Impact of Symmetric Vertical Sinusoid Alignments on Infrastructure Construction Costs: Optimizing Energy Consumption in Metropolitan Railway Lines Using Artificial Neural Networks

[EN] Minimizing energy consumption is a key issue from both an environmental and economic perspectives for railways systems; however, it is also important to reduce infrastructure construction costs. In the present work, an artificial neural network (ANN) was trained to estimate the energy consumption of a metropolitan railway line. This ANN was used to test hypothetical vertical alignments scenarios, proving that symmetric vertical sinusoid alignments (SVSA) can reduce energy consumption by up to 18.4% compared with a flat alignment. Finally, we analyzed the impact of SVSA application on infrastructure construction costs, considering different scenarios based on top-down excavation methods. When balancing reduction in energy consumption against infrastructure construction costs between SVSA and flat alignment, the extra construction costs due to SVSA have a return period of 25-300 years compared with a flat alignment, depending on the soil type and construction method used. Symmetric vertical sinusoid alignment layouts are thus suitable for scattered or soft soils, up to compacted intermediate geomaterials.This paper was realized thanks to the collaboration agreement signed between Ferrocarrils de la Generalitat Valenciana and Universitat Politecnica de Valencia, and funding obtained by the Spanish Ministry of Economy and Competitiveness through the project ''Strategies for the design and energy-efficient operation of railway and tramway infrastructure'' (Ref. TRA2011-26602).Pineda-Jaramillo, J.; Salvador Zuriaga, P.; Martínez Fernández, P.; Insa Franco, R. (2020). Impact of Symmetric Vertical Sinusoid Alignments on Infrastructure Construction Costs: Optimizing Energy Consumption in Metropolitan Railway Lines Using Artificial Neural Networks. Urban Rail Transit. 6(3):145-156. https://doi.org/10.1007/s40864-020-00130-714515663International Energy Agency (2018) Key world energy statistics. 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Predicting the traction power of metropolitan railway lines using different machine learning models

This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Rail Transportation on 2021, available online: http://www.tandfonline.com/10.1080/23248378.2020.1829513[EN] Railways are an efficient transport mean with lower energy consumption and emissions in comparison to other transport means for freight and passengers, and yet there is a growing need to increase their efficiency. To achieve this, it is needed to accurately predict their energy consumption, a task which is traditionally carried out using deterministic models which rely on data measured through money- and time-consuming methods. Using four basic (and cheap to measure) features (train speed, acceleration, track slope and radius of curvature) from MetroValencia (Spain), we predicted the traction power using different machine learning models, obtaining that a random forest model outperforms other approaches in such task. The results show the possibility of using basic features to predict the traction power in a metropolitan railway line, and the chance of using this model as a tool to assess different strategies in order to increase the energy efficiency in these lines.This work was supported by the Ministerio de Economia y Competitividad [TRA2011-26602].Pineda-Jaramillo, J.; Martínez Fernández, P.; Villalba Sanchis, I.; Salvador Zuriaga, P.; Insa Franco, R. (2021). Predicting the traction power of metropolitan railway lines using different machine learning models. International Journal of Rail Transportation. 9(5):461-478. https://doi.org/10.1080/23248378.2020.1829513S4614789

Embarazo por violación: la crisis múltiple

La presente investigación fue realizada por la Fundación SI MUJER de Cali, con el apoyo de COLCIENCIAS-BID, en un lapso de dieciocho meses, de los cuales catorce se concentraron en recolectar la información. El embarazo por violación es la más específica de las violencias de género y tanto aquél como sus consecuencias están poco documentadas, a pesar de su incidencia y de que la violencia contra las mujeres es una constante en nuestra civilización. Su escaso reconocimiento obedece, en parte, a que ha pasado mimetizada bajo expresiones de la cultura y del sistema patriarcal. De los innumerables impactos de la violación cuando se sobrevive a la misma, la preñez es el más crítico por las múltiples crisis que genera, ya que en momentos de gran fragilidad emocional le exige a la víctima tomar decisiones difíciles que repercuten en toda su vida y en la de su hijo/a. La maternidad obligada y la crianza, entregar para adopción el hijo/a o interrumpir el embarazo, están llenas de conflictos, de transgresiones, y tocan con valores, prejuicios, estigmas sociales y hasta sanciones legales para la mujer. De las 121 mujeres que constituyen la población estudiada, la mayoría son jóvenes pobres, y un 43.8% había cursado estudios primarios. El 58.7% con menos de 20 años, entre ellas 5 niñas de 11 y 12 años. El 34.7% nunca había tenido relaciones sexuales ni coitales, y 81.8% son solteras. Interrumpieron el embarazo el 63%; conservaron el hijo/a el 18%, y el 7% la/lo entregaron para adopción. El 12% usó anticoncepción de emergencia tras la violación. Los resultados, aunque no permiten hablar de incidencia o representatividad, ilustran la dimensión humana del fenómeno así como los mínimos recursos estatales (policiales, judiciales, de salud), sociales y familiares, para prevenir y tratar el embarazo por violación. A su vez, constituyen un referente inicial para el estudio del tema que no ha sido investigado de manera específica en la región

Potential for pancreatic maturation of differentiating human embryonic stem cells is sensitive to the specific pathway of definitive endoderm commitment

This study provides a detailed experimental and mathematical analysis of the impact of the initial pathway of definitive endoderm (DE) induction on later stages of pancreatic maturation. Human embryonic stem cells (hESCs) were induced to insulin-producing cells following a directed-differentiation approach. DE was induced following four alternative pathway modulations. DE derivatives obtained from these alternate pathways were subjected to pancreatic progenitor (PP) induction and maturation and analyzed at each stage. Results indicate that late stage maturation is influenced by the initial pathway of DE commitment. Detailed quantitative analysis revealed WNT3A and FGF2 induced DE cells showed highest expression of insulin, are closely aligned in gene expression patterning and have a closer resemblance to pancreatic organogenesis. Conversely, BMP4 at DE induction gave most divergent differentiation dynamics with lowest insulin upregulation, but highest glucagon upregulation. Additionally, we have concluded that early analysis of PP markers is indicative of its potential for pancreatic maturation. © 2014 Jaramillo et al

Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals

AIMS: Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry. METHODS: We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14 sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles. RESULTS: We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8% of the sample) showed thinner cortex, especially in the frontal and temporal lobes and was associated with diagnosis of BD, higher BMI, and older age. BD individuals in the low thickness cluster were more likely to have the diagnosis of bipolar disorder I and less likely to be treated with lithium. In contrast, clustering based on similarities in the cortical surface area was unrelated to BD or BMI and only tracked age and sex. CONCLUSIONS: We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The thinner cortex in individuals with higher BMI, which was additive and similar to the BD-associated alterations, may suggest that treating obesity could lower the extent of cortical thinning in BD

Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning)

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from theENIGMABipolar Disorder Working Group

MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large‐scale meta‐ and mega‐analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large‐scale, collaborative studies of mental illness

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

BACKGROUND Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia (N = 11,095), using a single image analysis protocol. METHODS We included T1-weighted data from 46 datasets (5,080 affected individuals and 6,015 controls) from the ENIGMA Consortium. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Analyses were also performed with respect to the use of antipsychotic medication and other clinical variables, as well as age and sex. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029). RESULTS Small average differences between cases and controls were observed for asymmetries in cortical thickness, specifically of the rostral anterior cingulate (d = −0.08, pFDR = 0.047) and the middle temporal gyrus (d = −0.07, pFDR = 0.048), both driven primarily by thinner cortices in the left hemisphere in schizophrenia. These asymmetries were not significantly associated with the use of antipsychotic medication or other clinical variables. Older individuals with schizophrenia showed a stronger average leftward asymmetry of pallidum volume than older controls (d = 0.08, pFDR = 9.0 × 10−3). The multivariate analysis revealed that 7% of the variance across all structural asymmetries was explained by case-control status (F = 1.87, p = 1.25 × 10−5). CONCLUSIONS Altered trajectories of asymmetrical brain development and/or lifespan asymmetry may contribute to schizophrenia pathophysiology. Small case-control differences of brain macro-structural asymmetry may manifest due to more substantial differences at the molecular, cytoarchitectonic or circuit levels, with functional relevance for lateralized cognitive processes

Mega-analysis of association between obesity and cortical morphology in bipolar disorders:ENIGMA study in 2832 participants

Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. Methods: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. Results: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. Conclusions: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.</p

Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders—ENIGMA study in people with bipolar disorders and obesity

Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather by variations across distributed brain networks. Here, we used principal component analysis (PCA) to identify patterns of covariance across brain regions and relate them to clinical and demographic variables in a large generalizable dataset of individuals with bipolar disorders and controls. We then compared performance of PCA and clustering on identical sample to identify which methodology was better in capturing links between brain and clinical measures. Using data from the ENIGMA-BD working group, we investigated T1-weighted structural MRI data from 2436 participants with BD and healthy controls, and applied PCA to cortical thickness and surface area measures. We then studied the association of principal components with clinical and demographic variables using mixed regression models. We compared the PCA model with our prior clustering analyses of the same data and also tested it in a replication sample of 327 participants with BD or schizophrenia and healthy controls. The first principal component, which indexed a greater cortical thickness across all 68 cortical regions, was negatively associated with BD, BMI, antipsychotic medications, and age and was positively associated with Li treatment. PCA demonstrated superior goodness of fit to clustering when predicting diagnosis and BMI. Moreover, applying the PCA model to the replication sample yielded significant differences in cortical thickness between healthy controls and individuals with BD or schizophrenia. Cortical thickness in the same widespread regional network as determined by PCA was negatively associated with different clinical and demographic variables, including diagnosis, age, BMI, and treatment with antipsychotic medications or lithium. PCA outperformed clustering and provided an easy-to-use and interpret method to study multivariate associations between brain structure and system-level variables. Practitioner Points: In this study of 2770 Individuals, we confirmed that cortical thickness in widespread regional networks as determined by principal component analysis (PCA) was negatively associated with relevant clinical and demographic variables, including diagnosis, age, BMI, and treatment with antipsychotic medications or lithium. Significant associations of many different system-level variables with the same brain network suggest a lack of one-to-one mapping of individual clinical and demographic factors to specific patterns of brain changes. PCA outperformed clustering analysis in the same data set when predicting group or BMI, providing a superior method for studying multivariate associations between brain structure and system-level variables.</p