Procedimiento metodológico para determinar líneas estratégicas de desarrollo municipal. Caso de estudio: Nuevitas

Se aplicó un procedimiento metodológico para determinar líneas estratégicas de desarrollo municipal, cuya basefue la prospectiva territorial desarrollada por Michel Godet. El aporte radica en la introducción al proceso de planificación territorial, de un enfoque prospectivo y una visión compartida de futuro entre los actores locales. Como caso de estudio se utilizó el municipio Nuevitas, provincia de Camagüey, Cuba. Los resultados fundamentales revelan que el sistema territorial está en condiciones de adoptar una estrategia ofensiva con las fortalezas que presenta.Los factores de cambio clave que tienen influencias indirectas potenciales más importantes son: altas potencialidades para el desarrollo turístico y las posibilidades reales de aplicación de las medidas para la actualización del modelo económico cubano.Entre los actores más dinámicos del territorio a mediano plazo se encuentran: el sector del turismo, la empresa agropecuaria, las terminales del puerto y el sector de la construcción. El escenario de anticipación revela que en el sistema territorial se concibe un cambio en su estructura económica a partir de la proyección de los factores de cambioclave más motrices y dependientes, con los cuales se determinaron las líneas estratégicas de desarrollo municipal, que permitieron establecer los programas y proyectos necesarios para alcanzar el modelo de desarrollo previsto

Diagnostic Procedure for Inter-Sector Relationships in the Model of Municipal Development

Several methods were applied to design a new diagnostic procedure of inter-sector relationships, and the coordination between development strategies and key economic sectors within the strategic planning system in the municipality of Nuevitas, province of Camaguey, Cuba. The methods included analysis-synthesis; systemic, to conceive the character of component relationships; interview, survey, and documentary research. They made possible the characterization of the current situation in the municipality. The diagnostic revealed that the analysis of inter-sector relationships is not usually made, due to ongoing deficiencies regarding a procedure design to perform situational strategic diagnostics. According to the results achieved, insufficiencies in inter-sector relationships among the institutions selected for the study were identified, as a reflection of the poor coordination among the sectors. Potentialities and restrictions, weaknesses, strengths, and opportunities were revealed, which called for the implementation of a diagnostic of inter-sector relationships in the area of development strategies. The methodological proposal rests on the supposition that diagnostics should establish methods to include analysis of horizontal relationships among the sectors, convergence with the local development strategy, and more efficiency of integrated development programs.                Several methods were applied to design a new diagnostic procedure of inter-sector relationships, and the coordination between development strategies and key economic sectors within the strategic planning system in the municipality of Nuevitas, province of Camaguey, Cuba. The methods included analysis-synthesis; systemic, to conceive the character of component relationships; interview, survey, and documentary research. They made possible the characterization of the current situation in the municipality. The diagnostic revealed that the analysis of inter-sector relationships is not usually made, due to ongoing deficiencies regarding a procedure design to perform situational strategic diagnostics. According to the results achieved, insufficiencies in inter-sector relationships among the institutions selected for the study were identified, as a reflection of the poor coordination among the sectors. Potentialities and restrictions, weaknesses, strengths, and opportunities were revealed, which called for the implementation of a diagnostic of inter-sector relationships in the area of development strategies. The methodological proposal rests on the supposition that diagnostics should establish methods to include analysis of horizontal relationships among the sectors, convergence with the local development strategy, and more efficiency of integrated development programs.               &nbsp

Método para el diagnóstico de las relaciones intersectoriales en el modelo de desarrollo municipal

Con el  objetivo de diseñar un método que permita el diagnóstico de las relaciones intersectoriales, y la coordinación entre las estrategias de desarrollo, y los sectores claves de la economía  en el sistema de gestión estratégica  del municipio de Nuevitas, provincia de Camagüey, se utilizaron los métodos de análisis, síntesis, el sistémico  para concebir el carácter de las interacciones entre sus componentes, las entrevistas, encuestas,  y el análisis documental, los que posibilitaron caracterizar la situación actual del municipio. Se develó en el diagnóstico que no se introduce el análisis de las relaciones intersectoriales, lo cual se encuentra influenciado, por las deficiencias que aún existen en cuanto al diseño de la metodología para el diagnóstico estratégico situacional. De acuerdo a los resultados obtenidos, se identificaron las insuficiencias existentes en cuanto al estado de las relaciones intersectoriales en las entidades seleccionadas, lo cual manifiesta  una deficiente coordinación entre los diferentes sectores, evidenciando las  potencialidades y restricciones, debilidades y amenazas, fortalezas y oportunidades que existen en el municipio, siendo necesario se elabore en el diagnóstico la problemática que afecta las relaciones intersectoriales en las estrategias de desarrollo. La propuesta metodológica para el diagnóstico tiene como principales supuestos, que los diagnósticos deben establecer métodos para incluir el análisis de las relaciones horizontales entre los diferentes sectores, hacia el logro de la convergencia con la estrategia de desarrollo en el municipio y una mayor eficiencia en los programas de desarrollo integral.  &nbsp

Diagnostic Procedure for Inter-Sector Relationships in the Model of Municipal Development

Several methods were applied to design a new diagnostic procedure of inter-sector relationships, and the coordination between development strategies and key economic sectors within the strategic planning system in the municipality of Nuevitas, province of Camaguey, Cuba. The methods included analysis-synthesis; systemic, to conceive the character of component relationships; interview, survey, and documentary research. They made possible the characterization of the current situation in the municipality. The diagnostic revealed that the analysis of inter-sector relationships is not usually made, due to ongoing deficiencies regarding a procedure design to perform situational strategic diagnostics. According to the results achieved, insufficiencies in inter-sector relationships among the institutions selected for the study were identified, as a reflection of the poor coordination among the sectors. Potentialities and restrictions, weaknesses, strengths, and opportunities were revealed, which called for the implementation of a diagnostic of inter-sector relationships in the area of development strategies. The methodological proposal rests on the supposition that diagnostics should establish methods to include analysis of horizontal relationships among the sectors, convergence with the local development strategy, and more efficiency of integrated development programs

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium. Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2. Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector

This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations

Studies of new Higgs boson interactions through nonresonant HH production in the b¯bγγ fnal state in pp collisions at √s = 13 TeV with the ATLAS detector

A search for nonresonant Higgs boson pair production in the b ¯bγγ fnal state is performed using 140 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. This analysis supersedes and expands upon the previous nonresonant ATLAS results in this fnal state based on the same data sample. The analysis strategy is optimised to probe anomalous values not only of the Higgs (H) boson self-coupling modifer κλ but also of the quartic HHV V (V = W, Z) coupling modifer κ2V . No signifcant excess above the expected background from Standard Model processes is observed. An observed upper limit µHH < 4.0 is set at 95% confdence level on the Higgs boson pair production cross-section normalised to its Standard Model prediction. The 95% confdence intervals for the coupling modifers are −1.4 < κλ < 6.9 and −0.5 < κ2V < 2.7, assuming all other Higgs boson couplings except the one under study are fxed to the Standard Model predictions. The results are interpreted in the Standard Model efective feld theory and Higgs efective feld theory frameworks in terms of constraints on the couplings of anomalous Higgs boson (self-)interactions