Development of nuclear emulsions operating in vacuum for the AEgIS experiment

For the first time the AEgIS (Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy) experiment will measure the Earth\u2019s local gravitational acceleration g on antimatter through the evaluation of the vertical displacement of an antihydrogen horizontal beam. This will be a model independent test of the Weak Equivalence Principle at the base of the general relativity. The initial goal of a g measurement with a relative uncertainty of 1% will be achieved with less than 1000 detected antihydrogens, provided that their vertical position could be determined with a precision of a few micrometers. An emulsion based detector is very suitable for this purpose featuring an intrinsic sub-micrometric spatial resolution. Nevertheless, the AEgIS experiment re- quires unprecedented operational conditions for this type of detector, namely vacuum environment and very low temperature. An intense R&D activity is presently going on to optimize the detector for the AEgIS experimental requirements with rather encouraging results

Topographic variation in redifferentiation capacity of chondrocytes in the adult human knee joint.

OBJECTIVES: The aim of this study was to investigate the topographic variation in matrix production and cell density in the adult human knee joint. Additionally, we have examined the redifferentiation potential of chondrocytes expanded in vitro from the different locations. METHOD: Full thickness cartilage-bone biopsies were harvested from seven separate anatomical locations of healthy knee joints from deceased adult human donors. Chondrocytes were isolated, expanded in vitro and redifferentiated in a pellet mass culture. Biochemical analysis of total collagen, proteoglycans and cellular content as well as histology and immunohistochemistry were performed on biopsies and pellets. RESULTS: In the biochemical analysis of the biopsies, we found lower proteoglycan to collagen (GAG/HP) ratio in the non-weight bearing (NWB) areas compared to the weight bearing (WB) areas. The chondrocytes harvested from different locations in femur showed a significantly better attachment and proliferation ability as well as good post-expansion chondrogenic capacity in pellet mass culture compared with the cells harvested from tibia. CONCLUSION: These results demonstrate that there are differences in extra cellular content within the adult human knee in respect to GAG/HP ratio. Additionally, the data show that clear differences between chondrocytes harvested from femur and tibia from healthy human knee joints exist and that the differences are not completely abolished during the process of de- and redifferentiation. These findings emphasize the importance of the understanding of topographic variation in articular cartilage biology when approaching new cartilage repair strategies

Measuring GBAR with emulsion detector

The motivation of the AEgIS experiment is to test the universality of free fall with antimatter. The goal is to reach a relative uncertainty of 1% for the measurement of the earth’s gravitational acceleration g on an antihydrogen beam. High vertex position resolution is required for a position detector. An emulsion based detector can measure the annihilation vertex of antihydrogen atoms with a resolution of 1-2 μm, which if realized in the actual experiment will enable a 1% measurement of g with less than 1000 H atoms. Developments and achievements on emulsion detectors for the AEgIS experiment are presented here

Measuring with , progress and perspectives

Aegis experiment's main goal is to measure the local gravitational acceleration of antihydrogen g and thus perform a direct test of the weak equivalence principle with antimatter. In the first phase of the experiment the aim is to measure g with 1% relative precision. This paper presents the antihydrogen production method and a description of some components of the experiment, which are necessary for the gravity measurement. Current status of the Aegis experimental apparatus is presented and recent commissioning results with antiprotons are outlined. In conclusion we discuss the short-term goals of the Aegis collaboration that will pave the way for the first gravity measurement in the near future

The AEgIS Experiment

The AEgIS experiment aims at performing the first test of the Weak Equivalence Principle of General Relativity in the antimatter sector by measuring the gravitational acceleration acting on a beam of cold antihydrogen to a precision of 1%. The installation of the apparatus is making good progress and large parts were taken into operation. Parasitic detector tests during the beamtime in December 2012 gave essential input for an optimal moiré deflectometer and the detector layout necessary to perform the gravity measurement

Detection of low energy antiproton annihilations in a segmented silicon detector

The goal of the AEbar gIS experiment at the Antiproton Decelerator (AD) at CERN, is to measure directly the Earth's gravitational acceleration on antimatter by measuring the free fall of a pulsed, cold antihydrogen beam. The final position of the falling antihydrogen will be detected by a position sensitive detector. This detector will consist of an active silicon part, where the annihilations take place, followed by an emulsion part. Together, they allow to achieve 1% precision on the measurement of bar g with about 600 reconstructed and time tagged annihilations. We present here the prospects for the development of the AEbar gIS silicon position sentive detector and the results from the first beam tests on a monolithic silicon pixel sensor, along with a comparison to Monte Carlo simulations

Particle tracking at 4K: The Fast Annihilation Cryogenic Tracking (FACT) detector for the AEgIS antimatter gravity experiment

The AEgIS experiment is an international collaboration with the main goal of performing the first direct measurement of the Earth's gravitational acceleration on antimatter. Critical to the success of AEgIS is the production of cold antihydrogen (H) atoms. The FACT detector is used to measure the production and temperature of the H atoms and for establishing the formation of a H beam. The operating requirements for this detector are very challenging: it must be able to identify each of the thousand or so annihilations in the 1 ms period of pulsed H production, operate at 4 K inside a 1 T solenoidal field and not produce more than 10 W of heat. The FACT detector consists of two concentric cylindrical layers of 400 scintillator fibres with a 1 mm diameter and a 0.6 mm pitch. The scintillating fibres are coupled to clear fibres which transport the scintillation light to 800 silicon photomultipliers. Each silicon photomultiplier signal is connected to a linear amplifier and a fast discriminator, the outputs of which are sampled continuously by Field Programmable Gate Arrays (FPGAs). In the course of the developments for the FACT detector we have established the performance of scintillating fibres at 4 K by means of a cosmic-ray tracker operating in a liquid helium cryostat. The FACT detector was installed in the AEgIS apparatus in December 2012 and will be used to study the H formation when the low energy antiproton physics programs resume at CERN in the Summer of 2014. This paper presents the design requirements and construction methods of the FACT detector and provides the first results of the detector commissioning

Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

International audienceBackground: Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences.Methods: We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children audiT of Anaesthesia pRactice IN Europe [NECTARINE]) in neonates and small infants with difficult tracheal intubation. The primary endpoint was the incidence of difficult intubation and the related complications. The secondary endpoints were the risk factors for severe hypoxaemia attributed to difficult airway management, and 30 and 90 day outcomes.Results: Tracheal intubation was planned in 4683 procedures. Difficult tracheal intubation, defined as two failed attempts of direct laryngoscopy, occurred in 266 children (271 procedures) with an incidence (95% confidence interval [CI]) of 5.8% (95% CI, 5.1-6.5). Bradycardia occurred in 8% of the cases with difficult intubation, whereas a significant decrease in oxygen saturation (SpO2<90% for 60 s) was reported in 40%. No associated risk factors could be identified among co-morbidities, surgical, or anaesthesia management. Using propensity scoring to adjust for confounders, difficult anaesthesia tracheal intubation did not lead to an increase in 30 and 90 day morbidity or mortality.Conclusions: The results of the present study demonstrate a high incidence of difficult tracheal intubation in children less than 60 weeks post-conceptual age commonly resulting in severe hypoxaemia. Reassuringly, the morbidity and mortality at 30 and 90 days was not increased by the occurrence of a difficult intubation event

Search for heavy resonances in the W/Z-tagged dijet mass spectrum in pp collisions at 7 TeV

A search has been made for massive resonances decaying into a quark and a vector boson, qW or qZ, or a pair of vector bosons, WW, WZ, or ZZ, where each vector boson decays to hadronic final states. This search is based on a data sample corresponding to an integrated luminosity of 5.0 fb 121 of proton\u2013proton collisions collected in the CMS experiment at the LHC in 2011 at a center-of-mass energy of 7 TeV. For sufficiently heavy resonances the decay products of each vector boson are merged into a single jet, and the event effectively has a dijet topology. The background from QCD dijet events is reduced using recently developed techniques that resolve jet substructure. A 95% CL lower limit is set on the mass of excited quark resonances decaying into qW (qZ) at 2.38 TeV (2.15 TeV) and upper limits are set on the cross section for resonances decaying to qW, qZ, WW, WZ, or ZZ final states

Search for long-lived particles in events with photons and missing energy in proton\u2013proton collisions at sqrt(s)=7 TeV

Results are presented from a search for long-lived neutralinos decaying into a photon and an invisible particle, a signature associated with gauge-mediated supersymmetry breaking in supersymmetric models. The analysis is based on a 4.9 inverse femtobarn sample of proton-proton collisions at 1as = 7 TeV, collected with the CMS detector at the LHC. The missing transverse energy and the time of arrival of the photon at the electromagnetic calorimeter are used to search for an excess of events over the expected background. No significant excess is observed, and lower limits at the 95% confidence level are obtained on the mass of the lightest neutralino, m(neutralino) > 220 GeV (for c tau 6000 mm (for m(neutralino) < 150 GeV)