Review of seasonal heat storage in large basins: water tanks and gravel-water pits

In order to respond to climatic change, many efforts have been made to reduce harmful gas emissions. According to energy policies, an important goal is the implementation of renewable energy sources, as well as electrical and oil combustion savings through energy conservation. This paper focuses on an extensive review of the technologies developed, so far, for central solar heating systems employing seasonal sensible water storage in artificial large scale basins. Among technologies developed since the late 70s, the use of underground spaces as an energy storage medium - Underground Thermal Energy Storage (UTES) - has been investigated and closely observed in experimental plants in many countries, most of them, as part of government programmes. These projects attempt to optimise technical and economic aspects within an international knowledge exchange; as a result, UTES is becoming a reliable option to save energy through energy conservation. Other alternatives to UTES include large water tanks and gravel-water pits, also called man-made or artificial aquifers. This implies developing this technology by construction and leaving natural aquifers untouched. The present article reviews most studies and results obtained in this particular area to show the technical and economical feasibility for each system and specifics problems occurred during construction and operation. Advantages and disadvantages are pointed out to compare both alternatives. The projects discussed have been carried out mainly in European states with some references to other countries

Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells

Histone acetylation is a key modification that regulates chromatin accessibility. Here we show that treatment with butyrate or other histone deacetylase (HDAC) inhibitors does not induce histone hyperacetylation in metaphase-arrested HeLa cells. When compared to similarly treated interphase cells, acetylation levels are significantly decreased in all four core histones and at all individual sites examined. However, the extent of the decrease varies, ranging from only slight reduction at H3K23 and H4K12 to no acetylation at H3K27 and barely detectable acetylation at H4K16. Our results show that the bulk effect is not due to increased or butyrate-insensitive HDAC activity, though these factors may play a role with some individual sites. We conclude that the lack of histone acetylation during mitosis is primarily due to changes in histone acetyltransferases (HATs) or changes in chromatin. The effects of protein phosphatase inhibitors on histone acetylation in cell lysates suggest that the reduced ability of histones to become acetylated in mitotic cells depends on protein phosphorylation

prospective study on the applicability of a kinematic femur rotation axis using a navigation system total knee arthroplasty

In der vorliegenden Studie wurde eine neue Rotationsachse, welche intraoperativ durch ein Navigationssystem aufgrund der intraoperativ erfassten Kinematik errechnet wurde, auf seine Anwendbarkeit überprüft. Die sogenannte funktionelle Femurrotationsachse ließ sich bei allen erfassten und auswertbaren Probanden berechnen und zeigte sich im Vergleich zu den traditionellen Rotationsachsen als mindestens gleichwertig. In Bezug zur TEA und zur Whiteside-Line fand sich eine signifikant geringere Streubreite, in Bezug zur PCL und den Beugespalt fanden sich keine signifikanten Unterschiede. Bei angewendeter MIS-Technik konnte eine korrekte Rotationspositionierung der Femurkomponente von 89,3 % erreicht werden. Dies ist besser als in der Literatur für konventionelle Zugänge beschrieben. Die Verwendung eines Navigationssystems unter Benutzung aller Achsen scheint eine Reduktion der Fehlpositionierung zu fördern.In this study, a new axis of rotation, which was calculated by a navigation system under the intraoperatively covered kinematics intraoperatively was examined for its applicability. The so-called functional rotation axis was calculated in all covered and valuable volunteers and was compared to the traditional rotation axes as at least equivalent. In relation to the TEA, and to the Whiteside-line, a significantly lower spread width was, in relation to the PCL and the flexion gap, no significant differences were found. Applied technique of MIS, a correct rotation positioning of the Femurkomponente of 89.3% has been achieved. This is better than reported in the literature for conventional approaches. Use a navigation system using all axes seems to promote a reduction of wrong position

Hanslick-Online/hsl-data-ct: Pre-Release v0.3.0

Der neue Release beinhaltet die Edition von 37 Kritiken (Oktober bis Dezember 1865 und die Jahre 1899 und 1900). Zudem wurden die Werkdaten umfassend angereichert, wenn möglich Werkverzeichnisnummern durchgängig nachgetragen und Autorinnen (v.a. Librettistinnen und Textdichter*innen) auch dann angeführt, wenn Hanslick diese nicht ausdrücklich erwähnt. Full Changelog: https://github.com/Hanslick-Online/hsl-data-ct/compare/v0.2.0...v.0.3.