an undetected secondary. To account for the additional uncertainty from binary contamination at a S/N~10, uncertainties of ~140 K and ~0.17 dex in [Fe/H] must be added in quadrature to the published uncertainties of the SSPP. (Abridged)Comment: 68 pages, 20 figures, 9 table

Expanding distribution of lethal amphibian fungus Batrachochytrium salamandrivorans in Europe

Emerging fungal diseases can drive amphibian species to local extinction. During 2010-2016, we examined 1,921 urodeles in 3 European countries. Presence of the chytrid fungus Batrachochytrium salamandrivorans at new locations and in urodeles of different species expands the known geographic and host range of the fungus and underpins its imminent threat to biodiversity

Pooling skin swabs does not inhibit qPCR detection of amphibian chytrid infection

Immediate and reliable pathogen detection in large numbers of samples is essential in wildlife disease monitoring and is often realized by DNA-based techniques. Pooling samples increases processing efficiency and reduces processing costs, and has been suggested as a viable technique for quantitative PCR detection of fungal amphibian pathogens of the genus Batrachochytrium. For these fungi, this diagnostic method has been validated by in vitro set ups that provided controlled test conditions but did not take into account potential effects from amphibian skin compounds (e.g. skin secretions and Microbiota) on the approach. Some of these skin compounds are known to cause PCR inhibition in single sample applications and could lead to false negative reactions and thereby hamper pathogen detection. In this study we examined the effect of skin compounds on the pooled extraction method by swabbing individuals of seven amphibian species (one Anura and six Caudata) prior to the inoculation of the swabs with chytrid zoospores. For each species, swabs were extracted in pools of different sizes (from one to four swabs) with only one swab per pool being inoculated with zoospores. There were no significant differences regarding the ability to detect zoospores when comparing pool sizes for any species, with a tendency for more false negatives when the inoculated swab had been inoculated with a single zoospore. This study provides further in vivo evidence for the viability of the pooled extraction method for DNA-based detection of pathogens

Chitosan – poly(butylene succinate) scaffolds and human bone marrow stromal cells induce bone repair in a mouse calvaria model

Tissue engineering sustains the need of a three-dimensional (3D) scaffold to promote the regeneration of tissues in volume. Usually, scaffolds are seeded with an adequate cell population, allowing their growth and maturation upon implantation in vivo. Previous studies obtained by our group evidenced significant growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) when seeded and cultured on melt-based porous chitosan fibre mesh scaffolds (cell constructs). Therefore, it is crucial to test the in vivo performance of these in vitro 3D cell constructs. In this study, chitosan-based scaffolds were seeded and cultured in vitro with hBMSCs for 3 weeks under osteogenic stimulation conditions and analysed for cell adhesion, proliferation and differentiation. Implantation of 2 weeks precultured cell constructs in osteogenic culture conditions was performed into critical cranial size defects in nude mice. The objective of this study was to verify the scaffold integration and new bone formation. At 8 weeks of implantation, scaffolds were harvested and prepared for micro-computed tomography (μCT) analysis. Retrieved implants showed good integration with the surrounding tissue and significant bone formation, more evident for the scaffolds cultured and implanted with human cells. The results of this work demonstrated that chitosan-based scaffolds, besides supporting in vitro proliferation and osteogenic differentiation of hBMSCs, induced bone formation in vivo. Thus, their osteogenic potential in orthotopic location in immunodeficient mice was validated, evidencing good prospects for their use in bone tissue-engineering therapies.Ana Costa-Pinto was supported by Scholarship No. SFRH/24735/2005 from the Portuguese Research Council (Fundacao para a Ciencia e a Tecnologia; FCT). This work was partially supported by the EU Integrated Project GENOS-TEM ('Adult mesenchymal stem cells engineering for connective tissue disorders: from the bench to the bedside'; Grant No. LSHB-CT-2003-5033161) and the European Network of Excellence EXPERTISSUES Project (Grant No. NMP3-CT-2004-500283)

The SCottish Alcoholic Liver disease Evaluation: a population-level matched cohort study of hospital-based costs, 1991-2011

Studies assessing the costs of alcoholic liver disease are lacking. We aimed to calculate the costs of hospitalisations before and after diagnosis compared to population controls matched by age, sex and socio-economic deprivation. We aimed to use population level data to identify a cohort of individuals hospitalised for the first time with alcoholic liver disease in Scotland between 1991 and 2011.Incident cases were classified by disease severity, sex, age group, socio-economic deprivation and year of index admission. 5 matched controls for every incident case were identified from the Scottish population level primary care database. Hospital costs were calculated for both cases and controls using length of stay from morbidity records and hospital-specific daily rates by specialty. Remaining lifetime costs were estimated using parametric survival models and predicted annual costs. 35,208 incident alcoholic liver disease hospitalisations were identified. Mean annual hospital costs for cases were 2.3 times that of controls pre diagnosis (£804 higher) and 10.2 times (£12,774 higher) post diagnosis. Mean incident admission cost was £6,663. Remaining lifetime cost for a male, 50-59 years old, living in the most deprived area diagnosed with acoholic liver disease was estimated to be £65,999 higher than the matched controls (£12,474 for 7.43 years remaining life compared to £1,224 for 21.8 years). In Scotland, alcoholic liver disease diagnosis is associated with significant increases in admissions to hospital both before and after diagnosis. Our results provide robust population level estimates of costs of alcoholic liver disease for the purposes of health-care delivery, planning and future cost-effectiveness analyses